Full name : Ariel Naomi
First name : Naomi
Mail : Israel Institute for Biological Research, PO Box 19, Ness-Ziona 70450
Zip Code :
City :
Country : Israel
Email : ariel@iibr.gov.il
Phone : 972-8-938-1529
Fax : 972-8-940-1404
Website :
Directory :
| Title : Poster (14) The aromatic trapping of histidine 447 in catalysis of acetylcholinesterases - |
| Author(s) : Shafferman A , Barak D , Kaplan D , Ordentlich A , Ariel N , Velan B |
| Ref : In: Cholinesterases in the Second Millennium: Biomolecular and Pathological Aspects , (Inestrosa NC, Campos EO) P. Universidad Catolica de Chile-FONDAP Biomedicina :327 , 2004 |
| PubMedID: |
| Title : The aromatic trapping of histidine 447 in catalysis of acetylcholinesterases - |
| Author(s) : Shafferman A , Barak D , Kaplan D , Ordentlich A , Ariel N , Velan B |
| Ref : In: Cholinesterases in the Second Millennium: Biomolecular and Pathological Aspects , (Inestrosa NC, Campos EO) P. Universidad Catolica de Chile-FONDAP Biomedicina :181 , 2004 |
| PubMedID: |
| Title : Surprising findings from the functional analysis of human acetylcholinesterase adducts of Alzheimer?s disease drugs. - |
| Author(s) : Ordentlich A , Barak D , Ariel N , Kronman C , Kaplan D , Velan B , Shafferman A |
| Ref : Cholinergic Mechanisms, CRC Press :177 , 2004 |
| PubMedID: |
| Title : Poster (21) Analysis of acetylcholinesterase adducts of alzheimer's drugs - |
| Author(s) : Ordentlich A , Kronman C , Barak D , Ariel N , Kaplan D , Velan B , Shafferman A |
| Ref : In: Cholinesterases in the Second Millennium: Biomolecular and Pathological Aspects , (Inestrosa NC, Campos EO) P. Universidad Catolica de Chile-FONDAP Biomedicina :332 , 2004 |
| PubMedID: |
| Title : Attempts to engineer an enzyme mimic of butyrylcholinesterase by substitution of the six divergent aromatic amino acids in the active center of acetylcholinesterase. - |
| Author(s) : Kaplan D , Ordentlich A , Barak D , Ariel N , Kronman C , Baruch V , Shafferman A |
| Ref : Cholinergic Mechanisms, CRC Press :601 , 2004 |
| PubMedID: |
| Title : The aromatic trapping of the catalytic histidine is essential for efficient catalysis in acetylcholinesterase - Barak_2002_Biochemistry_41_8245 |
| Author(s) : Barak D , Kaplan D , Ordentlich A , Ariel N , Velan B , Shafferman A |
| Ref : Biochemistry , 41 :8245 , 2002 |
| Abstract : Barak_2002_Biochemistry_41_8245 |
| ESTHER : Barak_2002_Biochemistry_41_8245 |
| PubMedSearch : Barak_2002_Biochemistry_41_8245 |
| PubMedID: 12081473 |
| Title : Does butyrylization of acetylcholinesterase through substitution of the six divergent aromatic amino acids in the active center gorge generate an enzyme mimic of butyrylcholinesterase? - Kaplan_2001_Biochemistry_40_7433 |
| Author(s) : Kaplan D , Ordentlich A , Barak D , Ariel N , Kronman C , Velan B , Shafferman A |
| Ref : Biochemistry , 40 :7433 , 2001 |
| Abstract : Kaplan_2001_Biochemistry_40_7433 |
| ESTHER : Kaplan_2001_Biochemistry_40_7433 |
| PubMedSearch : Kaplan_2001_Biochemistry_40_7433 |
| PubMedID: 11412096 |
| Title : Structures of recombinant native and E202Q mutant human acetylcholinesterase complexed with the snake-venom toxin fasciculin-II - Kryger_2000_Acta.Crystallogr.D.Biol.Crystallogr_56_1385 |
| Author(s) : Kryger G , Harel M , Giles K , Toker L , Velan B , Lazar A , Kronman C , Barak D , Ariel N , Shafferman A , Silman I , Sussman JL |
| Ref : Acta Crystallographica D Biol Crystallogr , 56 :1385 , 2000 |
| Abstract : Kryger_2000_Acta.Crystallogr.D.Biol.Crystallogr_56_1385 |
