Maspardin-ACP33-SPG21_like

Relationship

Family: Maspardin-ACP33-SPG21_like

Block: X

Parent Family: Abhydrolase_6

Comment

ACP33 binds the intracellular domain of CD4. Mutation S109A abolishes the interraction. S109 is in similar position as active site serine of a/b hydrolase. Maspardin-ACP33-SPG21 gene is mutated in Mast Syndrome (Cross and McKusick 1967, Simpson et al 2003), a Complicated Form of hereditary spastic paraplegia associated with dementia. Ishiura et al. (2014) reported 2 Japanese brothers with autosomal recessive SPG21. The patients had onset of gait disturbances in their fifties and sixties, much later than that reported by Cross and McKusick (1967). Maspardin is conserved in metazoans but independent losses of this gene occured in two relatively distant ecdysozoan taxa: dipterans and nematodes (Chertemps et al.). Extracellular vesicles from Echinococcus granulosus (Platyhelminthe-Cestode) larval stage contain an orthologue of maspardin (Nicolao 2019). A Novel alpha/beta-hydrolase gene IbMa, homologous to maspardin, enhances salt tolerance in transgenic Sweetpotato (Liu et al. 2014) OsMas1 in rice (Wang et al. 2022)

Database

Interpro : IPR000073 Alpha\/beta hydrolase fold-1 , IPR026151 Maspardin

PIRSF : No PIRSF

Pdoc : No Pdoc

Pfam : PF12697 Abhydrolase_6

Prints : No Print

EC Number : No EC Number

Sequences

Peptide in Fasta
Nucleotide in Fasta
Alignment with Multalin Text only
Seed alignment with MAFFT No colour
Alignment with MAFFT No colour
Dendrogram The dnd file

No structure scheme yet for this family

Genes Proteins in Maspardin-ACP33-SPG21_like family (150)

Fragments of genes in Maspardin-ACP33-SPG21_like family (25)

No fragment of genes

No substrate

No Inhibitor

References (14)

Title : OsMas1, a novel maspardin protein gene, confers the tolerance to salt and drought stresses by regulating ABA signaling in rice - Wang_2022_J.Integr.Agric__
Author(s) : Wang FB , Wan CZ , Niu HF , Qi MY , Li G , Zhang F , Hu LB , Ye YX , Wang ZX , Pei BL , Chen XH , Yuan CY
Ref : J.Integr.Agric , : , 2022
PubMedID:
Gene_locus related to this paper: orysa-q33aq0

Title : Extracellular vesicles from Echinococcus granulosus larval stage: Isolation, characterization and uptake by dendritic cells - Nicolao_2019_PLoS.Negl.Trop.Dis_13_e0007032
Author(s) : Nicolao MC , Rodriguez Rodrigues C , Cumino AC
Ref : PLoS Negl Trop Dis , 13 :e0007032 , 2019
PubMedID: 30615613
Gene_locus related to this paper: echgr-w6u7y4

Title : Loss of Maspardin Attenuates the Growth and Maturation of Mouse Cortical Neurons - Davenport_2016_Neurodegener.Dis_16_260
Author(s) : Davenport A , Bivona A , Latson W , Lemanski LF , Cheriyath V
Ref : Neurodegener Dis , 16 :260 , 2016
PubMedID: 26978163

Title : A Novel alpha\/beta-Hydrolase Gene IbMas Enhances Salt Tolerance in Transgenic Sweetpotato - Liu_2014_PLoS.One_9_e115128
Author(s) : Liu D , Wang L , Zhai H , Song X , He S , Liu Q
Ref : PLoS ONE , 9 :e115128 , 2014
PubMedID: 25501819
Gene_locus related to this paper: ipoba-a0a076l3m2

Title : Molecular epidemiology and clinical spectrum of hereditary spastic paraplegia in the Japanese population based on comprehensive mutational analyses - Ishiura_2014_J.Hum.Genet_59_163
Author(s) : Ishiura H , Takahashi Y , Hayashi T , Saito K , Furuya H , Watanabe M , Murata M , Suzuki M , Sugiura A , Sawai S , Shibuya K , Ueda N , Ichikawa Y , Kanazawa I , Goto J , Tsuji S
Ref : J Hum Genet , 59 :163 , 2014
PubMedID: 24451228
Gene_locus related to this paper: human-SPG21

