humla-1lipa

Thermomyces lanuginosus (Humicola lanuginosa) lipase (lip); Lipozyme TL; LIP_THELA lipolase TLL

Comment

Novozymes A\/S Lipozym TL is a 1,3 specific lipase originating from Thermomyces lanuginosus. Lipozym TL IM is an imobilized form of the enzyme on a non-compressible silica gel carrier. Lipozyme TL IM is a highly effective catalyst for interesterification and can rearrange fatty acids preferentially, but not uniquely in the 1-and 3 positions of the triglycerides. Lipozyme TL IM exhibits a high degree of substrate selectivity allowing bulky side chains\/large groups on the alcohol and acid part of the molecule. Lipozyme TL Lipolase TLL

Relationship

Family : Lipase_3

Block : L

Position in NCBI Life Tree : Thermomyces lanuginosus

(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.)

> cellular organisms N E > Eukaryota N E > Opisthokonta N E > Fungi N E > Dikarya N E > Ascomycota N E > saccharomyceta N E > Pezizomycotina N E > leotiomyceta N E > Eurotiomycetes N E > Eurotiomycetidae N E > Eurotiales N E > Trichocomaceae N E > Thermomyces N E > Thermomyces lanuginosus N E

Molecular evidence

No mutation

1TIB - Humicola lanuginosa triacylglycerol lipase 1DT3 - Humicola lanuginosa lipase in C8E5 polyoxyethylene detergent, closed lid, high ionic strength 1DT5 - Humicola lanuginosa lipase in C8E5 polyoxyethylene detergent, open lid, low ionic strength 1DU4 - Humicola lanuginosa lipase in di-C12-POC micella, closed lid, low ionic strength 1DTE - Humicola lanuginosa lipase in C8E5 polyoxyethylene detergent, closed lid, low ionic strength 1EIN - Humicola lanuginosa lipase in di-C12-POC micella, open lid, low ionic strength 7APN - Structure of Lipase TL from bulk agarose grown crystal 7APP - Structure of Lipase TL from capillary grown crystal in the presence of agarose 6XOK - X-ray structure of the rhombohedral form of the lipase from Thermomyces lanuginosa at 1.3 A resolution 6XS3 - X-ray structure of the monoclinic crystal form at 2.48 A resolution of lipase from Thermomyces (Humicola) lanuginosa at 298 K 6XRV - X-ray structure of the monoclinic crystal form at 1.43 A resolution of lipase from Thermomyces (Humicola) lanuginosa at 173 K 6O8V - The structure of lipase from Thermomyces Lanuginosa in complex with 1,3 diacylglycerol: Rhombohedral crystal form 6OR3 - Structure of an acyl intermediate of Thermomyces Lanuginosa lipase with palmitic acid in an orthorhombic crystal 6OSZ - High Resolution Structure of the Monoclinic Form of Thermomyces Lanuginosa Lipase Complexed with Its Catalytic Products 6O9F - The structure of Thermomyces Lanuginosa lipase in complex with 1,3 diacylglycerol in a monoclinic crystal form 5AP9 - Controlled lid-opening in Thermomyces lanuginosus lipase - a switch for activity and binding 6HW1 - Room temperature structure of lipase from T. lanuginosa at 2.5 A resolution 4ZGB - Structure of untreated lipase from Thermomyces lanuginosa at 2.3 A resolution 4KJX - Crystal structure of the complex of three phase partition treated lipase from Thermomyces lanuginosa with Lauric acid and P-nitrobenzaldehyde (PNB) at 2.1 resolution 4S0X - Structure of three phase partition - treated lipase from Thermomyces lanuginosa in complex with lauric acid at 2.1 A resolution 4GWL - Structure of three phase partition treated lipase from Thermomyces lanuginosa at 2.55A resolution 4GLB - Structure of p-nitrobenzaldehyde inhibited lipase from Thermomyces lanuginosa at 2.69 A resolution. 4GBG - Crystal structure of Ethyl acetoacetate treated lipase from Thermomyces lanuginosa at 2.9 A resolution 4GHW - Crystal structure of the complex of Fungal lipase from Thermomyces lanuginosa with decanoic acid at 2.6 A resolution 4GI1 - Structure of the complex of three phase partition treated lipase from Thermomyces lanuginosa with 16-hydroxypalmitic acid at 2.4 A resolution 4FLF - Structure of three phase partition treated lipase from Thermomyces lanuginosa at 2.15A resolution 4N8S - Crystal Structure of the ternary complex of lipase from Thermomyces lanuginosa with Ethylacetoacetate and P-nitrobenzaldehyde at 2.3 A resolution 4DYH - Crystal structure of glycosylated Lipase from Humicola lanuginosa at 2 Angstrom resolution 4EA6 - Crystal structure of Fungal lipase from Thermomyces(Humicola) lanuginosa at 2.30 Angstrom resolution. 1GT6 - S146A mutant of Thermomyces (Humicola) lanuginosa lipase complex with oleic acid

