Tetrazol

General

Tetrazoles are a class of synthetic organic heterocyclic compound, consisting of a 5-member ring of four nitrogen atoms and one carbon atom. Tetrazoles can act as bioisosteres for carboxylate groups because they have similar pKa and are deprotonated at physiological pH. Building block for many inhibitors of enzymes
Inhibitor Main targeted enzyme families Type Structure
Valsartan Pectinacetylesterase-Notum Not AlphaBeta Hydrolase target Drug Tetrazol Biphenyl
Fragment-923 Pectinacetylesterase-Notum Fragment inhibitor of Notum Tetrazol
HALSTS-1Q9 Haloalkane_dehalogenase-HLD2 HaloTag-ligand Tetrazol
HALSTS1 Haloalkane_dehalogenase-HLD2 HaloTag-ligand Tetrazol Organochlorine
AM6701 ABHD6-Lip Monoglyceridelipase_lysophospholip Biphenyl Urea derivative Cannabinoid-Receptor-ligand FAAH inhibitor Multitarget Carboxamide Tetrazol
LY2183240 Monoglyceridelipase_lysophospholip Arylacetamide_deacetylase ABHD6-Lip Cannabinoid-Receptor-ligand Biphenyl Urea derivative FAAH inhibitor Multitarget Carboxamide Tetrazol
Valsartan Pectinacetylesterase-Notum Not AlphaBeta Hydrolase target Drug Tetrazol Biphenyl
Fragment-923 Pectinacetylesterase-Notum Fragment inhibitor of Notum Tetrazol
HALSTS-1Q9 Haloalkane_dehalogenase-HLD2 HaloTag-ligand Tetrazol
HALSTS1 Haloalkane_dehalogenase-HLD2 HaloTag-ligand Tetrazol Organochlorine
AM6701 ABHD6-Lip Monoglyceridelipase_lysophospholip Biphenyl Urea derivative Cannabinoid-Receptor-ligand FAAH inhibitor Multitarget Carboxamide Tetrazol
LY2183240 Monoglyceridelipase_lysophospholip Arylacetamide_deacetylase ABHD6-Lip Cannabinoid-Receptor-ligand Biphenyl Urea derivative FAAH inhibitor Multitarget Carboxamide Tetrazol
Valsartan Pectinacetylesterase-Notum Not AlphaBeta Hydrolase target Drug Tetrazol Biphenyl
Fragment-923 Pectinacetylesterase-Notum Fragment inhibitor of Notum Tetrazol
HALSTS-1Q9 Haloalkane_dehalogenase-HLD2 HaloTag-ligand Tetrazol
HALSTS1 Haloalkane_dehalogenase-HLD2 HaloTag-ligand Tetrazol Organochlorine
AM6701 ABHD6-Lip Monoglyceridelipase_lysophospholip Biphenyl Urea derivative Cannabinoid-Receptor-ligand FAAH inhibitor Multitarget Carboxamide Tetrazol
LY2183240 Monoglyceridelipase_lysophospholip Arylacetamide_deacetylase ABHD6-Lip Cannabinoid-Receptor-ligand Biphenyl Urea derivative FAAH inhibitor Multitarget Carboxamide Tetrazol