Title : Hereditary spastic paraplegias with autosomal dominant, recessive, X-linked, or maternal trait of inheritance - Finsterer_2012_J.Neurol.Sci_318_1
Author(s) : Finsterer J , Loscher W , Quasthoff S , Wanschitz J , Auer-Grumbach M , Stevanin G
Ref : Journal of Neurology Sci , 318 :1 , 2012
PubMedID: 22554690
Gene_locus related to this paper: human-SPG21

Title : Characterization of maspardin, responsible for human Mast syndrome, in an insect species and analysis of its evolution in metazoans - Chertemps_2012_Naturwiss_99_537
Author(s) : Chertemps T , Montagne N , Bozzolan F , Maria A , Durand N , Maibeche-Coisne M
Ref : Naturwissenschaften , 99 :537 , 2012
PubMedID: 22729480
Gene_locus related to this paper: spoli-a0a023pts0

Title : [Study of the effect and mechanism of spastic paraplegia 21 protein on the replication of hepatitis B virus] - Gao_2011_Zhonghua.Gan.Zang.Bing.Za.Zhi_19_747
Author(s) : Gao GS , Weng PJ , Li RY , Ding SX
Ref : Zhonghua Gan Zang Bing Za Zhi , 19 :747 , 2011
PubMedID: 22409846
Gene_locus related to this paper: human-SPG21

Title : Targeted disruption of the Mast syndrome gene SPG21 in mice impairs hind limb function and alters axon branching in cultured cortical neurons - Soderblom_2010_Neurogenetics_11_369
Author(s) : Soderblom C , Stadler J , Jupille H , Blackstone C , Shupliakov O , Hanna MC
Ref : Neurogenetics , 11 :369 , 2010
PubMedID: 20661613
Gene_locus related to this paper: human-SPG21 , mouse-SPG21

Title : Interaction of the SPG21 protein ACP33\/maspardin with the aldehyde dehydrogenase ALDH16A1 - Hanna_2009_Neurogenetics_10_217
Author(s) : Hanna MC , Blackstone C
Ref : Neurogenetics , 10 :217 , 2009
PubMedID: 19184135
Gene_locus related to this paper: human-SPG21 , mouse-SPG21

Title : Differential brain transcriptome of beta4 nAChR subunit-deficient mice: is it the effect of the null mutation or the background strain? - Kedmi_2007_Physiol.Genomics_28_213
Author(s) : Kedmi M , Orr-Urtreger A
Ref : Physiol Genomics , 28 :213 , 2007
PubMedID: 16985005
Gene_locus related to this paper: human-SPG21

Title : Maspardin is mutated in mast syndrome, a complicated form of hereditary spastic paraplegia associated with dementia - Simpson_2003_Am.J.Hum.Genet_73_1147
Author(s) : Simpson MA , Cross H , Proukakis C , Pryde A , Hershberger R , Chatonnet A , Patton MA , Crosby AH
Ref : American Journal of Human Genetics , 73 :1147 , 2003
PubMedID: 14564668
Gene_locus related to this paper: human-SPG21

Title : Cloning of ACP33 as a novel intracellular ligand of CD4 - Zeitlmann_2001_J.Biol.Chem_276_9123
Author(s) : Zeitlmann L , Sirim P , Kremmer E , Kolanus W
Ref : Journal of Biological Chemistry , 276 :9123 , 2001
PubMedID: 11113139
Gene_locus related to this paper: human-SPG21 , mouse-SPG21

Title : The mast syndrome. A recessively inherited form of presenile dementia with motor disturbances -
Author(s) : Cross HE , McKusick VA
Ref : Archives of Neurology , 16 :1 , 1967
PubMedID: 6024251
Gene_locus related to this paper: human-SPG21