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Substrate Report for: PGE2-glyceryl-ester

prostaglandin E2 -glycerol [PGE2 -G]) and the 15-lipoxygenase (15-hydroxy-eicosatetraenoyl-glycerol [15-HETE-G) are the metabolites of 2-AG derived respectively from cyclooxygenase-2 and 15-lipoxygenase activities



General
Type: Acyl-Glycerol, Cannabinoid-Receptor-ligand, Natural
Chemical_Nomenclature: 2,3-dihydroxypropyl (Z)-7-[(1R,2R,3R)-3-hydroxy-2-[(E,3S)-3-hydroxyoct-1-enyl]-5-oxocyclopentyl]hept-5-enoate
Canonical SMILES: CCCCCC(C=CC1C(CC(=O)C1CC=CCCCC(=O)OCC(CO)O)O)O
InChI: InChI=1S/C23H38O7/c1-2-3-6-9-17(25)12-13-20-19(21(27)14-22(20)28)10-7-4-5-8-11-23(29)30-16-18(26)15-24/h4,7,12-13,17-20,22,24-26,28H,2-3,5-6,8-11,14-16H2,1H3/b7-4-,13-12+/t17-,18?,19+,20+,22+/m0/s1
InChIKey: RJXVYMMSQBYEHN-LVXZDWGESA-N
Other name(s): PGE2-G ; Prostaglandin E2-1-glyceryl ester ; Prostaglandin PGE(,2) 1-glycerol ; CHEBI:90230 ; 1(3)-glyceryl-PGE2
MW: 426.5
Formula: C23H38O7
CAS_number: 37497-47-5
PubChem: 24778489
IUPHAR:
Wikipedia:

Target families
PGE2-glyceryl-ester ligand of proteins in family: Monoglyceridelipase_lysophospholip, ABHD6-Lip, ABHD12-PHARC, Carb_B_Chordata
No structure

Protein target

References
Search PubMed for references concerning: PGE2-glyceryl-ester

2 more
    Title: Human leukocytes differentially express endocannabinoid-glycerol lipases and hydrolyze 2-arachidonoyl-glycerol and its metabolites from the 15-lipoxygenase and cyclooxygenase pathways
    Turcotte C, Dumais E, Archambault AS, Martin C, Blanchet MR, Bissonnette E, Boulet LP, Laviolette M, Di Marzo V, Flamand N
    Ref: J Leukoc Biol, 106:1337, 2019 : PubMed

            

    Title: Robust Hydrolysis of Prostaglandin Glycerol Esters by Human Monoacylglycerol Lipase (MAGL)
    Savinainen JR, Kansanen E, Pantsar T, Navia-Paldanius D, Parkkari T, Lehtonen M, Laitinen T, Nevalainen T, Poso A and Laitinen JT <1 more author(s)>
    Ref: Molecular Pharmacology, 86:522, 2014 : PubMed

            

    Title: Inactivation of lipid glyceryl ester metabolism in human THP1 monocytes/macrophages by activated organophosphorus insecticides: role of carboxylesterases 1 and 2
    Xie S, Borazjani A, Hatfield MJ, Edwards CC, Potter PM, Ross MK
    Ref: Chemical Research in Toxicology, 23:1890, 2010 : PubMed