| Title : 2-{N-[-(1-Benzylpiperidin-4-yl)alkyl]amino}-6-[(prop-2-yn-1-yl)amino]pyridine-3,5-dicarbonitriles Showing High Affinity for (1\/2) Receptors - Deuther-Conrad_2025_Int.J.Mol.Sci_26_ |
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| Ref : Int J Mol Sci , 26 : , 2025 |
| Abstract : |
| PubMedSearch : Deuther-Conrad_2025_Int.J.Mol.Sci_26_ |
| PubMedID: 39941036 |
| Title : Cholesterol Oxime Olesoxime Assessed as a Potential Ligand of Human Cholinesterases - Kolic_2024_Biomolecules_14_588 |
| Author(s) : Kolic D , Sinko G , Jean L , Chioua M , Dias J , Marco-Contelles J , Kovarik, Z , Kovarik Z |
| Ref : Biomolecules , 14 :588 , 2024 |
| Abstract : |
| PubMedSearch : Kolic_2024_Biomolecules_14_588 |
| PubMedID: 38785995 |
| Title : 8-Hydroxyquinolylnitrones as multifunctional ligands for the therapy of neurodegenerative diseases - Knez_2023_Acta.Pharmaceutica.Sinica.B_13_2152 |
| Author(s) : Knez D , Diez-Iriepa D , Chioua M , Gottinger A , Denic M , Chantegreil F , Nachon F , Brazzolotto X , Skrzypczak-Wiercioch A , Meden A , Pislar A , Kos J , Zakelj S , Stojan J , Salat K , Serrano J , Patricia Fernandez AP , Sanchez-Garcia A , Martinez-Murillo R , Binda C , Lopez-Munoz F , Gobec S , Marco-Contelles J |
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| Abstract : |
| PubMedSearch : Knez_2023_Acta.Pharmaceutica.Sinica.B_13_2152 |
| PubMedID: 37250172 |
| Gene_locus related to this paper: human-BCHE |
| Title : The Chemotype of Chromanones as a Privileged Scaffold for Multineurotarget Anti-Alzheimer Agents - Keuler_2022_ACS.Pharmacol.Transl.Sci_5_1097 |
| Author(s) : Keuler T , Lemke C , Elsinghorst PW , Iriepa I , Chioua M , Martinez-Grau MA , Beadle CD , Vetman T , Lopez-Munoz F , Wille T , Bartz U , Deuther-Conrad W , Marco-Contelles J , Gutschow M |
| Ref : ACS Pharmacol Transl Sci , 5 :1097 , 2022 |
| Abstract : |
| PubMedSearch : Keuler_2022_ACS.Pharmacol.Transl.Sci_5_1097 |
| PubMedID: 36407962 |
| Title : Acetylcholinesterase Inhibition of Diversely Functionalized Quinolinones for Alzheimer's Disease Therapy - Bautista-Aguilera_2020_Int.J.Mol.Sci_21_ |
| Author(s) : Bautista-Aguilera OM , Ismaili L , Chioua M , Andrys R , Schmidt M , Bzonek P , Martinez-Grau MA , Beadle CD , Vetman T , Lopez-Munoz F , Iriepa I , Refouvelet B , Musilek K , Marco-Contelles J |
| Ref : Int J Mol Sci , 21 : , 2020 |
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| PubMedSearch : Bautista-Aguilera_2020_Int.J.Mol.Sci_21_ |
| PubMedID: 32486316 |
| Title : Chromenones as Multineurotargeting Inhibitors of Human Enzymes - Lemke_2019_ACS.Omega_4_22161 |
| Author(s) : Lemke C , Christmann J , Yin J , Alonso JM , Serrano E , Chioua M , Ismaili L , Martinez-Grau MA , Beadle CD , Vetman T , Dato FM , Bartz U , Elsinghorst PW , Pietsch M , Muller CE , Iriepa I , Wille T , Marco-Contelles J , Gutschow M |
| Ref : ACS Omega , 4 :22161 , 2019 |
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| PubMedSearch : Lemke_2019_ACS.Omega_4_22161 |
| PubMedID: 31891098 |
| Title : QuinoxalineTacrine QT78, a Cholinesterase Inhibitor as a Potential Ligand for Alzheimer's Disease Therapy - Ramos_2019_Molecules_24_ |
| Author(s) : Ramos E , Palomino-Antolin A , Bartolini M , Iriepa I , Moraleda I , Diez-Iriepa D , Samadi A , Cortina CV , Chioua M , Egea J , Romero A , Marco-Contelles J |
| Ref : Molecules , 24 : , 2019 |
| Abstract : |
| PubMedSearch : Ramos_2019_Molecules_24_ |
| PubMedID: 30999586 |
| Title : Tacripyrimidines, the first tacrine-dihydropyrimidine hybrids, as multi-target-directed ligands for Alzheimer's disease - Chioua_2018_Eur.J.Med.Chem_155_839 |
