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Pyrethroid

The targets of pyrethroids are not Alpha\/beta hydrolases. The synthetic pyrethroids delay closure of the sodium channel, resulting in a sodium tail current that is characterized by a slow influx of sodium during the end of depolarization. Carboxylesterases are involved in elimination of Pyrethroids and mutations can enhance resistance to pyrethroids
Substrate Main targeted enzyme families Type Structure
Cyphenothrin Carb_B_Chordata Cyclopropyl Carboxylate Pyrethroid Insecticide
Prallethrin Carb_B_Chordata Carb_B_Bacteria Cyclopropyl Carboxylate Pyrethroid Insecticide
beta-Cyfluthrin HNLyase_Bact CarbLipBact_2 Cyanide Cyclopropyl Pyrethroid Insecticide
Fenvalerate Carb_B_Arthropoda Carb_B_Chordata HNLyase_Bact Pyrethroid Phenoxyphenyl Organochlorine
Esfenvalerate Carb_B_Arthropoda Carb_B_Chordata HNLyase_Bact Pyrethroid Phenoxyphenyl Organochlorine
Cypermethrin Carb_B_Arthropoda LYsophospholipase_carboxylesterase Carb_B_Chordata 6_AlphaBeta_hydrolase Haloperoxidase HNLyase_Bact Pyrethroid Insecticide Phenoxyphenyl Cyclopropyl Not AlphaBeta Hydrolase target Cyanide Organochlorine
Cypermethrine-analog-fluo-CpdII Carb_B_Arthropoda Carb_B_Chordata Pyrethroid Insecticide Naphthalen Cyclopropyl Not AlphaBeta Hydrolase target Cyanide Organochlorine
trans-Bifenthrin HNLyase_Bact Carb_B_Arthropoda Pyrethroid Insecticide Trifluoro Not AlphaBeta Hydrolase target Carbamate Cyclopropyl
Fenpropathrin Carb_B_Arthropoda Carb_B_Chordata Cholinesterase-like HNLyase_Bact Pyrethroid Insecticide Acaricide Cyanide Not AlphaBeta Hydrolase target Phenoxyphenyl Cyclopropyl
lambda-Cyhalothrin Carb_B_Arthropoda CarbLipBact_1 6_AlphaBeta_hydrolase HNLyase_Bact Pyrethroid Insecticide Phenoxyphenyl Cyanide Cyclopropyl
Deltamethrin Carboxylesterase Carb_B_Chordata Carb_B_Arthropoda Carb_B_Bacteria 6_AlphaBeta_hydrolase HNLyase_Bact Pyrethroid Insecticide Phenoxyphenyl Cyanide Cyclopropyl
Permethrin Carboxylesterase Carb_B_Chordata Carb_B_Arthropoda Carb_B_Bacteria HNLyase_Bact Pyrethroid Insecticide Drug Not AlphaBeta Hydrolase target Phenoxyphenyl Cyclopropyl