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schma-ACHE1

Schistosoma mansoni (Blood fluke, platyhelminth); Schistosoma rodhaini acetylcholinesterase SmAChE1 Smache1-smp_154600

Comment

This enzyme is called SmAChE1 in Tedla et al. 2019<\/A> and is inhibited by dichlorvos. || Other strain: Schistosoma mansoni (Blood fluke, platyhelminth)\; Schistosoma rodhaini

Relationship

Family : ACHE

Block : C

Position in NCBI Life Tree : Schistosoma mansoni

(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.)

> cellular organisms N E > Eukaryota N E > Opisthokonta N E > Metazoa N E > Eumetazoa N E > Bilateria N E > Platyhelminthes N E > Trematoda N E > Digenea N E > Strigeidida N E > Schistosomatoidea N E > Schistosomatidae N E > Schistosoma N E > Schistosoma mansoni N E

Molecular evidence

No mutation

No structure

No kinetic

No disease

No substrate

No inhibitor

Database

Sequence

Peptide

MSYGIVMNMN LCIITSFLLL DPVLSSRLNA FQNVNNVLIP SIENTIINNS IAADIDLHND KTTICSSDNP VVHTSVGIYC GLREIVHWPN GPASMVDVYY GIRYAQSPTG SLRFKKPVEP IPEPKKIFMA DKLPPTCPQP KDTMFQNSAA ARMWVPNTPM SEDCLFLNIW VPIKESNGSH PNSKEKLAVM LWIYGGSFYM GTSTLSVYDA RFLAARQNII VASMNYRLGS FGFLYMNTEE APGNMGLWDQ RLAMKWIKDH IEHFGGDPYR ITLFGESAGA VSVSTHVVSP WSHSYYNNAI MQSGSIFSNW GLATSEVSLN QTQRLAKILG CGYRSSNDQI KCLRSKSITE ILDAHDTMYD PASYFSVPFP PVLDNNFFPY ENSQSFRQLK YLKPSGALMF GINKNEGSYF LLYAFVSNSK WMKNLTDLPI TNRMDYLRCL RQVLDLDDDD ERPEFTEPLI RYTDFEYQTY QQLPTLESWT ERLEEISSDR SFKCPTINMA TAVTNDYRIP GRRRAHTLPV YFYEFQHRTV SLPMPKWTGT MHGYEIEYVF GIPFSPQFQA SFYRFTDEER QLSDIMMTYW ANFARTGDPN ILPDGRHVTD NLNPDDPDEI TEDQLKDSLS HKQGSKNPFI GWPEFRNSTK AYIVFRSAPA NLLVSTRPRH RQCLFWRRWY PALLQQVERN RQHCLGV

References (5)

Title : Novel cholinesterase paralogs of Schistosoma mansoni have perceived roles in cholinergic signaling and drug detoxification and are essential for parasite survival - Tedla_2019_PLoS.Pathog_15_e1008213
Author(s) : Tedla BA , Sotillo J , Pickering D , Eichenberger RM , Ryan S , Becker L , Loukas A , Pearson MS
Ref : PLoS Pathog , 15 :e1008213 , 2019
Abstract :
PubMedSearch : Tedla_2019_PLoS.Pathog_15_e1008213
PubMedID: 31809524
Gene_locus related to this paper: schma-ACHE1 , schma-ACHE2 , schma-BCHE

Title : Insects in anthelminthics research: Lady beetle-derived harmonine affects survival, reproduction and stem cell proliferation of Schistosoma mansoni - Kellershohn_2019_PLoS.Negl.Trop.Dis_13_e0007240
Author(s) : Kellershohn J , Thomas L , Grunweller A , Hartmann RK , Hardt M , Vilcinskas A , Grevelding CG , Haeberlein S
Ref : PLoS Negl Trop Dis , 13 :e0007240 , 2019
Abstract :
PubMedSearch : Kellershohn_2019_PLoS.Negl.Trop.Dis_13_e0007240
PubMedID: 30870428
Gene_locus related to this paper: schma-ACHE1 , schma-ACHE2

Title : The genome of the blood fluke Schistosoma mansoni - Berriman_2009_Nature_460_352
Author(s) : Berriman M , Haas BJ , LoVerde PT , Wilson RA , Dillon GP , Cerqueira GC , Mashiyama ST , Al-Lazikani B , Andrade LF , Ashton PD , Aslett MA , Bartholomeu DC , Blandin G , Caffrey CR , Coghlan A , Coulson R , Day TA , Delcher A , DeMarco R , Djikeng A , Eyre T , Gamble JA , Ghedin E , Gu Y , Hertz-Fowler C , Hirai H , Hirai Y , Houston R , Ivens A , Johnston DA , Lacerda D , Macedo CD , McVeigh P , Ning Z , Oliveira G , Overington JP , Parkhill J , Pertea M , Pierce RJ , Protasio AV , Quail MA , Rajandream MA , Rogers J , Sajid M , Salzberg SL , Stanke M , Tivey AR , White O , Williams DL , Wortman J , Wu W , Zamanian M , Zerlotini A , Fraser-Liggett CM , Barrell BG , El-Sayed NM
Ref : Nature , 460 :352 , 2009
Abstract :
PubMedSearch : Berriman_2009_Nature_460_352
PubMedID: 19606141
Gene_locus related to this paper: schma-ACHE1 , schma-ACHE2 , schma-c4qb79 , schma-c4qmk4 , schma-g4v9h7 , schma-BCHE , schma-g4vmf3

Title : Expression and comparative functional characterisation of recombinant acetylcholinesterase from three species of Schistosoma -
Author(s) : Bentley GN , Jones AK , Agnew A
Ref : Molecular & Biochemical Parasitology , 141 :119 , 2005
PubMedID: 15811534
Gene_locus related to this paper: schbo-ACHE , schha-ACHE , schma-ACHE1

Title : Mapping and sequencing of acetylcholinesterase genes from the platyhelminth blood fluke Schistosoma - Bentley_2003_Gene_314_103
Author(s) : Bentley GN , Jones AK , Agnew A
Ref : Gene , 314 :103 , 2003
Abstract :
PubMedSearch : Bentley_2003_Gene_314_103
PubMedID: 14527722
Gene_locus related to this paper: schbo-ACHE , schha-ACHE , schma-ACHE1