rhimi-lipas
Rhizomucor miehei lipas triacylglycerol lipase (Lipozyme RM IM) Palatase RML
Comment
Novozym 40086 is a 1,3 specific lipase originating from Rhizomucor mehei which is immobilized on a resin carrier. Novozym 40086 is a highly effective catalyst for stereoselective transesterification and ester hydrolysis. Anion-exchange resin inmobilized Lipozyme RM IM
Relationship
Family : Lipase_3
Block : L
Position in NCBI Life Tree : Rhizomucor miehei
(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.)
> cellular organisms N E > Eukaryota N E > Opisthokonta N E > Fungi N E > Mucoromycota N E > Mucoromycotina N E > Mucorales N E > Lichtheimiaceae N E > Rhizomucor N E > Rhizomucor miehei N EMolecular evidence
No mutation
1TGL - Rhizomucor miehei triacylglycerol lipase (CA-atoms only)
3TGL - Rhizomucor miehei triacylglycerol lipase
4TGL - Rhizomucor miehei triacylglycerol lipase + diethyl phosphonate
5TGL - Rhizomucor miehei triacylglycerol lipase + hexylphosphonate ethyl ester (CA-atoms only)
6QPP - Rhizomucor miehei lipase propeptide complex, native
6QPR - Rhizomucor miehei lipase propeptide complex, Ser95\/Ile96 deletion mutant
No kinetic
No disease
Sequence
Peptide
MVLKQRANYL GFLIVFFTAF LVEAVPIKRQ SNSTVDSLPP LIPSRTSAPS SSPSTTDPEA PAMSRNGPLP SDVETKYGMA LNATSYPDSV VQAMSIDGGI RAATSQEINE LTYYTTLSAN SYCRTVIPGA TWDCIHCDAT EDLKIIKTWS TLIYDTNAMV ARGDSEKTIY IVFRGSSSIR NWIADLTFVP VSYPPVSGTK VHKGFLDSYG EVQNELVATV LDQFKQYPSY KVAVTGHSLG GATALLCALD LYQREEGLSS SNLFLYTQGQ PRVGDPAFAN YVVSTGIPYR RTVNERDIVP HLPPAAFGFL HAGEEYWITD NSPETVQVCT SDLETSDCSN SIVPFTSVLD HLSYFGINTG LCT
References (21)
| Title : Active Site Studies to Explain Kinetics of Lipases in Organic Solvents Using Molecular Dynamics Simulations - Tjornelund_2024_J.Phys.Chem.B__ |
| Author(s) : Tjornelund HD , Brask J , Woodley JM , Peters GHJ |
| Ref : J Phys Chem B , : , 2024 |
| Abstract : |
| PubMedSearch : Tjornelund_2024_J.Phys.Chem.B__ |
| PubMedID: 39733341 |
| Gene_locus related to this paper: canar-LipB , humla-1lipa , rhimi-lipas |
| Title : Study of volatile compounds profiles in milk matrices using Enterococcus faecalis EstA and Rhizomucor miehei lipase - Velez_2023_Food.Res.Int_169_112861 |
| Author(s) : Velez MA , Wolf VI , Espariz M , Acciarri G , Magni C , Hynes E , Perotti MC |
| Ref : Food Res Int , 169 :112861 , 2023 |
| Abstract : |
| PubMedSearch : Velez_2023_Food.Res.Int_169_112861 |
| PubMedID: 37254435 |
| Gene_locus related to this paper: entfa-EF2728 , rhimi-lipas |
| Title : Enzymatic structural modification of monogalactosyldiacylglycerols for potential modulation of hydrophile-lipophile balance - Roh_2022_Food.Chem_385_132705 |
| Author(s) : Roh S , Lee S , Kim IH , Hee Kim B |
| Ref : Food Chem , 385 :132705 , 2022 |
| Abstract : |
| PubMedSearch : Roh_2022_Food.Chem_385_132705 |
| PubMedID: 35306234 |
| Gene_locus related to this paper: rhimi-lipas |
| Title : Effect of propeptide mutations on the directed evolution of Rhizomucor miehei lipase - Wang_2022_Protein.Pept.Lett__ |
| Author(s) : Wang J , Bai R , Wu N , Zhang Y , Hu L |
| Ref : Protein Pept Lett , : , 2022 |
| Abstract : |
| PubMedSearch : Wang_2022_Protein.Pept.Lett__ |
| PubMedID: 35289250 |
| Gene_locus related to this paper: rhimi-lipas |
| Title : Cutinases as stereoselective catalysts: Specific activity and enantioselectivity of cutinases and lipases for menthol and its analogs - Su_2020_Enzyme.Microb.Technol_133_109467 |
| Author(s) : Su A , Kiokekli S , Naviwala M , Shirke AN , Pavlidis IV , Gross RA |
| Ref : Enzyme Microb Technol , 133 :109467 , 2020 |
| Abstract : |
| PubMedSearch : Su_2020_Enzyme.Microb.Technol_133_109467 |
