PMSF
An enzyme inhibitor that inactivates cholinesterases, esterases, lipases, IRC-50 arvin, subtilisin, the fatty acid synthetase complex and many other serine hydrolases unrelated to alpha/beta hydrolases. Do not inhibit PlaB
General
Type : Sulfur Compound, Sulfonyl
Chemical_Nomenclature : Phenylmethylsulfonyl fluoride
Canonical SMILES : C1=CC=C(C=C1)CS(=O)(=O)F
InChI : InChI=1S\/C7H7FO2S\/c8-11(9,10)6-7-4-2-1-3-5-7\/h1-5H,6H2
InChIKey : YBYRMVIVWMBXKQ-UHFFFAOYSA-N
Other name(s) : Phenylmethanesulfonyl fluoride || Benzenemethanesulfonyl fluoride || alpha-Toluenesulfonyl fluoride
MW : 174.2
Formula : C7H7FO2S
CAS_number : 329-98-6
PubChem : 4784
UniChem : YBYRMVIVWMBXKQ-UHFFFAOYSA-N
Wikipedia : PMSF
Target
Families : PMSF ligand of proteins in family
BCHE
ACHE
LYsophospholipase_carboxylesterase
GTSAGmotif
Polyesterase-lipase-cutinase
Hormone-sensitive_lipase_like
RsbQ-like
CarbLipBact_2
Thioesterase
Dienelactone_hydrolase
Acetyl-esterase_deacetylase
Peptidase_S37
Peptidase_S15
Lactobacillus_peptidase
Cocaine_esterase
BioH
Bacterial_lip_FamI.5
Bacterial_lip_FamI.1
PolyAspartate-hydrolase
Cutinase
FAE-Bacterial-promiscuous
ABHD10
S9N_PREPL_Peptidase_S9
PE-PPE
Kynurenine-formamidase
DPP4N_Peptidase_S9
Pectinacetylesterase-Notum
Monoglyceridelipase_lysophospholip
CarbLipBact_1
Acetyl_esterase
Duf_1100-S
Structure :
1AUR
7V8X
7Q4H
8QD4
8QD5
8QD6
8QDB
6IGQ
5MII
6BJE
4ZRS
9JES
4XVC
4CG2
5YDJ
4KRY
4E15
4E14
3W05
3RLI
3H17
3H18
2CBG
1ZIY
1ZJ4
1ZJ5
1GGV
1M33
3M82
1WPR
Protein :
theet-q3ch51
emeni-q5avy9
human-ABHD10
human-PREPL
myctu-Rv1430
psefl-cxest
9bact-E40
thefu-q6a0i4
ecoli-Aes
orysj-Q10QA5
bac25-mglp
9bact-Q0GMU2
bacsu-FENB
psepu-clcd1
thema-TM0077
bacsu-RsbQ
ecoli-bioh
drome-CG9542
human-FAP
tubmm-TmEst2
human-NOTUM
cutac-e6dae5
9gamm-urc15994
9baci-EstD9
geost-est30
pholl-AntI
References (25)
| Title : Polyketide Trimming Shapes Dihydroxynaphthalene-Melanin and Anthraquinone Pigments - Schmalhofer_2024_Adv.Sci.(Weinh)__e2400184 |
| Author(s) : Schmalhofer M , Vagstad AL , Zhou Q , Bode HB , Groll M |
| Ref : Adv Sci (Weinh) , :e2400184 , 2024 |
| Abstract : |
| PubMedSearch : Schmalhofer_2024_Adv.Sci.(Weinh)__e2400184 |
| PubMedID: 38491909 |
| Title : Structural and biochemical insights into PsEst3, a new GHSR-type esterase obtained from Paenibacillus sp. R4 - Son_2023_IUCrJ_10_220 |
| Author(s) : Son J , Choi W , Kim H , Kim M , Lee JH , Shin SC , Kim HW |
| Ref : IUCrJ , 10 :220 , 2023 |
| Abstract : |
| PubMedSearch : Son_2023_IUCrJ_10_220 |
| PubMedID: 36862488 |
| Gene_locus related to this paper: 9mico-PsEst3 |
| Title : Discovery of a non-canonical prototype long-chain monoacylglycerol lipase through a structure-based endogenous reaction intermediate complex - Pinotsis_2023_Nat.Commun_14_7649 |
| Author(s) : Pinotsis N , Kruger A , Tomas N , Chatziefthymiou SD , Litz C , Mortensen SA , Daffe M , Marrakchi H , Antranikian G , Wilmanns M |
