Mus musculus RISC retinoid-inducible serine carboxypeptidase HSCP1 (serine carboxypeptidase 1)
Trembl Q99J29 is one aa diff from AK014680 cdna 4833411k15 || Trembl Q920A5 (RISC) Mus musculus (Mouse) retinoid-inducible serine carboxypeptidase in smouth muscle aorta and kidney || Kollmann et al. (2009) showed that the 55-kD mouse Scpep1 precursor protein was processed into a 35-kD N-terminal fragment and an 18-kD C-terminal fragment. Processing was mediated by a lysosomal serine proteinase and took place in the endosomal-lysosomal compartment. All 5 putative N-glycosylation sites of Scpep1 were N-glycosylated in mouse embryonic fibroblasts. Lee et al. (2009) showed that Scpep1 expression promoted growth and migration of mouse or rat smooth muscle cells (SMCs). Mutation analysis revealed that the stimulatory effects of Scpep1 on SMC growth and migration required the Scpep1 catalytic triad, but not cleavage of Scpep1. Immunohistochemical analysis of injured mouse and rat carotid arteries demonstrated increased Scpep1 expression in vessel walls where modulated SMCs were proliferative and migratory. By analyzing cultured mouse aortic vascular SMCs (AVSMCs), Pan et al. (2014) showed that Scpep1 had carboxypeptidase activity towards ET1 (EDN1), complementing the serine carboxypeptidase activity of CathA (CTSA). Analysis with purified recombinant protein confirmed that Scpep1 cleaved the C-terminal trp residue from ET1.
Family : Carboxypeptidase_S10
Block : X
Position in NCBI Life Tree : Mus musculus
(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.)
> cellular organisms N E > Eukaryota N E > Opisthokonta N E > Metazoa N E > Eumetazoa N E > Bilateria N E > Deuterostomia N E > Chordata N E > Craniata N E > Vertebrata N E > Gnathostomata N E > Teleostomi N E > Euteleostomi N E > Sarcopterygii N E > Dipnotetrapodomorpha N E > Tetrapoda N E > Amniota N E > Mammalia N E > Theria N E > Eutheria N E > Boreoeutheria N E > Euarchontoglires N E > Glires N E > Rodentia N E > Myomorpha N E > Muroidea N E > Muridae N E > Murinae N E > Mus [genus] N E > Mus [subgenus] N E > Mus musculus N EMELSRRICLV RLWLLLLSFL LGFSAGSAID WREPEGKEVW DYVTVRKDAH MFWWLYYATN PCKNFSELPL VMWLQGGPGG SSTGFGNFEE IGPLDTQLKP RNTTWLQWAS LLFVDNPVGT GFSYVNTTDA YAKDLDTVAS DMMVLLKSFF DCHKEFQTVP FYIFSESYGG KMAAGISVEL YKAVQQGTIK CNFSGVALGD SWISPVDSVL SWGPYLYSMS LLDNQGLAEV SDIAEQVLDA VNKGFYKEAT QLWGKAEMII EKNTDGVNFY NILTKSSPEK AMESSLEFLR SPLVRLCQRH VRHLQGDALS QLMNGPIKKK LKIIPEDISW GAQASYVFLS MEGDFMKPAI DVVDKLLAAG VNVTVYNGQL DLIVDTIGQE SWVQKLKWPQ LSKFNQLKWK ALYTDPKSSE TAAFVKSYEN LAFYWILKAG HMVPSDQGEM ALKMMKLVTK QE
| Title : Serine carboxypeptidase SCPEP1 and Cathepsin A play complementary roles in regulation of vasoconstriction via inactivation of endothelin-1 - Pan_2014_PLoS.Genet_10_e1004146 |
| Author(s) : Pan X , Grigoryeva L , Seyrantepe V , Peng J , Kollmann K , Tremblay J , Lavoie JL , Hinek A , Lubke T , Pshezhetsky AV |
