FAPI-74
General
Type : Piperazine, Quinoline, PET probe, Cyanide
Chemical_Nomenclature : 2-[4-(carboxymethyl)-7-[2-[4-[3-[4-[[2-[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl]carbamoyl]quinolin-6-yl]oxypropyl]piperazin-1-yl]-2-oxoethyl]-1,4,7-triazonan-1-yl]acetic acid
Canonical SMILES : C1C[C@H](N(C1)C(=O)CNC(=O)C2=C3C=C(C=CC3=NC=C2)OCCCN4CCN(CC4)C(=O)CN5CCN(CCN(CC5)CC(=O)O)CC(=O)O)C#N
InChI : InChI=1S\/C36H49N9O8\/c37-22-27-3-1-9-45(27)32(46)23-39-36(52)29-6-7-38-31-5-4-28(21-30(29)31)53-20-2-8-40-16-18-44(19-17-40)33(47)24-41-10-12-42(25-34(48)49)14-15-43(13-11-41)26-35(50)51\/h4-7,21,27H,1-3,8-20,23-26H2,(H,39,52)(H,48,49)(H,50,51)\/t27-\/m0\/s1
InChIKey : ZPDBPTLREULTFT-MHZLTWQESA-N
Other name(s) : FAPI74 || Q6B3ZN6AX9 || SCHEMBL21257235 || HY-147173 || CS-0530349 || (S)-2,2'-(7-(2-(4-(3-((4-((2-(2-Cyanopyrrolidin-1-yl)-2-oxoethyl)carbamoyl)quinolin-6-yl)oxy)propyl)piperazin-1-yl)-2-oxoethyl)-1,4,7-triazonane-1,4-diyl)diacetic acid
MW : 735.8
Formula : C36H49N9O8
CAS_number : 2374782-76-8
PubChem : 139400631
UniChem : ZPDBPTLREULTFT-MHZLTWQESA-N
Target
Families : FAPI-74 ligand of proteins in family
DPP4N_Peptidase_S9
Protein :
human-FAP
References (7)
| Title : Head-to-Head Intra-Individual Comparison of Biodistribution and Tumor Uptake of [(18)F]FAPI-74 with [(18)F]FDG in Patients with PDAC: A Prospective Exploratory Study - Novruzov_2023_Cancers.(Basel)_15_ |
| Author(s) : Novruzov E , Giesel FL , Mori Y , Choyke PL , Dabir M , Mamlins E , Schmitt D , Antke C , Pinto C , Soza-Ried C , Fernandez R , Amaral H , Kramer V , Badinez L |
| Ref : Cancers (Basel) , 15 : , 2023 |
| Abstract : |
| PubMedSearch : Novruzov_2023_Cancers.(Basel)_15_ |
| PubMedID: 37345133 |
| Title : Initial Evaluation of [(18)F]FAPI-74 PET for Various Histopathologically Confirmed Cancers and Benign Lesions - Watabe_2023_J.Nucl.Med_64_1225 |
| Author(s) : Watabe T , Naka S , Tatsumi M , Kamiya T , Kimura T , Shintani Y , Abe K , Miyake T , Shimazu K , Kobayashi S , Kurokawa Y , Eguchi H , Doki Y , Inohara H , Kato H , Mori Y , Cardinale J , Giesel FL |
| Ref : J Nucl Med , 64 :1225 , 2023 |
| Abstract : |
| PubMedSearch : Watabe_2023_J.Nucl.Med_64_1225 |
| PubMedID: 37268427 |
| Title : Subclass Analysis of Malignant, Inflammatory and Degenerative Pathologies Based on Multiple Timepoint FAPI-PET Acquisitions Using FAPI-02, FAPI-46 and FAPI-74 - Glatting_2022_Cancers.(Basel)_14_ |
| Author(s) : Glatting FM , Hoppner J , Kauczor HU , Huber PE , Kratochwil C , Giesel FL , Haberkorn U , Rohrich M |
| Ref : Cancers (Basel) , 14 : , 2022 |
| Abstract : |
| PubMedSearch : Glatting_2022_Cancers.(Basel)_14_ |
| PubMedID: 36358720 |
| Title : Repetitive Early (68)Ga-FAPI PET Acquisition Comparing (68)Ga-FAPI-02, (68)Ga-FAPI-46, and (68)Ga-FAPI-74: Methodologic and Diagnostic Implications for Malignant, Inflammatory\/Reactive, and Degenerative Lesions - Glatting_2022_J.Nucl.Med_63_1844 |
| Author(s) : Glatting FM , Hoppner J , Liew DP , van Genabith A , Spektor AM , Steinbach L , Hubert A , Kratochwil C , Giesel FL , Dendl K , Rathke H , Kauczor HU , Huber PE , Haberkorn U , Rohrich M |
| Ref : J Nucl Med , 63 :1844 , 2022 |
| Abstract : |
| PubMedSearch : Glatting_2022_J.Nucl.Med_63_1844 |
| PubMedID: 35618480 |
| Title : FAPI-74 PET\/CT Using Either (18)F-AlF or Cold-Kit (68)Ga Labeling: Biodistribution, Radiation Dosimetry, and Tumor Delineation in Lung Cancer Patients - Giesel_2021_J.Nucl.Med_62_201 |
| Author(s) : Giesel FL , Adeberg S , Syed M , Lindner T , Jimenez-Franco LD , Mavriopoulou E , Staudinger F , Tonndorf-Martini E , Regnery S , Rieken S , El Shafie R , Rohrich M , Flechsig P , Kluge A , Altmann A , Debus J , Haberkorn U , Kratochwil C |
| Ref : J Nucl Med , 62 :201 , 2021 |
| Abstract : |
| PubMedSearch : Giesel_2021_J.Nucl.Med_62_201 |
| PubMedID: 32591493 |
| Title : (18)F-labeled tracers targeting fibroblast activation protein - Lindner_2021_EJNMMI.Radiopharm.Chem_6_26 |
| Author(s) : Lindner T , Altmann A , Giesel F , Kratochwil C , Kleist C , Kramer S , Mier W , Cardinale J , Kauczor HU , Jager D , Debus J , Haberkorn U |
| Ref : EJNMMI Radiopharm Chem , 6 :26 , 2021 |
| Abstract : |
| PubMedSearch : Lindner_2021_EJNMMI.Radiopharm.Chem_6_26 |
| PubMedID: 34417894 |
| Title : Clinical translational evaluation of Al(18)F-NOTA-FAPI for fibroblast activation protein-targeted tumour imaging - Wang_2021_Eur.J.Nucl.Med.Mol.Imaging_48_4259 |
| Author(s) : Wang S , Zhou X , Xu X , Ding J , Liu S , Hou X , Li N , Zhu H , Yang Z |
| Ref : Eur J Nucl Med Mol Imaging , 48 :4259 , 2021 |
| Abstract : |
| PubMedSearch : Wang_2021_Eur.J.Nucl.Med.Mol.Imaging_48_4259 |
| PubMedID: 34165601 |