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Sodium:neurotransmitter symporter

General

Sodium:Neurotransmitter Symporter (NSS) is a membrane protein that clears neurotransmitters from the synapse by co-transporting them back into the neuron, using the energy from the sodium ((Na^{+})) gradient; key examples include transporters for dopamine (DAT), serotonin (SERT), and norepinephrine (NET), GABA, and glycine and are targets for antidepressants and stimulants. Used as building blocks of Multi-target drug ligand MTDL
Inhibitor Main targeted enzyme families Type Structure
Fluoxetine-rivastigmine-Cpd8 ACHE Drug Pro-Drug Carbamate Derivative of Rivastigmine Stigmine Multitarget Sodium:neurotransmitter symporter
Dichlorophenyl-methylamino-naphthalen-piperidine-carboxylate-Cpd8e ACHE BCHE Carboxylate Sodium:neurotransmitter symporter Multitarget Piperidine Naphthalen
Duloxetine BCHE Drug Multitarget Sodium:neurotransmitter symporter Naphthalen Sulfur Compound Thiophen