FLAP-sEH-dual-inhibitor-Cpd6
human-EPHX2 5-Lipoxygenase IC50 5.4 +/- 0.5 microM
General
Type : Urea derivative, Multitarget, Thiazole, Adamantyl, 5-Lipoxygenase inhibitor
Chemical_Nomenclature : 4-(3-(adamantan-1-ylmethyl)ureido)-2-amino-N-(4-aminobenzyl)benzamide
Canonical SMILES : C1C3CC2CC1(CC(C2)C3)CNC(=O)NC4=CC=C(C(=C4)N)C(NCC5=CC=C(C=C5)N)=O
InChI : InChI=1S\/C26H33N5O2\/c27-20-3-1-16(2-4-20)14-29-24(32)22-6-5-21(10-23(22)28)31-25(33)30-15-26-11-17-7-18(12-26)9-19(8-17)13-26\/h1-6,10,17-19H,7-9,11-15,27-28H2,(H,29,32)(H2,30,31,33)
InChIKey : YNWKFIUAZGUESV-UHFFFAOYSA-N
Other name(s) :
Target
Families : FLAP-sEH-dual-inhibitor-Cpd6 ligand of proteins in family
Epoxide_hydrolase
Protein :
human-EPHX2
mouse-hyes
References (1)
| Title : An adamantylureido-benzylamide aniline as FLAP\/sEH dual inhibitor: Rational design, in vitro and in vivo lipidomic profiling - Ciaglia_2025_Eur.J.Med.Chem_302_118338 |
| Author(s) : Ciaglia T , D'Avino D , Jordan PM , Di Micco S , Musella S , Engelbrecht H , Peltner LK , Di Sarno V , Merciai F , Perna S , Smaldone G , Di Matteo F , Napolitano V , Stimoli R , Bifulco G , Pepe G , Sommella EM , Basilicata MG , Aquino G , Gomez-Monterrey IM , Campiglia P , Ostacolo C , Werz O , Rossi A , Bertamino A , Manfra M |
| Ref : Eur Journal of Medicinal Chemistry , 302 :118338 , 2025 |
| Abstract : |
| PubMedSearch : Ciaglia_2025_Eur.J.Med.Chem_302_118338 |
| PubMedID: 41197472 |
| Gene_locus related to this paper: human-EPHX2 |