Peters N

References (3)

Title : The complete genome, comparative and functional analysis of Stenotrophomonas maltophilia reveals an organism heavily shielded by drug resistance determinants - Crossman_2008_Genome.Biol_9_R74
Author(s) : Crossman LC , Gould VC , Dow JM , Vernikos GS , Okazaki A , Sebaihia M , Saunders D , Arrowsmith C , Carver T , Peters N , Adlem E , Kerhornou A , Lord A , Murphy L , Seeger K , Squares R , Rutter S , Quail MA , Rajandream MA , Harris D , Churcher C , Bentley SD , Parkhill J , Thomson NR , Avison MB
Ref : Genome Biol , 9 :R74 , 2008
Abstract : BACKGROUND: Stenotrophomonas maltophilia is a nosocomial opportunistic pathogen of the Xanthomonadaceae. The organism has been isolated from both clinical and soil environments in addition to the sputum of cystic fibrosis patients and the immunocompromised. Whilst relatively distant phylogenetically, the closest sequenced relatives of S. maltophilia are the plant pathogenic xanthomonads. RESULTS: The genome of the bacteremia-associated isolate S. maltophilia K279a is 4,851,126 bp and of high G+C content. The sequence reveals an organism with a remarkable capacity for drug and heavy metal resistance. In addition to a number of genes conferring resistance to antimicrobial drugs of different classes via alternative mechanisms, nine resistance-nodulation-division (RND)-type putative antimicrobial efflux systems are present. Functional genomic analysis confirms a role in drug resistance for several of the novel RND efflux pumps. S. maltophilia possesses potentially mobile regions of DNA and encodes a number of pili and fimbriae likely to be involved in adhesion and biofilm formation that may also contribute to increased antimicrobial drug resistance. CONCLUSION: The panoply of antimicrobial drug resistance genes and mobile genetic elements found suggests that the organism can act as a reservoir of antimicrobial drug resistance determinants in a clinical environment, which is an issue of considerable concern.
ESTHER : Crossman_2008_Genome.Biol_9_R74
PubMedSearch : Crossman_2008_Genome.Biol_9_R74
PubMedID: 18419807
Gene_locus related to this paper: strm5-b4sjf3 , strm5-b4sly1 , strm5-b4smq6 , strm5-b4st20 , strm5-bioh , strmk-b2fhb1 , strmk-b2fju9 , strmk-b2fkx8 , strmk-b2fl50 , strmk-b2fl54 , strmk-b2flj0 , strmk-b2fnc5 , strmk-b2fre3 , strmk-b2frm1 , strmk-b2frs0 , strmk-b2fsp0 , strmk-b2ftw9 , strmk-b2fuf3 , strmk-metx , xanma-P95782 , strmk-b2fmj5 , strmk-b2fpy9 , strmk-b2ftk7 , strmk-b2frv5

