Luque FJ

References (35)

Title : Acetylcholinesterase: A Versatile Template to Coin Potent Modulators of Multiple Therapeutic Targets - Luque_2024_Acc.Chem.Res__
Author(s) : Luque FJ , Munoz-Torrero D
Ref : Acc Chem Res , : , 2024
PubMedID: 38333993

Title : In-vitro and in-silico studies of annelated 1,4,7,8-tetrahydroazocine ester derivatives as nanomolar selective inhibitors of human butyrylcholinesterase - de Candia_2023_Chem.Biol.Interact_14ChEPon_110741
Author(s) : de Candia M , Titov AA , Viayna A , Kulikova LN , Purgatorio R , Piergiovanni B , Niso M , Catto M , Voskressensky LG , Luque FJ , Altomare CD
Ref : Chemico-Biological Interactions , :110741 , 2023
PubMedID: 37839515

Title : Screening and Biological Evaluation of Soluble Epoxide Hydrolase Inhibitors: Assessing the Role of Hydrophobicity in the Pharmacophore-Guided Search of Novel Hits - Vazquez_2023_J.Chem.Inf.Model__
Author(s) : Vazquez J , Ginex T , Herrero A , Morisseau C , Hammock BD , Luque FJ
Ref : J Chem Inf Model , : , 2023
PubMedID: 37141492

Title : Three to Tango: Inhibitory Effect of Quercetin and Apigenin on Acetylcholinesterase, Amyloid- Aggregation and Acetylcholinesterase-Amyloid Interaction - Alvarez-Berbel_2022_Pharmaceutics_14_
Author(s) : Alvarez-Berbel I , Espargaro A , Viayna A , Caballero AB , Busquets MA , Gamez P , Luque FJ , Sabate R
Ref : Pharmaceutics , 14 : , 2022
PubMedID: 36365159

Title : Azobioisosteres of Curcumin with Pronounced Activity against Amyloid Aggregation, Intracellular Oxidative Stress, and Neuroinflammation - Hofmann_2021_Chemistry_27_6015
Author(s) : Hofmann J , Ginex T , Espargaro A , Scheiner M , Gunesch S , Arago M , Stigloher C , Sabate R , Luque FJ , Decker M
Ref : Chemistry , 27 :6015 , 2021
PubMedID: 33666306

Title : From virtual screening hits targeting a cryptic pocket in BACE-1 to a nontoxic brain permeable multitarget anti-Alzheimer lead with disease-modifying and cognition-enhancing effects - Pont_2021_Eur.J.Med.Chem_225_113779
Author(s) : Pont C , Ginex T , Grinan-Ferre C , Scheiner M , Mattellone A , Martinez N , Arce EM , Soriano-Fernandez Y , Naldi M , De Simone A , Barenys M , Gomez-Catalan J , Perez B , Sabate R , Andrisano V , Loza MI , Brea J , Bartolini M , Bolognesi ML , Decker M , Pallas M , Luque FJ , Munoz-Torrero D
Ref : Eur Journal of Medicinal Chemistry , 225 :113779 , 2021
PubMedID: 34418785

Title : Interplay between Ionization and Tautomerism in Bioactive beta-Enamino Ester-Containing Cyclic Compounds: Study of Annulated 1,2,3,6-Tetrahydroazocine Derivatives - Viayna_2020_J.Phys.Chem.B_124_28
Author(s) : Viayna A , Antermite SG , de Candia M , Altomare CD , Luque FJ
Ref : J Phys Chem B , 124 :28 , 2020
PubMedID: 31841339

Title : Centrally Active Multitarget Anti-Alzheimer Agents Derived from the Antioxidant Lead CR-6 - Perez-Areales_2020_J.Med.Chem_63_9360
Author(s) : Perez-Areales FJ , Garrido M , Aso E , Bartolini M , De Simone A , Espargaro A , Ginex T , Sabate R , Perez B , Andrisano V , Puigoriol-Illamola D , Pallas M , Luque FJ , Loza MI , Brea J , Ferrer I , Ciruela F , Messeguer A , Munoz-Torrero D
Ref : Journal of Medicinal Chemistry , 63 :9360 , 2020
PubMedID: 32706255

Title : Design, synthesis and multitarget biological profiling of second-generation anti-Alzheimer rhein-huprine hybrids - Perez-Areales_2017_Future.Med.Chem_9_965
Author(s) : Perez-Areales FJ , Betari N , Viayna A , Pont C , Espargaro A , Bartolini M , De Simone A , Rinaldi Alvarenga JF , Perez B , Sabate R , Lamuela-Raventos RM , Andrisano V , Luque FJ , Munoz-Torrero D
Ref : Future Med Chem , 9 :965 , 2017
PubMedID: 28632395

