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Phthalate

Phthalates, or phthalate esters, are esters of phthalic acid. They are mainly used as plasticizers, i.e., substances added to plastics to increase their flexibility, transparency, durability, and longevity. Phthalate esters are endocrine disruptors.
Substrate Main targeted enzyme families Type Structure
Dibutyl-phthalate HNLyase_Bact Carb_B_Chordata Hormone-sensitive_lipase_like Carb_B_Bacteria 6_AlphaBeta_hydrolase LYsophospholipase_carboxylesterase Fungal_carboxylesterase_lipase CarbLipBact_1 Lipase_3 Aryl ester Phthalate Plasticizer
mUPET1 Polyesterase-lipase-cutinase Tannase Coumarin Chromen Terephthalate Phthalate
mUPET2 Polyesterase-lipase-cutinase Tannase Coumarin Chromen Terephthalate Phthalate
mUPET3 Polyesterase-lipase-cutinase Tannase Coumarin Chromen Terephthalate Phthalate
p-NPhPET3 Polyesterase-lipase-cutinase Tannase pNP Chromogen Terephthalate Phthalate
DaBTaBDa Cutinase Polyesterase-lipase-cutinase Terephthalate Phthalate Polyester fragment
TdaBTaBTda Cutinase Polyesterase-lipase-cutinase Terephthalate Phthalate Polyester fragment
HaBTaBHa Cutinase Polyesterase-lipase-cutinase Terephthalate Phthalate Polyester fragment
Benzyl-butyl-phthalate Fungal_carboxylesterase_lipase Cutinase Phthalate Natural
o-phthalyl-carbacephem 6_AlphaBeta_hydrolase Phthalate Azabicyclo Organochlorine
N-(3-Carboxy-4-nitrophenyl)phthalamidic-acid 6_AlphaBeta_hydrolase pNP Phthalate
1,4-butanediol-terephthalate Terephthalate Polyester fragment
BEB Fungal_carboxylesterase_lipase Polymer Polyester Terephthalate Aromatic polyester Benzoate Polyester fragment
2PET Carb_B_Bacteria PAF-Acetylhydrolase Terephthalate Phthalate Polyester fragment
2HE(MHET)2 Polyesterase-lipase-cutinase Polymer Polyester Terephthalate Aromatic polyester Polyester fragment
ETETETE Polyesterase-lipase-cutinase Polymer Polyester Terephthalate Aromatic polyester Polyester fragment
TETET Polyesterase-lipase-cutinase Polymer Polyester Terephthalate Aromatic polyester Polyester fragment
EMT Polyesterase-lipase-cutinase Polymer Polyester Terephthalate Aromatic polyester Polyester fragment
EBT Polyesterase-lipase-cutinase Polymer Polyester Terephthalate Aromatic polyester Polyester fragment
Cyclo-tris-ethylene-terephthalate Cutinase Polyesterase-lipase-cutinase Polymer Polyester Terephthalate Aromatic polyester Polyester fragment
PBSTIL Polyesterase-lipase-cutinase Polymer Polyester Terephthalate co-polyester Aromatic polyester
Polytrimethylene-terephthalate Polymer Polyester Terephthalate Aromatic polyester
Polybutylene-terephthalate Polymer Polyester Terephthalate Aromatic polyester
DEHP Carb_B_Chordata Cutinase Carb_B_Bacteria Carbon-carbon_bond_hydrolase Pancreatic_lipase Hormone-sensitive_lipase_like CarbLipBact_1 Lipase_3 Phthalate Plasticizer
MEHP Carbon-carbon_bond_hydrolase AlphaBeta_hydrolase Hormone-sensitive_lipase_like Phthalate
Terephthalic-acid Terephthalate Phthalate Polyester fragment
