Nomoto H

References (4)

Title : Glycaemic control efficacy of switching from dipeptidyl peptidase-4 inhibitors to oral semaglutide in subjects with type 2 diabetes: A multicentre, prospective, randomized, open-label, parallel-group comparison study (SWITCH-SEMA 2 study) - Furusawa_2023_Diabetes.Obes.Metab__
Author(s) : Furusawa S , Nomoto H , Yokoyama H , Suzuki Y , Tsuzuki A , Takahashi K , Miya A , Kameda H , Cho KY , Takeuchi J , Nagai S , Taneda S , Kurihara Y , Nakamura A , Atsumi T
Ref : Diabetes Obes Metab , : , 2023
Abstract : AIM: To assess whether oral semaglutide provides better glycaemic control, compared with dipeptidyl peptidase-4 inhibitor (DPP-4i) continuation, in people with type 2 diabetes. MATERIALS AND METHODS: In this multicentre, open-label, prospective, randomized, parallel-group comparison study, participants receiving DPP-4is were either switched to oral semaglutide (3-14 mg/day) or continued on DPP-4is. The primary endpoint was the change in glycated haemoglobin (HbA1c) over 24 weeks. Secondary endpoints included changes in metabolic parameters and biomarkers, along with the occurrence of adverse events. Factors associated with HbA1c improvement were also explored. RESULTS: In total, 174 eligible participants were enrolled; 17 dropped out of the study. Consequently, 82 participants in the DPP-4i group and 75 participants in the semaglutide group completed the study and were included in the analysis. Improvement in HbA1c at week 24 was significantly greater when switching to semaglutide compared with DPP-4i continuation [-0.65 (95% confidence interval: -0.79, -0.51) vs. +0.05 (95% confidence interval: -0.07, 0.16) (p < .001)]. Body weight, lipid profiles and liver enzymes were significantly improved in the semaglutide group than in the DPP-4i continuation group. Multiple linear regression analysis revealed that baseline HbA1c and homeostasis model assessment 2-R were independently associated with HbA1c improvement after switching to semaglutide. Seven participants in the semaglutide group discontinued medication because of gastrointestinal symptoms. CONCLUSIONS: Although the potential for gastrointestinal symptoms should be carefully considered, switching from DPP-4is to oral semaglutide may be beneficial for glycaemic control and metabolic abnormalities in people with higher HbA1c and insulin resistance.
ESTHER : Furusawa_2023_Diabetes.Obes.Metab__
PubMedSearch : Furusawa_2023_Diabetes.Obes.Metab__
PubMedID: 38073422