| Ref : Nat Commun , 14 :7649 , 2023 |
| Abstract : |
| PubMedSearch : Pinotsis_2023_Nat.Commun_14_7649 |
| PubMedID: 38012138 |
| Title : Functional and molecular characterization of a cold-active lipase from Psychrobacter celer PU3 with potential antibiofilm property - Esakkiraj_2022_Int.J.Biol.Macromol__ |
| Author(s) : Esakkiraj P , Bharathi C , Ayyanna R , Jha N , Panigrahi A , Karthe P , Arul V |
| Ref : Int J Biol Macromol , : , 2022 |
| Abstract : |
| PubMedSearch : Esakkiraj_2022_Int.J.Biol.Macromol__ |
| PubMedID: 35504418 |
| Gene_locus related to this paper: 9gamm-urc15994 |
| Title : The grease trap: Uncovering the mechanism of the hydrophobic lid in Cutibacterium acnes lipase - Kim_2020_J.Lipid.Res__ |
| Author(s) : Kim HJ , Lee BJ , Kwon AR |
| Ref : J Lipid Res , : , 2020 |
| Abstract : |
| PubMedSearch : Kim_2020_J.Lipid.Res__ |
| PubMedID: 32165394 |
| Gene_locus related to this paper: cutac-e6dae5 |
| Title : Prolyl Endopeptidase-Like Facilitates the alpha-Synuclein Aggregation Seeding, and This Effect Is Reverted by Serine Peptidase Inhibitor PMSF - Santos_2020_Biomolecules_10_ |
| Author(s) : Santos GS , Oyadomari WY , Carvalho EA , Torquato RS , Oliveira V |
| Ref : Biomolecules , 10 : , 2020 |
| Abstract : |
| PubMedSearch : Santos_2020_Biomolecules_10_ |
| PubMedID: 32630529 |
| Gene_locus related to this paper: human-PREPL |
| Title : Carboxypeptidase in prolyl oligopeptidase family: Unique enzyme activation and substrate-screening mechanisms - Yadav_2019_J.Biol.Chem_294_89 |
| Author(s) : Yadav P , Goyal VD , Gaur NK , Kumar A , Gokhale SM , Jamdar SN , Makde RD |
| Ref : Journal of Biological Chemistry , 294 :89 , 2019 |
| Abstract : |
| PubMedSearch : Yadav_2019_J.Biol.Chem_294_89 |
| PubMedID: 30409909 |
| Gene_locus related to this paper: deira-DR0165 |
| Title : Lysophospholipases cooperate to mediate lipid homeostasis and lysophospholipid signaling - Wepy_2019_J.Lipid.Res_60_360 |
| Author(s) : Wepy JA , Galligan JJ , Kingsley PJ , Xu S , Goodman MC , Tallman KA , Rouzer CA , Marnett LJ |
| Ref : J Lipid Res , 60 :360 , 2019 |
| Abstract : |
| PubMedSearch : Wepy_2019_J.Lipid.Res_60_360 |
| PubMedID: 30482805 |
| Gene_locus related to this paper: human-LYPLA2 |
| Title : Enhancing the Thermostability of Feruloyl Esterase EstF27 by Directed Evolution and the Underlying Structural Basis - Cao_2015_J.Agric.Food.Chem_63_8225 |
| Author(s) : Cao LC , Chen R , Xie W , Liu YH |
| Ref : Journal of Agricultural and Food Chemistry , 63 :8225 , 2015 |
| Abstract : |
| PubMedSearch : Cao_2015_J.Agric.Food.Chem_63_8225 |
| PubMedID: 26329893 |
| Gene_locus related to this paper: 9bact-e7djy5 |
| Title : Interdomain hydrophobic interactions modulate the thermostability of microbial esterases from the hormone-sensitive lipase family - Li_2015_J.Biol.Chem_290_11188 |
| Author(s) : Li PY , Chen XL , Ji P , Li CY , Wang P , Zhang Y , Xie BB , Qin QL , Su HN , Zhou BC , Zhang YZ , Zhang XY |
