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| Title : Novel 6-alkyl-bridged 4-arylalkylpiperazin-1-yl derivatives of azepino[4,3-b]indol-1(2H)-one as potent BChE-selective inhibitors showing protective effects against neurodegenerative insults - Samarelli_2024_Eur.J.Med.Chem_270_116353 |
| Author(s) : Samarelli F , Purgatorio R , Lopopolo G , Deruvo C , Catto M , Andresini M , Carrieri A , Nicolotti O , De Palma A , Miniero DV , de Candia M , Altomare CD |
| Ref : Eur Journal of Medicinal Chemistry , 270 :116353 , 2024 |
| Abstract : Samarelli_2024_Eur.J.Med.Chem_270_116353 |
| ESTHER : Samarelli_2024_Eur.J.Med.Chem_270_116353 |
| PubMedSearch : Samarelli_2024_Eur.J.Med.Chem_270_116353 |
| PubMedID: 38579622 |
| Title : Novel Dual-Acting Hybrids Targeting Type-2 Cannabinoid Receptors and Cholinesterase Activity Show Neuroprotective Effects In Vitro and Amelioration of Cognitive Impairment In Vivo - Mugnaini_2024_ACS.Chem.Neurosci__ |
| Author(s) : Mugnaini C , Brizzi A , Paolino M , Scarselli E , Castelli R , de Candia M , Gambacorta N , Nicolotti O , Kostrzewa M , Kumar P , Mahmoud AM , Borgonetti V , Iannotta M , Morace A , Galeotti N , Maione S , Altomare CD , Ligresti A , Corelli F |
| Ref : ACS Chem Neurosci , : , 2024 |
| Abstract : Mugnaini_2024_ACS.Chem.Neurosci__ |
| ESTHER : Mugnaini_2024_ACS.Chem.Neurosci__ |
| PubMedSearch : Mugnaini_2024_ACS.Chem.Neurosci__ |
| PubMedID: 38372253 |
| Title : Chemical and Biological Evaluation of Novel 1H-Chromeno[3,2-c]pyridine Derivatives as MAO Inhibitors Endowed with Potential Anticancer Activity - Kulikova_2023_Int.J.Mol.Sci_24_ |
| Author(s) : Kulikova LN , Purgatorio R , Beloglazkin AA , Tafeenko VA , Reza RG , Levickaya DD , Sblano S , Boccarelli A , de Candia M , Catto M , Voskressensky LG , Altomare CD |
| Ref : Int J Mol Sci , 24 : , 2023 |
| Abstract : Kulikova_2023_Int.J.Mol.Sci_24_ |
| ESTHER : Kulikova_2023_Int.J.Mol.Sci_24_ |
| PubMedSearch : Kulikova_2023_Int.J.Mol.Sci_24_ |
| PubMedID: 37175433 |
| Title : Investigation on Novel E\/Z 2-Benzylideneindan-1-One-Based Photoswitches with AChE and MAO-B Dual Inhibitory Activity - Paolino_2023_Molecules_28_ |
| Author(s) : Paolino M , de Candia M , Purgatorio R , Catto M , Saletti M , Tondo AR , Nicolotti O , Cappelli A , Brizzi A , Mugnaini C , Corelli F , Altomare CD |
| Ref : Molecules , 28 : , 2023 |
| Abstract : Paolino_2023_Molecules_28_ |
| ESTHER : Paolino_2023_Molecules_28_ |
| PubMedSearch : Paolino_2023_Molecules_28_ |
| PubMedID: 37570828 |
| Title : In-vitro and in-silico studies of annelated 1,4,7,8-tetrahydroazocine ester derivatives as nanomolar selective inhibitors of human butyrylcholinesterase - de Candia_2023_Chem.Biol.Interact_14ChEPon_110741 |
| Author(s) : de Candia M , Titov AA , Viayna A , Kulikova LN , Purgatorio R , Piergiovanni B , Niso M , Catto M , Voskressensky LG , Luque FJ , Altomare CD |
| Ref : Chemico-Biological Interactions , :110741 , 2023 |
| Abstract : de Candia_2023_Chem.Biol.Interact_14ChEPon_110741 |
| ESTHER : de Candia_2023_Chem.Biol.Interact_14ChEPon_110741 |
| PubMedSearch : de Candia_2023_Chem.Biol.Interact_14ChEPon_110741 |
| PubMedID: 37839515 |
