PMSF

An enzyme inhibitor that inactivates cholinesterases, esterases, lipases, IRC-50 arvin, subtilisin, the fatty acid synthetase complex and many other serine hydrolases unrelated to alpha/beta hydrolases. Do not inhibit PlaB

General

Type : Sulfur Compound, Sulfonyl

Chemical_Nomenclature : Phenylmethylsulfonyl fluoride

Canonical SMILES : C1=CC=C(C=C1)CS(=O)(=O)F

InChI : InChI=1S\/C7H7FO2S\/c8-11(9,10)6-7-4-2-1-3-5-7\/h1-5H,6H2

InChIKey : YBYRMVIVWMBXKQ-UHFFFAOYSA-N

Other name(s) : Phenylmethanesulfonyl fluoride  ||  Benzenemethanesulfonyl fluoride  ||  alpha-Toluenesulfonyl fluoride


MW : 174.2

Formula : C7H7FO2S

CAS_number : 329-98-6

PubChem : 4784

UniChem : YBYRMVIVWMBXKQ-UHFFFAOYSA-N

Wikipedia : PMSF

References (25)

Title : Polyketide Trimming Shapes Dihydroxynaphthalene-Melanin and Anthraquinone Pigments - Schmalhofer_2024_Adv.Sci.(Weinh)__e2400184
Author(s) : Schmalhofer M , Vagstad AL , Zhou Q , Bode HB , Groll M
Ref : Adv Sci (Weinh) , :e2400184 , 2024
Abstract :
PubMedSearch : Schmalhofer_2024_Adv.Sci.(Weinh)__e2400184
PubMedID: 38491909

Title : Structural and biochemical insights into PsEst3, a new GHSR-type esterase obtained from Paenibacillus sp. R4 - Son_2023_IUCrJ_10_220
Author(s) : Son J , Choi W , Kim H , Kim M , Lee JH , Shin SC , Kim HW
Ref : IUCrJ , 10 :220 , 2023
Abstract :
PubMedSearch : Son_2023_IUCrJ_10_220
PubMedID: 36862488
Gene_locus related to this paper: 9mico-PsEst3

Title : Discovery of a non-canonical prototype long-chain monoacylglycerol lipase through a structure-based endogenous reaction intermediate complex - Pinotsis_2023_Nat.Commun_14_7649
Author(s) : Pinotsis N , Kruger A , Tomas N , Chatziefthymiou SD , Litz C , Mortensen SA , Daffe M , Marrakchi H , Antranikian G , Wilmanns M
Ref : Nat Commun , 14 :7649 , 2023
Abstract :
PubMedSearch : Pinotsis_2023_Nat.Commun_14_7649
PubMedID: 38012138

Title : Functional and molecular characterization of a cold-active lipase from Psychrobacter celer PU3 with potential antibiofilm property - Esakkiraj_2022_Int.J.Biol.Macromol__
Author(s) : Esakkiraj P , Bharathi C , Ayyanna R , Jha N , Panigrahi A , Karthe P , Arul V
Ref : Int J Biol Macromol , : , 2022
Abstract :
PubMedSearch : Esakkiraj_2022_Int.J.Biol.Macromol__
PubMedID: 35504418
Gene_locus related to this paper: 9gamm-urc15994

Title : The grease trap: Uncovering the mechanism of the hydrophobic lid in Cutibacterium acnes lipase - Kim_2020_J.Lipid.Res__
Author(s) : Kim HJ , Lee BJ , Kwon AR
Ref : J Lipid Res , : , 2020
Abstract :
PubMedSearch : Kim_2020_J.Lipid.Res__
PubMedID: 32165394
Gene_locus related to this paper: cutac-e6dae5

Title : Prolyl Endopeptidase-Like Facilitates the alpha-Synuclein Aggregation Seeding, and This Effect Is Reverted by Serine Peptidase Inhibitor PMSF - Santos_2020_Biomolecules_10_
Author(s) : Santos GS , Oyadomari WY , Carvalho EA , Torquato RS , Oliveira V
Ref : Biomolecules , 10 : , 2020
Abstract :
PubMedSearch : Santos_2020_Biomolecules_10_
PubMedID: 32630529
Gene_locus related to this paper: human-PREPL

Title : Lysophospholipases cooperate to mediate lipid homeostasis and lysophospholipid signaling - Wepy_2019_J.Lipid.Res_60_360
Author(s) : Wepy JA , Galligan JJ , Kingsley PJ , Xu S , Goodman MC , Tallman KA , Rouzer CA , Marnett LJ
Ref : J Lipid Res , 60 :360 , 2019
Abstract :
PubMedSearch : Wepy_2019_J.Lipid.Res_60_360
PubMedID: 30482805
Gene_locus related to this paper: human-LYPLA2

