ecoli-IROE

Escherichia coli, Enterobactin and Salmochelin Hydrolase IroE, Salmochelin siderophore protein

Comment

The proliferation of many pathogenic bacteria is limited by the scarcity of soluble iron in their environment. Many of these bacteria scavenge iron by synthesizing and exporting small molecule siderophores that chelate iron. Iron-bound siderophores are subsequently imported for metabolic processing. Three related serine hydrolases have been characterized biochemically in this pathway: Fes, IroD, and IroE. There are more than 200 strains. Other Uniprot entries and list of strains can be found with the link: Other strains

Relationship

Family : A85-IroE-IroD-Fes-Yiel

Block : X

Position in NCBI Life Tree : Escherichia coli

(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.)

> cellular organisms N E > Bacteria N E > Proteobacteria N E > Gammaproteobacteria N E > Enterobacterales N E > Enterobacteriaceae N E > Escherichia N E > Escherichia coli N E

Molecular evidence

No mutation

No kinetic

No disease

No substrate

DFP

Sequence

Peptide

MYAREYRSTR PHKAIFFHLS CLTLICSAQV YAEPDMRPLG PNIADKGSVF YHFSTTSFDS VDGTRHYRVW TAVPNTTAPA SGYPILYMLD GNAVMDRLDD ELLKQLSEKT PPVIVAVGYQ TNLPFDLNSR AYDYTPAAES RKTDLHSGRF SRKSGGSNNF RQLLETRIAP KVEQGLNIDR QRRGLWGHSY GGLFVLDSWL SSSYFRSYYS ASPSLGRGYD ALLSRVTAVE PLQFCAKHLA IMEGSATQGD NRETHAVGVL SKIHTTLTIL KDKGVNVVFW DFPNLGHGPM FNASFRQALL DISGENANYT AGCHELSH

References (23)

Title : Draft Genome Sequences of Extended-Spectrum beta-Lactamase-Producing Escherichia coli Strains Isolated from Patients in Lebanon - Tokajian_2014_Genome.Announc_2_e00123
Author(s) : Tokajian S , Eisen JA , Jospin G , Farra A , Coil DA
Ref : Genome Announc , 2 : , 2014
PubMedID: 24558252
Gene_locus related to this paper: ecoli-IROD , ecoli-IROE , ecoli-yaim , ecoli-ybff , ecoli-ycfp , ecoli-yqia , ecoli-YfhR , ecolx-f4suw9 , ecolx-g0dan0

Title : Nucleotide sequences of 16 transmissible plasmids identified in nine multidrug-resistant Escherichia coli isolates expressing an ESBL phenotype isolated from food-producing animals and healthy humans - Wang_2014_J.Antimicrob.Chemother_69_2658
Author(s) : Wang J , Stephan R , Power K , Yan Q , Hachler H , Fanning S
Ref : J Antimicrob Chemother , 69 :2658 , 2014
PubMedID: 24920651
Gene_locus related to this paper: ecoli-IROD , ecoli-IROE

Title : Draft Genome Sequence of Uropathogenic Escherichia coli Strain J96 - Klein_2013_Genome.Announc_1_E00245
Author(s) : Klein EA , Gitai Z
Ref : Genome Announc , 1 : , 2013
PubMedID: 23469357
Gene_locus related to this paper: ecoli-IROD , ecoli-IROE , ecoli-yaim , ecoli-ybff , ecoli-ycfp , ecoli-yqia

Title : Complete sequence of pJIE186-2, a plasmid carrying multiple virulence factors from a sequence type 131 Escherichia coli O25 strain - Zong_2013_Antimicrob.Agents.Chemother_57_597
Author(s) : Zong Z
Ref : Antimicrobial Agents & Chemotherapy , 57 :597 , 2013
PubMedID: 23070168
Gene_locus related to this paper: ecoli-IROD , ecoli-IROE

