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Substrate Report for: DEHP

Plasticizer that is added to PVC plastic to impart flexibility, leaches from the plastic into plasma.Chronic toxic effects such as carcinogenicity,embryo-toxicity,and testicular atrophy1 have been attributed to DEHP and its major metabolite MEHP in rodents.DEHP that leaches out of the PVC bags binds to the red cells membrane and stabilizes it and increases the storage time. DEHP is hydrolyzed to MEHP via the enzyme Bis(2-ethylhexyl)phthalate acylhydrolase (3. 1. 1. 60) and subsequently to phthalate


General
Type Phthalate
Chemical_Nomenclature bis(2-ethylhexyl) benzene-1,2-dicarboxylate
Canonical SMILES CCCCC(CC)COC(=O)C1=CC=CC=C1C(=O)OCC(CC)CCCC
InChI InChI=1S/C24H38O4/c1-5-9-13-19(7-3)17-27-23(25)21-15-11-12-16-22(21)24(26)28-18-20(8-4)14-10-6-2/h11-12,15-16,19-20H,5-10,13-14,17-18H2,1-4H3
InChIKey BJQHLKABXJIVAM-UHFFFAOYSA-N
Other name(s) Bis(2-ethylhexyl) phthalate ; Di(2-ethylhexyl)phthalate ; Di(2-ethylhexyl) phthalate ; bis(2-ethylhexyl)phthalate ; C6H4(COOC8H17)2
________________________________________________________________________________________________
MW|390.56
Formula|C24H38O4
CAS_number|117-81-7
PubChem|8343
UniChem|BJQHLKABXJIVAM-UHFFFAOYSA-N
IUPHAR|
Wikipedia|Bis(2-ethylhexyl)_phthalate


References:
Search PubMed for references concerning: DEHP

13 more
    Title: Re-characterization of mono-2-ethylhexyl phthalate hydrolase belonging to the serine hydrolase family
    Iwata M, Imaoka T, Nishiyama T, Fujii T
    Ref: J Biosci Bioeng, 122:140, 2016 : PubMed

            

    Title: Enzymatic hydrolysis of structurally diverse phthalic acid esters by porcine and bovine pancreatic cholesterol esterases
    Saito T, Hong P, Tanabe R, Nagai K, Kato K
    Ref: Chemosphere, 81:1544, 2010 : PubMed

            

    Title: A mono-2-ethylhexyl phthalate hydrolase from a Gordonia sp. that is able to dissimilate di-2-ethylhexyl phthalate
    Nishioka T, Iwata M, Imaoka T, Mutoh M, Egashira Y, Nishiyama T, Shin T, Fujii T
    Ref: Applied Environmental Microbiology, 72:2394, 2006 : PubMed