Title : Carboxypeptidase in prolyl oligopeptidase family: Unique enzyme activation and substrate-screening mechanisms - Yadav_2019_J.Biol.Chem_294_89
Author(s) : Yadav P , Goyal VD , Gaur NK , Kumar A , Gokhale SM , Jamdar SN , Makde RD
Ref : Journal of Biological Chemistry , 294 :89 , 2019
Abstract :
PubMedSearch : Yadav_2019_J.Biol.Chem_294_89
PubMedID: 30409909
Gene_locus related to this paper: deira-DR0165

Title : Enhancing the Thermostability of Feruloyl Esterase EstF27 by Directed Evolution and the Underlying Structural Basis - Cao_2015_J.Agric.Food.Chem_63_8225
Author(s) : Cao LC , Chen R , Xie W , Liu YH
Ref : Journal of Agricultural and Food Chemistry , 63 :8225 , 2015
Abstract :
PubMedSearch : Cao_2015_J.Agric.Food.Chem_63_8225
PubMedID: 26329893
Gene_locus related to this paper: 9bact-e7djy5

Title : Interdomain hydrophobic interactions modulate the thermostability of microbial esterases from the hormone-sensitive lipase family - Li_2015_J.Biol.Chem_290_11188
Author(s) : Li PY , Chen XL , Ji P , Li CY , Wang P , Zhang Y , Xie BB , Qin QL , Su HN , Zhou BC , Zhang YZ , Zhang XY
Ref : Journal of Biological Chemistry , 290 :11188 , 2015
Abstract :
PubMedSearch : Li_2015_J.Biol.Chem_290_11188
PubMedID: 25771540
Gene_locus related to this paper: 9bact-E40

Title : Structures of D14 and D14L in the strigolactone and karrikin signaling pathways - Kagiyama_2013_Genes.Cells_18_147
Author(s) : Kagiyama M , Hirano Y , Mori T , Kim SY , Kyozuka J , Seto Y , Yamaguchi S , Hakoshima T
Ref : Genes Cells , 18 :147 , 2013
Abstract :
PubMedSearch : Kagiyama_2013_Genes.Cells_18_147
PubMedID: 23301669
Gene_locus related to this paper: arath-KAI2.D14L , orysj-Q10QA5

Title : The PE16 (Rv1430) of Mycobacterium tuberculosis Is an Esterase Belonging to Serine Hydrolase Superfamily of Proteins - Sultana_2013_PLoS.One_8_e55320
Author(s) : Sultana R , Vemula MH , Banerjee S , Guruprasad L
Ref : PLoS ONE , 8 :e55320 , 2013
Abstract :
PubMedSearch : Sultana_2013_PLoS.One_8_e55320
PubMedID: 23383323
Gene_locus related to this paper: myctu-Rv1430

Title : Biochemical identification and crystal structure of kynurenine formamidase from Drosophila melanogaster. - Han_2012_Biochem.J_446_253
Author(s) : Han Q , Robinson H , Li J
Ref : Biochemical Journal , 446 :253 , 2012
Abstract :
PubMedSearch : Han_2012_Biochem.J_446_253
PubMedID: 22690733
Gene_locus related to this paper: drome-CG9542

Title : The structure of monoacylglycerol lipase from Bacillus sp. H257 reveals unexpected conservation of the cap architecture between bacterial and human enzymes - Rengachari_2012_Biochim.Biophys.Acta_1821_1012
Author(s) : Rengachari S , Bezerra GA , Riegler-Berket L , Gruber CC , Sturm C , Taschler U , Boeszoermenyi A , Dreveny I , Zimmermann R , Gruber K , Oberer M
Ref : Biochimica & Biophysica Acta , 1821 :1012 , 2012
Abstract :
PubMedSearch : Rengachari_2012_Biochim.Biophys.Acta_1821_1012
PubMedID: 22561231
Gene_locus related to this paper: bac25-mglp

Title : The crystal structure of an HSL-homolog EstE5 complex with PMSF reveals a unique configuration that inhibits the nucleophile Ser144 in catalytic triads - Nam_2009_Biochem.Biophys.Res.Commun_389_247
Author(s) : Nam KH , Kim SJ , Priyadarshi A , Kim HS , Hwang KY
Ref : Biochemical & Biophysical Research Communications , 389 :247 , 2009
Abstract :
PubMedSearch : Nam_2009_Biochem.Biophys.Res.Commun_389_247
PubMedID: 19715665
Gene_locus related to this paper: 9bact-Q0GMU2