Title : A conserved virulence plasmidic region contributes to the virulence of the multiresistant Escherichia coli meningitis strain S286 belonging to phylogenetic group C - Lemaitre_2013_PLoS.One_8_e74423
Author(s) : Lemaitre C , Mahjoub-Messai F , Dupont D , Caro V , Diancourt L , Bingen E , Bidet P , Bonacorsi S
Ref : PLoS ONE , 8 :e74423 , 2013
PubMedID: 24086343
Gene_locus related to this paper: ecoli-IROE

Title : Genome Sequences of Avian Pathogenic Escherichia coli Strains Isolated from Brazilian Commercial Poultry - Rojas_2013_Genome.Announc_1_e0011013
Author(s) : Rojas TC , Maluta RP , Parizzi LP , Koenigkan LV , Yang J , Yu J , Pereira GA , Dias da Silveira W
Ref : Genome Announc , 1 :e0011013 , 2013
PubMedID: 23516222
Gene_locus related to this paper: ecoli-d7xp23 , ecoli-IROD , ecoli-IROE , ecoli-estX , ecoli-yaim , ecoli-ybff , ecoli-ycfp , ecoli-yiel , ecoli-ypt1 , ecoli-yqia , ecoli-Z1930 , ecoli-YfhR

Title : Draft genome of a Brazilian avian-pathogenic Escherichia coli strain and in silico characterization of virulence-related genes - Rojas_2012_J.Bacteriol_194_3023
Author(s) : Rojas TC , Parizzi LP , Tiba MR , Chen L , Pereira GA , Sangal V , Yang J , Yu J , Dias da Silveira W
Ref : Journal of Bacteriology , 194 :3023 , 2012
PubMedID: 22582380
Gene_locus related to this paper: ecoli-IROD , ecoli-IROE , ecoli-ycfp , ecoli-YFBB , ecoli-ypt1 , ecoli-YfhR

Title : Genome sequence of a porcine extraintestinal pathogenic Escherichia coli strain - Tan_2011_J.Bacteriol_193_5038
Author(s) : Tan C , Xu Z , Zheng H , Liu W , Tang X , Shou J , Wu B , Wang S , Zhao GP , Chen H
Ref : Journal of Bacteriology , 193 :5038 , 2011
PubMedID: 21742868
Gene_locus related to this paper: ecoli-IROD , ecoli-IROE , ecoli-ycfp , ecoli-YFBB , ecoli-ypt1 , ecoli-yqia

Title : Complete genome sequence of adherent invasive Escherichia coli UM146 isolated from Ileal Crohn's disease biopsy tissue - Krause_2011_J.Bacteriol_193_583
Author(s) : Krause DO , Little AC , Dowd SE , Bernstein CN
Ref : Journal of Bacteriology , 193 :583 , 2011
PubMedID: 21075930
Gene_locus related to this paper: ecoli-rutD , ecoli-bioh , ecoli-C4836 , ecoli-entf , ecoli-IROD , ecoli-IROE , ecoli-yafa , ecoli-yaim , ecoli-ybff , ecoli-ycfp , ecoli-yeiG , ecoli-YFBB , ecoli-yiel , ecoli-yqia , ecoli-YfhR , ecout-q1r7l6

Title : Sequence analysis and characterization of a transferable hybrid plasmid encoding multidrug resistance and enabling zoonotic potential for extraintestinal Escherichia coli - Johnson_2010_Infect.Immun_78_1931
Author(s) : Johnson TJ , Jordan D , Kariyawasam S , Stell AL , Bell NP , Wannemuehler YM , Alarcon CF , Li G , Tivendale KA , Logue CM , Nolan LK
Ref : Infect Immun , 78 :1931 , 2010
PubMedID: 20160015
Gene_locus related to this paper: ecoli-IROD , ecoli-IROE , ecoli-rdmC , ecoli-ypt1