| Title : Synthesis, computational and experimental pharmacological studies for (thio)ether-triazine 5-HT(6)R ligands with noticeable action on AChE\/BChE and chalcogen-dependent intrinsic activity in search for new class of drugs against Alzheimer's disease - Czarnota-Lydka_2023_Eur.J.Med.Chem_259_115695 |
| Author(s) : Czarnota-Lydka K , Sudol-Talaj S , Kucwaj-Brysz K , Kurczab R , Satala G , de Candia M , Samarelli F , Altomare CD , Carocci A , Barbarossa A , eslawska E , Gluch-Lutwin M , Mordyl B , Kubacka M , Wilczynska-Zawal N , Jastrzebska-Wiesek M , Partyka A , Khan N , Wiecek M , Nitek W , Honkisz-Orzechowska E , Latacz G , Wesolowska A , Carrieri A , Handzlik J |
| Ref : Eur Journal of Medicinal Chemistry , 259 :115695 , 2023 |
| Abstract : Czarnota-Lydka_2023_Eur.J.Med.Chem_259_115695 |
| ESTHER : Czarnota-Lydka_2023_Eur.J.Med.Chem_259_115695 |
| PubMedSearch : Czarnota-Lydka_2023_Eur.J.Med.Chem_259_115695 |
| PubMedID: 37567058 |
| Title : Exploring Mannosylpurines as Copper Chelators and Cholinesterase Inhibitors with Potential for Alzheimer's Disease - Schino_2022_Pharmaceuticals.(Basel)_16_ |
| Author(s) : Schino I , Cantore M , de Candia M , Altomare CD , Maria C , Barros J , Cachatra V , Calado P , Shimizu K , Freitas AA , Oliveira MC , Ferreira MJ , Lopes JNC , Colabufo NA , Rauter AP |
| Ref : Pharmaceuticals (Basel) , 16 : , 2022 |
| Abstract : Schino_2022_Pharmaceuticals.(Basel)_16_ |
| ESTHER : Schino_2022_Pharmaceuticals.(Basel)_16_ |
| PubMedSearch : Schino_2022_Pharmaceuticals.(Basel)_16_ |
| PubMedID: 36678552 |
| Title : Synthesis of Isomeric 3-Benzazecines Decorated with Endocyclic Allene Moiety and Exocyclic Conjugated Double Bond and Evaluation of Their Anticholinesterase Activity - Titov_2022_Molecules_27_ |
| Author(s) : Titov AA , Purgatorio R , Obydennik AY , Listratova AV , Borisova TN , de Candia M , Catto M , Altomare CD , Varlamov AV , Voskressensky LG |
| Ref : Molecules , 27 : , 2022 |
| Abstract : Titov_2022_Molecules_27_ |
| ESTHER : Titov_2022_Molecules_27_ |
| PubMedSearch : Titov_2022_Molecules_27_ |
| PubMedID: 36234811 |
| Title : Design, synthesis and biological evaluation of light-driven on-off multitarget AChE and MAO-B inhibitors - Paolino_2022_RSC.Med.Chem_13_873 |
| Author(s) : Paolino M , Rullo M , Maramai S , de Candia M , Pisani L , Catto M , Mugnaini C , Brizzi A , Cappelli A , Olivucci M , Corelli F , Altomare CD |
| Ref : RSC Med Chem , 13 :873 , 2022 |
| Abstract : Paolino_2022_RSC.Med.Chem_13_873 |
| ESTHER : Paolino_2022_RSC.Med.Chem_13_873 |
| PubMedSearch : Paolino_2022_RSC.Med.Chem_13_873 |
| PubMedID: 35923722 |
| Title : Assessing the Role of a Malonamide Linker in the Design of Potent Dual Inhibitors of Factor Xa and Cholinesterases - Purgatorio_2022_Molecules_27_ |
| Author(s) : Purgatorio R , Gambacorta N , Samarelli F , Lopopolo G , de Candia M , Catto M , Nicolotti O , Altomare CD |
| Ref : Molecules , 27 : , 2022 |
| Abstract : Purgatorio_2022_Molecules_27_ |
| ESTHER : Purgatorio_2022_Molecules_27_ |
| PubMedSearch : Purgatorio_2022_Molecules_27_ |
| PubMedID: 35807514 |