DMT Tannase Carbon-carbon_bond_hydrolase Terephthalate Phthalate Polyester fragment
Diethyl-terephthalate Carbon-carbon_bond_hydrolase Carb_B_Bacteria Terephthalate Phthalate Polyester fragment
Diallyl-terephthalate Carbon-carbon_bond_hydrolase Terephthalate Phthalate Polyester fragment
BETE Polyesterase-lipase-cutinase Terephthalate Phthalate Polyester fragment
BHBT Polyesterase-lipase-cutinase Bacterial_lip_FamI.5 Terephthalate Phthalate Polyester fragment
3-PBT Polyesterase-lipase-cutinase Cutinase Terephthalate Phthalate Polyester fragment
BTa Polyesterase-lipase-cutinase Cutinase Terephthalate Phthalate Polyester fragment
HEB Carb_B_Bacteria Terephthalate Phthalate Polyester fragment
BECBA Carb_B_Bacteria Terephthalate Phthalate Polyester fragment
4-PET Polyesterase-lipase-cutinase PAF-Acetylhydrolase Terephthalate Phthalate Polyester fragment Polymer Polyester Aromatic polyester
3-PET Polyesterase-lipase-cutinase Tannase Terephthalate Phthalate Polymer Polyester Aromatic polyester Polyester fragment
BETEB Polyesterase-lipase-cutinase Cutinase Carb_B_Bacteria Bacterial_lip_FamI.5 UCP031982 Haloperoxidase 6_AlphaBeta_hydrolase CarbLipBact_2 Terephthalate Phthalate Polyester fragment
BHETA Tannase Terephthalate Phthalate Carboxamide
MpNPT Tannase Terephthalate Phthalate pNP Chromogen
Mono(2-hydroxyethyl)-terephthalate Terephthalate Phthalate Polyester fragment
MHET Polyesterase-lipase-cutinase Tannase Carb_B_Bacteria FAE-Bacterial-promiscuous CarbLipBact_2 ABHD6-Lip Terephthalate Phthalate Benzoate Polyester fragment
HEMT Polyesterase-lipase-cutinase Dienelactone_hydrolase Terephthalate Phthalate Polyester fragment
BHET-OH Polyesterase-lipase-cutinase Terephthalate Phthalate Polyester fragment
BHET Polyesterase-lipase-cutinase Tannase Carb_B_Bacteria Cutinase Hormone-sensitive_lipase_like FAE-Bacterial-promiscuous CarbLipBact_1 CarbLipBact_2 Dienelactone_hydrolase ABHD6-Lip Terephthalate Phthalate Polyester fragment
Polyethylene-terephthalate Polyesterase-lipase-cutinase 6_AlphaBeta_hydrolase Polyesterase-MGS0156-like Carb_B_Bacteria Duf_1400 Xaa-Pro-like_dom AlphaBeta_hydrolase FAE-Bacterial-promiscuous Chlorophyllase Hormone-sensitive_lipase_like Polymer Terephthalate Phthalate Polyester Aromatic polyester Benzoate
PBST Polymer Polyester Terephthalate co-polyester
PBAT Bacterial_lip_FamI.5 Carb_B_Bacteria Lipase_2 Polyesterase-lipase-cutinase Polyesterase-MGS0156-like 6_AlphaBeta_hydrolase BD-FAE Hormone-sensitive_lipase_like Cutinase Polymer Polyester Terephthalate co-polyester Butyrate Adipate
Monobutyl-phthalate Bacterial_esterase Hormone-sensitive_lipase_like Carbon-carbon_bond_hydrolase Aryl ester Phthalate
Dioctyl-phthalate HNLyase_Bact Aryl ester Phthalate
Dipentyl-phthalate Cholesterol_esterase Aryl ester Phthalate
Monomethyl-phthalate Hormone-sensitive_lipase_like Aryl ester Phthalate
Dimethyl-phthalate Hormone-sensitive_lipase_like HNLyase_Bact Aryl ester Phthalate
Dipropyl-phthalate Cutinase Fungal_carboxylesterase_lipase Cholesterol_esterase Aryl ester Phthalate
