Other strains: Neurospora tetrasperma (strains FGSC 2508 / ATCC MYA-4615 / P0657; FGSC 2509 / P0656) Quite close to cholinesteraes and neuroligins and farther related to Fungal_carboxylesterase_lipase, Long N-terminal extension.( this is now contradicted with new fungal carboxylesterases) only c-term Pfam A 246 - 775
(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.) > cellular organisms: NE > Eukaryota: NE > Opisthokonta: NE > Fungi: NE > Dikarya: NE > Ascomycota: NE > saccharomyceta: NE > Pezizomycotina: NE > leotiomyceta: NE > sordariomyceta: NE > Sordariomycetes: NE > Sordariomycetidae: NE > Sordariales: NE > Sordariaceae: NE > Neurospora: NE > Neurospora crassa: NE
Warning: This entry is a compilation of different species or line or strain with more than 90% amino acide identity. You can retrieve all strain data
(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.) Neurospora crassa OR74A: N, E.
Neurospora tetrasperma FGSC 2508: N, E.
Neurospora tetrasperma FGSC 2509: N, E.
LegendThis sequence has been compared to family alignement (MSA) red => minority aminoacid blue => majority aminoacid color intensity => conservation rate title => sequence position(MSA position)aminoacid rate Catalytic site Catalytic site in the MSA TSASSSVSIPISQTADTKDTSYSPSTTLMTATMTMTSEKQPGATATSPAV TLRQGRYNGVHLSVDYRFPKAIEAFRGVPFAQTTGGENRFRPPKALPDSD RTFQAVKFGENCPIGGTVGNGFGENCLNANIYRPAGLVDDDGLKTGDSNK RPALLPVVVYIHGGAFNGGMGSERNMASFVSWADAPMIGISFNYRVGALG FLPSALTAKEGLLNLGLRDQTMLLEWVRENVKAFGGDPDNVTIMGLSAGA HSIGHHIMYYARKESPAPFHRAILESGATTARAVLLPNHPRHLVQFREFL AAAGVDGLPDDQIFDHLRKLPLETIVRASKKVWDRYEPSVTWPFQPVIDG LHDQQQAISNNNSEVTPVLIPDLPITSWRQGKHLRIPVLTGFNTNEGAMF IPRQANTNDDFRSFFKTLIPTLTDADLAALEHLYPDPVTNPHSSNNPYRS VPVGMGAQWARLDAAYSHYAYICPVLQTAHFMSQAGLPVHVYRFAARGNW DVANHADEAPVVAHDMGFFRSFGPPRRSKGLRKVADGMNAAWGRFISGEK IIEVETDGKKGSGKRVVWPLFRTPFGDGDSELGRGGAGHKTADRNTERRW SSSPLWEQSSSGDDDVKPPEGTGRMIVFGEGNNERAGGSSPGTPAKEEVF NEILLKACRFWWDRIELSEGLGIRREEMGRSGKGTKARL
A large region of suppressed recombination surrounds the sex-determining locus of the self-fertile fungus Neurospora tetrasperma. This region encompasses nearly one-fifth of the N. tetrasperma genome and suppression of recombination is necessary for self-fertility. The similarity of the N. tetrasperma mating chromosome to plant and animal sex chromosomes and its recent origin (<5 MYA), combined with a long history of genetic and cytological research, make this fungus an ideal model for studying the evolutionary consequences of suppressed recombination. Here we compare genome sequences from two N. tetrasperma strains of opposite mating type to determine whether structural rearrangements are associated with the nonrecombining region and to examine the effect of suppressed recombination for the evolution of the genes within it. We find a series of three inversions encompassing the majority of the region of suppressed recombination and provide evidence for two different types of rearrangement mechanisms: the recently proposed mechanism of inversion via staggered single-strand breaks as well as ectopic recombination between transposable elements. In addition, we show that the N. tetrasperma mat a mating-type region appears to be accumulating deleterious substitutions at a faster rate than the other mating type (mat A) and thus may be in the early stages of degeneration.
Neurospora crassa is a central organism in the history of twentieth-century genetics, biochemistry and molecular biology. Here, we report a high-quality draft sequence of the N. crassa genome. The approximately 40-megabase genome encodes about 10,000 protein-coding genes--more than twice as many as in the fission yeast Schizosaccharomyces pombe and only about 25% fewer than in the fruitfly Drosophila melanogaster. Analysis of the gene set yields insights into unexpected aspects of Neurospora biology including the identification of genes potentially associated with red light photobiology, genes implicated in secondary metabolism, and important differences in Ca2+ signalling as compared with plants and animals. Neurospora possesses the widest array of genome defence mechanisms known for any eukaryotic organism, including a process unique to fungi called repeat-induced point mutation (RIP). Genome analysis suggests that RIP has had a profound impact on genome evolution, greatly slowing the creation of new genes through genomic duplication and resulting in a genome with an unusually low proportion of closely related genes.
