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| Title : Repurposing of 8-Hydroxyquinoline-based Butyrylcholinesterase and Cathepsin B Ligands as Potent Non-peptidic Deoxyribonuclease I Inhibitors - Gajic_2022_ChemMedChem__ |
| Author(s) : Gajic M , Knez D , Sosic I , Mravljak J , Meden A , Kosak U , Leitzbach L , George S , Hofmann B , Zivkovic A , Steinhilber D , Stark H , Gobec S , Smelcerovic A , Anderluh M |
| Ref : ChemMedChem , : , 2022 |
| Abstract : Gajic_2022_ChemMedChem__ |
| ESTHER : Gajic_2022_ChemMedChem__ |
| PubMedSearch : Gajic_2022_ChemMedChem__ |
| PubMedID: 34994078 |
| Title : Structure-Based Design of Dual Partial Peroxisome Proliferator-Activated Receptor gamma Agonists\/Soluble Epoxide Hydrolase Inhibitors - Lillich_2021_J.Med.Chem_64_17259 |
| Author(s) : Lillich FF , Willems S , Ni X , Kilu W , Borkowsky C , Brodsky M , Kramer JS , Brunst S , Hernandez-Olmos V , Heering J , Schierle S , Kestner RI , Mayser FM , Helmstadter M , Gobel T , Weizel L , Namgaladze D , Kaiser A , Steinhilber D , Pfeilschifter W , Kahnt AS , Proschak A , Chaikuad A , Knapp S , Merk D , Proschak E |
| Ref : Journal of Medicinal Chemistry , : , 2021 |
| Abstract : Lillich_2021_J.Med.Chem_64_17259 |
| ESTHER : Lillich_2021_J.Med.Chem_64_17259 |
| PubMedSearch : Lillich_2021_J.Med.Chem_64_17259 |
| PubMedID: 34818007 |
| Gene_locus related to this paper: human-EPHX2 |
| Title : Design, Synthesis, and Structure-Activity Relationship Studies of Dual Inhibitors of Soluble Epoxide Hydrolase and 5-Lipoxygenase - Hiesinger_2020_J.Med.Chem_63_11498 |
| Author(s) : Hiesinger K , Kramer JS , Beyer S , Eckes T , Brunst S , Flauaus C , Wittmann SK , Weizel L , Kaiser A , Kretschmer SBM , George S , Angioni C , Heering J , Geisslinger G , Schubert-Zsilavecz M , Schmidtko A , Pogoryelov D , Pfeilschifter J , Hofmann B , Steinhilber D , Schwalm S , Proschak E |
| Ref : Journal of Medicinal Chemistry , 63 :11498 , 2020 |
| Abstract : Hiesinger_2020_J.Med.Chem_63_11498 |
| ESTHER : Hiesinger_2020_J.Med.Chem_63_11498 |
| PubMedSearch : Hiesinger_2020_J.Med.Chem_63_11498 |
| PubMedID: 33044073 |
| Gene_locus related to this paper: human-EPHX2 |
| Title : Design of Dual Inhibitors of Soluble Epoxide Hydrolase and LTA4 Hydrolase - Hiesinger_2020_ACS.Med.Chem.Lett_11_298 |
| Author(s) : Hiesinger K , Schott A , Kramer JS , Blocher R , Witt F , Wittmann SK , Steinhilber D , Pogoryelov D , Gerstmeier J , Werz O , Proschak E |
| Ref : ACS Med Chem Lett , 11 :298 , 2020 |
| Abstract : Hiesinger_2020_ACS.Med.Chem.Lett_11_298 |
| ESTHER : Hiesinger_2020_ACS.Med.Chem.Lett_11_298 |
| PubMedSearch : Hiesinger_2020_ACS.Med.Chem.Lett_11_298 |
| PubMedID: 32184960 |
| Gene_locus related to this paper: human-EPHX2 |
| Title : Computer-Aided Selective Optimization of Side Activities of Talinolol - Hiesinger_2019_ACS.Med.Chem.Lett_10_899 |
| Author(s) : Hiesinger K , Kramer JS , Achenbach J , Moser D , Weber J , Wittmann SK , Morisseau C , Angioni C , Geisslinger G , Kahnt AS , Kaiser A , Proschak A , Steinhilber D , Pogoryelov D , Wagner K , Hammock BD , Proschak E |
| Ref : ACS Med Chem Lett , 10 :899 , 2019 |
| Abstract : Hiesinger_2019_ACS.Med.Chem.Lett_10_899 |
| ESTHER : Hiesinger_2019_ACS.Med.Chem.Lett_10_899 |
| PubMedSearch : Hiesinger_2019_ACS.Med.Chem.Lett_10_899 |
| PubMedID: 31223445 |
| Gene_locus related to this paper: human-EPHX2 |
| Title : Zafirlukast Is a Dual Modulator of Human Soluble Epoxide Hydrolase and Peroxisome Proliferator-Activated Receptor gamma - Gobel_2019_Front.Pharmacol_10_263 |
| Author(s) : Gobel T , Diehl O , Heering J , Merk D , Angioni C , Wittmann SK , Buscato E , Kottke R , Weizel L , Schader T , Maier TJ , Geisslinger G , Schubert-Zsilavecz M , Steinhilber D , Proschak E , Kahnt AS |
| Ref : Front Pharmacol , 10 :263 , 2019 |
