Phthalate

Phthalates, or phthalate esters, are esters of phthalic acid. They are mainly used as plasticizers, i.e., substances added to plastics to increase their flexibility, transparency, durability, and longevity. Phthalate esters are endocrine disruptors.

Substrate	Main targeted enzyme families	Type
Dibutyl-phthalate	HNLyase_Bact Carb_B_Chordata Hormone-sensitive_lipase_like Carb_B_Bacteria 6_AlphaBeta_hydrolase LYsophospholipase_carboxylesterase Fungal_carboxylesterase_lipase CarbLipBact_1 Lipase_3	Aryl ester Phthalate Plasticizer
PBTFu	Cutinase	Polymer Polyester Terephthalate Aromatic polyester
mUPET1	Polyesterase-lipase-cutinase Tannase	Coumarin Chromen Terephthalate Phthalate
mUPET2	Polyesterase-lipase-cutinase Tannase	Coumarin Chromen Terephthalate Phthalate
mUPET3	Polyesterase-lipase-cutinase Tannase	Coumarin Chromen Terephthalate Phthalate
p-NPhPET3	Polyesterase-lipase-cutinase Tannase	pNP Chromogen Terephthalate Phthalate
DaBTaBDa	Cutinase Polyesterase-lipase-cutinase	Terephthalate Phthalate Polyester fragment
TdaBTaBTda	Cutinase Polyesterase-lipase-cutinase	Terephthalate Phthalate Polyester fragment
HaBTaBHa	Cutinase Polyesterase-lipase-cutinase	Terephthalate Phthalate Polyester fragment
Benzyl-butyl-phthalate	Fungal_carboxylesterase_lipase Cutinase	Phthalate Natural
o-phthalyl-carbacephem	6_AlphaBeta_hydrolase	Phthalate Azabicyclo Organochlorine
N-(3-Carboxy-4-nitrophenyl)phthalamidic-acid	6_AlphaBeta_hydrolase	pNP Phthalate
1,4-butanediol-terephthalate		Terephthalate Polyester fragment
BEB	Fungal_carboxylesterase_lipase	Polymer Polyester Terephthalate Aromatic polyester Benzoate Polyester fragment
2PET	Carb_B_Bacteria PAF-Acetylhydrolase	Terephthalate Phthalate Polyester fragment
2HE(MHET)2	Polyesterase-lipase-cutinase	Polymer Polyester Terephthalate Aromatic polyester Polyester fragment
ETETETE	Polyesterase-lipase-cutinase	Polymer Polyester Terephthalate Aromatic polyester Polyester fragment
TETET	Polyesterase-lipase-cutinase	Polymer Polyester Terephthalate Aromatic polyester Polyester fragment
EMT	Polyesterase-lipase-cutinase	Polymer Polyester Terephthalate Aromatic polyester Polyester fragment
EBT	Polyesterase-lipase-cutinase	Polymer Polyester Terephthalate Aromatic polyester Polyester fragment
Cyclo-tris-ethylene-terephthalate	Cutinase Polyesterase-lipase-cutinase	Polymer Polyester Terephthalate Aromatic polyester Polyester fragment
PBSTIL	Polyesterase-lipase-cutinase	Polymer Polyester Terephthalate co-polyester Aromatic polyester
Polytrimethylene-terephthalate		Polymer Polyester Terephthalate Aromatic polyester
Polybutylene-terephthalate		Polymer Polyester Terephthalate Aromatic polyester
DEHP	Carb_B_Chordata Cutinase Carb_B_Bacteria Carbon-carbon_bond_hydrolase Pancreatic_lipase Hormone-sensitive_lipase_like CarbLipBact_1 Lipase_3	Phthalate Plasticizer
MEHP	Carbon-carbon_bond_hydrolase AlphaBeta_hydrolase Hormone-sensitive_lipase_like	Phthalate
Terephthalic-acid		Terephthalate Phthalate Polyester fragment
DMT	Tannase Carbon-carbon_bond_hydrolase	Terephthalate Phthalate Polyester fragment
Diethyl-terephthalate	Carbon-carbon_bond_hydrolase Carb_B_Bacteria	Terephthalate Phthalate Polyester fragment
Diallyl-terephthalate	Carbon-carbon_bond_hydrolase	Terephthalate Phthalate Polyester fragment
