Yoshizaki F

References (6)

Title : Abietane-type diterpenoids from the roots of Caryopteris mongolica and their cholinesterase inhibitory activities - Murata_2016_Phytochemistry_130_152
Author(s) : Murata T , Ishikawa Y , Saruul E , Selenge E , Sasaki K , Umehara K , Yoshizaki F , Batkhuu J
Ref : Phytochemistry , 130 :152 , 2016
Abstract : Eleven abietane-type diterpenoids and two known abietanes were isolated from the roots of Caryopteris mongolica, and their structures were characterized. The absolute configurations at C-5 and C-10 were determined from the NMR data, including from the nuclear Overhauser effect and CD spectra, and the absolute configuration of C-16 in the hydroxypropyl group was determined via a modified Mosher's method. Furthermore, the previously unknown absolute configuration of the C-15 of cyrtophyllone B was determined to be in an R-configuration using X-ray crystallography. To estimate the preventive effects of the isolates for neurodegenerative disease development, their inhibitory activities against acetylcholinesterase (AChE) from human erythrocytes and butyrylcholinesterase (BChE) from horse serum were evaluated.
ESTHER : Murata_2016_Phytochemistry_130_152
PubMedSearch : Murata_2016_Phytochemistry_130_152
PubMedID: 27298275

Title : Cholinesterase-inhibitory diterpenoids and chemical constituents from aerial parts of Caryopteris mongolica - Murata_2015_J.Nat.Med_69_471
Author(s) : Murata T , Selenge E , Oikawa S , Ageishi K , Batkhuu J , Sasaki K , Yoshizaki F
Ref : J Nat Med , 69 :471 , 2015
Abstract : A diterpenoid diglucoside (12,19-di-O-beta-D-glucopyranosyl-11-hydroxyabieta-8,11,13-triene-19-one), isoscutellarein 7-O-[beta-D-xylopyranosyl-(1-->2)]-beta-D-glucopyranoside, isoscutellarein 7-O-[alpha-L-rhamnopyranosyl-(1-->2)]-beta-D-glucopyranoside, hypolaetin 7-O-[6''-O-(p-E-coumaroyl)]-beta-D-glucopyranoside, hypolaetin 7-O-[6''-O-(E-caffeoyl)]-beta-D-glucopyranoside, and 15 known compounds were isolated from aerial parts of the Mongolian medicinal plant Caryopteris mongolica. The cholinesterase-inhibitory activities of the constituents were estimated. The abietane diterpenoids (12-O-demethylcryptojaponol and 6alpha-hydroxydemethylcryptojaponol) showed potent inhibitory activity against acetylcholinesterase from human erythrocytes and electric eel, and against butyrylcholinesterase from horse serum.
ESTHER : Murata_2015_J.Nat.Med_69_471
PubMedSearch : Murata_2015_J.Nat.Med_69_471
PubMedID: 25900047

Title : A lipase inhibitor monoterpene and monoterpene glycosides from Monarda punctata - Yamada_2010_Phytochemistry_71_1884
Author(s) : Yamada K , Murata T , Kobayashi K , Miyase T , Yoshizaki F
Ref : Phytochemistry , 71 :1884 , 2010
Abstract : An 80% acetone extract of Monarda punctata showed an inhibitory effect on lipase activity in isolated mouse plasma in vitro and carvacrol was obtained as the active constituent. It had an IC(5)(0) value of 4.07 mM invitro and suppressed elevations in blood triacylglycerol levels in olive oil-loaded mice. Furthermore, from the whole plant, 22 compounds were isolated. Six monoterpene glycosides, a flavone glucuronide, and other known compounds were identified based on the results of spectroscopic analyses.
ESTHER : Yamada_2010_Phytochemistry_71_1884
PubMedSearch : Yamada_2010_Phytochemistry_71_1884
PubMedID: 20832830

Title : Inhibitory effect of Myrica bark on lipase activity in mouse plasma and gastrointestinal tract - Kobayashi_2008_J.Med.Food_11_289
Author(s) : Kobayashi K , Ihara S , Kobata A , Itoh K , Kusunoki N , Yoshizaki F
Ref : J Med Food , 11 :289 , 2008
Abstract : As the methanol extract of Myrica bark inhibited the activity of lipase in isolated mouse plasma in vitro, the influence of the extract on this enzyme in the gastrointestinal tube was investigated after oral intake. The methanol extract depressed the elevation of blood triglyceride level in olive oil-fed mice. Myricetin and gallic acid were suspected to be responsible for the inhibition of the lipase activity in isolated mouse plasma in vitro. The contents of myricetin and gallic acid in the methanol extract seemed to be insufficient for the appearance of the depressive activity of the extract on lipase in the gastrointestinal tract in vivo. Myricitrin, which is present in abundance in the methanol extract (about 61%), did not show the inhibitory activity. However, this material suppressed the elevation of blood triglyceride level to a slightly smaller extent compared with the methanol extract by oral administration. Consequently, it was proposed that myricitrin may function as a prodrug, which reveals its activity after conversion to myricetin, the active substance, by enterobacilli in the gastrointestinal tract.
ESTHER : Kobayashi_2008_J.Med.Food_11_289
PubMedSearch : Kobayashi_2008_J.Med.Food_11_289
PubMedID: 18598171