| Title : Away from Flatness: Unprecedented Nitrogen-Bridged Cyclopenta[a]indene Derivatives as Novel Anti-Alzheimer Multitarget Agents - Titov_2021_ACS.Chem.Neurosci__ |
| Author(s) : Titov AA , Kobzev MS , Catto M , de Candia M , Gambacorta N , Denora N , Pisani L , Nicolotti O , Borisova TN , Varlamov AV , Voskressensky LG , Altomare CD |
| Ref : ACS Chem Neurosci , : , 2021 |
| Abstract : Titov_2021_ACS.Chem.Neurosci__ |
| ESTHER : Titov_2021_ACS.Chem.Neurosci__ |
| PubMedSearch : Titov_2021_ACS.Chem.Neurosci__ |
| PubMedID: 33395258 |
| Title : Homobivalent Lamellarin-Like Schiff Bases: In Vitro Evaluation of Their Cancer Cell Cytotoxicity and Multitargeting Anti-Alzheimer's Disease Potential - Nevskaya_2021_Molecules_26_ |
| Author(s) : Nevskaya AA , Anikina LV , Purgatorio R , Catto M , Nicolotti O , de Candia M , Pisani L , Borisova TN , Miftyakhova AR , Varlamov AV , Nevskaya EY , Borisov RS , Voskressensky LG , Altomare CD |
| Ref : Molecules , 26 : , 2021 |
| Abstract : Nevskaya_2021_Molecules_26_ |
| ESTHER : Nevskaya_2021_Molecules_26_ |
| PubMedSearch : Nevskaya_2021_Molecules_26_ |
| PubMedID: 33445600 |
| Title : Evaluation of water-soluble Mannich base prodrugs of 2,3,4,5-tetrahydroazepino[4,3-b]indol-1(6H)-one as multitarget-directed agents for Alzheimer's disease - Purgatorio_2021_ChemMedChem_16_589 |
| Author(s) : Purgatorio R , de Candia M , Catto M , Rullo M , Pisani L , Denora N , Carrieri A , Nevskaya AA , Voskressensky LG , Altomare CD |
| Ref : ChemMedChem , 16 :589 , 2021 |
| Abstract : Purgatorio_2021_ChemMedChem_16_589 |
| ESTHER : Purgatorio_2021_ChemMedChem_16_589 |
| PubMedSearch : Purgatorio_2021_ChemMedChem_16_589 |
| PubMedID: 33156950 |
| Title : First-in-Class Isonipecotamide-Based Thrombin and Cholinesterase Dual Inhibitors with Potential for Alzheimer Disease - Purgatorio_2021_Molecules_26_ |
| Author(s) : Purgatorio R , Gambacorta N , de Candia M , Catto M , Rullo M , Pisani L , Nicolotti O , Altomare CD |
| Ref : Molecules , 26 : , 2021 |
| Abstract : Purgatorio_2021_Molecules_26_ |
| ESTHER : Purgatorio_2021_Molecules_26_ |
| PubMedSearch : Purgatorio_2021_Molecules_26_ |
| PubMedID: 34500640 |
| Title : Scouting around 1,2,3,4-Tetrahydrochromeno[3,2-c]pyridin-10-ones for Single- and Multi-target Ligands Directed towards Relevant Alzheimer's Targets - Purgatorio_2020_ChemMedChem_15_1947 |
| Author(s) : Purgatorio R , Kulikova L , Pisani L , Catto M , de Candia M , Carrieri A , Cellamare S , De Palma A , Beloglazkin A , Raesi GR , Voskressensky L , Altomare CD |
| Ref : ChemMedChem , 15 :1947 , 2020 |
| Abstract : Purgatorio_2020_ChemMedChem_15_1947 |
| ESTHER : Purgatorio_2020_ChemMedChem_15_1947 |
| PubMedSearch : Purgatorio_2020_ChemMedChem_15_1947 |
| PubMedID: 32716595 |
| Title : Interplay between Ionization and Tautomerism in Bioactive beta-Enamino Ester-Containing Cyclic Compounds: Study of Annulated 1,2,3,6-Tetrahydroazocine Derivatives - Viayna_2020_J.Phys.Chem.B_124_28 |
| Author(s) : Viayna A , Antermite SG , de Candia M , Altomare CD , Luque FJ |
| Ref : J Phys Chem B , 124 :28 , 2020 |
| Abstract : Viayna_2020_J.Phys.Chem.B_124_28 |
| ESTHER : Viayna_2020_J.Phys.Chem.B_124_28 |
