Dasilva C

References (3)

Title : The grapevine genome sequence suggests ancestral hexaploidization in major angiosperm phyla - Jaillon_2007_Nature_449_463
Author(s) : Jaillon O , Aury JM , Noel B , Policriti A , Clepet C , Casagrande A , Choisne N , Aubourg S , Vitulo N , Jubin C , Vezzi A , Legeai F , Hugueney P , Dasilva C , Horner D , Mica E , Jublot D , Poulain J , Bruyere C , Billault A , Segurens B , Gouyvenoux M , Ugarte E , Cattonaro F , Anthouard V , Vico V , Del Fabbro C , Alaux M , Di Gaspero G , Dumas V , Felice N , Paillard S , Juman I , Moroldo M , Scalabrin S , Canaguier A , Le Clainche I , Malacrida G , Durand E , Pesole G , Laucou V , Chatelet P , Merdinoglu D , Delledonne M , Pezzotti M , Lecharny A , Scarpelli C , Artiguenave F , Pe ME , Valle G , Morgante M , Caboche M , Adam-Blondon AF , Weissenbach J , Quetier F , Wincker P
Ref : Nature , 449 :463 , 2007
Abstract : The analysis of the first plant genomes provided unexpected evidence for genome duplication events in species that had previously been considered as true diploids on the basis of their genetics. These polyploidization events may have had important consequences in plant evolution, in particular for species radiation and adaptation and for the modulation of functional capacities. Here we report a high-quality draft of the genome sequence of grapevine (Vitis vinifera) obtained from a highly homozygous genotype. The draft sequence of the grapevine genome is the fourth one produced so far for flowering plants, the second for a woody species and the first for a fruit crop (cultivated for both fruit and beverage). Grapevine was selected because of its important place in the cultural heritage of humanity beginning during the Neolithic period. Several large expansions of gene families with roles in aromatic features are observed. The grapevine genome has not undergone recent genome duplication, thus enabling the discovery of ancestral traits and features of the genetic organization of flowering plants. This analysis reveals the contribution of three ancestral genomes to the grapevine haploid content. This ancestral arrangement is common to many dicotyledonous plants but is absent from the genome of rice, which is a monocotyledon. Furthermore, we explain the chronology of previously described whole-genome duplication events in the evolution of flowering plants.
ESTHER : Jaillon_2007_Nature_449_463
PubMedSearch : Jaillon_2007_Nature_449_463
PubMedID: 17721507
Gene_locus related to this paper: vitvi-a5b6n6 , vitvi-a5b7c0 , vitvi-a5b8l9 , vitvi-a5bji4 , vitvi-a5bxd7 , vitvi-a5c1g2 , vitvi-a5c8p7 , vitvi-a7ntu2 , vitvi-a7pnb4 , vitvi-a7pus9 , vitvi-a7q3d1 , vitvi-a7qpz3 , vitvi-BIG8.1 , vitvi-d7sqb8 , vitvi-d7ssp2 , vitvi-d7sx57 , vitvi-d7t734 , vitvi-d7t940 , vitvi-d7tef1 , vitvi-d7tg96 , vitvi-d7tle9 , vitvi-d7tmb8 , vitvi-d7tpk8 , vitvi-d7tve2 , vitvi-d7tvr0 , vitvi-d7ubd6 , vitvi-f6hhx5 , vitvi-f6hi76 , vitvi-f6hqe0 , vitvi-f6hzf1.1 , vitvi-f6hzf1.2 , vitvi-d7ssd7 , vitvi-d7ssd8 , vitvi-d7ssd9 , vitvi-d7u935 , vitvi-f6gyw1 , vitvi-f6gyw2 , vitvi-f6gyw4 , vitvi-f6hqf1 , vitvi-f6hqf4 , vitvi-d7tum4 , vitvi-d7tba3 , vitvi-d7stm8 , vitvi-d7t3j3 , vitvi-d7uce5 , vitvi-f6he55 , vitvi-d7thp4 , vitvi-d7tfe6 , vitvi-e0cv10 , vitvi-f6gtp7 , vitvi-f6hva3 , vitvi-d7tqu0 , vitvi-f6hqq0 , vitvi-d7tci5 , vitvi-d7sut7 , vitvi-d7sut6 , vitvi-f6h317 , vitvi-f6h318 , vitvi-f6hsf1 , vitvi-f6hqd1 , vitvi-f6hqd0 , vitvi-f6hfp6 , vitvi-d7u2i4 , vitvi-f6gsx7 , vitvi-d7si01 , vitvi-d7si06 , vitvi-f6hz08 , vitvi-d7tr61 , vitvi-e0crl0 , vitvi-f6hrz4 , vitvi-f6i7l0