Diisobutyl-phthalate HNLyase_Bact Bacterial_esterase Aryl ester Phthalate
Monoethyl-phthalate Hormone-sensitive_lipase_like Phthalate
Diethyl-phthalate Hormone-sensitive_lipase_like Carb_B_Bacteria Dienelactone_hydrolase Aryl ester Phthalate
Dibutyl-phthalate HNLyase_Bact Carb_B_Chordata Hormone-sensitive_lipase_like Carb_B_Bacteria 6_AlphaBeta_hydrolase LYsophospholipase_carboxylesterase Fungal_carboxylesterase_lipase CarbLipBact_1 Lipase_3 Aryl ester Phthalate Plasticizer
mUPET1 Polyesterase-lipase-cutinase Tannase Coumarin Chromen Terephthalate Phthalate
mUPET2 Polyesterase-lipase-cutinase Tannase Coumarin Chromen Terephthalate Phthalate
mUPET3 Polyesterase-lipase-cutinase Tannase Coumarin Chromen Terephthalate Phthalate
p-NPhPET3 Polyesterase-lipase-cutinase Tannase pNP Chromogen Terephthalate Phthalate
DaBTaBDa Cutinase Polyesterase-lipase-cutinase Terephthalate Phthalate Polyester fragment
TdaBTaBTda Cutinase Polyesterase-lipase-cutinase Terephthalate Phthalate Polyester fragment
HaBTaBHa Cutinase Polyesterase-lipase-cutinase Terephthalate Phthalate Polyester fragment
Benzyl-butyl-phthalate Fungal_carboxylesterase_lipase Cutinase Phthalate Natural
o-phthalyl-carbacephem 6_AlphaBeta_hydrolase Phthalate Azabicyclo Organochlorine
N-(3-Carboxy-4-nitrophenyl)phthalamidic-acid 6_AlphaBeta_hydrolase pNP Phthalate
1,4-butanediol-terephthalate Terephthalate Polyester fragment
BEB Fungal_carboxylesterase_lipase Polymer Polyester Terephthalate Aromatic polyester Benzoate Polyester fragment
2PET Carb_B_Bacteria PAF-Acetylhydrolase Terephthalate Phthalate Polyester fragment
2HE(MHET)2 Polyesterase-lipase-cutinase Polymer Polyester Terephthalate Aromatic polyester Polyester fragment
ETETETE Polyesterase-lipase-cutinase Polymer Polyester Terephthalate Aromatic polyester Polyester fragment
TETET Polyesterase-lipase-cutinase Polymer Polyester Terephthalate Aromatic polyester Polyester fragment
EMT Polyesterase-lipase-cutinase Polymer Polyester Terephthalate Aromatic polyester Polyester fragment
EBT Polyesterase-lipase-cutinase Polymer Polyester Terephthalate Aromatic polyester Polyester fragment
Cyclo-tris-ethylene-terephthalate Cutinase Polyesterase-lipase-cutinase Polymer Polyester Terephthalate Aromatic polyester Polyester fragment
PBSTIL Polyesterase-lipase-cutinase Polymer Polyester Terephthalate co-polyester Aromatic polyester
Polytrimethylene-terephthalate Polymer Polyester Terephthalate Aromatic polyester
Polybutylene-terephthalate Polymer Polyester Terephthalate Aromatic polyester
DEHP Carb_B_Chordata Cutinase Carb_B_Bacteria Carbon-carbon_bond_hydrolase Pancreatic_lipase Hormone-sensitive_lipase_like CarbLipBact_1 Lipase_3 Phthalate Plasticizer
MEHP Carbon-carbon_bond_hydrolase AlphaBeta_hydrolase Hormone-sensitive_lipase_like Phthalate
Terephthalic-acid Terephthalate Phthalate Polyester fragment
DMT Tannase Carbon-carbon_bond_hydrolase Terephthalate Phthalate Polyester fragment
Diethyl-terephthalate Carbon-carbon_bond_hydrolase Carb_B_Bacteria Terephthalate Phthalate Polyester fragment