| Author(s) : Chioua M , Buzzi E , Moraleda I , Iriepa I , Maj M , Wnorowski A , Giovannini C , Tramarin A , Portali F , Ismaili L , Lopez-Alvarado P , Bolognesi ML , Jozwiak K , Menendez JC , Marco-Contelles J , Bartolini M |
| Ref : Eur Journal of Medicinal Chemistry , 155 :839 , 2018 |
| Abstract : |
| PubMedSearch : Chioua_2018_Eur.J.Med.Chem_155_839 |
| PubMedID: 29958119 |
| Title : New (benz)imidazolopyridino tacrines as nonhepatotoxic, cholinesterase inhibitors for Alzheimer disease - Boulebd_2017_Future.Med.Chem_9_723 |
| Author(s) : Boulebd H , Ismaili L , Martin H , Bonet A , Chioua M , Marco-Contelles J , Belfaitah A |
| Ref : Future Med Chem , 9 :723 , 2017 |
| Abstract : |
| PubMedSearch : Boulebd_2017_Future.Med.Chem_9_723 |
| PubMedID: 28485637 |
| Title : Synthesis and biological assessment of racemic benzochromenopyrimidinetriones as promising agents for Alzheimer's disease therapy - Dgachi_2017_Future.Med.Chem_9_715 |
| Author(s) : Dgachi Y , Martin H , Bonet A , Chioua M , Iriepa I , Moraleda I , Chabchoub F , Marco-Contelles J , Ismaili L |
| Ref : Future Med Chem , 9 :715 , 2017 |
| Abstract : |
| PubMedSearch : Dgachi_2017_Future.Med.Chem_9_715 |
| PubMedID: 28504912 |
| Title : Multitarget-Directed Ligands Combining Cholinesterase and Monoamine Oxidase Inhibition with Histamine H3 R Antagonism for Neurodegenerative Diseases - Bautista-Aguilera_2017_Angew.Chem.Int.Ed.Engl_56_12765 |
| Author(s) : Bautista-Aguilera OM , Hagenow S , Palomino-Antolin A , Farre-Alins V , Ismaili L , Joffrin PL , Jimeno ML , Soukup O , Janockova J , Kalinowsky L , Proschak E , Iriepa I , Moraleda I , Schwed JS , Romero Martinez A , Lopez-Munoz F , Chioua M , Egea J , Ramsay RR , Marco-Contelles J , Stark H |
| Ref : Angew Chem Int Ed Engl , 56 :12765 , 2017 |
| Abstract : |
| PubMedSearch : Bautista-Aguilera_2017_Angew.Chem.Int.Ed.Engl_56_12765 |
| PubMedID: 28861918 |
| Title : Imidazopyranotacrines as Non-Hepatotoxic, Selective Acetylcholinesterase Inhibitors, and Antioxidant Agents for Alzheimer's Disease Therapy - Boulebd_2016_Molecules_21_ |
| Author(s) : Boulebd H , Ismaili L , Bartolini M , Bouraiou A , Andrisano V , Martin H , Bonet A , Moraleda I , Iriepa I , Chioua M , Belfaitah A , Marco-Contelles J |
| Ref : Molecules , 21 : , 2016 |
| Abstract : |
| PubMedSearch : Boulebd_2016_Molecules_21_ |
| PubMedID: 27023499 |
| Title : Synthesis and Biological Evaluation of Benzochromenopyrimidinones as Cholinesterase Inhibitors and Potent Antioxidant, Non-Hepatotoxic Agents for Alzheimer's Disease - Dgachi_2016_Molecules_21_ |
| Author(s) : Dgachi Y , Bautista-Aguilera OM , Benchekroun M , Martin H , Bonet A , Knez D , Godyn J , Malawska B , Gobec S , Chioua M , Janockova J , Soukup O , Chabchoub F , Marco-Contelles J , Ismaili L |
| Ref : Molecules , 21 : , 2016 |
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| PubMedSearch : Dgachi_2016_Molecules_21_ |
| PubMedID: 27187348 |
| Title : Synthesis and Biological Assessment of Racemic Benzochromenopyrimidinimines as Antioxidant, Cholinesterase, and Abeta1-42 Aggregation Inhibitors for Alzheimer's Disease Therapy - Dgachi_2016_ChemMedChem_11_1318 |
| Author(s) : Dgachi Y , Ismaili L , Knez D , Benchekroun M , Martin H , Szalaj N , Wehle S , Bautista-Aguilera OM , Luzet V , Bonnet A , Malawska B , Gobec S , Chioua M , Decker M , Chabchoub F , Marco-Contelles J |
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| Abstract : |