| ESTHER : Kryger_2000_Acta.Crystallogr.D.Biol.Crystallogr_56_1385 |
| PubMedSearch : Kryger_2000_Acta.Crystallogr.D.Biol.Crystallogr_56_1385 |
| PubMedID: 11053835 |
| Gene_locus related to this paper: human-ACHE |
| Title : Exploring the active center of human acetylcholinesterase with stereomers of an organophosphorus inhibitor with two chiral centers - Ordentlich_1999_Biochemistry_38_3055 |
| Author(s) : Ordentlich A , Barak D , Kronman C , Benschop HP , De Jong LP , Ariel N , Barak R , Segall Y , Velan B , Shafferman A |
| Ref : Biochemistry , 38 :3055 , 1999 |
| Abstract : Ordentlich_1999_Biochemistry_38_3055 |
| ESTHER : Ordentlich_1999_Biochemistry_38_3055 |
| PubMedSearch : Ordentlich_1999_Biochemistry_38_3055 |
| PubMedID: 10074358 |
| Title : 3D Structure of a Complex of Human Acetylcholinesterase with Fasciculin-II at 2.7 Resolution - |
| Author(s) : Kryger G , Giles K , Harel M , Toker L , Velan B , Lazar A , Kronman C , Barak D , Ariel N , Shafferman A , Silman I , Sussman JL |
| Ref : In: Structure and Function of Cholinesterases and Related Proteins - Proceedings of Sixth International Meeting on Cholinesterases , (Doctor, B.P., Taylor, P., Quinn, D.M., Rotundo, R.L., Gentry, M.K. Eds) Plenum Publishing Corp. :370 , 1998 |
| PubMedID: |
| Title : Compatibility of Structures Inferred from Mutagenesis and from X-Ray Crystallography for Various AChE Complexes - |
| Author(s) : Ariel N , Ordentlich A , Barak D , Bino T , Velan B , Shafferman A |
| Ref : In: Structure and Function of Cholinesterases and Related Proteins - Proceedings of Sixth International Meeting on Cholinesterases , (Doctor, B.P., Taylor, P., Quinn, D.M., Rotundo, R.L., Gentry, M.K. Eds) Plenum Publishing Corp. :375 , 1998 |
| PubMedID: |
| Title : The 'aromatic patch' of three proximal residues in the human acetylcholinesterase active centre allows for versatile interaction modes with inhibitors - Ariel_1998_Biochem.J_335_95 |
| Author(s) : Ariel N , Ordentlich A , Barak D , Bino T , Velan B , Shafferman A |
| Ref : Biochemical Journal , 335 :95 , 1998 |
| Abstract : Ariel_1998_Biochem.J_335_95 |
| ESTHER : Ariel_1998_Biochem.J_335_95 |
| PubMedSearch : Ariel_1998_Biochem.J_335_95 |
| PubMedID: 9742217 |
| Title : Structural Modifications of the Omega Loop in Human Acetylcholinesterase - |
| Author(s) : Ariel N , Velan B , Barak D , Leitner M , Bino T , Ordentlich A , Shafferman A |
| Ref : In: Structure and Function of Cholinesterases and Related Proteins - Proceedings of Sixth International Meeting on Cholinesterases , (Doctor, B.P., Taylor, P., Quinn, D.M., Rotundo, R.L., Gentry, M.K. Eds) Plenum Publishing Corp. :453 , 1998 |
| PubMedID: |
| Title : Contribution of the Active Center Functional Architecture to AChE Reactivity Toward Substrates and Inhibitors - |
| Author(s) : Shafferman A , Ordentlich A , Barak D , Kronman C , Ariel N , Velan B |
| Ref : In: Structure and Function of Cholinesterases and Related Proteins - Proceedings of Sixth International Meeting on Cholinesterases , (Doctor, B.P., Taylor, P., Quinn, D.M., Rotundo, R.L., Gentry, M.K. Eds) Plenum Publishing Corp. :203 , 1998 |
| PubMedID: |
| Title : Bovine acetylcholinesterase: cloning, expression and characterization - Mendelson_1998_Biochem.J_334_251 |
| Author(s) : Mendelson I , Kronman C , Ariel N , Shafferman A , Velan B |
| Ref : Biochemical Journal , 334 :251 , 1998 |
| Abstract : Mendelson_1998_Biochem.J_334_251 |
| ESTHER : Mendelson_1998_Biochem.J_334_251 |
| PubMedSearch : Mendelson_1998_Biochem.J_334_251 |
| PubMedID: 9693127 |