BETE	Polyesterase-lipase-cutinase	Terephthalate Phthalate Polyester fragment
BHBT	Polyesterase-lipase-cutinase Bacterial_lip_FamI.5	Terephthalate Phthalate Polyester fragment
3-PBT	Polyesterase-lipase-cutinase Cutinase	Terephthalate Phthalate Polyester fragment
BTa	Polyesterase-lipase-cutinase Cutinase	Terephthalate Phthalate Polyester fragment
HEB	Carb_B_Bacteria	Terephthalate Phthalate Polyester fragment
BECBA	Carb_B_Bacteria	Terephthalate Phthalate Polyester fragment
4-PET	Polyesterase-lipase-cutinase PAF-Acetylhydrolase	Terephthalate Phthalate Polyester fragment Polymer Polyester Aromatic polyester
3-PET	Polyesterase-lipase-cutinase Tannase	Terephthalate Phthalate Polymer Polyester Aromatic polyester Polyester fragment
BETEB	Polyesterase-lipase-cutinase Cutinase Carb_B_Bacteria Bacterial_lip_FamI.5 UCP031982 Haloperoxidase 6_AlphaBeta_hydrolase CarbLipBact_2 ABHD6-Lip Aclacinomycin-methylesterase_RdmC Hormone-sensitive_lipase_like	Terephthalate Phthalate Polyester fragment
BHETA	Tannase	Terephthalate Phthalate Carboxamide
MpNPT	Tannase	Terephthalate Phthalate pNP Chromogen
Mono(2-hydroxyethyl)-terephthalate		Terephthalate Phthalate Polyester fragment
MHET	Polyesterase-lipase-cutinase Tannase Carb_B_Bacteria FAE-Bacterial-promiscuous CarbLipBact_2 ABHD6-Lip Hormone-sensitive_lipase_like	Terephthalate Phthalate Benzoate Polyester fragment
HEMT	Polyesterase-lipase-cutinase Dienelactone_hydrolase	Terephthalate Phthalate Polyester fragment
BHET-OH	Polyesterase-lipase-cutinase	Terephthalate Phthalate Polyester fragment
BHET	Polyesterase-lipase-cutinase Tannase Carb_B_Bacteria Cutinase Hormone-sensitive_lipase_like FAE-Bacterial-promiscuous CarbLipBact_1 CarbLipBact_2 Dienelactone_hydrolase ABHD6-Lip Aclacinomycin-methylesterase_RdmC	Terephthalate Phthalate Polyester fragment
Polyethylene-terephthalate	Polyesterase-lipase-cutinase 6_AlphaBeta_hydrolase Polyesterase-MGS0156-like Carb_B_Bacteria Duf_1400 Xaa-Pro-like_dom AlphaBeta_hydrolase FAE-Bacterial-promiscuous Chlorophyllase Hormone-sensitive_lipase_like ABHD6-Lip Aclacinomycin-methylesterase_RdmC	Polymer Terephthalate Phthalate Polyester Aromatic polyester Benzoate
PBST		Polymer Polyester Terephthalate co-polyester
PBAT	Bacterial_lip_FamI.5 Carb_B_Bacteria Lipase_2 Polyesterase-lipase-cutinase Polyesterase-MGS0156-like 6_AlphaBeta_hydrolase BD-FAE Hormone-sensitive_lipase_like Cutinase	Polymer Polyester Terephthalate co-polyester Butyrate Adipate
Monobutyl-phthalate	Bacterial_esterase Hormone-sensitive_lipase_like Carbon-carbon_bond_hydrolase	Aryl ester Phthalate
Dioctyl-phthalate	HNLyase_Bact	Aryl ester Phthalate
Dipentyl-phthalate	Cholesterol_esterase	Aryl ester Phthalate
Monomethyl-phthalate	Hormone-sensitive_lipase_like	Aryl ester Phthalate
Dimethyl-phthalate	Hormone-sensitive_lipase_like HNLyase_Bact LYsophospholipase_carboxylesterase	Aryl ester Phthalate
Dipropyl-phthalate	Cutinase Fungal_carboxylesterase_lipase Cholesterol_esterase	Aryl ester Phthalate
Diisobutyl-phthalate	HNLyase_Bact Bacterial_esterase LYsophospholipase_carboxylesterase	Aryl ester Phthalate
Monoethyl-phthalate	Hormone-sensitive_lipase_like	Phthalate
Diethyl-phthalate	Hormone-sensitive_lipase_like Carb_B_Bacteria Dienelactone_hydrolase LYsophospholipase_carboxylesterase	Aryl ester Phthalate