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| Title : Huprine X Attenuates The Neurotoxicity Induced by Kainic Acid, Especially Brain Inflammation - Relat_2018_Basic.Clin.Pharmacol.Toxicol_122_94 |
| Author(s) : Relat J , Perez B , Camps P , Munoz-Torrero D , Badia A , Victoria Clos M |
| Ref : Basic Clin Pharmacol Toxicol , 122 :94 , 2018 |
| Abstract : Relat_2018_Basic.Clin.Pharmacol.Toxicol_122_94 |
| ESTHER : Relat_2018_Basic.Clin.Pharmacol.Toxicol_122_94 |
| PubMedSearch : Relat_2018_Basic.Clin.Pharmacol.Toxicol_122_94 |
| PubMedID: 28724203 |
| Title : Neuroprotective Effects of the Multitarget Agent AVCRI104P3 in Brain of Middle-Aged Mice - Relat_2018_Int.J.Mol.Sci_19_ |
| Author(s) : Relat J , Come J , Perez B , Camps P , Munoz-Torrero D , Badia A , Gimenez-Llort L , Clos MV |
| Ref : Int J Mol Sci , 19 : , 2018 |
| Abstract : Relat_2018_Int.J.Mol.Sci_19_ |
| ESTHER : Relat_2018_Int.J.Mol.Sci_19_ |
| PubMedSearch : Relat_2018_Int.J.Mol.Sci_19_ |
| PubMedID: 30181440 |
| Title : Behavioural effects of novel multitarget anticholinesterasic derivatives in Alzheimer's disease - Gimenez-Llort_2017_Behav.Pharmacol_28_124 |
| Author(s) : Gimenez-Llort L , Ratia M , Perez B , Camps P , Munoz-Torrero D , Badia A , Clos MV |
| Ref : Behav Pharmacol , 28 :124 , 2017 |
| Abstract : Gimenez-Llort_2017_Behav.Pharmacol_28_124 |
| ESTHER : Gimenez-Llort_2017_Behav.Pharmacol_28_124 |
| PubMedSearch : Gimenez-Llort_2017_Behav.Pharmacol_28_124 |
| PubMedID: 28125507 |
| Title : AVCRI104P3, a novel multitarget compound with cognition-enhancing and anxiolytic activities: Studies in cognitively poor middle-aged mice - Gimenez-Llort_2015_Behav.Brain.Res_286_97 |
| Author(s) : Gimenez-Llort L , Ratia M , Perez B , Camps P , Munoz-Torrero D , Badia A , Clos MV |
| Ref : Behavioural Brain Research , 286 :97 , 2015 |
| Abstract : Gimenez-Llort_2015_Behav.Brain.Res_286_97 |
| ESTHER : Gimenez-Llort_2015_Behav.Brain.Res_286_97 |
| PubMedSearch : Gimenez-Llort_2015_Behav.Brain.Res_286_97 |
| PubMedID: 25732954 |
| Title : Undifferentiated and Differentiated PC12 Cells Protected by Huprines Against Injury Induced by Hydrogen Peroxide - Pera_2013_PLoS.One_8_e74344 |
| Author(s) : Pera M , Camps P , Munoz-Torrero D , Perez B , Badia A , Clos Guillen MV |
| Ref : PLoS ONE , 8 :e74344 , 2013 |
| Abstract : Pera_2013_PLoS.One_8_e74344 |
| ESTHER : Pera_2013_PLoS.One_8_e74344 |
| PubMedSearch : Pera_2013_PLoS.One_8_e74344 |
| PubMedID: 24086337 |
| Title : Huprine X and Huperzine A Improve Cognition and Regulate Some Neurochemical Processes Related with Alzheimer's Disease in Triple Transgenic Mice (3xTg-AD) - Ratia_2013_Neurodegener.Dis_11_129 |
| Author(s) : Ratia M , Gimenez-Llort L , Camps P , Munoz-Torrero D , Perez B , Clos MV , Badia A |
| Ref : Neurodegener Dis , 11 :129 , 2013 |
| Abstract : Ratia_2013_Neurodegener.Dis_11_129 |
| ESTHER : Ratia_2013_Neurodegener.Dis_11_129 |
| PubMedSearch : Ratia_2013_Neurodegener.Dis_11_129 |
| PubMedID: 22626981 |
| Title : Huprine-tacrine heterodimers as anti-amyloidogenic compounds of potential interest against Alzheimer's and prion diseases - Galdeano_2012_J.Med.Chem_55_661 |
| Author(s) : Galdeano C , Viayna E , Sola I , Formosa X , Camps P , Badia A , Clos MV , Relat J , Ratia M , Bartolini M , Mancini F , Andrisano V , Salmona M , Minguillon C , Gonzalez-Munoz GC , Rodriguez-Franco MI , Bidon-Chanal A , Luque FJ , Munoz-Torrero D |
| Ref : Journal of Medicinal Chemistry , 55 :661 , 2012 |
| Abstract : Galdeano_2012_J.Med.Chem_55_661 |
| ESTHER : Galdeano_2012_J.Med.Chem_55_661 |
| PubMedSearch : Galdeano_2012_J.Med.Chem_55_661 |
| PubMedID: 22185619 |
| Title : Expanding the multipotent profile of huprine-tacrine heterodimers as disease-modifying anti-Alzheimer agents - Munoz-Torrero_2012_Neurodegener.Dis_10_96 |
| Author(s) : Munoz-Torrero D , Pera M , Relat J , Ratia M , Galdeano C , Viayna E , Sola I , Formosa X , Camps P , Badia A , Clos MV |
| Ref : Neurodegener Dis , 10 :96 , 2012 |
| Abstract : Munoz-Torrero_2012_Neurodegener.Dis_10_96 |