| PubMedSearch : Dgachi_2016_ChemMedChem_11_1318 |
| PubMedID: 26804623 |
| Title : Pyranopyrazolotacrines as nonneurotoxic, Abeta-anti-aggregating and neuroprotective agents for Alzheimer's disease - Chioua_2015_Future.Med.Chem_7_845 |
| Author(s) : Chioua M , Perez-Pena J , Garcia-Font N , Moraleda I , Iriepa I , Soriano E , Marco-Contelles J , Oset-Gasque MJ |
| Ref : Future Med Chem , 7 :845 , 2015 |
| Abstract : |
| PubMedSearch : Chioua_2015_Future.Med.Chem_7_845 |
| PubMedID: 26061104 |
| Title : Multipotent cholinesterase\/monoamine oxidase inhibitors for the treatment of Alzheimer's disease: design, synthesis, biochemical evaluation, ADMET, molecular modeling, and QSAR analysis of novel donepezil-pyridyl hybrids - Bautista-Aguilera_2014_Drug.Des.Devel.Ther_8_1893 |
| Author(s) : Bautista-Aguilera OM , Esteban G , Chioua M , Nikolic K , Agbaba D , Moraleda I , Iriepa I , Soriano E , Samadi A , Unzeta M , Marco-Contelles J |
| Ref : Drug Des Devel Ther , 8 :1893 , 2014 |
| Abstract : |
| PubMedSearch : Bautista-Aguilera_2014_Drug.Des.Devel.Ther_8_1893 |
| PubMedID: 25378907 |
| Title : N-Methyl-N-((1-methyl-5-(3-(1-(2-methylbenzyl)piperidin-4-yl)propoxy)-1H-indol-2- yl)methyl)prop-2-yn-1-amine, a new cholinesterase and monoamine oxidase dual inhibitor - Bautista-Aguilera_2014_J.Med.Chem_57_10455 |
| Author(s) : Bautista-Aguilera OM , Samadi A , Chioua M , Nikolic K , Filipic S , Agbaba D , Soriano E , de Andres L , Rodriguez-Franco MI , Alcaro S , Ramsay RR , Ortuso F , Yanez M , Marco-Contelles J |
| Ref : Journal of Medicinal Chemistry , 57 :10455 , 2014 |
| Abstract : |
| PubMedSearch : Bautista-Aguilera_2014_J.Med.Chem_57_10455 |
| PubMedID: 25418133 |
| Title : Isoxazolotacrines as non-toxic and selective butyrylcholinesterase inhibitors for Alzheimer's disease - Cherif_2014_Future.Med.Chem_6_1883 |
| Author(s) : Cherif O , Allouche F , Chabchoub F , Chioua M , Soriano E , Yanez M , Cacabelos R , Romero A , Lopez MG , Marco-Contelles J |
| Ref : Future Med Chem , 6 :1883 , 2014 |
| Abstract : |
| PubMedSearch : Cherif_2014_Future.Med.Chem_6_1883 |
| PubMedID: 25495982 |
| Title : Synthesis, pharmacological assessment, and molecular modeling of acetylcholinesterase\/butyrylcholinesterase inhibitors: effect against amyloid-beta-induced neurotoxicity - Silva_2013_ACS.Chem.Neurosci_4_547 |
| Author(s) : Silva D , Chioua M , Samadi A , Agostinho P , Garcao P , Lajarin-Cuesta R , de los Rios C , Iriepa I , Moraleda I , Gonzalez-Lafuente L , Mendes E , Perez C , Rodriguez-Franco MI , Marco-Contelles J , Carmo Carreiras M |
| Ref : ACS Chem Neurosci , 4 :547 , 2013 |
| Abstract : |
| PubMedSearch : Silva_2013_ACS.Chem.Neurosci_4_547 |
| PubMedID: 23379636 |
| Title : Pyridonepezils, new dual AChE inhibitors as potential drugs for the treatment of Alzheimer's disease: Synthesis, biological assessment, and molecular modeling - Samadi_2012_Eur.J.Med.Chem_57C_296 |
| Author(s) : Samadi A , Estrada M , Perez C , Rodriguez-Franco MI , Iriepa I , Moraleda I , Chioua M , Marco-Contelles J |
| Ref : Eur Journal of Medicinal Chemistry , 57C :296 , 2012 |
| Abstract : |
| PubMedSearch : Samadi_2012_Eur.J.Med.Chem_57C_296 |
| PubMedID: 23078965 |
| Title : Multipotent MAO and cholinesterase inhibitors for the treatment of Alzheimer's disease: synthesis, pharmacological analysis and molecular modeling of heterocyclic substituted alkyl and cycloalkyl propargyl amine - Samadi_2012_Eur.J.Med.Chem_52_251 |
| Author(s) : Samadi A , de los Rios C , Bolea I , Chioua M , Iriepa I , Moraleda I , Bartolini M , Andrisano V , Galvez E , Valderas C , Unzeta M , Marco-Contelles J |