Title : Novel Levetiracetam Derivatives That Are Effective against the Alzheimer-like Phenotype in Mice: Synthesis, in Vitro, ex Vivo, and in Vivo Efficacy Studies - Sola_2015_J.Med.Chem_58_6018
Author(s) : Sola I , Aso E , Frattini D , Lopez-Gonzalez I , Espargaro A , Sabate R , Di Pietro O , Luque FJ , Clos MV , Ferrer I , Munoz-Torrero D
Ref : Journal of Medicinal Chemistry , 58 :6018 , 2015
PubMedID: 26181606

Title : Tetrahydrobenzo[h][1,6]naphthyridine-6-chlorotacrine hybrids as a new family of anti-Alzheimer agents targeting beta-amyloid, tau, and cholinesterase pathologies - Di Pietro_2014_Eur.J.Med.Chem_84C_107
Author(s) : Di Pietro O , Perez-Areales FJ , Juarez-Jimenez J , Espargaro A , Clos MV , Perez B , Lavilla R , Sabate R , Luque FJ , Munoz-Torrero D
Ref : Eur Journal of Medicinal Chemistry , 84C :107 , 2014
PubMedID: 25016233

Title : Shogaol-huprine hybrids: Dual antioxidant and anticholinesterase agents with beta-amyloid and tau anti-aggregating properties - Perez-Areales_2014_Bioorg.Med.Chem_22_5298
Author(s) : Perez-Areales FJ , Di Pietro O , Espargaro A , Vallverdu-Queralt A , Galdeano C , Ragusa IM , Viayna E , Guillou C , Clos MV , Perez B , Sabate R , Lamuela-Raventos RM , Luque FJ , Munoz-Torrero D
Ref : Bioorganic & Medicinal Chemistry , 22 :5298 , 2014
PubMedID: 25156301

Title : Synthesis and multitarget biological profiling of a novel family of rhein derivatives as disease-modifying anti-Alzheimer agents - Viayna_2014_J.Med.Chem_57_2549
Author(s) : Viayna E , Sola I , Bartolini M , De Simone A , Tapia-Rojas C , Serrano FG , Sabate R , Juarez-Jimenez J , Perez B , Luque FJ , Andrisano V , Clos MV , Inestrosa NC , Munoz-Torrero D
Ref : Journal of Medicinal Chemistry , 57 :2549 , 2014
PubMedID: 24568372

Title : 1,2,3,4-Tetrahydrobenzo[h][1,6]naphthyridines as a new family of potent peripheral-to-midgorge-site inhibitors of acetylcholinesterase: Synthesis, pharmacological evaluation and mechanistic studies - Di Pietro_2013_Eur.J.Med.Chem_73C_141
Author(s) : Di Pietro O , Viayna E , Vicente-Garcia E , Bartolini M , Ramon R , Juarez-Jimenez J , Clos MV , Perez B , Andrisano V , Luque FJ , Lavilla R , Munoz-Torrero D
Ref : Eur Journal of Medicinal Chemistry , 73C :141 , 2013
PubMedID: 24389509

Title : Huprine-tacrine heterodimers as anti-amyloidogenic compounds of potential interest against Alzheimer's and prion diseases - Galdeano_2012_J.Med.Chem_55_661
Author(s) : Galdeano C , Viayna E , Sola I , Formosa X , Camps P , Badia A , Clos MV , Relat J , Ratia M , Bartolini M , Mancini F , Andrisano V , Salmona M , Minguillon C , Gonzalez-Munoz GC , Rodriguez-Franco MI , Bidon-Chanal A , Luque FJ , Munoz-Torrero D
Ref : Journal of Medicinal Chemistry , 55 :661 , 2012
PubMedID: 22185619

Title : Synthesis, biological evaluation, and molecular modeling of donepezil and N-[(5-(benzyloxy)-1-methyl-1H-indol-2-yl)methyl]-N-methylprop-2-yn-1-amine hybrids as new multipotent cholinesterase\/monoamine oxidase inhibitors for the treatment of Alzheimer's disease - Bolea_2011_J.Med.Chem_54_8251
Author(s) : Bolea I , Juarez-Jimenez J , de los Rios C , Chioua M , Pouplana R , Luque FJ , Unzeta M , Marco-Contelles J , Samadi A
Ref : Journal of Medicinal Chemistry , 54 :8251 , 2011
PubMedID: 22023459

