thema-TM0077
Thermotoga maritima, Thermotoga naphthophila, Thermotoga petrophila, Thermotoga neapolitana, acetyl xylan esterase (TM0077) (axeA) CE7
Comment
Other strains: Thermotoga maritima (strain ATCC 43589 \/ MSB8 \/ DSM 3109 \/ JCM 10099) Thermotoga sp. (strain RQ2), Thermotoga naphthophila (strains ATCC BAA-489 \/ DSM 13996 \/ JCM 10882 \/ RKU-10\; RKU-1 \/ ATCC BAA-488 \/ DSM 13995) Thermotoga petrophila (strain RKU-1 \/ ATCC BAA-488 \/ DSM 13995), Thermotoga neapolitana (strain ATCC 49049 \/ DSM 4359 \/ NS-E) || TM0077 from Thermotoga maritima belongs to the carbohydrate esterase family 7 and is active on a variety of acetylated compounds, including cephalosporin C. TM0077 is an acetyl esterase and not an acetyl xylan esterase
Relationship
Family : Acetyl-esterase_deacetylase
Block : X
Position in NCBI Life Tree : Thermotoga maritima
(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.)
> cellular organisms N E > Bacteria N E > Thermotogae [phylum] N E > Thermotogae [class] N E > Thermotogales N E > Thermotogaceae N E > Thermotoga N E > Thermotoga maritima N EMolecular evidence
Sequence
Peptide
MAFFDLPLEE LKKYRPERYE EKDFDEFWEE TLAESEKFPL DPVFERMESH LKTVEAYDVT FSGYRGQRIK GWLLVPKLEE EKLPCVVQYI GYNGGRGFPH DWLFWPSMGY ICFVMDTRGQ GSGWLKGDTP DYPEGPVDPQ YPGFMTRGIL DPRTYYYRRV FTDAVRAVEA AASFPQVDQE RIVIAGGSQG GGIALAVSAL SKKAKALLCD VPFLCHFRRA VQLVDTHPYA EITNFLKTHR DKEEIVFRTL SYFDGVNFAA RAKIPALFSV GLMDNICPPS TVFAAYNYYA GPKEIRIYPY NNHEGGGSFQ AVEQVKFLKK LFEKG
References (8)
| Title : Structural role of a conserved active site cis proline in the Thermotoga maritima acetyl esterase from the carbohydrate esterase family 7 - Singh_2017_Proteins_85_694 |
| Author(s) : Singh MK , Manoj N |
| Ref : Proteins , 85 :694 , 2017 |
| Abstract : |
| PubMedSearch : Singh_2017_Proteins_85_694 |
| PubMedID: 28097692 |
| Gene_locus related to this paper: thema-TM0077 |
| Title : Role of an N-terminal extension in stability and catalytic activity of a hyperthermostable alpha\/beta hydrolase fold esterase - Singh_2017_Protein.Eng.Des.Sel_30_559 |
| Author(s) : Singh MK , Shivakumaraswamy S , Gummadi SN , Manoj N |
| Ref : Protein Engineering Des Sel , 30 :559 , 2017 |
| Abstract : |
| PubMedSearch : Singh_2017_Protein.Eng.Des.Sel_30_559 |
| PubMedID: 28967962 |
| Gene_locus related to this paper: thema-TM0077 |
| Title : An extended loop in CE7 carbohydrate esterase family is dispensable for oligomerization but required for activity and thermostability - Singh_2016_J.Struct.Biol_194_434 |
| Author(s) : Singh MK , Manoj N |
| Ref : J Struct Biol , 194 :434 , 2016 |
| Abstract : |
| PubMedSearch : Singh_2016_J.Struct.Biol_194_434 |
| PubMedID: 27085421 |
| Gene_locus related to this paper: thema-TM0077 |
| Title : Crystal structure of Thermotoga maritima acetyl esterase complex with a substrate analog: Insights into the distinctive substrate specificity in the CE7 carbohydrate esterase family - Singh_2016_Biochem.Biophys.Res.Commun_476_63 |
| Author(s) : Singh MK , Manoj N |
| Ref : Biochemical & Biophysical Research Communications , 476 :63 , 2016 |
| Abstract : |
| PubMedSearch : Singh_2016_Biochem.Biophys.Res.Commun_476_63 |
| PubMedID: 27181355 |
| Gene_locus related to this paper: thema-TM0077 |
| Title : Functional and structural characterization of a thermostable acetyl esterase from Thermotoga maritima - Levisson_2012_Proteins_80_1545 |
| Author(s) : Levisson M , Han GW , Deller MC , Xu Q , Biely P , Hendriks S , Ten Eyck LF , Flensburg C , Roversi P , Miller MD , McMullan D , von Delft F , Kreusch A , Deacon AM , Van der Oost J , Lesley SA , Elsliger MA , Kengen SW , Wilson IA |
| Ref : Proteins , 80 :1545 , 2012 |
| Abstract : |
| PubMedSearch : Levisson_2012_Proteins_80_1545 |
| PubMedID: 22411095 |
| Gene_locus related to this paper: thema-TM0077 |
| Title : The structural basis for the narrow substrate specificity of an acetyl esterase from Thermotoga maritima - Hedge_2012_Biochim.Biophys.Acta_1824_1024 |
| Author(s) : Hedge MK , Gehring AM , Adkins CT , Weston LA , Lavis LD , Johnson RJ |
| Ref : Biochimica & Biophysica Acta , 1824 :1024 , 2012 |
| Abstract : |
| PubMedSearch : Hedge_2012_Biochim.Biophys.Acta_1824_1024 |
| PubMedID: 22659119 |
| Gene_locus related to this paper: thema-TM0077 |
| Title : Hyperthermostable acetyl xylan esterase - Drzewiecki_2010_Microb.Biotechnol_3_84 |
| Author(s) : Drzewiecki K , Angelov A , Ballschmiter M , Tiefenbach KJ , Sterner R , Liebl W |
| Ref : Microb Biotechnol , 3 :84 , 2010 |
| Abstract : |
| PubMedSearch : Drzewiecki_2010_Microb.Biotechnol_3_84 |
| PubMedID: 21255309 |
| Gene_locus related to this paper: thema-TM0077 |
| Title : Evidence for lateral gene transfer between Archaea and bacteria from genome sequence of Thermotoga maritima - Nelson_1999_Nature_399_323 |
| Author(s) : Nelson KE , Clayton RA , Gill SR , Gwinn ML , Dodson RJ , Haft DH , Hickey EK , Peterson JD , Nelson WC , Ketchum KA , McDonald L , Utterback TR , Malek JA , Linher KD , Garrett MM , Stewart AM , Cotton MD , Pratt MS , Phillips CA , Richardson D , Heidelberg J , Sutton GG , Fleischmann RD , Eisen JA , White O , Salzberg SL , Smith HO , Venter JC , Fraser CM |
| Ref : Nature , 399 :323 , 1999 |
| Abstract : |
| PubMedSearch : Nelson_1999_Nature_399_323 |
| PubMedID: 10360571 |
| Gene_locus related to this paper: thema-ESTA , thema-q9x0d6 , thema-q9x042 , thema-TM0033 , thema-TM0053 , thema-TM0077 , thema-TM0336 , thema-TM1160 , thema-TM1350 |