Title : The medaka draft genome and insights into vertebrate genome evolution - Kasahara_2007_Nature_447_714
Author(s) : Kasahara M , Naruse K , Sasaki S , Nakatani Y , Qu W , Ahsan B , Yamada T , Nagayasu Y , Doi K , Kasai Y , Jindo T , Kobayashi D , Shimada A , Toyoda A , Kuroki Y , Fujiyama A , Sasaki T , Shimizu A , Asakawa S , Shimizu N , Hashimoto S , Yang J , Lee Y , Matsushima K , Sugano S , Sakaizumi M , Narita T , Ohishi K , Haga S , Ohta F , Nomoto H , Nogata K , Morishita T , Endo T , Shin IT , Takeda H , Morishita S , Kohara Y
Ref : Nature , 447 :714 , 2007
Abstract : Teleosts comprise more than half of all vertebrate species and have adapted to a variety of marine and freshwater habitats. Their genome evolution and diversification are important subjects for the understanding of vertebrate evolution. Although draft genome sequences of two pufferfishes have been published, analysis of more fish genomes is desirable. Here we report a high-quality draft genome sequence of a small egg-laying freshwater teleost, medaka (Oryzias latipes). Medaka is native to East Asia and an excellent model system for a wide range of biology, including ecotoxicology, carcinogenesis, sex determination and developmental genetics. In the assembled medaka genome (700 megabases), which is less than half of the zebrafish genome, we predicted 20,141 genes, including approximately 2,900 new genes, using 5'-end serial analysis of gene expression tag information. We found single nucleotide polymorphisms (SNPs) at an average rate of 3.42% between the two inbred strains derived from two regional populations; this is the highest SNP rate seen in any vertebrate species. Analyses based on the dense SNP information show a strict genetic separation of 4 million years (Myr) between the two populations, and suggest that differential selective pressures acted on specific gene categories. Four-way comparisons with the human, pufferfish (Tetraodon), zebrafish and medaka genomes revealed that eight major interchromosomal rearrangements took place in a remarkably short period of approximately 50 Myr after the whole-genome duplication event in the teleost ancestor and afterwards, intriguingly, the medaka genome preserved its ancestral karyotype for more than 300 Myr.
ESTHER : Kasahara_2007_Nature_447_714
PubMedSearch : Kasahara_2007_Nature_447_714
PubMedID: 17554307
Gene_locus related to this paper: fugru-3cxest , fugru-4cxest , fugru-4neur , fugru-ACHE , fugru-ACHEE , fugru-balip , fugru-BCHE , fugru-BCHEB , fugru-cxest , oryla-ACHE , oryla-BCHE , oryla-d2x2i4 , oryla-h2m6h1 , oryla-h2m7w4 , oryla-h2m361 , oryla-h2mbn6 , oryla-h2mfw1 , oryla-h2mhi0 , oryla-h2mhl7 , oryla-h2mpb5 , oryla-h2mqz5 , oryla-h2mvs7 , oryla-h2mz49 , oryla-h2n1l9 , oryla-nlgn2 , takru-1neur , takru-2bneur , takru-3bneur , takru-h2rke7 , takru-h2rmg3 , takru-h2rsj9 , takru-h2rw77 , takru-h2ryq0 , takru-h2sci9 , takru-h2se90 , takru-h2spg7 , takru-h2sxi1 , takru-h2ts55 , takru-h2ts56 , takru-h2uxa9 , takru-h2vaf1 , takru-nlgn2a , takru-nlgn3a , takru-nlgn4a , oryla-h2mff8 , oryla-h2m2f0 , oryla-h2ler5 , takru-h2tsm6 , takru-h2tq49 , takru-h2tq47 , takru-h2s286 , takru-h2tng4 , takru-h2tq50 , takru-h2tng3 , takru-h2tng2 , oryla-h2lj38 , oryla-h2mxe6 , takru-h2tq48 , oryla-h2lf11 , takru-h2u5j0 , takru-h2rpm8 , oryla-h2n273 , oryla-h2n271 , oryla-h2lum7 , takru-h2tpz2 , takru-h2u3j1 , oryla-h2mdv3 , takru-h2tzm9 , takru-h2u8u6 , oryla-h2lcw8 , oryla-h2lc35 , oryla-h2ln66 , oryla-h2m8k0 , oryla-h2mdj7 , oryla-h2lw61 , oryla-h2lxe3 , oryla-h2l8y7 , oryla-h2mr84 , oryla-h2mr95 , oryla-h2mcz6 , oryla-h2lxr5 , oryla-h2ly57 , oryla-a0a3p9kz03 , oryla-a0a3p9hfu1 , oryla-h2m307 , oryla-h2lch5 , oryla-h2ldw9 , oryla-a0a3b3ic40 , oryla-h2ldi5 , oryla-h2mun1 , oryla-a0a3p9jla3

Title : Genome sequence of the ultrasmall unicellular red alga Cyanidioschyzon merolae 10D - Matsuzaki_2004_Nature_428_653
Author(s) : Matsuzaki M , Misumi O , Shin IT , Maruyama S , Takahara M , Miyagishima SY , Mori T , Nishida K , Yagisawa F , Yoshida Y , Nishimura Y , Nakao S , Kobayashi T , Momoyama Y , Higashiyama T , Minoda A , Sano M , Nomoto H , Oishi K , Hayashi H , Ohta F , Nishizaka S , Haga S , Miura S , Morishita T , Kabeya Y , Terasawa K , Suzuki Y , Ishii Y , Asakawa S , Takano H , Ohta N , Kuroiwa H , Tanaka K , Shimizu N , Sugano S , Sato N , Nozaki H , Ogasawara N , Kohara Y , Kuroiwa T
Ref : Nature , 428 :653 , 2004
Abstract : Small, compact genomes of ultrasmall unicellular algae provide information on the basic and essential genes that support the lives of photosynthetic eukaryotes, including higher plants. Here we report the 16,520,305-base-pair sequence of the 20 chromosomes of the unicellular red alga Cyanidioschyzon merolae 10D as the first complete algal genome. We identified 5,331 genes in total, of which at least 86.3% were expressed. Unique characteristics of this genomic structure include: a lack of introns in all but 26 genes; only three copies of ribosomal DNA units that maintain the nucleolus; and two dynamin genes that are involved only in the division of mitochondria and plastids. The conserved mosaic origin of Calvin cycle enzymes in this red alga and in green plants supports the hypothesis of the existence of single primary plastid endosymbiosis. The lack of a myosin gene, in addition to the unexpressed actin gene, suggests a simpler system of cytokinesis. These results indicate that the C. merolae genome provides a model system with a simple gene composition for studying the origin, evolution and fundamental mechanisms of eukaryotic cells.
ESTHER : Matsuzaki_2004_Nature_428_653
PubMedSearch : Matsuzaki_2004_Nature_428_653
PubMedID: 15071595
Gene_locus related to this paper: cyam1-m1vi61 , cyam1-m1vhh9