Title : Tacrine-based dual binding site acetylcholinesterase inhibitors as potential disease-modifying anti-Alzheimer drug candidates - Camps_2010_Chem.Biol.Interact_187_411
Author(s) : Camps P , Formosa X , Galdeano C , Gomez T , Munoz-Torrero D , Ramirez L , Viayna E , Gomez E , Isambert N , Lavilla R , Badia A , Clos MV , Bartolini M , Mancini F , Andrisano V , Bidon-Chanal A , Huertas O , Dafni T , Luque FJ
Ref : Chemico-Biological Interactions , 187 :411 , 2010
PubMedID: 20167211

Title : Structural determinants of the multifunctional profile of dual binding site acetylcholinesterase inhibitors as anti-Alzheimer agents - Galdeano_2010_Curr.Pharm.Des_16_2818
Author(s) : Galdeano C , Viayna E , Arroyo P , Bidon-Chanal A , Blas JR , Munoz-Torrero D , Luque FJ
Ref : Curr Pharm Des , 16 :2818 , 2010
PubMedID: 20698824

Title : Novel huprine derivatives with inhibitory activity toward beta-amyloid aggregation and formation as disease-modifying anti-Alzheimer drug candidates - Viayna_2010_ChemMedChem_5_1855
Author(s) : Viayna E , Gomez T , Galdeano C , Ramirez L , Ratia M , Badia A , Clos MV , Verdaguer E , Junyent F , Camins A , Pallas M , Bartolini M , Mancini F , Andrisano V , Arce MP , Rodriguez-Franco MI , Bidon-Chanal A , Luque FJ , Camps P , Munoz-Torrero D
Ref : ChemMedChem , 5 :1855 , 2010
PubMedID: 20859987

Title : Reactivity versus steric effects in fluorinated ketones as esterase inhibitors: a quantum mechanical and molecular dynamics study - Rayo_2010_J.Mol.Model_16_1753
Author(s) : Rayo J , Munoz L , Rosell G , Hammock BD , Guerrero A , Luque FJ , Pouplana R
Ref : J Mol Model , 16 :1753 , 2010
PubMedID: 20676708

Title : Pyrano[3,2-c]quinoline-6-chlorotacrine hybrids as a novel family of acetylcholinesterase- and beta-amyloid-directed anti-Alzheimer compounds - Camps_2009_J.Med.Chem_52_5365
Author(s) : Camps P , Formosa X , Galdeano C , Munoz-Torrero D , Ramirez L , Gomez E , Isambert N , Lavilla R , Badia A , Clos MV , Bartolini M , Mancini F , Andrisano V , Arce MP , Rodriguez-Franco MI , Huertas O , Dafni T , Luque FJ
Ref : Journal of Medicinal Chemistry , 52 :5365 , 2009
PubMedID: 19663388

Title : New tacrine-dihydropyridine hybrids that inhibit acetylcholinesterase, calcium entry, and exhibit neuroprotection properties - Leon_2008_Bioorg.Med.Chem_16_7759
Author(s) : Leon R , de los Rios C , Marco-Contelles J , Huertas O , Barril X , Luque FJ , Lopez MG , Garcia AG , Villarroya M
Ref : Bioorganic & Medicinal Chemistry , 16 :7759 , 2008
PubMedID: 18640842

Title : Novel donepezil-based inhibitors of acetyl- and butyrylcholinesterase and acetylcholinesterase-induced beta-amyloid aggregation - Camps_2008_J.Med.Chem_51_3588
Author(s) : Camps P , Formosa X , Galdeano C , Gomez T , Munoz-Torrero D , Scarpellini M , Viayna E , Badia A , Clos MV , Camins A , Pallas M , Bartolini M , Mancini F , Andrisano V , Estelrich J , Lizondo M , Bidon-Chanal A , Luque FJ
Ref : Journal of Medicinal Chemistry , 51 :3588 , 2008
PubMedID: 18517184

Title : Binding of 13-amidohuprines to acetylcholinesterase: exploring the ligand-induced conformational change of the gly117-gly118 peptide bond in the oxyanion hole - Camps_2006_J.Med.Chem_49_6833
Author(s) : Camps P , Gomez E , Munoz-Torrero D , Badia A , Clos MV , Curutchet C , Munoz-Muriedas J , Luque FJ
Ref : Journal of Medicinal Chemistry , 49 :6833 , 2006
PubMedID: 17154513

Title : Donepezil-tacrine hybrid related derivatives as new dual binding site inhibitors of AChE - Alonso_2005_Bioorg.Med.Chem_13_6588
Author(s) : Alonso D , Dorronsoro I , Rubio L , Munoz P , Garcia-Palomero E , del Monte M , Bidon-Chanal A , Orozco M , Luque FJ , Castro A , Medina M , Martinez A
Ref : Bioorganic & Medicinal Chemistry , 13 :6588 , 2005
PubMedID: 16230018