Diallyl-terephthalate Carbon-carbon_bond_hydrolase Terephthalate Phthalate Polyester fragment
BETE Polyesterase-lipase-cutinase Terephthalate Phthalate Polyester fragment
BHBT Polyesterase-lipase-cutinase Bacterial_lip_FamI.5 Terephthalate Phthalate Polyester fragment
3-PBT Polyesterase-lipase-cutinase Cutinase Terephthalate Phthalate Polyester fragment
BTa Polyesterase-lipase-cutinase Cutinase Terephthalate Phthalate Polyester fragment
HEB Carb_B_Bacteria Terephthalate Phthalate Polyester fragment
BECBA Carb_B_Bacteria Terephthalate Phthalate Polyester fragment
4-PET Polyesterase-lipase-cutinase PAF-Acetylhydrolase Terephthalate Phthalate Polyester fragment Polymer Polyester Aromatic polyester
3-PET Polyesterase-lipase-cutinase Tannase Terephthalate Phthalate Polymer Polyester Aromatic polyester Polyester fragment
BETEB Polyesterase-lipase-cutinase Cutinase Carb_B_Bacteria Bacterial_lip_FamI.5 UCP031982 Haloperoxidase 6_AlphaBeta_hydrolase CarbLipBact_2 Terephthalate Phthalate Polyester fragment
BHETA Tannase Terephthalate Phthalate Carboxamide
MpNPT Tannase Terephthalate Phthalate pNP Chromogen
Mono(2-hydroxyethyl)-terephthalate Terephthalate Phthalate Polyester fragment
MHET Polyesterase-lipase-cutinase Tannase Carb_B_Bacteria FAE-Bacterial-promiscuous CarbLipBact_2 ABHD6-Lip Terephthalate Phthalate Benzoate Polyester fragment
HEMT Polyesterase-lipase-cutinase Dienelactone_hydrolase Terephthalate Phthalate Polyester fragment
BHET-OH Polyesterase-lipase-cutinase Terephthalate Phthalate Polyester fragment
BHET Polyesterase-lipase-cutinase Tannase Carb_B_Bacteria Cutinase Hormone-sensitive_lipase_like FAE-Bacterial-promiscuous CarbLipBact_1 CarbLipBact_2 Dienelactone_hydrolase ABHD6-Lip Terephthalate Phthalate Polyester fragment
Polyethylene-terephthalate Polyesterase-lipase-cutinase 6_AlphaBeta_hydrolase Polyesterase-MGS0156-like Carb_B_Bacteria Duf_1400 Xaa-Pro-like_dom AlphaBeta_hydrolase FAE-Bacterial-promiscuous Chlorophyllase Hormone-sensitive_lipase_like Polymer Terephthalate Phthalate Polyester Aromatic polyester Benzoate
PBST Polymer Polyester Terephthalate co-polyester
PBAT Bacterial_lip_FamI.5 Carb_B_Bacteria Lipase_2 Polyesterase-lipase-cutinase Polyesterase-MGS0156-like 6_AlphaBeta_hydrolase BD-FAE Hormone-sensitive_lipase_like Cutinase Polymer Polyester Terephthalate co-polyester Butyrate Adipate
Monobutyl-phthalate Bacterial_esterase Hormone-sensitive_lipase_like Carbon-carbon_bond_hydrolase Aryl ester Phthalate
Dioctyl-phthalate HNLyase_Bact Aryl ester Phthalate
Dipentyl-phthalate Cholesterol_esterase Aryl ester Phthalate
Monomethyl-phthalate Hormone-sensitive_lipase_like Aryl ester Phthalate
Dimethyl-phthalate Hormone-sensitive_lipase_like HNLyase_Bact Aryl ester Phthalate
Dipropyl-phthalate Cutinase Fungal_carboxylesterase_lipase Cholesterol_esterase Aryl ester Phthalate
Diisobutyl-phthalate HNLyase_Bact Bacterial_esterase Aryl ester Phthalate
Monoethyl-phthalate Hormone-sensitive_lipase_like Phthalate