No kinetic

No disease

Database

Sequence

Peptide

MRSSLVLFFV SAWTALASPI RREVSQDLFN QFNLFAQYSA AAYCGKNNDA PAGTNITCTG NACPEVEKAD ATFLYSFEDS GVGDVTGFLA LDNTNKLIVL SFRGSRSIEN WIGNLNFDLK EINDICSGCR GHDGFTSSWR SVADTLRQKV EDAVREHPDY RVVFTGHSLG GALATVAGAD LRGNGYDIDV FSYGAPRVGN RAFAEFLTVQ TGGTLYRITH TNDIVPRLPP REFGYSHSSP EYWIKSGTLV PVTRNDIVKI EGIDATGGNN QPNIPDIPAH LWYFGLIGTC L

References (55)

Title : Single-Particle Tracking of Thermomyces lanuginosus Lipase Reveals How Mutations in the Lid Region Remodel Its Diffusion - Iversen_2023_Biomolecules_13_631
Author(s) : Iversen JF , Bohr SS , Pinholt HD , Moses ME , Iversen L , Christensen SM , Hatzakis NS , Zhang M
Ref : Biomolecules , 13 :631 , 2023
PubMedID: 37189378
Gene_locus related to this paper: humla-1lipa

Title : Discovery of the Key Mutation Site Influencing the Thermostability of Thermomyces lanuginosus Lipase by Rosetta Design Programs - Zhu_2022_Int.J.Mol.Sci_23_
Author(s) : Zhu E , Xiang X , Wan S , Miao H , Han N , Huang Z
Ref : Int J Mol Sci , 23 : , 2022
PubMedID: 36012226
Gene_locus related to this paper: humla-1lipa

Title : Production of Cross-Linked Lipase Crystals at a Preparative Scale - Fernandez-Penas_2021_Cryst.Growth.Des_21_1698
Author(s) : Fernandez-Penas R , Verdugo-Escamilla C , Martinez-Rodriguez S , Gavira JA
Ref : Cryst Growth Des , 21 :1698 , 2021
PubMedID:
Gene_locus related to this paper: humla-1lipa

Title : Immobilization of Lipozyme TL 100L for methyl esterification of soybean oil deodorizer distillate - Zheng_2020_3.Biotech_10_51
Author(s) : Zheng J , Wei W , Wang S , Li X , Zhang Y , Wang Z
Ref : 3 Biotech , 10 :51 , 2020
PubMedID: 32002342
Gene_locus related to this paper: humla-1lipa

Title : Cutinases as stereoselective catalysts: Specific activity and enantioselectivity of cutinases and lipases for menthol and its analogs - Su_2020_Enzyme.Microb.Technol_133_109467
Author(s) : Su A , Kiokekli S , Naviwala M , Shirke AN , Pavlidis IV , Gross RA
Ref : Enzyme Microb Technol , 133 :109467 , 2020
PubMedID: 31874689
Gene_locus related to this paper: humin-cut , canar-LipB , humla-1lipa , rhimi-lipas

Title : The Crystal Structures of Thermomyces (Humicola) Lanuginosa Lipase in Complex with Enzymatic Reactants - McPherson_2020_Curr.Enzym.Inhib_16_199
Author(s) : McPherson A , Larson SB , Kalasky A
Ref : Curr Enzym Inhib , 16 :199 , 2020
PubMedID:
Gene_locus related to this paper: humla-1lipa