| PubMedID: 31874689 |
| Gene_locus related to this paper: humin-cut , canar-LipB , humla-1lipa , rhimi-lipas |
| Title : Improved production of recombinant Rhizomucor miehei lipase by coexpressing protein folding chaperones in Pichia pastoris, which triggered ER stress - Huang_2020_Bioengineered_11_375 |
| Author(s) : Huang J , Zhao Q , Chen L , Zhang C , Bu W , Zhang X , Zhang K , Yang Z |
| Ref : Bioengineered , 11 :375 , 2020 |
| Abstract : |
| PubMedSearch : Huang_2020_Bioengineered_11_375 |
| PubMedID: 32175802 |
| Gene_locus related to this paper: rhimi-lipas |
| Title : Novel Inhibitory Function of the Rhizomucor miehei Lipase Propeptide and Three-Dimensional Structures of Its Complexes with the Enzyme - Moroz_2019_ACS.Omega_4_9964 |
| Author(s) : Moroz OV , Blagova E , Reiser V , Saikia R , Dalal S , Jorgensen CI , Bhatia VK , Baunsgaard L , Andersen B , Svendsen A , Wilson KS |
| Ref : ACS Omega , 4 :9964 , 2019 |
| Abstract : |
| PubMedSearch : Moroz_2019_ACS.Omega_4_9964 |
| PubMedID: 31460089 |
| Gene_locus related to this paper: rhimi-lipas |
| Title : Enhancing the Thermostability of Rhizomucor miehei Lipase with a Limited Screening Library by Rational-Design Point Mutations and Disulfide Bonds - Li_2018_Appl.Environ.Microbiol_84_ |
| Author(s) : Li G , Fang X , Su F , Chen Y , Xu L , Yan Y |
| Ref : Applied Environmental Microbiology , 84 : , 2018 |
| Abstract : |
| PubMedSearch : Li_2018_Appl.Environ.Microbiol_84_ |
| PubMedID: 29101200 |
| Gene_locus related to this paper: rhimi-lipas |
| Title : Ester synthesis in aqueous media by lipase: alcoholysis, esterification and substrate hydrophobicity: ester synthesis in aqueous media - Sun_2015_J.Food.Biochem_39_11 |
| Author(s) : Sun J , Liu SQ |
| Ref : J Food Biochem , 39 :11 , 2015 |
| Abstract : |
| PubMedSearch : Sun_2015_J.Food.Biochem_39_11 |
| PubMedID: |
| Gene_locus related to this paper: rhimi-lipas |
| Title : Selective ethanolysis of sunflower oil with Lipozyme RM IM, an immobilized Rhizomucor miehei lipase, to obtain a biodiesel-like biofuel, which avoids glycerol production through the monoglyceride formation - Calero_2014_N.Biotechnol_31_596 |
| Author(s) : Calero J , Verdugo C , Luna D , Sancho ED , Luna C , Posadillo A , Bautista FM , Romero AA |
| Ref : N Biotechnol , 31 :596 , 2014 |
| Abstract : |
| PubMedSearch : Calero_2014_N.Biotechnol_31_596 |
| PubMedID: 24594272 |
| Gene_locus related to this paper: rhimi-lipas |
| Title : Lipozyme RM IM-catalyzed acidolysis of Cinnamomum camphora seed oil with oleic acid to produce human milk fat substitutes enriched in medium-chain fatty acids - Zou_2014_J.Agric.Food.Chem_62_10594 |
| Author(s) : Zou XG , Hu JN , Zhao ML , Zhu XM , Li HY , Liu XR , Liu R , Deng ZY |
| Ref : Journal of Agricultural and Food Chemistry , 62 :10594 , 2014 |
| Abstract : |
| PubMedSearch : Zou_2014_J.Agric.Food.Chem_62_10594 |
| PubMedID: 25298236 |
| Gene_locus related to this paper: rhimi-lipas |
| Title : Enhanced activity of Rhizomucor miehei lipase by directed evolution with simultaneous evolution of the propeptide - Wang_2012_Appl.Microbiol.Biotechnol_96_443 |
| Author(s) : Wang J , Wang D , Wang B , Mei ZH , Liu J , Yu HW |
| Ref : Applied Microbiology & Biotechnology , 96 :443 , 2012 |
| Abstract : |
| PubMedSearch : Wang_2012_Appl.Microbiol.Biotechnol_96_443 |
| PubMedID: 22584429 |
| Gene_locus related to this paper: rhimi-lipas |
| Title : Promiscuous Behavior of Rhizomucor miehei Lipase in the Synthesis of N-Substituted beta-Amino Esters - Monsalve_2012_European.J.Org.Chem_2012_1164 |
| Author(s) : Monsalve LM , Gillanders F , Baldessari A |
| Ref : European J Org Chem , 2012 :1164 , 2012 |