Title : The thioesterase domain of the fengycin biosynthesis cluster: a structural base for the macrocyclization of a non-ribosomal lipopeptide - Samel_2006_J.Mol.Biol_359_876
Author(s) : Samel SA , Wagner B , Marahiel MA , Essen LO
Ref : Journal of Molecular Biology , 359 :876 , 2006
Abstract :
PubMedSearch : Samel_2006_J.Mol.Biol_359_876
PubMedID: 16697411
Gene_locus related to this paper: bacsu-FENB

Title : Crystal structures of RsbQ, a stress-response regulator in Bacillus subtilis - Kaneko_2005_Protein.Sci_14_558
Author(s) : Kaneko T , Tanaka N , Kumasaka T
Ref : Protein Science , 14 :558 , 2005
Abstract :
PubMedSearch : Kaneko_2005_Protein.Sci_14_558
PubMedID: 15632289
Gene_locus related to this paper: bacsu-RsbQ

Title : Following directed evolution with crystallography: structural changes observed in changing the substrate specificity of dienelactone hydrolase - Kim_2005_Acta.Crystallogr.D.Biol.Crystallogr_61_920
Author(s) : Kim HK , Liu JW , Carr PD , Ollis DL
Ref : Acta Crystallographica D Biol Crystallogr , 61 :920 , 2005
Abstract :
PubMedSearch : Kim_2005_Acta.Crystallogr.D.Biol.Crystallogr_61_920
PubMedID: 15983415
Gene_locus related to this paper: psepu-clcd1

Title : Molecular cloning and characterization of two thermostable carboxyl esterases from Geobacillus stearothermophilus - Ewis_2004_Gene_329_187
Author(s) : Ewis HE , Abdelal AT , Lu CD
Ref : Gene , 329 :187 , 2004
Abstract :
PubMedSearch : Ewis_2004_Gene_329_187
PubMedID: 15033540
Gene_locus related to this paper: geost-est30 , geost-est50

Title : Integrating structure, bioinformatics, and enzymology to discover function: BioH, a new carboxylesterase from Escherichia coli - Sanishvili_2003_J.Biol.Chem_278_26039
Author(s) : Sanishvili R , Yakunin AF , Laskowski RA , Skarina T , Evdokimova E , Doherty-Kirby A , Lajoie GA , Thornton JM , Arrowsmith CH , Savchenko A , Joachimiak A , Edwards AM
Ref : Journal of Biological Chemistry , 278 :26039 , 2003
Abstract :
PubMedSearch : Sanishvili_2003_J.Biol.Chem_278_26039
PubMedID: 12732651
Gene_locus related to this paper: ecoli-bioh

Title : Inactivation studies of acetylcholinesterase with phenylmethylsulfonyl fluoride - Kraut_2000_Mol.Pharmacol_57_1243
Author(s) : Kraut D , Goff H , Pai RK , Hosea NA , Silman I , Sussman JL , Taylor P , Voet JG
Ref : Molecular Pharmacology , 57 :1243 , 2000
Abstract :
PubMedSearch : Kraut_2000_Mol.Pharmacol_57_1243
PubMedID: 10825396

Title : Phenylmethylsulfonyl fluoride inhibitory effects on acetylcholinesterase of brain and muscle - Skau_1999_Neuropharmacol_38_691
Author(s) : Skau KA , Shipley MT
Ref : Neuropharmacology , 38 :691 , 1999
Abstract :
PubMedSearch : Skau_1999_Neuropharmacol_38_691
PubMedID: 10340306

Title : Crystal structure of carboxylesterase from Pseudomonas fluorescens, an alpha\/beta hydrolase with broad substrate specificity - Kim_1997_Structure_5_1571
Author(s) : Kim KK , Song HK , Shin DH , Hwang KY , Choe S , Yoo OJ , Suh SW
Ref : Structure , 5 :1571 , 1997
Abstract :
PubMedSearch : Kim_1997_Structure_5_1571
PubMedID: 9438866
Gene_locus related to this paper: psefl-cxest

Title : Inactivation of the protease inhibitor phenylmethylsulfonyl fluoride in buffers -
Author(s) : James GT
Ref : Analytical Biochemistry , 86 :574 , 1978
PubMedID: 26289

Title : The action of phenylmethylsulfonyl fluoride on human acetylcholinesterase, chymotyrpsin and trypsin -
Author(s) : Turini P , Kurooka S , Steer M , Corbascio AN , Singer TP
Ref : Journal of Pharmacology & Experimental Therapeutics , 167 :98 , 1969
PubMedID: 4306345