Title : N-terminal domain replacement changes an archaeal monoacylglycerol lipase into a triacylglycerol lipase - Soni_2019_Biotechnol.Biofuels_12_110
Author(s) : Soni S , Sathe SS , Sheth RR , Tiwari P , Vadgama RN , Odaneth AA , Lali AM , Chandrayan SK
Ref : Biotechnol Biofuels , 12 :110 , 2019
PubMedID: 31080517
Gene_locus related to this paper: humla-1lipa , theon-b6ywd5

Title : A simple and versatile microfluidic device for efficient biomacromolecule crystallization and structural analysis by serial crystallography - de Wijn_2019_IUCrJ_6_454
Author(s) : de Wijn R , Hennig O , Roche J , Engilberge S , Rollet K , Fernandez-Millan P , Brillet K , Betat H , Morl M , Roussel A , Girard E , Mueller-Dieckmann C , Fox GC , Olieric V , Gavira JA , Lorber B , Sauter C
Ref : IUCrJ , 6 :454 , 2019
PubMedID: 31098026
Gene_locus related to this paper: humla-1lipa

Title : Direct observation of Thermomyces lanuginosus lipase diffusional states by Single Particle Tracking and their remodeling by mutations and inhibition - Bohr_2019_Sci.Rep_9_16169
Author(s) : Bohr SS , Lund PM , Kallenbach AS , Pinholt H , Thomsen J , Iversen L , Svendsen A , Christensen SM , Hatzakis NS
Ref : Sci Rep , 9 :16169 , 2019
PubMedID: 31700110
Gene_locus related to this paper: humla-1lipa

Title : Monomyristin and Monopalmitin Derivatives: Synthesis and Evaluation as Potential Antibacterial and Antifungal Agents - Jumina_2018_Molecules_23_
Author(s) : Jumina J , Nurmala A , Fitria A , Pranowo D , Sholikhah EN , Kurniawan YS , Kuswandi B
Ref : Molecules , 23 : , 2018
PubMedID: 30501124
Gene_locus related to this paper: humla-1lipa

Title : Efficient kinetic resolution of (+\/-)-menthol by a lipase from Thermomyces lanuginosus - De Yan_2017_Biotechnol.Appl.Biochem_64_87
Author(s) : De Yan H , Li Q , Wang Z
Ref : Biotechnol Appl Biochem , 64 :87 , 2017
PubMedID: 26549685
Gene_locus related to this paper: humla-1lipa

Title : Enhancement of stability of a lipase by subjecting to three phase partitioning (TPP): structures of native and TPP-treated lipase from Thermomyces lanuginosa - Kumar_2015_Sustain.Chem.Process_3_14
Author(s) : Kumar M , Mukherjee J , Sinha M , Kaur P , Sharma S , Singh TP , Gupta MN
Ref : Sustain Chem Process , 3 :14 , 2017
PubMedID:
Gene_locus related to this paper: humla-1lipa

Title : High-yield synthesis of bioactive ethyl cinnamate by enzymatic esterification of cinnamic acid - Wang_2016_Food.Chem_190_629
Author(s) : Wang Y , Zhang DH , Zhang JY , Chen N , Zhi GY
Ref : Food Chem , 190 :629 , 2016
PubMedID: 26213020
Gene_locus related to this paper: humla-1lipa

Title : Lipases That Activate at High Solvent Polarities - Skjold-Jorgensen_2016_Biochemistry_55_146
Author(s) : Skjold-Jorgensen J , Vind J , Svendsen A , Bjerrum MJ
Ref : Biochemistry , 55 :146 , 2016
PubMedID: 26645098
Gene_locus related to this paper: humla-1lipa

Title : Controlled lid-opening in Thermomyces lanuginosus lipase- An engineered switch for studying lipase function - Skjold-Jorgensen_2016_Biochim.Biophys.Acta_1865_20
Author(s) : Skjold-Jorgensen J , Vind J , Moroz OV , Blagova E , Bhatia VK , Svendsen A , Wilson KS , Bjerrum MJ
Ref : Biochimica & Biophysica Acta , 1865 :20 , 2016
PubMedID: 27693248
Gene_locus related to this paper: humla-1lipa

Title : Promoting protein self-association in non-glycosylated Thermomyces lanuginosus lipase based on crystal lattice contacts - Madsen_2015_Biochim.Biophys.Acta_1854_1914
Author(s) : Madsen JK , Sorensen TR , Kaspersen JD , Silow MB , Vind J , Pedersen JS , Svendsen A , Otzen DE
Ref : Biochimica & Biophysica Acta , 1854 :1914 , 2015
PubMedID: 26431886
Gene_locus related to this paper: humla-1lipa

