PMSF
An enzyme inhibitor that inactivates cholinesterases, esterases, lipases, IRC-50 arvin, subtilisin, the fatty acid synthetase complex and many other serine hydrolases unrelated to alpha/beta hydrolases. Do not inhibit PlaB
General
Type : Sulfur Compound, Sulfonyl
Chemical_Nomenclature : Phenylmethylsulfonyl fluoride
Canonical SMILES : C1=CC=C(C=C1)CS(=O)(=O)F
InChI : InChI=1S\/C7H7FO2S\/c8-11(9,10)6-7-4-2-1-3-5-7\/h1-5H,6H2
InChIKey : YBYRMVIVWMBXKQ-UHFFFAOYSA-N
Other name(s) : Phenylmethanesulfonyl fluoride, Benzenemethanesulfonyl fluoride, alpha-Toluenesulfonyl fluoride
MW : 174.2
Formula : C7H7FO2S
CAS_number : 329-98-6
PubChem : 4784
UniChem : YBYRMVIVWMBXKQ-UHFFFAOYSA-N
Wikipedia : PMSF
Target
Families : PMSF ligand of proteins in family
BCHE
ACHE
LYsophospholipase_carboxylesterase
GTSAGmotif
Polyesterase-lipase-cutinase
Hormone-sensitive_lipase_like
RsbQ-like
CarbLipBact_2
Thioesterase
Dienelactone_hydrolase
Acetyl-esterase_deacetylase
Peptidase_S37
Peptidase_S15
Lactobacillus_peptidase
Cocaine_esterase
BioH
Bacterial_lip_FamI.5
Bacterial_lip_FamI.1
PolyAspartate-hydrolase
Cutinase
FAE-Bacterial-promiscuous
ABHD10
S9N_PREPL_Peptidase_S9
PE-PPE
Kynurenine-formamidase
DPP4N_Peptidase_S9
Pectinacetylesterase-Notum
Monoglyceridelipase_lysophospholip
CarbLipBact_1
Acetyl_esterase
Duf_1100-S
Protein :
theet-q3ch51
emeni-q5avy9
human-ABHD10
human-PREPL
myctu-Rv1430
psefl-cxest
9bact-E40
thefu-q6a0i4
ecoli-Aes
orysj-Q10QA5
bac25-mglp
9bact-Q0GMU2
bacsu-FENB
psepu-clcd1
thema-TM0077
bacsu-RsbQ
ecoli-bioh
drome-CG9542
human-FAP
tubmm-TmEst2
human-NOTUM
cutac-e6dae5
9gamm-urc15994
9baci-EstD9
geost-est30
pholl-AntI
References (25)
| Title : Polyketide Trimming Shapes Dihydroxynaphthalene-Melanin and Anthraquinone Pigments - Schmalhofer_2024_Adv.Sci.(Weinh)__e2400184 |
| Author(s) : Schmalhofer M , Vagstad AL , Zhou Q , Bode HB , Groll M |
| Ref : Adv Sci (Weinh) , :e2400184 , 2024 |
| PubMedID: 38491909 |
| Title : Structural and biochemical insights into PsEst3, a new GHSR-type esterase obtained from Paenibacillus sp. R4 - Son_2023_IUCrJ_10_220 |
| Author(s) : Son J , Choi W , Kim H , Kim M , Lee JH , Shin SC , Kim HW |
| Ref : IUCrJ , 10 :220 , 2023 |
| PubMedID: 36862488 |
| Gene_locus related to this paper: 9mico-PsEst3 |
| Title : Discovery of a non-canonical prototype long-chain monoacylglycerol lipase through a structure-based endogenous reaction intermediate complex - Pinotsis_2023_Nat.Commun_14_7649 |
| Author(s) : Pinotsis N , Kruger A , Tomas N , Chatziefthymiou SD , Litz C , Mortensen SA , Daffe M , Marrakchi H , Antranikian G , Wilmanns M |
| Ref : Nat Commun , 14 :7649 , 2023 |
| PubMedID: 38012138 |
| Title : Functional and molecular characterization of a cold-active lipase from Psychrobacter celer PU3 with potential antibiofilm property - Esakkiraj_2022_Int.J.Biol.Macromol__ |
| Author(s) : Esakkiraj P , Bharathi C , Ayyanna R , Jha N , Panigrahi A , Karthe P , Arul V |
| Ref : Int J Biol Macromol , : , 2022 |
| PubMedID: 35504418 |
| Gene_locus related to this paper: 9gamm-urc15994 |
| Title : Prolyl Endopeptidase-Like Facilitates the alpha-Synuclein Aggregation Seeding, and This Effect Is Reverted by Serine Peptidase Inhibitor PMSF - Santos_2020_Biomolecules_10_ |
| Author(s) : Santos GS , Oyadomari WY , Carvalho EA , Torquato RS , Oliveira V |