Title : The draft genome of Ciona intestinalis: insights into chordate and vertebrate origins - Dehal_2002_Science_298_2157
Author(s) : Dehal P , Satou Y , Campbell RK , Chapman J , Degnan B , De Tomaso A , Davidson B , Di Gregorio A , Gelpke M , Goodstein DM , Harafuji N , Hastings KE , Ho I , Hotta K , Huang W , Kawashima T , Lemaire P , Martinez D , Meinertzhagen IA , Necula S , Nonaka M , Putnam N , Rash S , Saiga H , Satake M , Terry A , Yamada L , Wang HG , Awazu S , Azumi K , Boore J , Branno M , Chin-Bow S , DeSantis R , Doyle S , Francino P , Keys DN , Haga S , Hayashi H , Hino K , Imai KS , Inaba K , Kano S , Kobayashi K , Kobayashi M , Lee BI , Makabe KW , Manohar C , Matassi G , Medina M , Mochizuki Y , Mount S , Morishita T , Miura S , Nakayama A , Nishizaka S , Nomoto H , Ohta F , Oishi K , Rigoutsos I , Sano M , Sasaki A , Sasakura Y , Shoguchi E , Shin-I T , Spagnuolo A , Stainier D , Suzuki MM , Tassy O , Takatori N , Tokuoka M , Yagi K , Yoshizaki F , Wada S , Zhang C , Hyatt PD , Larimer F , Detter C , Doggett N , Glavina T , Hawkins T , Richardson P , Lucas S , Kohara Y , Levine M , Satoh N , Rokhsar DS
Ref : Science , 298 :2157 , 2002
Abstract : The first chordates appear in the fossil record at the time of the Cambrian explosion, nearly 550 million years ago. The modern ascidian tadpole represents a plausible approximation to these ancestral chordates. To illuminate the origins of chordate and vertebrates, we generated a draft of the protein-coding portion of the genome of the most studied ascidian, Ciona intestinalis. The Ciona genome contains approximately 16,000 protein-coding genes, similar to the number in other invertebrates, but only half that found in vertebrates. Vertebrate gene families are typically found in simplified form in Ciona, suggesting that ascidians contain the basic ancestral complement of genes involved in cell signaling and development. The ascidian genome has also acquired a number of lineage-specific innovations, including a group of genes engaged in cellulose metabolism that are related to those in bacteria and fungi.
ESTHER : Dehal_2002_Science_298_2157
PubMedSearch : Dehal_2002_Science_298_2157
PubMedID: 12481130
Gene_locus related to this paper: cioin-141645 , cioin-147959 , cioin-150181 , cioin-154370 , cioin-ACHE1 , cioin-ACHE2 , cioin-cxest , cioin-f6qcp0 , cioin-f6r8z1 , cioin-f6u176 , cioin-f6vac9 , cioin-f6x584 , cioin-f6xa69 , cioin-f6y403 , cioin-h2xqb4 , cioin-H2XTI0 , cioin-F6T1M3 , cioin-H2XUP7 , cioin-CIN.7233 , cioin-F6V269 , cioin-Cin16330 , cioin-h2xua2 , cioin-f6vaa5 , cioin-f6v9x6 , cioin-f6swc9 , cioin-f7amz2 , cioin-f6s021 , cioin-h2xxq9 , cioin-h2xne6 , cioin-f6ynr2