Title : Identification of protective and broadly conserved vaccine antigens from the genome of extraintestinal pathogenic Escherichia coli - Moriel_2010_Proc.Natl.Acad.Sci.U.S.A_107_9072
Author(s) : Moriel DG , Bertoldi I , Spagnuolo A , Marchi S , Rosini R , Nesta B , Pastorello I , Corea VA , Torricelli G , Cartocci E , Savino S , Scarselli M , Dobrindt U , Hacker J , Tettelin H , Tallon LJ , Sullivan S , Wieler LH , Ewers C , Pickard D , Dougan G , Fontana MR , Rappuoli R , Pizza M , Serino L
Ref : Proc Natl Acad Sci U S A , 107 :9072 , 2010
PubMedID: 20439758
Gene_locus related to this paper: ecoli-Aes , ecoli-rutD , ecoli-bioh , ecoli-C0410 , ecoli-C2429 , ecoli-C2451 , ecoli-C4836 , ecoli-dlhh , ecoli-entf , ecoli-fes , ecoli-IROD , ecoli-IROE , ecoli-pldb , ecoli-ptrb , ecoli-yafa , ecoli-yaim , ecoli-ybff , ecoli-ycfp , ecoli-ycjy , ecoli-yeiG , ecoli-YFBB , ecoli-yghX , ecoli-yhet , ecoli-yjfp , ecoli-YNBC , ecoli-ypfh , ecoli-yqia , ecoli-Z1930 , ecoli-YfhR , ecout-q1r7l6 , yerpe-YBTT

Title : Horizontal gene transfer of a ColV plasmid has resulted in a dominant avian clonal type of Salmonella enterica serovar Kentucky - Johnson_2010_PLoS.One_5_e15524
Author(s) : Johnson TJ , Thorsness JL , Anderson CP , Lynne AM , Foley SL , Han J , Fricke WF , McDermott PF , White DG , Khatri M , Stell AL , Flores C , Singer RS
Ref : PLoS ONE , 5 :e15524 , 2010
PubMedID: 21203520
Gene_locus related to this paper: ecoli-IROE

Title : The conserved portion of the putative virulence region contributes to virulence of avian pathogenic Escherichia coli - Tivendale_2009_Microbiology_155_450
Author(s) : Tivendale KA , Noormohammadi AH , Allen JL , Browning GF
Ref : Microbiology , 155 :450 , 2009
PubMedID: 19202093
Gene_locus related to this paper: ecoli-IROD , ecoli-IROE , ecoli-ypt1

Title : Structural characterization of enterobactin hydrolase IroE - Larsen_2006_Biochemistry_45_10184
Author(s) : Larsen NA , Lin H , Wei R , Fischbach MA , Walsh CT
Ref : Biochemistry , 45 :10184 , 2006
PubMedID: 16922493
Gene_locus related to this paper: ecoli-IROE

Title : Identification of genes subject to positive selection in uropathogenic strains of Escherichia coli: a comparative genomics approach - Chen_2006_Proc.Natl.Acad.Sci.U.S.A_103_5977
Author(s) : Chen SL , Hung CS , Xu J , Reigstad CS , Magrini V , Sabo A , Blasiar D , Bieri T , Meyer RR , Ozersky P , Armstrong JR , Fulton RS , Latreille JP , Spieth J , Hooton TM , Mardis ER , Hultgren SJ , Gordon JI
Ref : Proc Natl Acad Sci U S A , 103 :5977 , 2006
PubMedID: 16585510
Gene_locus related to this paper: ecoli-Aes , ecoli-rutD , ecoli-bioh , ecoli-C0410 , ecoli-C2429 , ecoli-C2451 , ecoli-C4836 , ecoli-dlhh , ecoli-entf , ecoli-fes , ecoli-IROD , ecoli-IROE , ecoli-pldb , ecoli-ptrb , ecoli-yafa , ecoli-yaim , ecoli-ybff , ecoli-ycfp , ecoli-ycjy , ecoli-yeiG , ecoli-YFBB , ecoli-yghX , ecoli-yhet , ecoli-yiel , ecoli-yjfp , ecoli-YNBC , ecoli-ypfh , ecoli-ypt1 , ecoli-yqia , ecoli-YfhR , ecout-q1r7l6 , yerpe-YBTT

