T-401
Inhibition of mouse MAGL using 2-AG as substrate incubated for 30 mins IC50 0.013 microM' || can be fluorinated with 18F to form a PET radio ligand
General
Type : Pyrrolidine, Piperazine, PET probe, Pyridine, Thiazole, Sulfur Compound
Chemical_Nomenclature : (4R)-1-{3-[2-Fluoro-4-methylpyridin-3-yl]phenyl}-4-[4-(1,3-thiazol-2-ylcarbonyl)piperazin-1-yl]pyrrolidin-2-one || 1-[3-(2-fluoro-4-methylpyridin-3-yl)phenyl]-4-[4-(1,3-thiazole-2-carbonyl)piperazin-1-yl]pyrrolidin-2-one
Canonical SMILES : CC1=C(C(=NC=C1)F)C2=CC(=CC=C2)N3C[C@@H](CC3=O)N4CCN(CC4)C(=O)C5=NC=CS5 || CC1=C(C(=NC=C1)F)C2=CC(=CC=C2)N3CC(CC3=O)N4CCN(CC4)C(=O)C5=NC=CS5
InChI : InChI=1S\/C24H24FN5O2S\/c1-16-5-6-26-22(25)21(16)17-3-2-4-18(13-17)30-15-19(14-20(30)31)28-8-10-29(11-9-28)24(32)23-27-7-12-33-23\/h2-7,12-13,19H,8-11,14-15H2,1H3\/t19-\/m1\/s1 || InChI=1S\/C24H24FN5O2S\/c1-16-5-6-26-22(25)21(16)17-3-2-4-18(13-17)30-15-19(14-20(30)31)28-8-10-29(11-9-28)24(32)23-27-7-12-33-23\/h2-7,12-13,19H,8-11,14-15H2,1H3
InChIKey : BSDIMVPELJZNRU-LJQANCHMSA-N || BSDIMVPELJZNRU-UHFFFAOYSA-N
Other name(s) : Eba93ntr7P || CHEMBL5090045 || BDBM50584758 || T401 || SCHEMBL20695508
MW : 465.5
Formula : C24H24FN5O2S
CAS_number :
PubChem : 165412132, 137456219
UniChem : BSDIMVPELJZNRU-LJQANCHMSA-N, BSDIMVPELJZNRU-UHFFFAOYSA-N
Target
Families : T-401 ligand of proteins in family
Monoglyceridelipase_lysophospholip
Protein :
human-MGLL
mouse-MGLL
References (12)
| Title : Binding of the monoacylglycerol lipase (MAGL) radiotracer [(3)H]T-401 in the rat brain after status epilepticus - Mikkelsen_2024_Neurochem.Int__105717 |
| Author(s) : Mikkelsen JD , Aripaka SS , Egilmez CB , Pazarlar BA |
| Ref : Neurochem Int , :105717 , 2024 |
| Abstract : |
| PubMedSearch : Mikkelsen_2024_Neurochem.Int__105717 |
| PubMedID: 38447759 |
| Gene_locus related to this paper: human-MGLL |
| Title : Binding of the monoacylglycerol lipase (MAGL) radiotracer [(3)H]T-401 in the rat brain after status epilepticus - Mikkelsen_2024_Neurochem.Int__105717 |
| Author(s) : Mikkelsen JD , Aripaka SS , Egilmez CB , Pazarlar BA |
| Ref : Neurochem Int , :105717 , 2024 |
| Abstract : |
| PubMedSearch : Mikkelsen_2024_Neurochem.Int__105717 |
| PubMedID: 38447759 |
| Gene_locus related to this paper: human-MGLL |
| Title : Binding of the monoacylglycerol lipase (MAGL) radiotracer [(3)H]T-401 in the rat brain after status epilepticus - Mikkelsen_2024_Neurochem.Int__105717 |
| Author(s) : Mikkelsen JD , Aripaka SS , Egilmez CB , Pazarlar BA |
| Ref : Neurochem Int , :105717 , 2024 |
| Abstract : |
| PubMedSearch : Mikkelsen_2024_Neurochem.Int__105717 |
| PubMedID: 38447759 |
| Gene_locus related to this paper: human-MGLL |
