Dichlorophenyl-methylamino-naphthalen-piperidine-carboxylate-Cpd8e
hAChE IC50 157 nM; hBChE IC50 4 nM
General
Type : Carboxylate, Sodium:neurotransmitter symporter, Multitarget, Piperidine, Naphthalen
Chemical_Nomenclature : (5S,8S)-5-(3,4-dichlorophenyl)-8-(methylamino)-5,6,7,8-tetrahydronaphthalen-2-yl piperidine-1-carboxylate
Canonical SMILES : C1CCN(CC1)C(OC2=CC3=C(C=C2)[C@@H](CC[C@@H]3NC)C4=CC(=C(C=C4)Cl)Cl)=O
InChI : InChI=1S\/C23H26Cl2N2O2\/c1-26-22-10-8-17(15-5-9-20(24)21(25)13-15)18-7-6-16(14-19(18)22)29-23(28)27-11-3-2-4-12-27\/h5-7,9,13-14,17,22,26H,2-4,8,10-12H2,1H3\/t17-,22-\/m0\/s1
InChIKey : RRTZUYKPGCUFIN-JTSKRJEESA-N
Other name(s) : Compound 8e
Target
Families : Dichlorophenyl-methylamino-naphthalen-piperidine-carboxylate-Cpd8e ligand of proteins in family
ACHE
BCHE
Protein :
human-ACHE
human-BCHE
References (1)
| Title : Access to novel potent pleiotropic prodrugs, targeting both butyrylcholinesterase and serotonin reuptake, with anti-amnesic activities in Alzheimer's disease model - Travers-Lesage_2026_Eur.J.Med.Chem_307_118670 |
| Author(s) : Travers-Lesage V , Crouzier L , Antonijevic M , Wang A , Toublet FX , Davis A , Modeste F , Brazzolotto X , Nachon F , Since M , Maurice T , Rochais C , Dallemagne P |
| Ref : Eur Journal of Medicinal Chemistry , 307 :118670 , 2026 |
| Abstract : |
| PubMedSearch : Travers-Lesage_2026_Eur.J.Med.Chem_307_118670 |
| PubMedID: 41702369 |