MHET

product of hydrolysis of Polyethylene-terephthalate or HEMT model substrate. Polyethylene terephthalate is the most common thermoplastic polymer resin of the polyester family and is used in fibers for clothing, containers for liquids and foods. Degradation of PET using hydrolytic enzymes leads to the release of hydrolysis products such as BHET (bis(2-hydroxyethyl) terephthalate), MHET (mono-(2-hydroxyethyl) terephthalic acid), TPA (terephthalic acid) and EG (ethylene glycol)

General

Type : Terephthalate, Phthalate, Benzoate

Chemical_Nomenclature : 4-(2-hydroxyethoxycarbonyl)benzoic acid

Canonical SMILES : C1=CC(=CC=C1C(=O)O)C(=O)OCCO

InChI : InChI=1S\/C10H10O5\/c11-5-6-15-10(14)8-3-1-7(2-4-8)9(12)13\/h1-4,11H,5-6H2,(H,12,13)

InChIKey : BCBHDSLDGBIFIX-UHFFFAOYSA-N

Other name(s) : 4-((2-Hydroxyethoxy)carbonyl)benzoic acid  ||  Mono(ethylene terephthalate)  ||  Ethylene glycol, cyclic ester with (C7-C11)dibasic acids  ||  AC1L5ATF  ||  ET  ||  C9C  ||  4-[(2-hydroxyethoxy)carbonyl]benzoate  ||  1,4-Benzenedicarboxylic acid, mono(2-hydroxyethyl) ester  ||  CTK0G1127  ||  CHEBI:131701  ||  CHEBI:131704


MW : 210.18

Formula : C10H10O5

CAS_number : 1137-99-1

PubChem : 174073,    22062452

UniChem : BCBHDSLDGBIFIX-UHFFFAOYSA-N

Target

Families : MHET ligand of proteins in family
Polyesterase-lipase-cutinase Tannase

Structure :
7W1I

Protein :
idesa-peth idesa-mheth thefu-q6a0i3 thefu-q6a0i4 9bact-g9by57

References (11)

Title : Complete bio-degradation of poly(butylene adipate-co-terephthalate) via engineered cutinases - Yang_2023_Nat.Commun_14_1645
Author(s) : Yang Y , Min J , Xue T , Jiang P , Liu X , Peng R , Huang JW , Qu Y , Li X , Ma N , Tsai FC , Dai L , Zhang Q , Liu Y , Chen CC , Guo RT
Ref : Nat Commun , 14 :1645 , 2023
Abstract :
PubMedSearch : Yang_2023_Nat.Commun_14_1645
PubMedID: 36964144
Gene_locus related to this paper: idesa-peth , thefu-q6a0i4

Title : Substrate-Binding Mode of a Thermophilic PET Hydrolase and Engineering the Enzyme to Enhance the Hydrolytic Efficacy - Zeng_2022_ACS.Catal_12_3033
Author(s) : Zeng W , Li X , Yang Y , Min J , Huang JW , Liu W , Niu D , Yang X , Han X , Zhang L , Dai L , Chen CC , Guo RT
Ref : ACS Catal , 12 :3033 , 2022
Abstract :
PubMedSearch : Zeng_2022_ACS.Catal_12_3033
PubMedID:
Gene_locus related to this paper: 9bact-g9by57

Title : Novel efficient enzymatic synthesis of the key-reaction intermediate of PET depolymerization, mono(2-hydroxyethyl terephthalate) - MHET - de Queiros Eugenio_2022_J.Biotechnol__
Author(s) : de Queiros Eugenio E , Campisano ISP , Dias AG , de Castro AM , Coelho MAZ , Langone MAP
Ref : J Biotechnol , : , 2022
Abstract :
PubMedSearch : de Queiros Eugenio_2022_J.Biotechnol__
PubMedID: 36063976
Gene_locus related to this paper: humin-cut

Title : Structure-function analysis of two closely related cutinases from Thermobifida cellulosilytica - Baath_2021_Biotechnol.Bioeng__
Author(s) : Baath JA , Novy V , Carneiro LV , Guebitz GM , Olsson L , Westh P , Ribitsch D
Ref : Biotechnol Bioeng , : , 2021
Abstract :
PubMedSearch : Baath_2021_Biotechnol.Bioeng__
PubMedID: 34755331
Gene_locus related to this paper: thefu-q6a0i4 , thefu-q6a0i3