| Abstract : |
| PubMedSearch : Monsalve_2012_European.J.Org.Chem_2012_1164 |
| PubMedID: |
| Gene_locus related to this paper: rhimi-lipas |
| Title : High yield of wax ester synthesized from cetyl alcohol and octanoic acid by lipozyme RMIM and Novozym 435 - Kuo_2012_Int.J.Mol.Sci_13_11694 |
| Author(s) : Kuo CH , Chen HH , Chen JH , Liu YC , Shieh CJ |
| Ref : Int J Mol Sci , 13 :11694 , 2012 |
| Abstract : |
| PubMedSearch : Kuo_2012_Int.J.Mol.Sci_13_11694 |
| PubMedID: 23109878 |
| Gene_locus related to this paper: rhimi-lipas |
| Title : Optimization of 2-ethylhexyl palmitate production using lipozyme RM IM as catalyst in a solvent-free system - Richetti_2010_Appl.Biochem.Biotechnol_160_2498 |
| Author(s) : Richetti A , Leite SG , Antunes OA , de Souza AL , Lerin LA , Dallago RM , Paroul N , Di Luccio M , Oliveira JV , Treichel H , de Oliveira D |
| Ref : Appl Biochem Biotechnol , 160 :2498 , 2010 |
| Abstract : |
| PubMedSearch : Richetti_2010_Appl.Biochem.Biotechnol_160_2498 |
| PubMedID: 19701809 |
| Gene_locus related to this paper: rhimi-lipas |
| Title : Enhancing thermostability of a Rhizomucor miehei lipase by engineering a disulfide bond and displaying on the yeast cell surface - Han_2009_Appl.Microbiol.Biotechnol_85_117 |
| Author(s) : Han ZL , Han SY , Zheng SP , Lin Y |
| Ref : Applied Microbiology & Biotechnology , 85 :117 , 2009 |
| Abstract : |
| PubMedSearch : Han_2009_Appl.Microbiol.Biotechnol_85_117 |
| PubMedID: 19533118 |
| Gene_locus related to this paper: rhimi-lipas |
| Title : Lipase-catalyzed synthesis of quinate and glucuronate fatty esters - Villeneuve_2002_Eur.J.Lipid.Sci.Tech_104_394 |
| Author(s) : Villeneuve P , Hills G , Bachain P , Pina M , Caro Y , Barea B , Guyot B , Gruning B , Graille J |
| Ref : Eur.J.Lipid.Sci.Tech , 104 :394 , 2002 |
| Abstract : |
| PubMedSearch : Villeneuve_2002_Eur.J.Lipid.Sci.Tech_104_394 |
| PubMedID: |
| Gene_locus related to this paper: rhimi-lipas |
| Title : The crystal and molecular structure of the Rhizomucor miehei triacylglyceride lipase at 1.9 A resolution - Derewenda_1992_J.Mol.Biol_227_818 |
| Author(s) : Derewenda ZS , Derewenda U , Dodson GG |
| Ref : Journal of Molecular Biology , 227 :818 , 1992 |
| Abstract : |
| PubMedSearch : Derewenda_1992_J.Mol.Biol_227_818 |
| PubMedID: 1404390 |
| Gene_locus related to this paper: rhimi-lipas |
| Title : A model for interfacial activation in lipases from the structure of a fungal lipase-inhibitor complex [see comments] - Brzozowski_1991_Nature_351_491 |
| Author(s) : Brzozowski AM , Derewenda U , Derewenda ZS , Dodson GG , Lawson DM , Turkenburg JP , Bjorkling F , Huge-Jensen B , Patkar SA , Thim L |
| Ref : Nature , 351 :491 , 1991 |
| Abstract : |
| PubMedSearch : Brzozowski_1991_Nature_351_491 |
| PubMedID: 2046751 |
| Gene_locus related to this paper: rhimi-lipas |
| Title : A serine protease triad forms the catalytic centre of a triacylglycerol lipase - Brady_1990_Nature_343_767 |
| Author(s) : Brady L , Brzozowski AM , Derewenda ZS , Dodson E , Dodson G , Tolley S , Turkenburg JP , Christiansen L , Huge-Jensen B , Norskov L , Thim L , Menge U |
| Ref : Nature , 343 :767 , 1990 |
| Abstract : |
| PubMedSearch : Brady_1990_Nature_343_767 |
| PubMedID: 2304552 |
| Gene_locus related to this paper: rhimi-lipas |
| Title : Rhizomucor miehei triglyceride lipase is synthesized as a precursor - Boel_1988_Lipids_230_701 |
| Author(s) : Boel E , Huge-Jensen B , Christensen M , Thim L , Fiil NP |
| Ref : Lipids , 23 (7) :701 , 1988 |
| Abstract : |
| PubMedSearch : Boel_1988_Lipids_230_701 |
| PubMedID: 3419283 |
| Gene_locus related to this paper: rhimi-lipas |