| Abstract : Gobel_2019_Front.Pharmacol_10_263 |
| ESTHER : Gobel_2019_Front.Pharmacol_10_263 |
| PubMedSearch : Gobel_2019_Front.Pharmacol_10_263 |
| PubMedID: 30949053 |
| Title : Discovery of the First in Vivo Active Inhibitors of the Soluble Epoxide Hydrolase Phosphatase Domain - Kramer_2019_J.Med.Chem_62_8443 |
| Author(s) : Kramer JS , Woltersdorf S , Duflot T , Hiesinger K , Lillich FF , Knoll F , Wittmann SK , Klingler FM , Brunst S , Chaikuad A , Morisseau C , Hammock BD , Buccellati C , Sala A , Rovati GE , Leuillier M , Fraineau S , Rondeaux J , Hernandez-Olmos V , Heering J , Merk D , Pogoryelov D , Steinhilber D , Knapp S , Bellien J , Proschak E |
| Ref : Journal of Medicinal Chemistry , 62 :8443 , 2019 |
| Abstract : Kramer_2019_J.Med.Chem_62_8443 |
| ESTHER : Kramer_2019_J.Med.Chem_62_8443 |
| PubMedSearch : Kramer_2019_J.Med.Chem_62_8443 |
| PubMedID: 31436984 |
| Title : A Dual Modulator of Farnesoid X Receptor and Soluble Epoxide Hydrolase To Counter Nonalcoholic Steatohepatitis - Schmidt_2017_J.Med.Chem_60_7703 |
| Author(s) : Schmidt J , Rotter M , Weiser T , Wittmann S , Weizel L , Kaiser A , Heering J , Goebel T , Angioni C , Wurglics M , Paulke A , Geisslinger G , Kahnt A , Steinhilber D , Proschak E , Merk D |
| Ref : Journal of Medicinal Chemistry , 60 :7703 , 2017 |
| Abstract : Schmidt_2017_J.Med.Chem_60_7703 |
| ESTHER : Schmidt_2017_J.Med.Chem_60_7703 |
| PubMedSearch : Schmidt_2017_J.Med.Chem_60_7703 |
| PubMedID: 28845983 |
| Title : N-Benzylbenzamides: A Novel Merged Scaffold for Orally Available Dual Soluble Epoxide Hydrolase\/Peroxisome Proliferator-Activated Receptor gamma Modulators - Blocher_2016_J.Med.Chem_59_61 |
| Author(s) : Blocher R , Lamers C , Wittmann SK , Merk D , Hartmann M , Weizel L , Diehl O , Bruggerhoff A , Boss M , Kaiser A , Schader T , Gobel T , Grundmann M , Angioni C , Heering J , Geisslinger G , Wurglics M , Kostenis E , Brune B , Steinhilber D , Schubert-Zsilavecz M , Kahnt AS , Proschak E |
| Ref : Journal of Medicinal Chemistry , 59 :61 , 2016 |
| Abstract : Blocher_2016_J.Med.Chem_59_61 |
| ESTHER : Blocher_2016_J.Med.Chem_59_61 |
| PubMedSearch : Blocher_2016_J.Med.Chem_59_61 |
| PubMedID: 26595749 |
| Title : Design, Synthesis and Cellular Characterization of a Dual Inhibitor of 5-Lipoxygenase and Soluble Epoxide Hydrolase - Meirer_2016_Molecules_22_ |
| Author(s) : Meirer K , Glatzel D , Kretschmer S , Wittmann SK , Hartmann M , Blocher R , Angioni C , Geisslinger G , Steinhilber D , Hofmann B , Furst R , Proschak E |
| Ref : Molecules , 22 : , 2016 |
| Abstract : Meirer_2016_Molecules_22_ |
| ESTHER : Meirer_2016_Molecules_22_ |
| PubMedSearch : Meirer_2016_Molecules_22_ |
| PubMedID: 28036068 |
| Title : Exploring the chemical space of multitarget ligands using aligned self-organizing maps - Achenbach_2013_ACS.Med.Chem.Lett_4_1169 |
| Author(s) : Achenbach J , Klingler FM , Blocher R , Moser D , Hafner AK , Rodl CB , Kretschmer S , Kruger B , Lohr F , Stark H , Hofmann B , Steinhilber D , Proschak E |
| Ref : ACS Med Chem Lett , 4 :1169 , 2013 |
| Abstract : Achenbach_2013_ACS.Med.Chem.Lett_4_1169 |
| ESTHER : Achenbach_2013_ACS.Med.Chem.Lett_4_1169 |
| PubMedSearch : Achenbach_2013_ACS.Med.Chem.Lett_4_1169 |
| PubMedID: 24900624 |
| Title : Synthesis and structure-activity relationship studies of novel dual inhibitors of soluble epoxide hydrolase and 5-lipoxygenase - Meirer_2013_J.Med.Chem_56_1777 |
| Author(s) : Meirer K , Rodl CB , Wisniewska JM , George S , Hafner AK , Buscato EL , Klingler FM , Hahn S , Berressem D , Wittmann SK , Steinhilber D , Hofmann B , Proschak E |
| Ref : Journal of Medicinal Chemistry , 56 :1777 , 2013 |
| Abstract : Meirer_2013_J.Med.Chem_56_1777 |
| ESTHER : Meirer_2013_J.Med.Chem_56_1777 |
| PubMedSearch : Meirer_2013_J.Med.Chem_56_1777 |
| PubMedID: 23356879 |