not active on hMAO-A ; IC50 hMAO-B 4.46 +/- 0.18 microM; IC50 hAChE 0.0290 +/- 0.0030 microM; IC50 hBChE 0.0011 +/- 0.00031 microM
Type : Quinoline, Multitarget, Monoamine-oxidase-inhibitor
Chemical_Nomenclature : 1-(8-oxidanylquinolin-2-yl)-N-(phenylmethyl)methanimine oxide
Canonical SMILES : c1ccc(cc1)C\/[N+](=C\/c2ccc3cccc(c3n2)O)\/[O-]
InChI : InChI=1S\/C17H14N2O2\/c20-16-8-4-7-14-9-10-15(18-17(14)16)12-19(21)11-13-5-2-1-3-6-13\/h1-10,12,20H,11H2\/b19-12-
InChIKey : SHXQVJVENHOUOF-UNOMPAQXSA-N
Other name(s) : (Z)-N-benzyl-1-(8-hydroxyquinolin-2-yl)methanimine oxide || 1-(8-oxidanylquinolin-2-yl)-~{N}-(phenylmethyl)methanimine oxide || Quinolylnitrone 19 || QN19
Families : AI0-7QBQ ligand of proteins in family
BCHE
ACHE
Structure :
7QBQ
Protein :
human-BCHE
human-ACHE
Title : 8-Hydroxyquinolylnitrones as multifunctional ligands for the therapy of neurodegenerative diseases - Knez_2023_Acta.Pharmaceutica.Sinica.B_13_2152 |
Author(s) : Knez D , Diez-Iriepa D , Chioua M , Gottinger A , Denic M , Chantegreil F , Nachon F , Brazzolotto X , Skrzypczak-Wiercioch A , Meden A , Pislar A , Kos J , Zakelj S , Stojan J , Salat K , Serrano J , Patricia Fernandez AP , Sanchez-Garcia A , Martinez-Murillo R , Binda C , Lopez-Munoz F , Gobec S , Marco-Contelles J |
Ref : Acta Pharmaceutica Sinica B , 13 :2152 , 2023 |
Abstract : |
PubMedSearch : Knez_2023_Acta.Pharmaceutica.Sinica.B_13_2152 |
PubMedID: 37250172 |
Gene_locus related to this paper: human-BCHE |