| Gene_locus related to this paper: bovin-ACHE |
| Title : Does Electrostatic Attraction or Steering by Charged Residues within the Gorge Contribute to the Reactivity of AChE? - |
| Author(s) : Ordentlich A , Barak D , Stein D , Berman D , Kronman C , Ariel N , Velan B , Shafferman A |
| Ref : In: Structure and Function of Cholinesterases and Related Proteins - Proceedings of Sixth International Meeting on Cholinesterases , (Doctor, B.P., Taylor, P., Quinn, D.M., Rotundo, R.L., Gentry, M.K. Eds) Plenum Publishing Corp. :234 , 1998 |
| PubMedID: |
| Title : Functional characteristics of the oxyanion hole in human acetylcholinesterase - Ordentlich_1998_J.Biol.Chem_273_19509 |
| Author(s) : Ordentlich A , Barak D , Kronman C , Ariel N , Segall Y , Velan B , Shafferman A |
| Ref : Journal of Biological Chemistry , 273 :19509 , 1998 |
| Abstract : Ordentlich_1998_J.Biol.Chem_273_19509 |
| ESTHER : Ordentlich_1998_J.Biol.Chem_273_19509 |
| PubMedSearch : Ordentlich_1998_J.Biol.Chem_273_19509 |
| PubMedID: 9677373 |
| Title : 3D Structure at 2.7 Resolution of Native and E202Q Mutant Human Acetylcholinesterase Complexed with Fasciculin-II - |
| Author(s) : Kryger G , Giles K , Harel M , Toker L , Velan B , Lazar A , Kronman C , Barak D , Ariel N , Shafferman A , Silman I , Sussman JL |
| Ref : In: Structure and Function of Cholinesterases and Related Proteins - Proceedings of Sixth International Meeting on Cholinesterases , (Doctor, B.P., Taylor, P., Quinn, D.M., Rotundo, R.L., Gentry, M.K. Eds) Plenum Publishing Corp. :323 , 1998 |
| PubMedID: |
| Title : Aging of somanyl-acetylcholinesterase adducts: facts and models [letter] - |
| Author(s) : Shafferman A , Ordentlich A , Barak D , Stein D , Ariel N , Velan B |
| Ref : Biochemical Journal , 324 :996 , 1997 |
| PubMedID: 9235881 |
| Title : The architecture of human acetylcholinesterase active center probed by interactions with selected organophosphate inhibitors - Ordentlich_1996_J.Biol.Chem_271_11953 |
| Author(s) : Ordentlich A , Barak D , Kronman C , Ariel N , Segall Y , Velan B , Shafferman A |
| Ref : Journal of Biological Chemistry , 271 :11953 , 1996 |
| Abstract : Ordentlich_1996_J.Biol.Chem_271_11953 |
| ESTHER : Ordentlich_1996_J.Biol.Chem_271_11953 |
| PubMedSearch : Ordentlich_1996_J.Biol.Chem_271_11953 |
| PubMedID: 8662593 |
| Title : Structural modifications of the omega loop in human acetylcholinesterase - Velan_1996_FEBS.Lett_395_22 |
| Author(s) : Velan B , Barak D , Ariel N , Leitner M , Bino T , Ordentlich A , Shafferman A |
| Ref : FEBS Letters , 395 :22 , 1996 |
| Abstract : Velan_1996_FEBS.Lett_395_22 |
| ESTHER : Velan_1996_FEBS.Lett_395_22 |
| PubMedSearch : Velan_1996_FEBS.Lett_395_22 |
| PubMedID: 8849682 |
| Title : Aging of phosphylated human acetylcholinesterase: catalytic processes mediated by aromatic and polar residues of the active centre - Shafferman_1996_Biochem.J_318_833 |
| Author(s) : Shafferman A , Ordentlich A , Barak D , Stein D , Ariel N , Velan B |
| Ref : Biochemical Journal , 318 :833 , 1996 |
| Abstract : Shafferman_1996_Biochem.J_318_833 |
| ESTHER : Shafferman_1996_Biochem.J_318_833 |
| PubMedSearch : Shafferman_1996_Biochem.J_318_833 |
| PubMedID: 8836126 |
| Title : Contribution of aromatic moieties of tyrosine 133 and of the anionic subsite tryptophan 86 to catalytic efficiency and allosteric modulation of acetylcholinesterase - Ordentlich_1995_J.Biol.Chem_270_2082 |
| Author(s) : Ordentlich A , Barak D , Kronman C , Ariel N , Segall Y , Velan B , Shafferman A |