Diethyl-phthalate Hormone-sensitive_lipase_like Carb_B_Bacteria Dienelactone_hydrolase Aryl ester Phthalate
Dibutyl-phthalate HNLyase_Bact Carb_B_Chordata Hormone-sensitive_lipase_like Carb_B_Bacteria 6_AlphaBeta_hydrolase LYsophospholipase_carboxylesterase Fungal_carboxylesterase_lipase CarbLipBact_1 Lipase_3 Aryl ester Phthalate Plasticizer
mUPET1 Polyesterase-lipase-cutinase Tannase Coumarin Chromen Terephthalate Phthalate
mUPET2 Polyesterase-lipase-cutinase Tannase Coumarin Chromen Terephthalate Phthalate
mUPET3 Polyesterase-lipase-cutinase Tannase Coumarin Chromen Terephthalate Phthalate
p-NPhPET3 Polyesterase-lipase-cutinase Tannase pNP Chromogen Terephthalate Phthalate
DaBTaBDa Cutinase Polyesterase-lipase-cutinase Terephthalate Phthalate Polyester fragment
TdaBTaBTda Cutinase Polyesterase-lipase-cutinase Terephthalate Phthalate Polyester fragment
HaBTaBHa Cutinase Polyesterase-lipase-cutinase Terephthalate Phthalate Polyester fragment
Benzyl-butyl-phthalate Fungal_carboxylesterase_lipase Cutinase Phthalate Natural
o-phthalyl-carbacephem 6_AlphaBeta_hydrolase Phthalate Azabicyclo Organochlorine
N-(3-Carboxy-4-nitrophenyl)phthalamidic-acid 6_AlphaBeta_hydrolase pNP Phthalate
1,4-butanediol-terephthalate Terephthalate Polyester fragment
BEB Fungal_carboxylesterase_lipase Polymer Polyester Terephthalate Aromatic polyester Benzoate Polyester fragment
2PET Carb_B_Bacteria PAF-Acetylhydrolase Terephthalate Phthalate Polyester fragment
2HE(MHET)2 Polyesterase-lipase-cutinase Polymer Polyester Terephthalate Aromatic polyester Polyester fragment
ETETETE Polyesterase-lipase-cutinase Polymer Polyester Terephthalate Aromatic polyester Polyester fragment
TETET Polyesterase-lipase-cutinase Polymer Polyester Terephthalate Aromatic polyester Polyester fragment
EMT Polyesterase-lipase-cutinase Polymer Polyester Terephthalate Aromatic polyester Polyester fragment
EBT Polyesterase-lipase-cutinase Polymer Polyester Terephthalate Aromatic polyester Polyester fragment
Cyclo-tris-ethylene-terephthalate Cutinase Polyesterase-lipase-cutinase Polymer Polyester Terephthalate Aromatic polyester Polyester fragment
PBSTIL Polyesterase-lipase-cutinase Polymer Polyester Terephthalate co-polyester Aromatic polyester
Polytrimethylene-terephthalate Polymer Polyester Terephthalate Aromatic polyester
Polybutylene-terephthalate Polymer Polyester Terephthalate Aromatic polyester
DEHP Carb_B_Chordata Cutinase Carb_B_Bacteria Carbon-carbon_bond_hydrolase Pancreatic_lipase Hormone-sensitive_lipase_like CarbLipBact_1 Lipase_3 Phthalate Plasticizer
MEHP Carbon-carbon_bond_hydrolase AlphaBeta_hydrolase Hormone-sensitive_lipase_like Phthalate
Terephthalic-acid Terephthalate Phthalate Polyester fragment
DMT Tannase Carbon-carbon_bond_hydrolase Terephthalate Phthalate Polyester fragment
Diethyl-terephthalate Carbon-carbon_bond_hydrolase Carb_B_Bacteria Terephthalate Phthalate Polyester fragment
Diallyl-terephthalate Carbon-carbon_bond_hydrolase Terephthalate Phthalate Polyester fragment
