schma-BCHE

Schistosoma mansoni (Blood fluke, platyhelminth) BC026374 protein SmBChE1 Smbche1-Smp_125350

Comment

This enzyme is called SmBChE1 in Tedla et al. 2019<\/A> and is inhibited by dichlorvos A0A3Q0KKW0 replaced G4V715 which was incomplete. This enzyme is peculiar as it has a Q (Gln) instead of H (His) in the catalytic triad

Relationship

Family : Cholinesterase-like

Block : C

Position in NCBI Life Tree : Schistosoma mansoni

(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.)

> cellular organisms N E > Eukaryota N E > Opisthokonta N E > Metazoa N E > Eumetazoa N E > Bilateria N E > Platyhelminthes N E > Trematoda N E > Digenea N E > Strigeidida N E > Schistosomatoidea N E > Schistosomatidae N E > Schistosoma N E > Schistosoma mansoni N E

Molecular evidence

No mutation

No structure

No kinetic

No disease

No substrate

No inhibitor

Database

Sequence

Peptide

MFLVSPLNFE IFCSCLQLLP VISWADQIVI RTNYGAVSGK QKYIHGKNVF QFLGIPFAKP PTGDLRFRYP EPPDPWSNTL DATKPPNTCM QPLPESQEFL DATTRVWLNT TKMSEDCLYL NIWTRANNNN YSHAIDDRNH MMLESSAIFG PKGGRPVMVW IHGGSLIRGS SSIEMYNGAY LAGKMNVVVV SIQYRLGPLG FLYLGNDEIP GNQGLMDQVA GLQWVRENIA YFGGNPQQIT LFGHSGGVIC VALHLISPIS NHLFQQAILQ SGSPLAWWAV ESSHTALEKT RLLAQLSGCN AVTDSNGQYS KELVKCLQSV DSETLVVNQW HMHLLRNGEN SSRTNQLKKL YRNRASHHLL STAGYYFDLP FKPVVSAPFL PEWPYEVLGS GKLNIRHRIM LGVNKDEGMY HLVQSLRMYF MSPGSWPQIP REFRHGIALM DPLDLLAFYI MDENFLQSVL LQATVFEYQI PSRALGTGSW TSLEVVKALN EVGGDYNIKC PVVEFADFYS RGPNAQVFLY SFEHRTSGLT WPQWTGIMQG YEAEYIFGAP FNQAFTDNYY NFTLEEKRLS EEMMQFWTNF ASTGSPNLNP GEFHTRNKEL YWDRYETYSP HSVAVLSESS SSSSSSSIAI SGVSVSSVLS SSVSSETSSF KTRNDDSRKH MVFTLPRSYI SKNLRRHYCM FWREQLPMLR ERILYNSACK SRQSTTQYEV TNDIHKQPVE SFGTLYPNII KSSEFNTTKR NQASYNLQLK VNYILSLYII YYYHDYYFDY

References (2)

Title : Novel cholinesterase paralogs of Schistosoma mansoni have perceived roles in cholinergic signaling and drug detoxification and are essential for parasite survival - Tedla_2019_PLoS.Pathog_15_e1008213
Author(s) : Tedla BA , Sotillo J , Pickering D , Eichenberger RM , Ryan S , Becker L , Loukas A , Pearson MS
Ref : PLoS Pathog , 15 :e1008213 , 2019
PubMedID: 31809524
Gene_locus related to this paper: schma-ACHE1 , schma-ACHE2 , schma-BCHE