Tacrine-pyridinealdoxime-2
General
Type : Oxime, Pyridine-aldoxime, Uncharged Oxime, Derivative of Tacrine, Acridine
Chemical_Nomenclature : 6-[4-[(7-chloro-1,2,3,4-tetrahydroacridin-9-yl)amino]butyl]-2-[(hydroxyamino)methylidene]pyridin-3-one
Canonical SMILES : C1CCC2=NC3=C(C=C(C=C3)Cl)C(=C2C1)NCCCCC4=NC(=CNO)C(=O)C=C4
InChI : InChI=1S\/C23H25ClN4O2\/c24-15-8-10-20-18(13-15)23(17-6-1-2-7-19(17)28-20)25-12-4-3-5-16-9-11-22(29)21(27-16)14-26-30\/h8-11,13-14,26,30H,1-7,12H2,(H,25,28)
InChIKey : AEGVBHAVNJPGMI-UHFFFAOYSA-N, ZLZVGRFUOYNPFA-UHFFFAOYSA-N, ZLZVGRFUOYNPFA-KGENOOAVSA-N
Other name(s) : 6-(4-((7-Chloro-1,2,3,4-tetrahydroacridin-9-yl)amino)butyl)-3-hydroxypicolinaldehyde oxime || SCHEMBL16739350 || SCHEMBL18065467 || SCHEMBL18086633
MW : 424.92
Formula : C23H25ClN4O2
CAS_number :
PubChem : 131749942
UniChem : AEGVBHAVNJPGMI-UHFFFAOYSA-N, ZLZVGRFUOYNPFA-UHFFFAOYSA-N, ZLZVGRFUOYNPFA-KGENOOAVSA-N
References (2)
| Title : Structure-Based Optimization of Nonquaternary Reactivators of Acetylcholinesterase Inhibited by Organophosphorus Nerve Agents - Santoni_2018_J.Med.Chem_61_7630 |
| Author(s) : Santoni G , de Sousa J , De la Mora E , Dias J , Jean L , Sussman JL , Silman I , Renard PY , Brown RCD , Weik M , Baati R , Nachon F |
| Ref : Journal of Medicinal Chemistry , 61 :7630 , 2018 |
| Abstract : |
| PubMedSearch : Santoni_2018_J.Med.Chem_61_7630 |
| PubMedID: 30125110 |
| Gene_locus related to this paper: torca-ACHE |
| Title : Design, synthesis and biological evaluation of novel tetrahydroacridine pyridine- aldoxime and -amidoxime hybrids as efficient uncharged reactivators of nerve agent-inhibited human acetylcholinesterase - Kliachyna_2014_Eur.J.Med.Chem_78C_455 |
| Author(s) : Kliachyna M , Santoni G , Nussbaum V , Renou J , Sanson B , Colletier JP , Arboleas M , Loiodice M , Weik M , Jean L , Renard PY , Nachon F , Baati R |
| Ref : Eur Journal of Medicinal Chemistry , 78C :455 , 2014 |
| Abstract : |
| PubMedSearch : Kliachyna_2014_Eur.J.Med.Chem_78C_455 |
| PubMedID: 24704618 |