Title : First chemoenzymatic stereodivergent synthesis of both enantiomers of promethazine and ethopropazine - Borowiecki_2014_Beilstein.J.Org.Chem_10_3038
Author(s) : Borowiecki P , Paprocki D , Dranka M
Ref : Beilstein J Org Chem , 10 :3038 , 2014
PubMedID: 25670974
Gene_locus related to this paper: canar-LipB , humla-1lipa

Title : Key residues responsible for enhancement of catalytic efficiency of Thermomyces lanuginosus lipase Lip revealed by complementary protein engineering strategy - Li_2014_J.Biotechnol_188C_29
Author(s) : Li XJ , Zheng RC , Ma HY , Huang JF , Zheng YG
Ref : J Biotechnol , 188C :29 , 2014
PubMedID: 25116359
Gene_locus related to this paper: humla-1lipa

Title : Thermophilic esterase from Thermomyces lanuginosus: molecular cloning, functional expression and biochemical characterization - Li_2014_Protein.Expr.Purif_101_1
Author(s) : Li XJ , Zheng RC , Wu ZM , Ding X , Zheng YG
Ref : Protein Expr Purif , 101 :1 , 2014
PubMedID: 24859676
Gene_locus related to this paper: humla-1lipa

Title : Altering the activation mechanism in Thermomyces lanuginosus lipase - Skjold-Jorgensen_2014_Biochemistry_53_4152
Author(s) : Skjold-Jorgensen J , Vind J , Svendsen A , Bjerrum MJ
Ref : Biochemistry , 53 :4152 , 2014
PubMedID: 24870718
Gene_locus related to this paper: humla-1lipa

Title : Thermomyces lanuginosus Lipase with Closed Lid Catalyzes Elimination of Acetic Acid from 11-Acetyl-Prostaglandin E2 - Villo_2014_ChemCatChem_6_1998
Author(s) : Villo L , Metsala A , Tamp S , Parve J , Vallikivi I , Jarving I , Samel N , Lille U , Pehk T , Parve O
Ref : ChemCatChem , 6 :1998 , 2014
PubMedID:
Gene_locus related to this paper: humla-1lipa

Title : Improved production of butyl butyrate with lipase from Thermomyces lanuginosus immobilized on styrene-divinylbenzene beads - Martins_2013_Bioresour.Technol_134_417
Author(s) : Martins AB , Friedrich JL , Cavalheiro JC , Garcia-Galan C , Barbosa O , Ayub MA , Fernandez-Lafuente R , Rodrigues RC
Ref : Bioresour Technol , 134 :417 , 2013
PubMedID: 23499180
Gene_locus related to this paper: humla-1lipa

Title : Variant of the Thermomyces lanuginosus lipase with improved kinetic stability: A candidate for enzyme replacement therapy - Wang_2013_Biophys.Chem_172C_43
Author(s) : Wang H , Hagedorn J , Svendsen A , Borch K , Otzen DE
Ref : Biophysical Chemistry , 172C :43 , 2013
PubMedID: 23357413
Gene_locus related to this paper: humla-1lipa

Title : Optimized butyl butyrate synthesis catalyzed by Thermomyces lanuginosus lipase - Martins_2013_Biotechnol.Prog_29_1416
Author(s) : Martins AB , Friedrich JL , Rodrigues RC , Garcia-Galan C , Fernandez-Lafuente R , Ayub MA
Ref : Biotechnol Prog , 29 :1416 , 2013
PubMedID: 23946156
Gene_locus related to this paper: humla-1lipa

Title : Kinetic biosynthesis of L-ascorbyl acetate by immobilized Thermomyces lanuginosus lipase (Lipozyme TLIM) - Zhang_2011_Bioprocess.Biosyst.Eng_34_1163
Author(s) : Zhang DH , Lv YQ , Zhi GY , Yuwen LX
Ref : Bioprocess Biosyst Eng , 34 :1163 , 2011
PubMedID: 21744121
Gene_locus related to this paper: humla-1lipa