| Ref : Eur Journal of Medicinal Chemistry , 52 :251 , 2012 |
| Abstract : |
| PubMedSearch : Samadi_2012_Eur.J.Med.Chem_52_251 |
| PubMedID: 22503231 |
| Title : Synthesis and pharmacological assessment of diversely substituted pyrazolo[3,4-b]quinoline, and benzo[b]pyrazolo[4,3-g][1,8]naphthyridine derivatives - Silva_2011_Eur.J.Med.Chem_46_4676 |
| Author(s) : Silva D , Chioua M , Samadi A , Carmo Carreiras M , Jimeno ML , Mendes E , Rios Cde L , Romero A , Villarroya M , Lopez MG , Marco-Contelles J |
| Ref : Eur Journal of Medicinal Chemistry , 46 :4676 , 2011 |
| Abstract : |
| PubMedSearch : Silva_2011_Eur.J.Med.Chem_46_4676 |
| PubMedID: 21715067 |
| Title : Synthesis, biological evaluation, and molecular modeling of donepezil and N-[(5-(benzyloxy)-1-methyl-1H-indol-2-yl)methyl]-N-methylprop-2-yn-1-amine hybrids as new multipotent cholinesterase\/monoamine oxidase inhibitors for the treatment of Alzheimer's disease - Bolea_2011_J.Med.Chem_54_8251 |
| Author(s) : Bolea I , Juarez-Jimenez J , de los Rios C , Chioua M , Pouplana R , Luque FJ , Unzeta M , Marco-Contelles J , Samadi A |
| Ref : Journal of Medicinal Chemistry , 54 :8251 , 2011 |
| Abstract : |
| PubMedSearch : Bolea_2011_J.Med.Chem_54_8251 |
| PubMedID: 22023459 |
| Title : Synthesis and biological assessment of diversely substituted furo[2,3-b]quinolin-4-amine and pyrrolo[2,3-b]quinolin-4-amine derivatives, as novel tacrine analogues - Martins_2011_Eur.J.Med.Chem_46_6119 |
| Author(s) : Martins C , Carreiras MC , Leon R , de los Rios C , Bartolini M , Andrisano V , Iriepa I , Moraleda I , Galvez E , Garcia M , Egea J , Samadi A , Chioua M , Marco-Contelles J |
| Ref : Eur Journal of Medicinal Chemistry , 46 :6119 , 2011 |
| Abstract : |
| PubMedSearch : Martins_2011_Eur.J.Med.Chem_46_6119 |
| PubMedID: 22000936 |
| Title : Synthesis, biological assessment and molecular modeling of new multipotent MAO and cholinesterase inhibitors as potential drugs for the treatment of Alzheimer's disease - Samadi_2011_Eur.J.Med.Chem_46_4665 |
| Author(s) : Samadi A , Chioua M , Bolea I , de los Rios C , Iriepa I , Moraleda I , Bastida A , Esteban G , Unzeta M , Galvez E , Marco-Contelles J |
| Ref : Eur Journal of Medicinal Chemistry , 46 :4665 , 2011 |
| Abstract : |
| PubMedSearch : Samadi_2011_Eur.J.Med.Chem_46_4665 |
| PubMedID: 21669479 |
| Title : Multipotent drugs with cholinergic and neuroprotective properties for the treatment of Alzheimer and neuronal vascular diseases. I. Synthesis, biological assessment, and molecular modeling of simple and readily available 2-aminopyridine-, and 2-chloropyridine-3,5-dicarbonitriles - Samadi_2010_Bioorg.Med.Chem_18_5861 |
| Author(s) : Samadi A , Marco-Contelles J , Soriano E , Alvarez-Perez M , Chioua M , Romero A , Gonzalez-Lafuente L , Gandia L , Roda JM , Lopez MG , Villarroya M , Garcia AG , Rios Cde L |
| Ref : Bioorganic & Medicinal Chemistry , 18 :5861 , 2010 |
| Abstract : |
| PubMedSearch : Samadi_2010_Bioorg.Med.Chem_18_5861 |
| PubMedID: 20656495 |
| Title : Molecular modelling, synthesis and acetylcholinesterase inhibition of ethyl 5-amino-2-methyl-6,7,8,9-tetrahydrobenzo[b][1,8]naphthyridine-3-carboxylate - Soriano_2010_Bioorg.Med.Chem.Lett_20_2950 |
| Author(s) : Soriano E , Samadi A , Chioua M , de los Rios C , Marco-Contelles J |
| Ref : Bioorganic & Medicinal Chemistry Lett , 20 :2950 , 2010 |
| Abstract : |
| PubMedSearch : Soriano_2010_Bioorg.Med.Chem.Lett_20_2950 |
| PubMedID: 20350807 |