| Ref : Biomolecules , 10 : , 2020 |
| PubMedID: 32630529 |
| Gene_locus related to this paper: human-PREPL |
| Title : The grease trap: Uncovering the mechanism of the hydrophobic lid in Cutibacterium acnes lipase - Kim_2020_J.Lipid.Res__ |
| Author(s) : Kim HJ , Lee BJ , Kwon AR |
| Ref : J Lipid Res , : , 2020 |
| PubMedID: 32165394 |
| Gene_locus related to this paper: cutac-e6dae5 |
| Title : Carboxypeptidase in prolyl oligopeptidase family: Unique enzyme activation and substrate-screening mechanisms - Yadav_2019_J.Biol.Chem_294_89 |
| Author(s) : Yadav P , Goyal VD , Gaur NK , Kumar A , Gokhale SM , Jamdar SN , Makde RD |
| Ref : Journal of Biological Chemistry , 294 :89 , 2019 |
| PubMedID: 30409909 |
| Gene_locus related to this paper: deira-DR0165 |
| Title : Lysophospholipases cooperate to mediate lipid homeostasis and lysophospholipid signaling - Wepy_2019_J.Lipid.Res_60_360 |
| Author(s) : Wepy JA , Galligan JJ , Kingsley PJ , Xu S , Goodman MC , Tallman KA , Rouzer CA , Marnett LJ |
| Ref : J Lipid Res , 60 :360 , 2019 |
| PubMedID: 30482805 |
| Gene_locus related to this paper: human-LYPLA2 |
| Title : Enhancing the Thermostability of Feruloyl Esterase EstF27 by Directed Evolution and the Underlying Structural Basis - Cao_2015_J.Agric.Food.Chem_63_8225 |
| Author(s) : Cao LC , Chen R , Xie W , Liu YH |
| Ref : Journal of Agricultural and Food Chemistry , 63 :8225 , 2015 |
| PubMedID: 26329893 |
| Gene_locus related to this paper: 9bact-e7djy5 |
| Title : Interdomain hydrophobic interactions modulate the thermostability of microbial esterases from the hormone-sensitive lipase family - Li_2015_J.Biol.Chem_290_11188 |
| Author(s) : Li PY , Chen XL , Ji P , Li CY , Wang P , Zhang Y , Xie BB , Qin QL , Su HN , Zhou BC , Zhang YZ , Zhang XY |
| Ref : Journal of Biological Chemistry , 290 :11188 , 2015 |
| PubMedID: 25771540 |
| Gene_locus related to this paper: 9bact-E40 |
| Title : Structures of D14 and D14L in the strigolactone and karrikin signaling pathways - Kagiyama_2013_Genes.Cells_18_147 |
| Author(s) : Kagiyama M , Hirano Y , Mori T , Kim SY , Kyozuka J , Seto Y , Yamaguchi S , Hakoshima T |
| Ref : Genes Cells , 18 :147 , 2013 |
| PubMedID: 23301669 |
| Gene_locus related to this paper: arath-KAI2.D14L , orysj-Q10QA5 |
| Title : The PE16 (Rv1430) of Mycobacterium tuberculosis Is an Esterase Belonging to Serine Hydrolase Superfamily of Proteins - Sultana_2013_PLoS.One_8_e55320 |
| Author(s) : Sultana R , Vemula MH , Banerjee S , Guruprasad L |
| Ref : PLoS ONE , 8 :e55320 , 2013 |
| PubMedID: 23383323 |
| Gene_locus related to this paper: myctu-Rv1430 |
| Title : The structure of monoacylglycerol lipase from Bacillus sp. H257 reveals unexpected conservation of the cap architecture between bacterial and human enzymes - Rengachari_2012_Biochim.Biophys.Acta_1821_1012 |
| Author(s) : Rengachari S , Bezerra GA , Riegler-Berket L , Gruber CC , Sturm C , Taschler U , Boeszoermenyi A , Dreveny I , Zimmermann R , Gruber K , Oberer M |
| Ref : Biochimica & Biophysica Acta , 1821 :1012 , 2012 |
| PubMedID: 22561231 |
| Gene_locus related to this paper: bac25-mglp |
| Title : Biochemical identification and crystal structure of kynurenine formamidase from Drosophila melanogaster. - Han_2012_Biochem.J_446_253 |
| Author(s) : Han Q , Robinson H , Li J |