BETE Polyesterase-lipase-cutinase Terephthalate Phthalate Polyester fragment
BHBT Polyesterase-lipase-cutinase Bacterial_lip_FamI.5 Terephthalate Phthalate Polyester fragment
3-PBT Polyesterase-lipase-cutinase Cutinase Terephthalate Phthalate Polyester fragment
BTa Polyesterase-lipase-cutinase Cutinase Terephthalate Phthalate Polyester fragment
HEB Carb_B_Bacteria Terephthalate Phthalate Polyester fragment
BECBA Carb_B_Bacteria Terephthalate Phthalate Polyester fragment
4-PET Polyesterase-lipase-cutinase PAF-Acetylhydrolase Terephthalate Phthalate Polyester fragment Polymer Polyester Aromatic polyester
3-PET Polyesterase-lipase-cutinase Tannase Terephthalate Phthalate Polymer Polyester Aromatic polyester Polyester fragment
BETEB Polyesterase-lipase-cutinase Cutinase Carb_B_Bacteria Bacterial_lip_FamI.5 UCP031982 Haloperoxidase 6_AlphaBeta_hydrolase CarbLipBact_2 Terephthalate Phthalate Polyester fragment
BHETA Tannase Terephthalate Phthalate Carboxamide
MpNPT Tannase Terephthalate Phthalate pNP Chromogen
Mono(2-hydroxyethyl)-terephthalate Terephthalate Phthalate Polyester fragment
MHET Polyesterase-lipase-cutinase Tannase Carb_B_Bacteria FAE-Bacterial-promiscuous CarbLipBact_2 ABHD6-Lip Terephthalate Phthalate Benzoate Polyester fragment
HEMT Polyesterase-lipase-cutinase Dienelactone_hydrolase Terephthalate Phthalate Polyester fragment
BHET-OH Polyesterase-lipase-cutinase Terephthalate Phthalate Polyester fragment
BHET Polyesterase-lipase-cutinase Tannase Carb_B_Bacteria Cutinase Hormone-sensitive_lipase_like FAE-Bacterial-promiscuous CarbLipBact_1 CarbLipBact_2 Dienelactone_hydrolase ABHD6-Lip Terephthalate Phthalate Polyester fragment
Polyethylene-terephthalate Polyesterase-lipase-cutinase 6_AlphaBeta_hydrolase Polyesterase-MGS0156-like Carb_B_Bacteria Duf_1400 Xaa-Pro-like_dom AlphaBeta_hydrolase FAE-Bacterial-promiscuous Chlorophyllase Hormone-sensitive_lipase_like Polymer Terephthalate Phthalate Polyester Aromatic polyester Benzoate
PBST Polymer Polyester Terephthalate co-polyester
PBAT Bacterial_lip_FamI.5 Carb_B_Bacteria Lipase_2 Polyesterase-lipase-cutinase Polyesterase-MGS0156-like 6_AlphaBeta_hydrolase BD-FAE Hormone-sensitive_lipase_like Cutinase Polymer Polyester Terephthalate co-polyester Butyrate Adipate
Monobutyl-phthalate Bacterial_esterase Hormone-sensitive_lipase_like Carbon-carbon_bond_hydrolase Aryl ester Phthalate
Dioctyl-phthalate HNLyase_Bact Aryl ester Phthalate
Dipentyl-phthalate Cholesterol_esterase Aryl ester Phthalate
Monomethyl-phthalate Hormone-sensitive_lipase_like Aryl ester Phthalate
Dimethyl-phthalate Hormone-sensitive_lipase_like HNLyase_Bact Aryl ester Phthalate
Dipropyl-phthalate Cutinase Fungal_carboxylesterase_lipase Cholesterol_esterase Aryl ester Phthalate
Diisobutyl-phthalate HNLyase_Bact Bacterial_esterase Aryl ester Phthalate
Monoethyl-phthalate Hormone-sensitive_lipase_like Phthalate
Diethyl-phthalate Hormone-sensitive_lipase_like Carb_B_Bacteria Dienelactone_hydrolase Aryl ester Phthalate