Tacrine-pentylmethylene-tolylsulfonamide

IC50 microM AChE 0.131 +/- 0.01 BChE 0.0680 +/- 0.0014

General

Type : Alkyl linked bis-ligand, Derivative of Tacrine, Sulfur Compound, Sulfonamide, Benzenesulfonamide

Chemical_Nomenclature : 4-Methyl-N-(5-(1,2,3,4-tetrahydro-acridin-9-ylamino)-pentyl)-benzenesulfonamide

Canonical SMILES : N(CCCCCN[S](=O)(=O)C1=CC=C(C=C1)C)C2=C4C(=NC3=CC=CC=C23)CCCC4

InChI : InChI=1S\/C25H31N3O2S\/c1-19-13-15-20(16-14-19)31(29,30)27-18-8-2-7-17-26-25-21-9-3-5-11-23(21)28-24-12-6-4-10-22(24)25\/h3,5,9,11,13-16,27H,2,4,6-8,10,12,17-18H2,1H3,(H,26,28)

InChIKey : AZQJBDNDDDGKPV-UHFFFAOYSA-N

Other name(s) : Compound 7h


MW : 437.59

Formula : C25H31N3O2S

CAS_number :

PubChem :

UniChem : AZQJBDNDDDGKPV-UHFFFAOYSA-N

Target

Families : Tacrine-pentylmethylene-tolylsulfonamide ligand of proteins in family
ACHE BCHE

Protein :
human-ACHE human-BCHE

References (1)

Title : New Hybrids of 4-Amino-2,3-polymethylene-quinoline and p-Tolylsulfonamide as Dual Inhibitors of Acetyl- and Butyrylcholinesterase and Potential Multifunctional Agents for Alzheimer's Disease Treatment - Makhaeva_2020_Molecules_25_3915
Author(s) : Makhaeva GF , Kovaleva NV , Boltneva NP , Lushchekina SV , Astakhova TY , Rudakova EV , Proshin AN , Serkov IV , Radchenko EV , Palyulin VA , Bachurin SO , Richardson RJ
Ref : Molecules , 25 :3915 , 2020
Abstract :
PubMedSearch : Makhaeva_2020_Molecules_25_3915
PubMedID: 32867324