| Ref : PLoS Genet , 10 :e1004146 , 2014 |
| Abstract : |
| PubMedSearch : Pan_2014_PLoS.Genet_10_e1004146 |
| PubMedID: 24586188 |
| Gene_locus related to this paper: human-SCPEP1 , mouse-RISC |
| Title : Molecular characterization and gene disruption of mouse lysosomal putative serine carboxypeptidase 1 - Kollmann_2009_Febs.j_276_1356 |
| Author(s) : Kollmann K , Damme M , Deuschl F , Kahle J , D'Hooge R , Lullmann-Rauch R , Lubke T |
| Ref : Febs J , 276 :1356 , 2009 |
| Abstract : |
| PubMedSearch : Kollmann_2009_Febs.j_276_1356 |
| PubMedID: 19187242 |
| Gene_locus related to this paper: human-SCPEP1 , mouse-RISC |
| Title : Functional characterization of a putative serine carboxypeptidase in vascular smooth muscle cells - Lee_2009_Circ.Res_105_271 |
| Author(s) : Lee TH , Chen J , Miano JM |
| Ref : Circulation Research , 105 :271 , 2009 |
| Abstract : |
| PubMedSearch : Lee_2009_Circ.Res_105_271 |
| PubMedID: 19574551 |
| Gene_locus related to this paper: human-SCPEP1 , mouse-RISC |
| Title : Tissue expression of the novel serine carboxypeptidase Scpep1 - Lee_2006_J.Histochem.Cytochem_54_701 |
| Author(s) : Lee TH , Streb JW , Georger MA , Miano JM |
| Ref : Journal of Histochemistry & Cytochemistry , 54 :701 , 2006 |
| Abstract : |
| PubMedSearch : Lee_2006_J.Histochem.Cytochem_54_701 |
| PubMedID: 16461364 |
| Gene_locus related to this paper: human-SCPEP1 , mouse-RISC |
| Title : Cloning of a novel retinoid-inducible serine carboxypeptidase from vascular smooth muscle cells - Chen_2001_J.Biol.Chem_276_34175 |
| Author(s) : Chen J , Streb JW , Maltby KM , Kitchen CM , Miano JM |
| Ref : Journal of Biological Chemistry , 276 :34175 , 2001 |
| Abstract : |
| PubMedSearch : Chen_2001_J.Biol.Chem_276_34175 |
| PubMedID: 11447226 |
| Gene_locus related to this paper: human-SCPEP1 , mouse-RISC , ratno-RISC |
| Title : Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes - Carninci_2000_Genome.Res_10_1617 |
| Author(s) : Carninci P , Shibata Y , Hayatsu N , Sugahara Y , Shibata K , Itoh M , Konno H , Okazaki Y , Muramatsu M , Hayashizaki Y |
| Ref : Genome Res , 10 :1617 , 2000 |
| Abstract : |
| PubMedSearch : Carninci_2000_Genome.Res_10_1617 |
| PubMedID: 11042159 |
| Gene_locus related to this paper: mouse-1plip , mouse-1plrp , mouse-abhd5 , mouse-Abhd8 , mouse-cauxin , mouse-Ces1g , mouse-CPMac , mouse-dpp8 , mouse-hslip , mouse-hyes , mouse-lipli , mouse-LIPN , mouse-pafa , mouse-Ppgb , mouse-q3uuq7 , mouse-Q9DAI6 , mouse-RISC |
| Title : High-efficiency full-length cDNA cloning - |
| Author(s) : Carninci P , Hayashizaki Y |
| Ref : Methods Enzymol , 303 :19 , 1999 |
| PubMedID: 10349636 |
| Gene_locus related to this paper: mouse-1plip , mouse-1plrp , mouse-abhd5 , mouse-Abhd8 , mouse-cauxin , mouse-Ces1g , mouse-CPMac , mouse-dpp8 , mouse-hslip , mouse-lipli , mouse-LIPN , mouse-Ppgb , mouse-q3uuq7 , mouse-Q9DAI6 , mouse-RISC |