| Title : First-in-human in vivo undefined imaging and quantification of monoacylglycerol lipase in the brain: a PET study with (18)F-T-401 - Takahata_2022_Eur.J.Nucl.Med.Mol.Imaging__ |
| Author(s) : Takahata K , Seki C , Kimura Y , Kubota M , Ichise M , Sano Y , Yamamoto Y , Tagai K , Shimada H , Kitamura S , Matsuoka K , Endo H , Shinotoh H , Kawamura K , Zhang MR , Takado Y , Higuchi M |
| Ref : Eur J Nucl Med Mol Imaging , : , 2022 |
| Abstract : |
| PubMedSearch : Takahata_2022_Eur.J.Nucl.Med.Mol.Imaging__ |
| PubMedID: 35022846 |
| Gene_locus related to this paper: human-MGLL |
| Title : Development of High Brain-Penetrant and Reversible Monoacylglycerol Lipase PET Tracers for Neuroimaging - He_2022_J.Med.Chem_65_2191 |
| Author(s) : He Y , Schild M , Grether U , Benz J , Leibrock L , Heer D , Topp A , Collin L , Kuhn B , Wittwer M , Keller C , Gobbi LC , Schibli R , Mu L |
| Ref : Journal of Medicinal Chemistry , 65 :2191 , 2022 |
| Abstract : |
| PubMedSearch : He_2022_J.Med.Chem_65_2191 |
| PubMedID: 35089028 |
| Gene_locus related to this paper: human-MGLL , mouse-MGLL |
| Title : Development of High Brain-Penetrant and Reversible Monoacylglycerol Lipase PET Tracers for Neuroimaging - He_2022_J.Med.Chem_65_2191 |
| Author(s) : He Y , Schild M , Grether U , Benz J , Leibrock L , Heer D , Topp A , Collin L , Kuhn B , Wittwer M , Keller C , Gobbi LC , Schibli R , Mu L |
| Ref : Journal of Medicinal Chemistry , 65 :2191 , 2022 |
| Abstract : |
| PubMedSearch : He_2022_J.Med.Chem_65_2191 |
| PubMedID: 35089028 |
| Gene_locus related to this paper: human-MGLL , mouse-MGLL |
| Title : First-in-human in vivo undefined imaging and quantification of monoacylglycerol lipase in the brain: a PET study with (18)F-T-401 - Takahata_2022_Eur.J.Nucl.Med.Mol.Imaging__ |
| Author(s) : Takahata K , Seki C , Kimura Y , Kubota M , Ichise M , Sano Y , Yamamoto Y , Tagai K , Shimada H , Kitamura S , Matsuoka K , Endo H , Shinotoh H , Kawamura K , Zhang MR , Takado Y , Higuchi M |
| Ref : Eur J Nucl Med Mol Imaging , : , 2022 |
| Abstract : |
| PubMedSearch : Takahata_2022_Eur.J.Nucl.Med.Mol.Imaging__ |
| PubMedID: 35022846 |
| Gene_locus related to this paper: human-MGLL |
| Title : Development of High Brain-Penetrant and Reversible Monoacylglycerol Lipase PET Tracers for Neuroimaging - He_2022_J.Med.Chem_65_2191 |
| Author(s) : He Y , Schild M , Grether U , Benz J , Leibrock L , Heer D , Topp A , Collin L , Kuhn B , Wittwer M , Keller C , Gobbi LC , Schibli R , Mu L |
| Ref : Journal of Medicinal Chemistry , 65 :2191 , 2022 |
| Abstract : |
| PubMedSearch : He_2022_J.Med.Chem_65_2191 |
| PubMedID: 35089028 |
