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Substrate Report for: DEHP

peroxisome proliferator, plasticizer. EPA has classified DEHP as a Group B2, probable human carcinogen. DEHP hydrolyzes to MEHP via the enzyme Bis(2-ethylhexyl)phthalate acylhydrolase (3. 1. 1. 60) and subsequently to phthalate


General
Type Phthalate
Chemical_Nomenclature bis(2-ethylhexyl) benzene-1,2-dicarboxylate
Canonical SMILES CCCCC(CC)COC(=O)C1=CC=CC=C1C(=O)OCC(CC)CCCC
InChI InChI=1S/C24H38O4/c1-5-9-13-19(7-3)17-27-23(25)21-15-11-12-16-22(21)24(26)28-18-20(8-4)14-10-6-2/h11-12,15-16,19-20H,5-10,13-14,17-18H2,1-4H3
InChIKey BJQHLKABXJIVAM-UHFFFAOYSA-N
Other name(s) Bis(2-ethylhexyl) phthalate ; Di(2-ethylhexyl)phthalate ; Di(2-ethylhexyl) phthalate ; bis(2-ethylhexyl)phthalate ; C6H4(COOC8H17)2
________________________________________________________________________________________________
MW|390.56
Formula|C24H38O4
CAS_number|117-81-7
PubChem|8343
UniChem|BJQHLKABXJIVAM-UHFFFAOYSA-N
IUPHAR|
Wikipedia|Bis(2-ethylhexyl)_phthalate


References:
Search PubMed for references concerning: DEHP

10 more
    Title: Re-characterization of mono-2-ethylhexyl phthalate hydrolase belonging to the serine hydrolase family
    Iwata M, Imaoka T, Nishiyama T, Fujii T
    Ref: J Biosci Bioeng, 122:140, 2016 : PubMed

            

    Title: Enzymatic hydrolysis of structurally diverse phthalic acid esters by porcine and bovine pancreatic cholesterol esterases
    Saito T, Hong P, Tanabe R, Nagai K, Kato K
    Ref: Chemosphere, 81:1544, 2010 : PubMed

            

    Title: A mono-2-ethylhexyl phthalate hydrolase from a Gordonia sp. that is able to dissimilate di-2-ethylhexyl phthalate
    Nishioka T, Iwata M, Imaoka T, Mutoh M, Egashira Y, Nishiyama T, Shin T, Fujii T
    Ref: Applied Environmental Microbiology, 72:2394, 2006 : PubMed