Title : Ionic strength-dependent denaturation of Thermomyces lanuginosus lipase induced by SDS - Fano_2011_Arch.Biochem.Biophys_506_92
Author(s) : Fano M , van de Weert M , Moeller EH , Kruse NA , Frokjaer S
Ref : Archives of Biochemistry & Biophysics , 506 :92 , 2011
PubMedID: 21093408
Gene_locus related to this paper: humla-1lipa

Title : Study of Soybean Oil Hydrolysis Catalyzed by Thermomyces lanuginosus Lipase and Its Application to Biodiesel Production via Hydroesterification - Cavalcanti-Oliveira_2010_Enzyme.Res_2011_618692
Author(s) : Cavalcanti-Oliveira E , da Silva PR , Ramos AP , Aranda DA , Freire DM
Ref : Enzyme Res , 2011 :618692 , 2010
PubMedID: 21052517
Gene_locus related to this paper: humla-1lipa

Title : Influence of glycosylation on the adsorption of Thermomyces lanuginosus lipase to hydrophobic and hydrophilic surfaces - Pinholt_2010_Eur.J.Pharm.Sci_40_273
Author(s) : Pinholt C , Fano M , Wiberg C , Hostrup S , Bukrinsky JT , Frokjaer S , Norde W , Jorgensen L
Ref : Eur J Pharm Sci , 40 :273 , 2010
PubMedID: 20380877
Gene_locus related to this paper: humla-1lipa

Title : Improved enzymatic activity of Thermomyces lanuginosus lipase immobilized in a hydrophobic particulate mesoporous carrier - Sorensen_2010_J.Colloid.Interface.Sci_343_359
Author(s) : Sorensen MH , Ng JB , Bergstrom L , Alberius PC
Ref : J Colloid Interface Sci , 343 :359 , 2010
PubMedID: 20022021
Gene_locus related to this paper: humla-1lipa

Title : Thermomyces lanuginosus lipase-catalyzed regioselective acylation of nucleosides: Enzyme substrate recognition - Li_2009_J.Biotechnol_140_250
Author(s) : Li N , Zong MH , Ma D
Ref : J Biotechnol , 140 :250 , 2009
PubMedID: 19428721
Gene_locus related to this paper: humla-1lipa

Title : Improved reactivation of immobilized-stabilized lipase from Thermomyces lanuginosus by its coating with highly hydrophilic polymers - Rodrigues_2009_J.Biotechnol_144_113
Author(s) : Rodrigues RC , Bolivar JM , Volpato G , Filice M , Godoy C , Fernandez-Lafuente R , Guisan JM
Ref : J Biotechnol , 144 :113 , 2009
PubMedID: 19737586
Gene_locus related to this paper: humla-1lipa

Title : Fatty acid selectivity of lipases during acidolysis reaction between oleic acid and monoacid triacylglycerols - Karabulut_2009_J.Agric.Food.Chem_57_10466
Author(s) : Karabulut I , Durmaz G , Hayaloglu AA
Ref : Journal of Agricultural and Food Chemistry , 57 :10466 , 2009
PubMedID: 19835376
Gene_locus related to this paper: humla-1lipa

Title : Thermomyces lanuginosus lipase in the liquid-crystalline phases of aqueous phytantriol: X-ray diffraction and vibrational spectroscopic studies - Misiunas_2008_Biophys.Chem_134_144
Author(s) : Misiunas A , Talaikyte Z , Niaura G , Razumas V , Nylander T
Ref : Biophysical Chemistry , 134 :144 , 2008
PubMedID: 18329781
Gene_locus related to this paper: humla-1lipa

Title : Differential adsorption of variants of the Thermomyces lanuginosus lipase on a hydrophobic surface suggests a role for local flexibility - Otzen_2008_Colloids.Surf.B.Biointerfaces_64_223
Author(s) : Otzen D
Ref : Colloids Surf B Biointerfaces , 64 :223 , 2008
PubMedID: 18321685
Gene_locus related to this paper: humla-1lipa

Title : Adsorption and activity of Thermomyces lanuginosus lipase on hydrophobic and hydrophilic surfaces measured with dual polarization interferometry (DPI) and confocal microscopy - Sonesson_2008_Colloids.Surf.B.Biointerfaces_61_208
Author(s) : Sonesson AW , Callisen TH , Brismar H , Elofsson UM
Ref : Colloids Surf B Biointerfaces , 61 :208 , 2008
PubMedID: 17890066
Gene_locus related to this paper: humla-1lipa