Title : Role of pathogenicity island-associated integrases in the genome plasticity of uropathogenic Escherichia coli strain 536 - Hochhut_2006_Mol.Microbiol_61_584
Author(s) : Hochhut B , Wilde C , Balling G , Middendorf B , Dobrindt U , Brzuszkiewicz E , Gottschalk G , Carniel E , Hacker J
Ref : Molecular Microbiology , 61 :584 , 2006
PubMedID: 16879640
Gene_locus related to this paper: ecoli-Aes , ecoli-rutD , ecoli-bioh , ecoli-C0410 , ecoli-C2429 , ecoli-C2451 , ecoli-C4836 , ecoli-dlhh , ecoli-entf , ecoli-fes , ecoli-IROD , ecoli-IROE , ecoli-pldb , ecoli-ptrb , ecoli-yafa , ecoli-yaim , ecoli-ybff , ecoli-ycfp , ecoli-ycjy , ecoli-yeiG , ecoli-YFBB , ecoli-yghX , ecoli-yhet , ecoli-yiel , ecoli-yjfp , ecoli-YNBC , ecoli-ypfh , ecoli-yqia , ecoli-YfhR , ecolx-q707d7 , yerpe-YBTT

Title : Complete DNA sequence of a ColBM plasmid from avian pathogenic Escherichia coli suggests that it evolved from closely related ColV virulence plasmids - Johnson_2006_J.Bacteriol_188_5975
Author(s) : Johnson TJ , Johnson SJ , Nolan LK
Ref : Journal of Bacteriology , 188 :5975 , 2006
PubMedID: 16885466
Gene_locus related to this paper: ecoli-IROD , ecoli-IROE , ecoli-ypt1

Title : In vitro characterization of salmochelin and enterobactin trilactone hydrolases IroD, IroE, and Fes - Lin_2005_J.Am.Chem.Soc_127_11075
Author(s) : Lin H , Fischbach MA , Liu DR , Walsh CT
Ref : Journal of the American Chemical Society , 127 :11075 , 2005
PubMedID: 16076215
Gene_locus related to this paper: ecoli-fes , ecoli-IROD , ecoli-IROE

Title : Analysis of the genome structure of the nonpathogenic probiotic Escherichia coli strain Nissle 1917 - Grozdanov_2004_J.Bacteriol_186_5432
Author(s) : Grozdanov L , Raasch C , Schulze J , Sonnenborn U , Gottschalk G , Hacker J , Dobrindt U
Ref : Journal of Bacteriology , 186 :5432 , 2004
PubMedID: 15292145
Gene_locus related to this paper: ecoli-C3633 , ecoli-C3636 , ecoli-IROD , ecoli-IROE

Title : Characterization of an iroBCDEN gene cluster on a transmissible plasmid of uropathogenic Escherichia coli: evidence for horizontal transfer of a chromosomal virulence factor - Sorsa_2003_Infect.Immun_71_3285
Author(s) : Sorsa LJ , Dufke S , Heesemann J , Schubert S
Ref : Infect Immun , 71 :3285 , 2003
PubMedID: 12761110
Gene_locus related to this paper: ecoli-IROD , ecoli-IROE

Title : S-Fimbria-encoding determinant sfa(I) is located on pathogenicity island III(536) of uropathogenic Escherichia coli strain 536 - Dobrindt_2001_Infect.Immun_69_4248
Author(s) : Dobrindt U , Blum-Oehler G , Hartsch T , Gottschalk G , Ron EZ , Funfstuck R , Hacker J
Ref : Infect Immun , 69 :4248 , 2001
PubMedID: 11401961
Gene_locus related to this paper: ecoli-IROD , ecoli-IROE