schma-ACHE2

Schistosoma mansoni (Blood fluke, platyhelminth) acetylcholinesterase SmAChE2 Smache2-smp_136690

Comment

This enzyme is called SmAChE2 in Tedla et al. 2019<\/A> and is inhibited by dichlorvos

Relationship

Family : ACHE

Block : C

Position in NCBI Life Tree : Schistosoma mansoni

(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.)

> cellular organisms N E > Eukaryota N E > Opisthokonta N E > Metazoa N E > Eumetazoa N E > Bilateria N E > Platyhelminthes N E > Trematoda N E > Digenea N E > Strigeidida N E > Schistosomatoidea N E > Schistosomatidae N E > Schistosoma N E > Schistosoma mansoni N E

Molecular evidence

No mutation

No structure

No kinetic

No disease

No substrate

No inhibitor

Database

Sequence

Peptide

MLLSFTHLSV VSLFSIIIIP TTVKSNTLKP IEIPLTHGGS VIGKEEIVNI DGQEVKVNSF LGIPYASKPI GKLRFAPPEK HPGWKGKYNA TTLSPTCWQY IFTGFDAVNA AGKMWINNTE MSEDCLYLNV WTPKSSVDSP HLPVMVWIYG GGFTSGSANL QVYNGAILSA TQNVIIVSMQ YRVGAFGFLR LKPNITDQTQ TDALGNQGLL DQLMALKWVS ENIGQFHGDP NQVTIFGESA GAVSVSILWM SPIAQPYFRR AILQSGSLYA RWGLDNADEA HEKADVFTRE CGCQSPSVDR KASLECLRKL DPLTLVNQLD SINVAIGKHR YDAVRKYLLP RYHKQEPFLL SQSTSTRLYF DVPLQPVIDG YLVPKHPDHI FNEKNKLKQN PELLIGVNTN EAMFFLLPGI AIKDTQFLFS NGSVIMPSTM ELAGKKKPFK EGEEIADFYW ITATQILDES HMRPGLAKMP SYYYNLPLTS SPKRGYYDPD TVYIHDEELL RRLDKFAGDL DFACPTLNFA EQVARLPNAK VFLYHFNKRT ESLPMPKWTG VMHGYEIEYI FGIPYDPEFS KQFYNFTDPE KIFSSRIMKM WTNFAKTGHP SKSNDGKIST PEWPLFHSTD GFVSNNPDYL ILEDETKLGS GLHRDRCAFW LHEMQDMKDI WFNRCDPGSG IKPTGNYILI LGSGLLLFIG IFYG

References (4)

Title : A novel, non-neuronal acetylcholinesterase of schistosome parasites is essential for definitive host infection - Skelly_2023_Front.Immunol_14_1056469
Author(s) : Skelly PJ , Da , x , dara AA
Ref : Front Immunol , 14 :1056469 , 2023
PubMedID: 36798133
Gene_locus related to this paper: schma-ACHE2

Title : Novel cholinesterase paralogs of Schistosoma mansoni have perceived roles in cholinergic signaling and drug detoxification and are essential for parasite survival - Tedla_2019_PLoS.Pathog_15_e1008213
Author(s) : Tedla BA , Sotillo J , Pickering D , Eichenberger RM , Ryan S , Becker L , Loukas A , Pearson MS
Ref : PLoS Pathog , 15 :e1008213 , 2019
PubMedID: 31809524
Gene_locus related to this paper: schma-ACHE1 , schma-ACHE2 , schma-BCHE

Title : Insects in anthelminthics research: Lady beetle-derived harmonine affects survival, reproduction and stem cell proliferation of Schistosoma mansoni - Kellershohn_2019_PLoS.Negl.Trop.Dis_13_e0007240
Author(s) : Kellershohn J , Thomas L , Grunweller A , Hartmann RK , Hardt M , Vilcinskas A , Grevelding CG , Haeberlein S
Ref : PLoS Negl Trop Dis , 13 :e0007240 , 2019
PubMedID: 30870428
Gene_locus related to this paper: schma-ACHE1 , schma-ACHE2