| Gene_locus related to this paper: human-MGLL , mouse-MGLL |
| Title : First-in-human in vivo undefined imaging and quantification of monoacylglycerol lipase in the brain: a PET study with (18)F-T-401 - Takahata_2022_Eur.J.Nucl.Med.Mol.Imaging__ |
| Author(s) : Takahata K , Seki C , Kimura Y , Kubota M , Ichise M , Sano Y , Yamamoto Y , Tagai K , Shimada H , Kitamura S , Matsuoka K , Endo H , Shinotoh H , Kawamura K , Zhang MR , Takado Y , Higuchi M |
| Ref : Eur J Nucl Med Mol Imaging , : , 2022 |
| Abstract : |
| PubMedSearch : Takahata_2022_Eur.J.Nucl.Med.Mol.Imaging__ |
| PubMedID: 35022846 |
| Gene_locus related to this paper: human-MGLL |
| Title : Design, Synthesis, and Evaluation of (4 R)-1-{3-[2-((18)F)Fluoro-4-methylpyridin-3-yl]phenyl}-4-[4-(1,3-thiazol-2-ylcarbo nyl)piperazin-1-yl]pyrrolidin-2-one ([(18)F]T-401) as a Novel Positron-Emission Tomography Imaging Agent for Monoacylglycerol Lipase - Hattori_2019_J.Med.Chem_62_2362 |
| Author(s) : Hattori Y , Aoyama K , Maeda J , Arimura N , Takahashi Y , Sasaki M , Fujinaga M , Seki C , Nagai Y , Kawamura K , Yamasaki T , Zhang MR , Higuchi M , Koike T |
| Ref : Journal of Medicinal Chemistry , 62 :2362 , 2019 |
| Abstract : |
| PubMedSearch : Hattori_2019_J.Med.Chem_62_2362 |
| PubMedID: 30753069 |
| Gene_locus related to this paper: human-MGLL |
| Title : Design, Synthesis, and Evaluation of (4 R)-1-{3-[2-((18)F)Fluoro-4-methylpyridin-3-yl]phenyl}-4-[4-(1,3-thiazol-2-ylcarbo nyl)piperazin-1-yl]pyrrolidin-2-one ([(18)F]T-401) as a Novel Positron-Emission Tomography Imaging Agent for Monoacylglycerol Lipase - Hattori_2019_J.Med.Chem_62_2362 |
| Author(s) : Hattori Y , Aoyama K , Maeda J , Arimura N , Takahashi Y , Sasaki M , Fujinaga M , Seki C , Nagai Y , Kawamura K , Yamasaki T , Zhang MR , Higuchi M , Koike T |
| Ref : Journal of Medicinal Chemistry , 62 :2362 , 2019 |
| Abstract : |
| PubMedSearch : Hattori_2019_J.Med.Chem_62_2362 |
| PubMedID: 30753069 |
| Gene_locus related to this paper: human-MGLL |
| Title : Design, Synthesis, and Evaluation of (4 R)-1-{3-[2-((18)F)Fluoro-4-methylpyridin-3-yl]phenyl}-4-[4-(1,3-thiazol-2-ylcarbo nyl)piperazin-1-yl]pyrrolidin-2-one ([(18)F]T-401) as a Novel Positron-Emission Tomography Imaging Agent for Monoacylglycerol Lipase - Hattori_2019_J.Med.Chem_62_2362 |
| Author(s) : Hattori Y , Aoyama K , Maeda J , Arimura N , Takahashi Y , Sasaki M , Fujinaga M , Seki C , Nagai Y , Kawamura K , Yamasaki T , Zhang MR , Higuchi M , Koike T |
| Ref : Journal of Medicinal Chemistry , 62 :2362 , 2019 |
| Abstract : |
| PubMedSearch : Hattori_2019_J.Med.Chem_62_2362 |
| PubMedID: 30753069 |
| Gene_locus related to this paper: human-MGLL |