A1IKC
IC50 microM hAChE 33.1 +/-5.8; hBChE 0.53 +/- 0.06; p38alphaMAPK 0.046 +/- 0.011
General
Type : Naphthalen, Pyridine, Pyridazine, p38-MAPK-inhibitor, Multitarget
Chemical_Nomenclature : N1,N1-dimethyl-N2-(6-(naphthalen-2-yl)-5-(pyridin-4-yl)pyridazin-3-yl)ethane-1,2-diamine
Canonical SMILES : CN(C)CCNC3=NN=C(C2=CC1=CC=CC=C1C=C2)C(=C3)C4=CC=NC=C4
InChI : InChI=1S\/C23H23N5\/c1-28(2)14-13-25-22-16-21(18-9-11-24-12-10-18)23(27-26-22)20-8-7-17-5-3-4-6-19(17)15-20\/h3-12,15-16H,13-14H2,1-2H3,(H,25,26)
InChIKey : XDYGRRRDJKDODS-UHFFFAOYSA-N
Other name(s) : Compound 8
MW : 369.468
Formula : C23H23N5
CAS_number :
PubChem : 176490067
UniChem : XDYGRRRDJKDODS-UHFFFAOYSA-N
Target
References (1)
| Title : Dual Inhibitors of p38alpha Mitogen-Activated Protein Kinase and Butyrylcholinesterase for the Modulation of Neuroinflammation and Cognitive Dysfunction - Knez_2026_J.Med.Chem_69_19891 |
| Author(s) : Knez D , Malinak D , Meden A , Ferjancic Benetik S , Pislar A , Kohoutova Z , Vondrackova I , Psotka M , Lycka A , Pulkrabkova L , Soukup O , Skarka A , Andrys R , Brazzolotto X , Igert A , Dias J , Nachon F , Detka J , Targosinski F , Hliabovich D , Brunzelle JS , Shuvalova L , Salat K , Roy SM , Watterson DM , Musilek K , Gobec S |
| Ref : Journal of Medicinal Chemistry , 69 :19891 , 2026 |
| Abstract : |
| PubMedSearch : Knez_2026_J.Med.Chem_69_19891 |
| PubMedID: 42679157 |
| Gene_locus related to this paper: human-BCHE |