| Ref : Journal of Biological Chemistry , 290 :11188 , 2015 |
| Abstract : |
| PubMedSearch : Li_2015_J.Biol.Chem_290_11188 |
| PubMedID: 25771540 |
| Gene_locus related to this paper: 9bact-E40 |
| Title : The PE16 (Rv1430) of Mycobacterium tuberculosis Is an Esterase Belonging to Serine Hydrolase Superfamily of Proteins - Sultana_2013_PLoS.One_8_e55320 |
| Author(s) : Sultana R , Vemula MH , Banerjee S , Guruprasad L |
| Ref : PLoS ONE , 8 :e55320 , 2013 |
| Abstract : |
| PubMedSearch : Sultana_2013_PLoS.One_8_e55320 |
| PubMedID: 23383323 |
| Gene_locus related to this paper: myctu-Rv1430 |
| Title : Structures of D14 and D14L in the strigolactone and karrikin signaling pathways - Kagiyama_2013_Genes.Cells_18_147 |
| Author(s) : Kagiyama M , Hirano Y , Mori T , Kim SY , Kyozuka J , Seto Y , Yamaguchi S , Hakoshima T |
| Ref : Genes Cells , 18 :147 , 2013 |
| Abstract : |
| PubMedSearch : Kagiyama_2013_Genes.Cells_18_147 |
| PubMedID: 23301669 |
| Gene_locus related to this paper: arath-KAI2.D14L , orysj-Q10QA5 |
| Title : The structure of monoacylglycerol lipase from Bacillus sp. H257 reveals unexpected conservation of the cap architecture between bacterial and human enzymes - Rengachari_2012_Biochim.Biophys.Acta_1821_1012 |
| Author(s) : Rengachari S , Bezerra GA , Riegler-Berket L , Gruber CC , Sturm C , Taschler U , Boeszoermenyi A , Dreveny I , Zimmermann R , Gruber K , Oberer M |
| Ref : Biochimica & Biophysica Acta , 1821 :1012 , 2012 |
| Abstract : |
| PubMedSearch : Rengachari_2012_Biochim.Biophys.Acta_1821_1012 |
| PubMedID: 22561231 |
| Gene_locus related to this paper: bac25-mglp |
| Title : Biochemical identification and crystal structure of kynurenine formamidase from Drosophila melanogaster. - Han_2012_Biochem.J_446_253 |
| Author(s) : Han Q , Robinson H , Li J |
| Ref : Biochemical Journal , 446 :253 , 2012 |
| Abstract : |
| PubMedSearch : Han_2012_Biochem.J_446_253 |
| PubMedID: 22690733 |
| Gene_locus related to this paper: drome-CG9542 |
| Title : The crystal structure of an HSL-homolog EstE5 complex with PMSF reveals a unique configuration that inhibits the nucleophile Ser144 in catalytic triads - Nam_2009_Biochem.Biophys.Res.Commun_389_247 |
| Author(s) : Nam KH , Kim SJ , Priyadarshi A , Kim HS , Hwang KY |
| Ref : Biochemical & Biophysical Research Communications , 389 :247 , 2009 |
| Abstract : |
| PubMedSearch : Nam_2009_Biochem.Biophys.Res.Commun_389_247 |
| PubMedID: 19715665 |
| Gene_locus related to this paper: 9bact-Q0GMU2 |
| Title : The thioesterase domain of the fengycin biosynthesis cluster: a structural base for the macrocyclization of a non-ribosomal lipopeptide - Samel_2006_J.Mol.Biol_359_876 |
| Author(s) : Samel SA , Wagner B , Marahiel MA , Essen LO |
| Ref : Journal of Molecular Biology , 359 :876 , 2006 |
| Abstract : |
| PubMedSearch : Samel_2006_J.Mol.Biol_359_876 |
| PubMedID: 16697411 |
