thema-TM0077

Thermotoga maritima, Thermotoga naphthophila, Thermotoga petrophila, Thermotoga neapolitana, acetyl xylan esterase (TM0077) (axeA) CE7

Comment

Other strains: Thermotoga maritima (strain ATCC 43589 \/ MSB8 \/ DSM 3109 \/ JCM 10099) Thermotoga sp. (strain RQ2), Thermotoga naphthophila (strains ATCC BAA-489 \/ DSM 13996 \/ JCM 10882 \/ RKU-10\; RKU-1 \/ ATCC BAA-488 \/ DSM 13995) Thermotoga petrophila (strain RKU-1 \/ ATCC BAA-488 \/ DSM 13995), Thermotoga neapolitana (strain ATCC 49049 \/ DSM 4359 \/ NS-E) || TM0077 from Thermotoga maritima belongs to the carbohydrate esterase family 7 and is active on a variety of acetylated compounds, including cephalosporin C. TM0077 is an acetyl esterase and not an acetyl xylan esterase

Relationship

Family : Acetyl-esterase_deacetylase

Block : X

Position in NCBI Life Tree : Thermotoga maritima

(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.)

> cellular organisms N E > Bacteria N E > Thermotogae [phylum] N E > Thermotogae [class] N E > Thermotogales N E > Thermotogaceae N E > Thermotoga N E > Thermotoga maritima N E

Sequence

Peptide

MAFFDLPLEE LKKYRPERYE EKDFDEFWEE TLAESEKFPL DPVFERMESH LKTVEAYDVT FSGYRGQRIK GWLLVPKLEE EKLPCVVQYI GYNGGRGFPH DWLFWPSMGY ICFVMDTRGQ GSGWLKGDTP DYPEGPVDPQ YPGFMTRGIL DPRTYYYRRV FTDAVRAVEA AASFPQVDQE RIVIAGGSQG GGIALAVSAL SKKAKALLCD VPFLCHFRRA VQLVDTHPYA EITNFLKTHR DKEEIVFRTL SYFDGVNFAA RAKIPALFSV GLMDNICPPS TVFAAYNYYA GPKEIRIYPY NNHEGGGSFQ AVEQVKFLKK LFEKG

References (8)

Title : Structural role of a conserved active site cis proline in the Thermotoga maritima acetyl esterase from the carbohydrate esterase family 7 - Singh_2017_Proteins_85_694
Author(s) : Singh MK , Manoj N
Ref : Proteins , 85 :694 , 2017
PubMedID: 28097692
Gene_locus related to this paper: thema-TM0077

Title : Role of an N-terminal extension in stability and catalytic activity of a hyperthermostable alpha\/beta hydrolase fold esterase - Singh_2017_Protein.Eng.Des.Sel_30_559
Author(s) : Singh MK , Shivakumaraswamy S , Gummadi SN , Manoj N
Ref : Protein Engineering Des Sel , 30 :559 , 2017
PubMedID: 28967962
Gene_locus related to this paper: thema-TM0077

Title : An extended loop in CE7 carbohydrate esterase family is dispensable for oligomerization but required for activity and thermostability - Singh_2016_J.Struct.Biol_194_434
Author(s) : Singh MK , Manoj N
Ref : J Struct Biol , 194 :434 , 2016
PubMedID: 27085421
Gene_locus related to this paper: thema-TM0077

Title : Crystal structure of Thermotoga maritima acetyl esterase complex with a substrate analog: Insights into the distinctive substrate specificity in the CE7 carbohydrate esterase family - Singh_2016_Biochem.Biophys.Res.Commun_476_63
Author(s) : Singh MK , Manoj N
Ref : Biochemical & Biophysical Research Communications , 476 :63 , 2016
PubMedID: 27181355
Gene_locus related to this paper: thema-TM0077

Title : Functional and structural characterization of a thermostable acetyl esterase from Thermotoga maritima - Levisson_2012_Proteins_80_1545
Author(s) : Levisson M , Han GW , Deller MC , Xu Q , Biely P , Hendriks S , Ten Eyck LF , Flensburg C , Roversi P , Miller MD , McMullan D , von Delft F , Kreusch A , Deacon AM , Van der Oost J , Lesley SA , Elsliger MA , Kengen SW , Wilson IA
Ref : Proteins , 80 :1545 , 2012
PubMedID: 22411095
Gene_locus related to this paper: thema-TM0077

Title : The structural basis for the narrow substrate specificity of an acetyl esterase from Thermotoga maritima - Hedge_2012_Biochim.Biophys.Acta_1824_1024
Author(s) : Hedge MK , Gehring AM , Adkins CT , Weston LA , Lavis LD , Johnson RJ
Ref : Biochimica & Biophysica Acta , 1824 :1024 , 2012
PubMedID: 22659119
Gene_locus related to this paper: thema-TM0077

Title : Hyperthermostable acetyl xylan esterase - Drzewiecki_2010_Microb.Biotechnol_3_84
Author(s) : Drzewiecki K , Angelov A , Ballschmiter M , Tiefenbach KJ , Sterner R , Liebl W
Ref : Microb Biotechnol , 3 :84 , 2010
PubMedID: 21255309
Gene_locus related to this paper: thema-TM0077

Title : Evidence for lateral gene transfer between Archaea and bacteria from genome sequence of Thermotoga maritima - Nelson_1999_Nature_399_323
Author(s) : Nelson KE , Clayton RA , Gill SR , Gwinn ML , Dodson RJ , Haft DH , Hickey EK , Peterson JD , Nelson WC , Ketchum KA , McDonald L , Utterback TR , Malek JA , Linher KD , Garrett MM , Stewart AM , Cotton MD , Pratt MS , Phillips CA , Richardson D , Heidelberg J , Sutton GG , Fleischmann RD , Eisen JA , White O , Salzberg SL , Smith HO , Venter JC , Fraser CM
Ref : Nature , 399 :323 , 1999
PubMedID: 10360571
Gene_locus related to this paper: thema-ESTA , thema-q9x0d6 , thema-q9x042 , thema-TM0033 , thema-TM0053 , thema-TM0077 , thema-TM0336 , thema-TM1160 , thema-TM1350