| Ref : Journal of Biological Chemistry , 270 :2082 , 1995 |
| Abstract : Ordentlich_1995_J.Biol.Chem_270_2082 |
| ESTHER : Ordentlich_1995_J.Biol.Chem_270_2082 |
| PubMedSearch : Ordentlich_1995_J.Biol.Chem_270_2082 |
| PubMedID: 7836436 |
| Title : Electrostatic Attraction by Surface Charge does not Contribute to the Catalytic Efficiency of Acetylcholinesterase - |
| Author(s) : Barak D , Ordentlich A , Kronman C , Ber R , Bino T , Ariel N , Osman R , Velan B , Shafferman A |
| Ref : In Enzyme of the Cholinesterase Family - Proceedings of Fifth International Meeting on Cholinesterases , (Quinn, D.M., Balasubramanian, A.S., Doctor, B.P., Taylor, P., Eds) Plenum Publishing Corp. :223 , 1995 |
| PubMedID: |
| Title : Allosteric modulation of acetylcholinesterase activity by peripheral ligands involves a conformational transition of the anionic subsite - Barak_1995_Biochemistry_34_15444 |
| Author(s) : Barak D , Ordentlich A , Bromberg A , Kronman C , Marcus D , Lazar A , Ariel N , Velan B , Shafferman A |
| Ref : Biochemistry , 34 :15444 , 1995 |
| Abstract : Barak_1995_Biochemistry_34_15444 |
| ESTHER : Barak_1995_Biochemistry_34_15444 |
| PubMedSearch : Barak_1995_Biochemistry_34_15444 |
| PubMedID: 7492545 |
| Title : Molecular Aspects of Catalysis and of Allosteric Regulation of Aceytlcholinesterases - |
| Author(s) : Shafferman A , Ordentlich A , Barak D , Kronman C , Ariel N , Leitner M , Segall Y , Bromberg A , Reuveny S , Marcus D , Bino T , Lazar A , Cohen S , Velan B |
| Ref : In Enzyme of the Cholinesterase Family - Proceedings of Fifth International Meeting on Cholinesterases , (Quinn, D.M., Balasubramanian, A.S., Doctor, B.P., Taylor, P., Eds) Plenum Publishing Corp. :189 , 1995 |
| PubMedID: |
| Title : Amino Acids Determining Specificity to OP-Agents and Facilitating the Aging Process in Human Acetylcholinesterase - |
| Author(s) : Ordentlich A , Kronman C , Stein D , Ariel N , Reuveny S , Marcus D , Segall Y , Barak D , Velan B , Shafferman A |
| Ref : In Enzyme of the Cholinesterase Family - Proceedings of Fifth International Meeting on Cholinesterases , (Quinn, D.M., Balasubramanian, A.S., Doctor, B.P., Taylor, P., Eds) Plenum Publishing Corp. :221 , 1995 |
| PubMedID: |
| Title : Acetylcholinesterase peripheral anionic site degeneracy conferred by amino acid arrays sharing a common core - Barak_1994_J.Biol.Chem_269_6296 |
| Author(s) : Barak D , Kronman C , Ordentlich A , Ariel N , Bromberg A , Marcus D , Lazar A , Velan B , Shafferman A |
| Ref : Journal of Biological Chemistry , 269 :6296 , 1994 |
| Abstract : Barak_1994_J.Biol.Chem_269_6296 |
| ESTHER : Barak_1994_J.Biol.Chem_269_6296 |
| PubMedSearch : Barak_1994_J.Biol.Chem_269_6296 |
| PubMedID: 8119978 |
| Title : Electrostatic attraction by surface charge does not contribute to the catalytic efficiency of acetylcholinesterase - Shafferman_1994_EMBO.J_13_3448 |
| Author(s) : Shafferman A , Ordentlich A , Barak D , Kronman C , Ber R , Bino T , Ariel N , Osman R , Velan B |
| Ref : EMBO Journal , 13 :3448 , 1994 |
| Abstract : Shafferman_1994_EMBO.J_13_3448 |
| ESTHER : Shafferman_1994_EMBO.J_13_3448 |
| PubMedSearch : Shafferman_1994_EMBO.J_13_3448 |
| PubMedID: 8062821 |
| Title : Recombinant human acetylcholinesterase - Enzyme engineering - |
| Author(s) : Shafferman A , Velan B , Barak D , Kronman C , Ordentlich A , Flashner Y , Leitner M , Segal Y , Grosfeld H , Stein D , Ariel N |
| Ref : Medical Defense Bioscience Review , 3 :1097 , 1993 |
| PubMedID: |