| Gene_locus related to this paper: bacsu-FENB |
| Title : Following directed evolution with crystallography: structural changes observed in changing the substrate specificity of dienelactone hydrolase - Kim_2005_Acta.Crystallogr.D.Biol.Crystallogr_61_920 |
| Author(s) : Kim HK , Liu JW , Carr PD , Ollis DL |
| Ref : Acta Crystallographica D Biol Crystallogr , 61 :920 , 2005 |
| Abstract : |
| PubMedSearch : Kim_2005_Acta.Crystallogr.D.Biol.Crystallogr_61_920 |
| PubMedID: 15983415 |
| Gene_locus related to this paper: psepu-clcd1 |
| Title : Crystal structures of RsbQ, a stress-response regulator in Bacillus subtilis - Kaneko_2005_Protein.Sci_14_558 |
| Author(s) : Kaneko T , Tanaka N , Kumasaka T |
| Ref : Protein Science , 14 :558 , 2005 |
| Abstract : |
| PubMedSearch : Kaneko_2005_Protein.Sci_14_558 |
| PubMedID: 15632289 |
| Gene_locus related to this paper: bacsu-RsbQ |
| Title : Molecular cloning and characterization of two thermostable carboxyl esterases from Geobacillus stearothermophilus - Ewis_2004_Gene_329_187 |
| Author(s) : Ewis HE , Abdelal AT , Lu CD |
| Ref : Gene , 329 :187 , 2004 |
| Abstract : |
| PubMedSearch : Ewis_2004_Gene_329_187 |
| PubMedID: 15033540 |
| Gene_locus related to this paper: geost-est30 , geost-est50 |
| Title : Integrating structure, bioinformatics, and enzymology to discover function: BioH, a new carboxylesterase from Escherichia coli - Sanishvili_2003_J.Biol.Chem_278_26039 |
| Author(s) : Sanishvili R , Yakunin AF , Laskowski RA , Skarina T , Evdokimova E , Doherty-Kirby A , Lajoie GA , Thornton JM , Arrowsmith CH , Savchenko A , Joachimiak A , Edwards AM |
| Ref : Journal of Biological Chemistry , 278 :26039 , 2003 |
| Abstract : |
| PubMedSearch : Sanishvili_2003_J.Biol.Chem_278_26039 |
| PubMedID: 12732651 |
| Gene_locus related to this paper: ecoli-bioh |
| Title : Inactivation studies of acetylcholinesterase with phenylmethylsulfonyl fluoride - Kraut_2000_Mol.Pharmacol_57_1243 |
| Author(s) : Kraut D , Goff H , Pai RK , Hosea NA , Silman I , Sussman JL , Taylor P , Voet JG |
| Ref : Molecular Pharmacology , 57 :1243 , 2000 |
| Abstract : |
| PubMedSearch : Kraut_2000_Mol.Pharmacol_57_1243 |
| PubMedID: 10825396 |
| Title : Phenylmethylsulfonyl fluoride inhibitory effects on acetylcholinesterase of brain and muscle - Skau_1999_Neuropharmacol_38_691 |
| Author(s) : Skau KA , Shipley MT |
| Ref : Neuropharmacology , 38 :691 , 1999 |
| Abstract : |
| PubMedSearch : Skau_1999_Neuropharmacol_38_691 |
| PubMedID: 10340306 |
| Title : Crystal structure of carboxylesterase from Pseudomonas fluorescens, an alpha\/beta hydrolase with broad substrate specificity - Kim_1997_Structure_5_1571 |
| Author(s) : Kim KK , Song HK , Shin DH , Hwang KY , Choe S , Yoo OJ , Suh SW |
| Ref : Structure , 5 :1571 , 1997 |
| Abstract : |
| PubMedSearch : Kim_1997_Structure_5_1571 |
| PubMedID: 9438866 |
| Gene_locus related to this paper: psefl-cxest |