Title : Improvement of biodiesel production by lipozyme TL IM-catalyzed methanolysis using response surface methodology and acyl migration enhancer - Wang_2008_Bioresour.Technol_99_7232
Author(s) : Wang Y , Wu H , Zong MH
Ref : Bioresour Technol , 99 :7232 , 2008
PubMedID: 18262410
Gene_locus related to this paper: humla-1lipa

Title : A comparative study on two fungal lipases from Thermomyces lanuginosus and Yarrowia lipolytica shows the combined effects of detergents and pH on lipase adsorption and activity - Aloulou_2007_Biochim.Biophys.Acta_1771_1446
Author(s) : Aloulou A , Puccinelli D , de Caro A , Leblond Y , Carriere F
Ref : Biochimica & Biophysica Acta , 1771 :1446 , 2007
PubMedID: 18022403
Gene_locus related to this paper: humla-1lipa

Title : Mobility of Thermomyces lanuginosus lipase on a trimyristin substrate surface - Sonesson_2007_Langmuir_23_2706
Author(s) : Sonesson AW , Brismar H , Callisen TH , Elofsson UM
Ref : Langmuir , 23 :2706 , 2007
PubMedID: 17261037
Gene_locus related to this paper: humla-1lipa

Title : Activation, inhibition, and destabilization of Thermomyces lanuginosus lipase by detergents - Mogensen_2005_Biochemistry_44_1719
Author(s) : Mogensen JE , Sehgal P , Otzen DE
Ref : Biochemistry , 44 :1719 , 2005
PubMedID: 15683256
Gene_locus related to this paper: humla-1lipa

Title : Implications of surface charge and curvature for the binding orientation of Thermomyces lanuginosus lipase on negatively charged or zwitterionic phospholipid vesicles as studied by ESR spectroscopy - Hedin_2005_Biochemistry_44_16658
Author(s) : Hedin EM , Hoyrup P , Patkar SA , Vind J , Svendsen A , Hult K
Ref : Biochemistry , 44 :16658 , 2005
PubMedID: 16342956
Gene_locus related to this paper: humla-1lipa

Title : Interfacial orientation of Thermomyces lanuginosa lipase on phospholipid vesicles investigated by electron spin resonance relaxation spectroscopy - Hedin_2002_Biochemistry_41_14185
Author(s) : Hedin EM , Hoyrup P , Patkar SA , Vind J , Svendsen A , Fransson L , Hult K
Ref : Biochemistry , 41 :14185 , 2002
PubMedID: 12450382
Gene_locus related to this paper: humla-1lipa

Title : Binding of Thermomyces (Humicola) lanuginosa lipase to the mixed micelles of cis-parinaric acid\/NaTDC - Yapoudjian_2002_Eur.J.Biochem_269_1613
Author(s) : Yapoudjian S , Ivanova MG , Brzozowski AM , Patkar SA , Vind J , Svendsen A , Verger R
Ref : European Journal of Biochemistry , 269 :1613 , 2002
PubMedID: 11895431
Gene_locus related to this paper: humla-1lipa

Title : Impact of the tryptophan residues of Humicola lanuginosa lipase on its thermal stability - Zhu_2001_Biochim.Biophys.Acta_1547_329
Author(s) : Zhu K , Jutila A , Tuominen EK , Patkar SA , Svendsen A , Kinnunen PK
Ref : Biochimica & Biophysica Acta , 1547 :329 , 2001
PubMedID: 11410289
Gene_locus related to this paper: humla-1lipa

Title : Structural origins of the interfacial activation in Thermomyces (Humicola) lanuginosa lipase - Brzozowski_2000_Biochemistry_39_15071
Author(s) : Brzozowski AM , Savage H , Verma CS , Turkenburg JP , Lawson DM , Svendsen A , Patkar S
Ref : Biochemistry , 39 :15071 , 2000
PubMedID: 11106485
Gene_locus related to this paper: humla-1lipa

Title : Effect of the lipid interface on the catalytic activity and spectroscopic properties of a fungal lipase - Cajal_2000_Biochimie_82_1053
Author(s) : Cajal Y , Svendsen A , De Bolos J , Patkar SA , Alsina MA
Ref : Biochimie , 82 :1053 , 2000
PubMedID: 11099802
Gene_locus related to this paper: humla-1lipa