| PubMedSearch : Viayna_2020_J.Phys.Chem.B_124_28 |
| PubMedID: 31841339 |
| Title : A Prospective Repurposing of Dantrolene as a Multitarget Agent for Alzheimer's Disease - Bolognino_2019_Molecules_24_ |
| Author(s) : Bolognino I , Giangregorio N , Pisani L , de Candia M , Purgatorio R , Tonazzi A , Altomare CD , Cellamare S , Catto M |
| Ref : Molecules , 24 : , 2019 |
| Abstract : Bolognino_2019_Molecules_24_ |
| ESTHER : Bolognino_2019_Molecules_24_ |
| PubMedSearch : Bolognino_2019_Molecules_24_ |
| PubMedID: 31775359 |
| Title : Investigating 1,2,3,4,5,6-hexahydroazepino[4,3-b]indole as scaffold of butyrylcholinesterase-selective inhibitors with additional neuroprotective activities for Alzheimer's disease - Purgatorio_2019_Eur.J.Med.Chem_177_414 |
| Author(s) : Purgatorio R , de Candia M , Catto M , Carrieri A , Pisani L , De Palma A , Toma M , Ivanova OA , Voskressensky LG , Altomare CD |
| Ref : Eur Journal of Medicinal Chemistry , 177 :414 , 2019 |
| Abstract : Purgatorio_2019_Eur.J.Med.Chem_177_414 |
| ESTHER : Purgatorio_2019_Eur.J.Med.Chem_177_414 |
| PubMedSearch : Purgatorio_2019_Eur.J.Med.Chem_177_414 |
| PubMedID: 31158754 |
| Title : Chasing ChEs-MAO B Multi-Targeting 4-Aminomethyl-7-Benzyloxy-2H-Chromen-2-ones - Rullo_2019_Molecules_24_ |
| Author(s) : Rullo M , Catto M , Carrieri A , de Candia M , Altomare CD , Pisani L |
| Ref : Molecules , 24 : , 2019 |
| Abstract : Rullo_2019_Molecules_24_ |
| ESTHER : Rullo_2019_Molecules_24_ |
| PubMedSearch : Rullo_2019_Molecules_24_ |
| PubMedID: 31835376 |
| Title : The position of fluorine in CP-118,954 affects AChE inhibition potency and PET imaging quantification for AChE expression in the rat brain - Lee_2017_Eur.J.Pharm.Sci_109_209 |
| Author(s) : Lee BC , Moon BS , Park HS , Jung JH , Park DD , de Candia M , Denora N , Altomare CD , Kim SE |
| Ref : Eur J Pharm Sci , 109 :209 , 2017 |
| Abstract : Lee_2017_Eur.J.Pharm.Sci_109_209 |
| ESTHER : Lee_2017_Eur.J.Pharm.Sci_109_209 |
| PubMedSearch : Lee_2017_Eur.J.Pharm.Sci_109_209 |
| PubMedID: 28818531 |
| Title : New azepino[4,3-b]indole derivatives as nanomolar selective inhibitors of human butyrylcholinesterase showing protective effects against NMDA-induced neurotoxicity - de Candia_2016_Eur.J.Med.Chem_125_288 |
| Author(s) : de Candia M , Zaetta G , Denora N , Tricarico D , Majellaro M , Cellamare S , Altomare CD |
| Ref : Eur Journal of Medicinal Chemistry , 125 :288 , 2016 |
| Abstract : de Candia_2016_Eur.J.Med.Chem_125_288 |
| ESTHER : de Candia_2016_Eur.J.Med.Chem_125_288 |
| PubMedSearch : de Candia_2016_Eur.J.Med.Chem_125_288 |
| PubMedID: 27688184 |
| Title : Ester derivatives of annulated tetrahydroazocines: a new class of selective acetylcholinesterase inhibitors - Carotti_2006_Bioorg.Med.Chem_14_7205 |
| Author(s) : Carotti A , de Candia M , Catto M , Borisova TN , Varlamov AV , Mendez-Alvarez E , Soto-Otero R , Voskressensky LG , Altomare CD |
| Ref : Bioorganic & Medicinal Chemistry , 14 :7205 , 2006 |
| Abstract : Carotti_2006_Bioorg.Med.Chem_14_7205 |
| ESTHER : Carotti_2006_Bioorg.Med.Chem_14_7205 |
| PubMedSearch : Carotti_2006_Bioorg.Med.Chem_14_7205 |
| PubMedID: 16843666 |