Title : The genome of the simian and human malaria parasite Plasmodium knowlesi - Pain_2008_Nature_455_799
Author(s) : Pain A , Bohme U , Berry AE , Mungall K , Finn RD , Jackson AP , Mourier T , Mistry J , Pasini EM , Aslett MA , Balasubrammaniam S , Borgwardt K , Brooks K , Carret C , Carver TJ , Cherevach I , Chillingworth T , Clark TG , Galinski MR , Hall N , Harper D , Harris D , Hauser H , Ivens A , Janssen CS , Keane T , Larke N , Lapp S , Marti M , Moule S , Meyer IM , Ormond D , Peters N , Sanders M , Sanders S , Sargeant TJ , Simmonds M , Smith F , Squares R , Thurston S , Tivey AR , Walker D , White B , Zuiderwijk E , Churcher C , Quail MA , Cowman AF , Turner CM , Rajandream MA , Kocken CH , Thomas AW , Newbold CI , Barrell BG , Berriman M
Ref : Nature , 455 :799 , 2008
Abstract : Plasmodium knowlesi is an intracellular malaria parasite whose natural vertebrate host is Macaca fascicularis (the 'kra' monkey); however, it is now increasingly recognized as a significant cause of human malaria, particularly in southeast Asia. Plasmodium knowlesi was the first malaria parasite species in which antigenic variation was demonstrated, and it has a close phylogenetic relationship to Plasmodium vivax, the second most important species of human malaria parasite (reviewed in ref. 4). Despite their relatedness, there are important phenotypic differences between them, such as host blood cell preference, absence of a dormant liver stage or 'hypnozoite' in P. knowlesi, and length of the asexual cycle (reviewed in ref. 4). Here we present an analysis of the P. knowlesi (H strain, Pk1(A+) clone) nuclear genome sequence. This is the first monkey malaria parasite genome to be described, and it provides an opportunity for comparison with the recently completed P. vivax genome and other sequenced Plasmodium genomes. In contrast to other Plasmodium genomes, putative variant antigen families are dispersed throughout the genome and are associated with intrachromosomal telomere repeats. One of these families, the KIRs, contains sequences that collectively match over one-half of the host CD99 extracellular domain, which may represent an unusual form of molecular mimicry.
ESTHER : Pain_2008_Nature_455_799
PubMedSearch : Pain_2008_Nature_455_799
PubMedID: 18843368
Gene_locus related to this paper: plakh-b3kz42 , plakh-b3kz45 , plakh-b3l0y4 , plakh-b3l1r3 , plakh-b3l8u5 , plakh-b3l336 , plakh-b3l571 , plakh-b3la01 , plakh-b3lb44

Title : Comparative genomic analysis of three Leishmania species that cause diverse human disease - Peacock_2007_Nat.Genet_39_839
Author(s) : Peacock CS , Seeger K , Harris D , Murphy L , Ruiz JC , Quail MA , Peters N , Adlem E , Tivey A , Aslett M , Kerhornou A , Ivens A , Fraser A , Rajandream MA , Carver T , Norbertczak H , Chillingworth T , Hance Z , Jagels K , Moule S , Ormond D , Rutter S , Squares R , Whitehead S , Rabbinowitsch E , Arrowsmith C , White B , Thurston S , Bringaud F , Baldauf SL , Faulconbridge A , Jeffares D , Depledge DP , Oyola SO , Hilley JD , Brito LO , Tosi LR , Barrell B , Cruz AK , Mottram JC , Smith DF , Berriman M
Ref : Nat Genet , 39 :839 , 2007
Abstract : Leishmania parasites cause a broad spectrum of clinical disease. Here we report the sequencing of the genomes of two species of Leishmania: Leishmania infantum and Leishmania braziliensis. The comparison of these sequences with the published genome of Leishmania major reveals marked conservation of synteny and identifies only approximately 200 genes with a differential distribution between the three species. L. braziliensis, contrary to Leishmania species examined so far, possesses components of a putative RNA-mediated interference pathway, telomere-associated transposable elements and spliced leader-associated SLACS retrotransposons. We show that pseudogene formation and gene loss are the principal forces shaping the different genomes. Genes that are differentially distributed between the species encode proteins implicated in host-pathogen interactions and parasite survival in the macrophage.
ESTHER : Peacock_2007_Nat.Genet_39_839
PubMedSearch : Peacock_2007_Nat.Genet_39_839
PubMedID: 17572675
Gene_locus related to this paper: leibr-a4h6l0 , leibr-a4h6l1 , leibr-a4h9b6 , leibr-a4h908 , leibr-a4h956 , leibr-a4h959 , leibr-a4h960 , leibr-a4hen1 , leibr-a4hf07 , leibr-a4hgl0 , leibr-a4hhu6 , leibr-a4hj94 , leibr-a4hk72 , leibr-a4hpa8 , leibr-a4hpz5 , leiin-a4huz4 , leiin-a4hxe0 , leiin-a4hxh8 , leiin-a4hxi1 , leiin-a4hxn7 , leiin-a4hyv9 , leiin-a4i1v9 , leiin-a4i4z6 , leiin-a4i6n9 , leiin-a4i7q7 , leiin-a4idl6 , leima-e9ady6 , leima-OPB , leima-q4q0t5 , leima-q4q8a8 , leima-q4q398 , leima-q4q942 , leima-q4qe85 , leima-q4qe86 , leima-q4qj45