Title : Genome duplication in the teleost fish Tetraodon nigroviridis reveals the early vertebrate proto-karyotype - Jaillon_2004_Nature_431_946
Author(s) : Jaillon O , Aury JM , Brunet F , Petit JL , Stange-Thomann N , Mauceli E , Bouneau L , Fischer C , Ozouf-Costaz C , Bernot A , Nicaud S , Jaffe D , Fisher S , Lutfalla G , Dossat C , Segurens B , Dasilva C , Salanoubat M , Levy M , Boudet N , Castellano S , Anthouard V , Jubin C , Castelli V , Katinka M , Vacherie B , Biemont C , Skalli Z , Cattolico L , Poulain J , de Berardinis V , Cruaud C , Duprat S , Brottier P , Coutanceau JP , Gouzy J , Parra G , Lardier G , Chapple C , McKernan KJ , McEwan P , Bosak S , Kellis M , Volff JN , Guigo R , Zody MC , Mesirov J , Lindblad-Toh K , Birren B , Nusbaum C , Kahn D , Robinson-Rechavi M , Laudet V , Schachter V , Quetier F , Saurin W , Scarpelli C , Wincker P , Lander ES , Weissenbach J , Roest Crollius H
Ref : Nature , 431 :946 , 2004
Abstract : Tetraodon nigroviridis is a freshwater puffer fish with the smallest known vertebrate genome. Here, we report a draft genome sequence with long-range linkage and substantial anchoring to the 21 Tetraodon chromosomes. Genome analysis provides a greatly improved fish gene catalogue, including identifying key genes previously thought to be absent in fish. Comparison with other vertebrates and a urochordate indicates that fish proteins have diverged markedly faster than their mammalian homologues. Comparison with the human genome suggests approximately 900 previously unannotated human genes. Analysis of the Tetraodon and human genomes shows that whole-genome duplication occurred in the teleost fish lineage, subsequent to its divergence from mammals. The analysis also makes it possible to infer the basic structure of the ancestral bony vertebrate genome, which was composed of 12 chromosomes, and to reconstruct much of the evolutionary history of ancient and recent chromosome rearrangements leading to the modern human karyotype.
ESTHER : Jaillon_2004_Nature_431_946
PubMedSearch : Jaillon_2004_Nature_431_946
PubMedID: 15496914
Gene_locus related to this paper: tetng-3neur , tetng-4neur , tetng-ACHE , tetng-BCHE , tetng-h3cfz4 , tetng-h3ci57 , tetng-h3cl30 , tetng-h3cnh2 , tetng-nlgn2b , tetng-h3czr1 , tetng-h3dbr5 , tetng-nlgn2a , tetng-nlgn3b , tetng-q4ref8 , tetng-q4rjp3 , tetng-q4rjy3 , tetng-q4rk53 , tetng-q4rk63 , tetng-q4rk66 , tetng-q4rkk3 , tetng-q4rli3 , tetng-q4rn09 , tetng-q4rqj4 , tetng-q4rqz6 , tetng-q4rr22 , tetng-q4rru9 , tetng-q4rtq6 , tetng-q4rvf8 , tetng-q4rwa0 , tetng-q4rx90 , tetng-q4ryv8 , tetng-q4ryz3 , tetng-q4s0h8 , tetng-q4s5x0 , tetng-q4s6r1 , tetng-q4s6t6 , tetng-q4s7e3 , tetng-q4s7x6 , tetng-q4s8t5 , tetng-q4s9w9 , tetng-q4s050 , tetng-q4s091 , tetng-q4s144 , tetng-q4s309 , tetng-q4s578 , tetng-q4sal4 , tetng-q4sbm6 , tetng-q4sbp0 , tetng-q4sbu0 , tetng-q4sd49 , tetng-q4ser6 , tetng-q4sfm7 , tetng-q4sgm5 , tetng-q4sgv2 , tetng-q4sh74 , tetng-q4shl7 , tetng-q4si60 , tetng-q4sie5 , tetng-q4sku6 , tetng-q4smu0 , tetng-q4smy3 , tetng-q4snp0 , tetng-q4snq3 , tetng-q4spa7 , tetng-q4spq0 , tetng-q4sqr3 , tetng-q4sty0 , tetng-q4suu2 , tetng-q4suz1 , tetng-q4sxh3 , tetng-q4syn6 , tetng-q4szk0 , tetng-q4szy0 , tetng-q4t3m9 , tetng-q4t4a1 , tetng-q4t6m1 , tetng-q4t7r6 , tetng-q4t173 , tetng-q4t826 , tetng-q4t920 , tetng-q4ta33 , tetng-q4tab8 , tetng-q4tb62 , tetng-q4tbe2 , tetng-h3dbw2 , tetng-h3cpc8 , tetng-h3cjy0 , tetng-h3d966 , tetng-h3d3e3 , tetng-h3d961 , tetng-h3ctg6 , tetng-h3dde8 , tetng-h3dde9 , tetng-h3det9 , tetng-h3cre8 , tetng-h3dfb4 , tetng-h3clj8

Title : Hypothemycin inhibits the proliferative response and modulates the production of cytokines during T cell activation - Camacho_1999_Immunopharmacology_44_255
Author(s) : Camacho R , Staruch MJ , Dasilva C , Koprak S , Sewell T , Salituro G , Dumont FJ
Ref : Immunopharmacology , 44 :255 , 1999
Abstract : Hypothemycin, a resorcylic acid lactone antibiotic, was identified as active in a screen for inhibitors of T cell activation. It was found to inhibit the proliferation of mouse and human T cells stimulated with anti-CD3 mAb + PMA and of human PBMC stimulated with anti-CD3 mAb alone. This inhibition was partially reversed by exogenous IL-2 indicating that it is not due to non-specific toxicity. Hypothemycin potently suppressed the production of IL-2 (IC50: 9 nM) but affected IL-2-induced proliferation to a lesser extent (IC50: 194 nM). Hypothemycin also inhibited IL-6, IL-10, IFN-gamma and TNF-alpha production. By contrast, it markedly enhanced the production of IL-4, IL-5 and IL-13. These effects were seen both at the mRNA and protein secretion levels. Analysis of the effect of hypothemycin on CD69 induction suggested that it disrupts calcineurin-independent rather than calcineurin-dependent signaling. Furthermore, hypothemycin was able to inhibit the phosphorylation of ERK1/2 induced by PMA treatment of T cells. Therefore, hypothemycin represents an inhibitor of T cell activation with a novel mode of action and unique modulatory activity on cytokine production.
ESTHER : Camacho_1999_Immunopharmacology_44_255
PubMedSearch : Camacho_1999_Immunopharmacology_44_255
PubMedID: 10598882
Gene_locus related to this paper: hypsb-hpm3