WWL153
JMN4 exhibited superior potency for inhibiting recombinant mouse (IC50 = 90 nM) and human (IC50 = 5.9 nM) Lp-PLA2 compared to either WWL153 (IC50 = 290 nM for mouse Lp-PLA2; IC50 = 250 nM for human Lp-PLA2) or P9 (IC50 = 470 nM for mouse Lp-PLA2; IC50 = 100 nM for human Lp-PLA2)
General
Type : Piperazine, Quinoline, pNP
Chemical_Nomenclature : (4-nitrophenyl) 4-(2-methylquinolin-4-yl)piperazine-1-carboxylate
Canonical SMILES : CC1=NC2=CC=CC=C2C(=C1)N3CCN(CC3)C(=O)OC4=CC=C(C=C4)[N+](=O)[O-]
InChI : InChI=1S\/C21H20N4O4\/c1-15-14-20(18-4-2-3-5-19(18)22-15)23-10-12-24(13-11-23)21(26)29-17-8-6-16(7-9-17)25(27)28\/h2-9,14H,10-13H2,1H3
InChIKey : MJCKCSRESUVXIX-UHFFFAOYSA-N
Other name(s) : MLS003173352 || SMR001877206 || 4-nitrophenyl 4-(2-methylquinolin-4-yl)piperazine-1-carboxylate || MLS003874820 || CHEMBL2133819
MW : 392.4
Formula : C21H20N4O4
CAS_number :
PubChem : 46829224
UniChem : MJCKCSRESUVXIX-UHFFFAOYSA-N
Target
Families : WWL153 ligand of proteins in family
PAF-Acetylhydrolase
Protein :
human-PLA2G7
References (2)
| Title : Selective inhibitors and tailored activity probes for lipoprotein-associated phospholipase A(2) - Nagano_2013_Bioorg.Med.Chem.Lett_23_839 |
| Author(s) : Nagano JM , Hsu KL , Whitby LR , Niphakis MJ , Speers AE , Brown SJ , Spicer T , Fernandez-Vega V , Ferguson J , Hodder P , Srinivasan P , Gonzalez TD , Rosen H , Bahnson BJ , Cravatt BF |
| Ref : Bioorganic & Medicinal Chemistry Lett , 23 :839 , 2013 |
| Abstract : |
| PubMedSearch : Nagano_2013_Bioorg.Med.Chem.Lett_23_839 |
| PubMedID: 23260346 |
| Title : Superfamily-wide portrait of serine hydrolase inhibition achieved by library-versus-library screening - Bachovchin_2010_Proc.Natl.Acad.Sci.U.S.A_107_20941 |
| Author(s) : Bachovchin DA , Ji T , Li W , Simon GM , Blankman JL , Adibekian A , Hoover H , Niessen S , Cravatt BF |
| Ref : Proc Natl Acad Sci U S A , 107 :20941 , 2010 |
| Abstract : |
| PubMedSearch : Bachovchin_2010_Proc.Natl.Acad.Sci.U.S.A_107_20941 |
| PubMedID: 21084632 |