Title : Structural insight into molecular mechanism of poly(ethylene terephthalate) degradation - Joo_2018_Nat.Commun_9_382
Author(s) : Joo S , Cho IJ , Seo H , Son HF , Sagong HY , Shin TJ , Choi SY , Lee SY , Kim KJ
Ref : Nat Commun , 9 :382 , 2018
Abstract :
PubMedSearch : Joo_2018_Nat.Commun_9_382
PubMedID: 29374183
Gene_locus related to this paper: idesa-peth

Title : New insights into the function and global distribution of polyethylene terephthalate (PET) degrading bacteria and enzymes in marine and terrestrial metagenomes - Danso_2018_Appl.Environ.Microbiol_84_e2773
Author(s) : Danso D , Schmeisser C , Chow J , Zimmermann W , Wei R , Leggewie C , Li X , Hazen T , Streit WR
Ref : Applied Environmental Microbiology , 84 :e2773 , 2018
Abstract :
PubMedSearch : Danso_2018_Appl.Environ.Microbiol_84_e2773
PubMedID: 29427431
Gene_locus related to this paper: 9burk-PET10 , 9burk-PET11 , 9gamm-a0a0d4l7e6 , 9alte-n6vy44 , 9zzzz-a0a0f9x315 , deiml-e8u721 , olean-r4ykl9 , vibga-a0a1z2siq1 , 9burk-a0a0g3bi90 , 9bact-c3ryl0 , 9actn-h6wx58 , idesa-peth , 9bact-g9by57 , acide-PBSA , morsp-lip1

Title : Active Site Flexibility as a Hallmark for Efficient PET Degradation by I. sakaiensis PETase - Fecker_2018_Biophys.J_114_1302
Author(s) : Fecker T , Galaz-Davison P , Engelberger F , Narui Y , Sotomayor M , Parra LP , Ramirez-Sarmiento CA
Ref : Biophysical Journal , 114 :1302 , 2018
Abstract :
PubMedSearch : Fecker_2018_Biophys.J_114_1302
PubMedID: 29590588
Gene_locus related to this paper: idesa-peth

Title : Characterization and engineering of a plastic-degrading aromatic polyesterase - Austin_2018_Proc.Natl.Acad.Sci.U.S.A_115_E4350
Author(s) : Austin HP , Allen MD , Donohoe BS , Rorrer NA , Kearns FL , Silveira RL , Pollard BC , Dominick G , Duman R , El Omari K , Mykhaylyk V , Wagner A , Michener WE , Amore A , Skaf MS , Crowley MF , Thorne AW , Johnson CW , Woodcock HL , McGeehan JE , Beckham GT
Ref : Proc Natl Acad Sci U S A , 115 :E4350 , 2018
Abstract :
PubMedSearch : Austin_2018_Proc.Natl.Acad.Sci.U.S.A_115_E4350
PubMedID: 29666242
Gene_locus related to this paper: idesa-peth

Title : Structural insight into catalytic mechanism of PET hydrolase - Han_2017_Nat.Commun_8_2106
Author(s) : Han X , Liu W , Huang JW , Ma J , Zheng Y , Ko TP , Xu L , Cheng YS , Chen CC , Guo RT
Ref : Nat Commun , 8 :2106 , 2017
Abstract :
PubMedSearch : Han_2017_Nat.Commun_8_2106
PubMedID: 29235460
Gene_locus related to this paper: idesa-peth

Title : A bacterium that degrades and assimilates poly(ethylene terephthalate) - Yoshida_2016_Science_351_1196
Author(s) : Yoshida S , Hiraga K , Takehana T , Taniguchi I , Yamaji H , Maeda Y , Toyohara K , Miyamoto K , Kimura Y , Oda K
Ref : Science , 351 :1196 , 2016
Abstract :
PubMedSearch : Yoshida_2016_Science_351_1196
PubMedID: 26965627
Gene_locus related to this paper: idesa-mheth , idesa-peth

Title : Crystal Structure and Thermodynamic and Kinetic Stability of Metagenome-Derived LC-Cutinase - Sulaiman_2014_Biochemistry_53_1858
Author(s) : Sulaiman S , You DJ , Kanaya E , Koga Y , Kanaya S
Ref : Biochemistry , 53 :1858 , 2014
Abstract :
PubMedSearch : Sulaiman_2014_Biochemistry_53_1858
PubMedID: 24593046
Gene_locus related to this paper: 9bact-g9by57