| Title : Dissection of the human acetylcholinesterase active center determinants of substrate specificity. Identification of residues constituting the anionic site, the hydrophobic site, and the acyl pocket - Ordentlich_1993_J.Biol.Chem_268_17083 |
| Author(s) : Ordentlich A , Barak D , Kronman C , Flashner Y , Leitner M , Segall Y , Ariel N , Cohen S , Velan B , Shafferman A |
| Ref : Journal of Biological Chemistry , 268 :17083 , 1993 |
| Abstract : Ordentlich_1993_J.Biol.Chem_268_17083 |
| ESTHER : Ordentlich_1993_J.Biol.Chem_268_17083 |
| PubMedSearch : Ordentlich_1993_J.Biol.Chem_268_17083 |
| PubMedID: 8349597 |
| Gene_locus related to this paper: human-ACHE , human-BCHE |
| Title : Engineering resistance to 'aging' of phosphylated human acetylcholinesterase. Role of hydrogen bond network in the active center - Ordentlich_1993_FEBS.Lett_334_215 |
| Author(s) : Ordentlich A , Kronman C , Barak D , Stein D , Ariel N , Marcus D , Velan B , Shafferman A |
| Ref : FEBS Letters , 334 :215 , 1993 |
| Abstract : Ordentlich_1993_FEBS.Lett_334_215 |
| ESTHER : Ordentlich_1993_FEBS.Lett_334_215 |
| PubMedSearch : Ordentlich_1993_FEBS.Lett_334_215 |
| PubMedID: 8224249 |
| Title : Direct observation and elucidation of the structures of aged and nonaged phosphorylated cholinesterases by 31P NMR spectroscopy - Segall_1993_Biochemistry_32_13441 |
| Author(s) : Segall Y , Waysbort D , Barak D , Ariel N , Doctor BP , Grunwald J , Ashani Y |
| Ref : Biochemistry , 32 :13441 , 1993 |
| Abstract : Segall_1993_Biochemistry_32_13441 |
| ESTHER : Segall_1993_Biochemistry_32_13441 |
| PubMedSearch : Segall_1993_Biochemistry_32_13441 |
| PubMedID: 8257680 |
| Title : Substrate inhibition of acetylcholinesterase: residues affecting signal transduction from the surface to the catalytic center - Shafferman_1992_EMBO.J_11_3561 |
| Author(s) : Shafferman A , Velan B , Ordentlich A , Kronman C , Grosfeld H , Leitner M , Flashner Y , Cohen S , Barak D , Ariel N |
| Ref : EMBO Journal , 11 :3561 , 1992 |
| Abstract : Shafferman_1992_EMBO.J_11_3561 |
| ESTHER : Shafferman_1992_EMBO.J_11_3561 |
| PubMedSearch : Shafferman_1992_EMBO.J_11_3561 |
| PubMedID: 1396557 |
| Title : Mutagenesis of human acetylcholinesterase. Identification of residues involved in catalytic activity and in polypeptide folding - Shafferman_1992_J.Biol.Chem_267_17640 |
| Author(s) : Shafferman A , Kronman C , Flashner Y , Leitner M , Grosfeld H , Ordentlich A , Gozes Y , Cohen S , Ariel N , Barak D , Harel M , Silman I , Sussman JL , Velan B |
| Ref : Journal of Biological Chemistry , 267 :17640 , 1992 |
| Abstract : Shafferman_1992_J.Biol.Chem_267_17640 |
| ESTHER : Shafferman_1992_J.Biol.Chem_267_17640 |
| PubMedSearch : Shafferman_1992_J.Biol.Chem_267_17640 |
| PubMedID: 1517212 |
| Title : Molecular Models for Human AChE and its Phosphonylation Products - |
| Author(s) : Barak D , Ariel N , Velan B |
| Ref : In Multidisciplinary approaches to cholinesterase functions - Proceedings of Fourth International Meeting on Cholinesterases , (Shafferman, A. and Velan, B., Eds) Plenum Press, New York :195 , 1992 |
| PubMedID: |
| Title : Serologically defined linear epitopes in the E2 envelope glycoprotein of Semliki Forest virus - Ariel_1990_Arch.Virol_113_99 |
| Author(s) : Ariel N , Lehrer S , Elhanaty E , Sabo T , Brodt P , Lachmi B , Katz D , Levin R , Grosfeld H , Velan B , et al. |
| Ref : Arch Virol , 113 :99 , 1990 |
| Abstract : Ariel_1990_Arch.Virol_113_99 |
| ESTHER : Ariel_1990_Arch.Virol_113_99 |
| PubMedSearch : Ariel_1990_Arch.Virol_113_99 |
| PubMedID: 1696808 |