Title : Design, synthesis, and biological evaluation of dual binding site acetylcholinesterase inhibitors: new disease-modifying agents for Alzheimer's disease - Munoz-Ruiz_2005_J.Med.Chem_48_7223
Author(s) : Munoz-Ruiz P , Rubio L , Garcia-Palomero E , Dorronsoro I , del Monte-Millan M , Valenzuela R , Usan P , de Austria C , Bartolini M , Andrisano V , Bidon-Chanal A , Orozco M , Luque FJ , Medina M , Martinez A
Ref : Journal of Medicinal Chemistry , 48 :7223 , 2005
PubMedID: 16279781

Title : Synthesis, biological evaluation and molecular modelling of diversely functionalized heterocyclic derivatives as inhibitors of acetylcholinesterase\/butyrylcholinesterase and modulators of Ca2+ channels and nicotinic receptors - Marco_2004_Bioorg.Med.Chem_12_2199
Author(s) : Marco JL , de los Rios C , Garcia AG , Villarroya M , Carreiras MC , Martins C , Eleuterio A , Morreale A , Orozco M , Luque FJ
Ref : Bioorganic & Medicinal Chemistry , 12 :2199 , 2004
PubMedID: 15080920

Title : Modulation of binding strength in several classes of active site inhibitors of acetylcholinesterase studied by comparative binding energy analysis - Martin-Santamaria_2004_J.Med.Chem_47_4471
Author(s) : Martin-Santamaria S , Munoz-Muriedas J , Luque FJ , Gago F
Ref : Journal of Medicinal Chemistry , 47 :4471 , 2004
PubMedID: 15317459

Title : Molecular modelling approaches to the design of acetylcholinesterase inhibitors: new challenges for the treatment of Alzheimer's disease - Munoz-Muriedas_2004_Curr.Pharm.Des_10_3131
Author(s) : Munoz-Muriedas J , Lopez JM , Orozco M , Luque FJ
Ref : Curr Pharm Des , 10 :3131 , 2004
PubMedID: 15544503

Title : Rational design of reversible acetylcholinesterase inhibitors - Barril_2002_Mini.Rev.Med.Chem_2_27
Author(s) : Barril X , Kalko SG , Orozco M , Luque FJ
Ref : Mini Rev Med Chem , 2 :27 , 2002
PubMedID: 12369955

Title : 3D structure of Torpedo californica acetylcholinesterase complexed with huprine X at 2.1 A resolution: kinetic and molecular dynamic correlates - Dvir_2002_Biochemistry_41_2970
Author(s) : Dvir H , Wong DM , Harel M , Barril X , Orozco M , Luque FJ , Munoz-Torrero D , Camps P , Rosenberry TL , Silman I , Sussman JL
Ref : Biochemistry , 41 :2970 , 2002
PubMedID: 11863435
Gene_locus related to this paper: torca-ACHE

Title : Synthesis, in Vitro Pharmacology, and Molecular Modeling of syn-Huprines as Acetylcholinesterase Inhibitors - Camps_2001_J.Med.Chem_44_4733
Author(s) : Camps P , Gomez E , Munoz-Torrero D , Badia A , Vivas NM , Barril X , Orozco M , Luque FJ
Ref : Journal of Medicinal Chemistry , 44 :4733 , 2001
PubMedID: 11741490

Title : New tacrine-huperzine A hybrids (huprines): highly potent tight-binding acetylcholinesterase inhibitors of interest for the treatment of Alzheimer's disease - Camps_2000_J.Med.Chem_43_4657
Author(s) : Camps P , El Achab R , Morral J , Munoz-Torrero D , Badia A , Banos JE , Vivas NM , Barril X , Orozco M , Luque FJ
Ref : Journal of Medicinal Chemistry , 43 :4657 , 2000
PubMedID: 11101357

Title : Synthesis, in vitro pharmacology, and molecular modeling of very potent tacrine-huperzine A hybrids as acetylcholinesterase inhibitors of potential interest for the treatment of Alzheimer's disease - Camps_1999_J.Med.Chem_42_3227
Author(s) : Camps P , El Achab R , Gorbig DM , Morral J , Munoz-Torrero D , Badia A , Eladi Banos J , Vivas NM , Barril X , Orozco M , Luque FJ
Ref : Journal of Medicinal Chemistry , 42 :3227 , 1999
PubMedID: 10464010

Title : Predicting relative binding free energies of tacrine-huperzine A hybrids as inhibitors of acetylcholinesterase - Barril_1999_J.Med.Chem_42_5110
Author(s) : Barril X , Orozco M , Luque FJ
Ref : Journal of Medicinal Chemistry , 42 :5110 , 1999
PubMedID: 10602696