Gene_Locus Report

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Gene_locus Report for: aspa1-aneh

Aspergillus aculeatus (strain ATCC 16872 / CBS 172.66 / WB 5094). Aculenes biosynthesis cluster protein HA

Relationship
Family|Proline_iminopeptidase
Block| X
Position in NCBI Life Tree|Aspergillus aculeatus
(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.)
> cellular organisms: N E > Eukaryota: N E > Opisthokonta: N E > Fungi: N E > Dikarya: N E > Ascomycota: N E > saccharomyceta: N E > Pezizomycotina: N E > leotiomyceta: N E > Eurotiomycetes: N E > Eurotiomycetidae: N E > Eurotiales: N E > Aspergillaceae: N E > Aspergillus: N E > Aspergillus subgen. Circumdati: N E > Aspergillus aculeatus: N E


Molecular evidence
Database
No mutation
No structure
No kinetic





No Substrate
No inhibitor
2 Genbank : KV878977, XP_020056259
1 UniProt : A0A1L9WUM2
1 UniProt : A0A1L9WUM2
1 Interpro : A0A1L9WUM2
1 Pfam : A0A1L9WUM2
1 PIRSF : A0A1L9WUM2
1 SUPERFAM : A0A1L9WUM2
Sequence
Graphical view for this peptide sequence: aspa1-aneh
Colored MSA for Proline_iminopeptidase (raw)
MAVEQNIAPAKLIDRFSHDGPGKCRTSEWRFEVPLNHSKPDEGTVRLFAR
SIHCVLGVDDPELPWMLYLQGGPGLGCKTPLEYAWLPSILEKGYRVLFLD
ERGTGQSSPITAKTLAQQGDHKKQADLLKRFRADNIVRDCEAVRKHLYQD
APADQSKWSVMAASFGGFCAISYVSMFPNSLVEVFIGGGPCPMVNEPGQV
IPRLFAVAARRNEVYYKKYPEDVGRVKRIIKYLKENKVALSKGTLTPERF
QQLGVMLGLHGGIDYIHGVVQRTDNDLDMFKFLTAPTLDLIENSGMAHNV
IYSLLQEPMYCQGKAGGWCADKCRKADPRFSLNERNAQIWFTGEAIFSDM
FESYDELKDLKPVAELLARSSDWGQLYNEAQLARNEVPVYVATAVEDMYV
SYDLGCHTASKVKNLQQVVNNTWYHDAVETKASEVMPALFALKEDRID
Legend This sequence has been compared to family alignement (MSA)
red => minority aminoacid
blue => majority aminoacid
color intensity => conservation rate
title => sequence position(MSA position)aminoacid rate
Catalytic site
Catalytic site in the MSA

MAVEQNIAPAKLIDRFSHDGPGKCRTSEWRFEVPLNHSKPDEGTVRLFAR
SIHCVLGVDDPELPWMLYLQGGPGLGCKTPLEYAWLPSILEKGYRVLFLD
ERGTGQSSPITAKTLAQQGDHKKQADLLKRFRADNIVRDCEAVRKHLYQD
APADQSKWSVMAASFGGFCAISYVSMFPNSLVEVFIGGGPCPMVNEPGQV
IPRLFAVAARRNEVYYKKYPEDVGRVKRIIKYLKENKVALSKGTLTPERF
QQLGVMLGLHGGIDYIHGVVQRTDNDLDMFKFLTAPTLDLIENSGMAHNV
IYSLLQEPMYCQGKAGGWCADKCRKADPRFSLNERNAQIWFTGEAIFSDM
FESYDELKDLKPVAELLARSSDWGQLYNEAQLARNEVPVYVATAVEDMYV
SYDLGCHTASKVKNLQQVVNNTWYHDAVETKASEVMPALFALKEDRID


References
    Title: The Biosynthesis of Norsesquiterpene Aculenes Requires Three Cytochrome P450 Enzymes to Catalyze a Stepwise Demethylation Process
    Lee CF, Chen LX, Chiang CY, Lai CY, Lin HC
    Ref: Angew Chem Int Ed Engl, 58:18414, 2019 : PubMed

            

    Title: Comparative genomics reveals high biological diversity and specific adaptations in the industrially and medically important fungal genus Aspergillus
    de Vries RP, Riley R, Wiebenga A, Aguilar-Osorio G, Amillis S, Uchima CA, Anderluh G, Asadollahi M, Askin M and Grigoriev IV <107 more author(s)>
    Ref: Genome Biol, 18:28, 2017 : PubMed

            

    Title: Manipulating the expression rate and enantioselectivity of an epoxide hydrolase by using directed evolution
    Reetz MT, Zheng H
    Ref: Chembiochem, 12:1529, 2011 : PubMed

            


Other Papers


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Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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