| Ref : Biochemical Journal , 446 :253 , 2012 |
| PubMedID: 22690733 |
| Gene_locus related to this paper: drome-CG9542 |
| Title : The crystal structure of an HSL-homolog EstE5 complex with PMSF reveals a unique configuration that inhibits the nucleophile Ser144 in catalytic triads - Nam_2009_Biochem.Biophys.Res.Commun_389_247 |
| Author(s) : Nam KH , Kim SJ , Priyadarshi A , Kim HS , Hwang KY |
| Ref : Biochemical & Biophysical Research Communications , 389 :247 , 2009 |
| PubMedID: 19715665 |
| Gene_locus related to this paper: 9bact-Q0GMU2 |
| Title : The thioesterase domain of the fengycin biosynthesis cluster: a structural base for the macrocyclization of a non-ribosomal lipopeptide - Samel_2006_J.Mol.Biol_359_876 |
| Author(s) : Samel SA , Wagner B , Marahiel MA , Essen LO |
| Ref : Journal of Molecular Biology , 359 :876 , 2006 |
| PubMedID: 16697411 |
| Gene_locus related to this paper: bacsu-FENB |
| Title : Following directed evolution with crystallography: structural changes observed in changing the substrate specificity of dienelactone hydrolase - Kim_2005_Acta.Crystallogr.D.Biol.Crystallogr_61_920 |
| Author(s) : Kim HK , Liu JW , Carr PD , Ollis DL |
| Ref : Acta Crystallographica D Biol Crystallogr , 61 :920 , 2005 |
| PubMedID: 15983415 |
| Gene_locus related to this paper: psepu-clcd1 |
| Title : Crystal structures of RsbQ, a stress-response regulator in Bacillus subtilis - Kaneko_2005_Protein.Sci_14_558 |
| Author(s) : Kaneko T , Tanaka N , Kumasaka T |
| Ref : Protein Science , 14 :558 , 2005 |
| PubMedID: 15632289 |
| Gene_locus related to this paper: bacsu-RsbQ |
| Title : Molecular cloning and characterization of two thermostable carboxyl esterases from Geobacillus stearothermophilus - Ewis_2004_Gene_329_187 |
| Author(s) : Ewis HE , Abdelal AT , Lu CD |
| Ref : Gene , 329 :187 , 2004 |
| PubMedID: 15033540 |
| Gene_locus related to this paper: geost-est30 , geost-est50 |
| Title : Integrating structure, bioinformatics, and enzymology to discover function: BioH, a new carboxylesterase from Escherichia coli - Sanishvili_2003_J.Biol.Chem_278_26039 |
| Author(s) : Sanishvili R , Yakunin AF , Laskowski RA , Skarina T , Evdokimova E , Doherty-Kirby A , Lajoie GA , Thornton JM , Arrowsmith CH , Savchenko A , Joachimiak A , Edwards AM |
| Ref : Journal of Biological Chemistry , 278 :26039 , 2003 |
| PubMedID: 12732651 |
| Gene_locus related to this paper: ecoli-bioh |
| Title : Inactivation studies of acetylcholinesterase with phenylmethylsulfonyl fluoride - Kraut_2000_Mol.Pharmacol_57_1243 |
| Author(s) : Kraut D , Goff H , Pai RK , Hosea NA , Silman I , Sussman JL , Taylor P , Voet JG |
| Ref : Molecular Pharmacology , 57 :1243 , 2000 |
| PubMedID: 10825396 |
| Title : Phenylmethylsulfonyl fluoride inhibitory effects on acetylcholinesterase of brain and muscle - Skau_1999_Neuropharmacol_38_691 |
| Author(s) : Skau KA , Shipley MT |
| Ref : Neuropharmacology , 38 :691 , 1999 |
| PubMedID: 10340306 |
| Title : Crystal structure of carboxylesterase from Pseudomonas fluorescens, an alpha\/beta hydrolase with broad substrate specificity - Kim_1997_Structure_5_1571 |
| Author(s) : Kim KK , Song HK , Shin DH , Hwang KY , Choe S , Yoo OJ , Suh SW |
| Ref : Structure , 5 :1571 , 1997 |
| PubMedID: 9438866 |
| Gene_locus related to this paper: psefl-cxest |