Title : Constituents of Rhodiola rosea showing inhibitory effect on lipase activity in mouse plasma and alimentary canal - Kobayashi_2008_Planta.Med_74_1716
Author(s) : Kobayashi K , Yamada K , Murata T , Hasegawa T , Takano F , Koga K , Fushiya S , Batkhuu J , Yoshizaki F
Ref : Planta Med , 74 :1716 , 2008
Abstract : As a methanol extract of the rhizome of Rhodiola rosea inhibits the activity of lipase in isolated mouse plasma in vitro and in the mouse gastrointestinal tube in vivo, the active components in this plant were investigated. After fractionation and separation processes, rhodionin and rhodiosin were isolated as active ingredients. Their IC50 values were 0.093 mM and 0.133 mM in vitro, respectively. Both compounds significantly suppressed the elevation of the postprandial blood triglyceride level, e.g., by 45.6 % (150 mg/kg, 60 min after oral administration) and 57.6 % (200 mg/kg, 180 min after oral administration), respectively. Consequently, we anticipate the application of this plant and its constituents to the treatment of lifestyle-related diseases such as hyperlipidemia and exogeneous obesity and to health foods.
ESTHER : Kobayashi_2008_Planta.Med_74_1716
PubMedSearch : Kobayashi_2008_Planta.Med_74_1716
PubMedID: 18982538

Title : The draft genome of Ciona intestinalis: insights into chordate and vertebrate origins - Dehal_2002_Science_298_2157
Author(s) : Dehal P , Satou Y , Campbell RK , Chapman J , Degnan B , De Tomaso A , Davidson B , Di Gregorio A , Gelpke M , Goodstein DM , Harafuji N , Hastings KE , Ho I , Hotta K , Huang W , Kawashima T , Lemaire P , Martinez D , Meinertzhagen IA , Necula S , Nonaka M , Putnam N , Rash S , Saiga H , Satake M , Terry A , Yamada L , Wang HG , Awazu S , Azumi K , Boore J , Branno M , Chin-Bow S , DeSantis R , Doyle S , Francino P , Keys DN , Haga S , Hayashi H , Hino K , Imai KS , Inaba K , Kano S , Kobayashi K , Kobayashi M , Lee BI , Makabe KW , Manohar C , Matassi G , Medina M , Mochizuki Y , Mount S , Morishita T , Miura S , Nakayama A , Nishizaka S , Nomoto H , Ohta F , Oishi K , Rigoutsos I , Sano M , Sasaki A , Sasakura Y , Shoguchi E , Shin-I T , Spagnuolo A , Stainier D , Suzuki MM , Tassy O , Takatori N , Tokuoka M , Yagi K , Yoshizaki F , Wada S , Zhang C , Hyatt PD , Larimer F , Detter C , Doggett N , Glavina T , Hawkins T , Richardson P , Lucas S , Kohara Y , Levine M , Satoh N , Rokhsar DS
Ref : Science , 298 :2157 , 2002
Abstract : The first chordates appear in the fossil record at the time of the Cambrian explosion, nearly 550 million years ago. The modern ascidian tadpole represents a plausible approximation to these ancestral chordates. To illuminate the origins of chordate and vertebrates, we generated a draft of the protein-coding portion of the genome of the most studied ascidian, Ciona intestinalis. The Ciona genome contains approximately 16,000 protein-coding genes, similar to the number in other invertebrates, but only half that found in vertebrates. Vertebrate gene families are typically found in simplified form in Ciona, suggesting that ascidians contain the basic ancestral complement of genes involved in cell signaling and development. The ascidian genome has also acquired a number of lineage-specific innovations, including a group of genes engaged in cellulose metabolism that are related to those in bacteria and fungi.
ESTHER : Dehal_2002_Science_298_2157
PubMedSearch : Dehal_2002_Science_298_2157
PubMedID: 12481130
Gene_locus related to this paper: cioin-141645 , cioin-147959 , cioin-150181 , cioin-154370 , cioin-ACHE1 , cioin-ACHE2 , cioin-cxest , cioin-f6qcp0 , cioin-f6r8z1 , cioin-f6u176 , cioin-f6vac9 , cioin-f6x584 , cioin-f6xa69 , cioin-f6y403 , cioin-h2xqb4 , cioin-H2XTI0 , cioin-F6T1M3 , cioin-H2XUP7 , cioin-CIN.7233 , cioin-F6V269 , cioin-Cin16330 , cioin-h2xua2 , cioin-f6vaa5 , cioin-f6v9x6 , cioin-f6swc9 , cioin-f7amz2 , cioin-f6s021 , cioin-h2xxq9 , cioin-h2xne6 , cioin-f6ynr2