Title : Detergent-induced conformational changes of Humicola lanuginosa lipase studied by fluorescence spectroscopy - Jutila_2000_Biophys.J_78_1634
Author(s) : Jutila A , Zhu K , Patkar SA , Vind J , Svendsen A , Kinnunen PK
Ref : Biophysical Journal , 78 :1634 , 2000
PubMedID: 10692347
Gene_locus related to this paper: humla-1lipa

Title : Interfacial control of lid opening in Thermomyces lanuginosa lipase - Cajal_2000_Biochemistry_39_413
Author(s) : Cajal Y , Svendsen A , Girona V , Patkar SA , Alsina MA
Ref : Biochemistry , 39 :413 , 2000
PubMedID: 10631003
Gene_locus related to this paper: humla-1lipa

Title : Active serine involved in the stabilization of the active site loop in the Humicola lanuginosa lipase - Peters_1998_Biochemistry_37_12375
Author(s) : Peters GH , Svendsen A , Langberg H , Vind J , Patkar SA , Toxvaerd S , Kinnunen PK
Ref : Biochemistry , 37 :12375 , 1998
PubMedID: 9730809
Gene_locus related to this paper: humla-1lipa

Title : The role of Glu87 and Trp89 in the lid of Humicola lanuginosa lipase - Martinelle_1996_Protein.Eng_9_519
Author(s) : Martinelle M , Holmquist M , Clausen IG , Patkar S , Svendsen A , Hult K
Ref : Protein Engineering , 9 :519 , 1996
PubMedID: 8862552
Gene_locus related to this paper: humla-1lipa

Title : The importance of non-charged amino acids in antibody binding to Humicola lanuginosa lipase - Naver_1995_Scand.J.Immunol_41_443
Author(s) : Naver H , Lovborg U
Ref : Scand J Immunol , 41 :443 , 1995
PubMedID: 7536956
Gene_locus related to this paper: humla-1lipa

Title : Probing a functional role of Glu87 and Trp89 in the lid of Humicola lanuginosa lipase through transesterification reactions in organic solvent - Holmquist_1995_J.Protein.Chem_14_217
Author(s) : Holmquist M , Clausen IG , Patkar S , Svendsen A , Hult K
Ref : J Protein Chem , 14 :217 , 1995
PubMedID: 7662109
Gene_locus related to this paper: humla-1lipa

Title : Conformational lability of lipases observed in the absence of an oil-water interface: crystallographic studies of enzymes from the fungi Humicola lanuginosa and Rhizopus delemar - Derewenda_1994_J.Lipid.Res_35_524
Author(s) : Derewenda U , Swenson L , Wei Y , Green R , Kobos PM , Joerger R , Haas MJ , Derewenda ZS
Ref : J Lipid Res , 35 :524 , 1994
PubMedID: 8014587
Gene_locus related to this paper: humla-1lipa , rhidl-lipas

Title : An unusual buried polar cluster in a family of fungal lipases - Derewenda_1994_Nat.Struct.Biol_1_36
Author(s) : Derewenda U , Swenson L , Green R , Wei Y , Dodson GG , Yamaguchi S , Haas MJ , Derewenda ZS
Ref : Nat Struct Biol , 1 :36 , 1994
PubMedID: 7656005
Gene_locus related to this paper: humla-1lipa , penca-mdgli , rhidl-lipas

Title : Current progress in crystallographic studies of new lipases from filamentous fungi - Derewenda_1994_Protein.Eng_7_551
Author(s) : Derewenda U , Swenson L , Green R , Wei Y , Yamaguchi S , Joerger R , Haas MJ , Derewenda ZS
Ref : Protein Engineering , 7 :551 , 1994
PubMedID: 8029211
Gene_locus related to this paper: humla-1lipa , penca-mdgli , rhidl-lipas

Title : Trp89 in the lid of Humicola lanuginosa lipase is important for efficient hydrolysis of tributyrin - Holmquist_1994_Lipids_29_599
Author(s) : Holmquist M , Martinelle M , Clausen IG , Patkar S , Svendsen A , Hult K
Ref : Lipids , 29 :599 , 1994
PubMedID: 7815893
Gene_locus related to this paper: humla-1lipa