| ESTHER : Munoz-Torrero_2012_Neurodegener.Dis_10_96 |
| PubMedSearch : Munoz-Torrero_2012_Neurodegener.Dis_10_96 |
| PubMedID: 22236498 |
| Title : Huprines as a new family of dual acting trypanocidal-antiplasmodial agents - Defaux_2011_Bioorg.Med.Chem_19_1702 |
| Author(s) : Defaux J , Sala M , Formosa X , Galdeano C , Taylor MC , Alobaid WA , Kelly JM , Wright CW , Camps P , Munoz-Torrero D |
| Ref : Bioorganic & Medicinal Chemistry , 19 :1702 , 2011 |
| Abstract : Defaux_2011_Bioorg.Med.Chem_19_1702 |
| ESTHER : Defaux_2011_Bioorg.Med.Chem_19_1702 |
| PubMedSearch : Defaux_2011_Bioorg.Med.Chem_19_1702 |
| PubMedID: 21315611 |
| Title : Effect of huprine X on beta-amyloid, synaptophysin and alpha7 neuronal nicotinic acetylcholine receptors in the brain of 3xTg-AD and APPswe transgenic mice - Hedberg_2010_Neurodegener.Dis_7_379 |
| Author(s) : Hedberg MM , Clos MV , Ratia M , Gonzalez D , Lithner CU , Camps P , Munoz-Torrero D , Badia A , Gimenez-Llort L , Nordberg A |
| Ref : Neurodegener Dis , 7 :379 , 2010 |
| Abstract : Hedberg_2010_Neurodegener.Dis_7_379 |
| ESTHER : Hedberg_2010_Neurodegener.Dis_7_379 |
| PubMedSearch : Hedberg_2010_Neurodegener.Dis_7_379 |
| PubMedID: 20689242 |
| Title : Novel huprine derivatives with inhibitory activity toward beta-amyloid aggregation and formation as disease-modifying anti-Alzheimer drug candidates - Viayna_2010_ChemMedChem_5_1855 |
| Author(s) : Viayna E , Gomez T , Galdeano C , Ramirez L , Ratia M , Badia A , Clos MV , Verdaguer E , Junyent F , Camins A , Pallas M , Bartolini M , Mancini F , Andrisano V , Arce MP , Rodriguez-Franco MI , Bidon-Chanal A , Luque FJ , Camps P , Munoz-Torrero D |
| Ref : ChemMedChem , 5 :1855 , 2010 |
| Abstract : Viayna_2010_ChemMedChem_5_1855 |
| ESTHER : Viayna_2010_ChemMedChem_5_1855 |
| PubMedSearch : Viayna_2010_ChemMedChem_5_1855 |
| PubMedID: 20859987 |
| Title : Tacrine-based dual binding site acetylcholinesterase inhibitors as potential disease-modifying anti-Alzheimer drug candidates - Camps_2010_Chem.Biol.Interact_187_411 |
| Author(s) : Camps P , Formosa X , Galdeano C , Gomez T , Munoz-Torrero D , Ramirez L , Viayna E , Gomez E , Isambert N , Lavilla R , Badia A , Clos MV , Bartolini M , Mancini F , Andrisano V , Bidon-Chanal A , Huertas O , Dafni T , Luque FJ |
| Ref : Chemico-Biological Interactions , 187 :411 , 2010 |
| Abstract : Camps_2010_Chem.Biol.Interact_187_411 |
| ESTHER : Camps_2010_Chem.Biol.Interact_187_411 |
| PubMedSearch : Camps_2010_Chem.Biol.Interact_187_411 |
| PubMedID: 20167211 |
| Title : Pyrano[3,2-c]quinoline-6-chlorotacrine hybrids as a novel family of acetylcholinesterase- and beta-amyloid-directed anti-Alzheimer compounds - Camps_2009_J.Med.Chem_52_5365 |
| Author(s) : Camps P , Formosa X , Galdeano C , Munoz-Torrero D , Ramirez L , Gomez E , Isambert N , Lavilla R , Badia A , Clos MV , Bartolini M , Mancini F , Andrisano V , Arce MP , Rodriguez-Franco MI , Huertas O , Dafni T , Luque FJ |
| Ref : Journal of Medicinal Chemistry , 52 :5365 , 2009 |
| Abstract : Camps_2009_J.Med.Chem_52_5365 |
| ESTHER : Camps_2009_J.Med.Chem_52_5365 |
| PubMedSearch : Camps_2009_J.Med.Chem_52_5365 |
| PubMedID: 19663388 |
| Title : Novel donepezil-based inhibitors of acetyl- and butyrylcholinesterase and acetylcholinesterase-induced beta-amyloid aggregation - Camps_2008_J.Med.Chem_51_3588 |
| Author(s) : Camps P , Formosa X , Galdeano C , Gomez T , Munoz-Torrero D , Scarpellini M , Viayna E , Badia A , Clos MV , Camins A , Pallas M , Bartolini M , Mancini F , Andrisano V , Estelrich J , Lizondo M , Bidon-Chanal A , Luque FJ |
| Ref : Journal of Medicinal Chemistry , 51 :3588 , 2008 |
| Abstract : Camps_2008_J.Med.Chem_51_3588 |
| ESTHER : Camps_2008_J.Med.Chem_51_3588 |
| PubMedSearch : Camps_2008_J.Med.Chem_51_3588 |
| PubMedID: 18517184 |
| Title : Effect of acetylcholinesterase inhibitors on AChE-induced PrP106-126 aggregation - Clos_2006_J.Mol.Neurosci_30_89 |
| Author(s) : Clos MV , Pera M , Ratia M , Roman S , Camps P , Munoz-Torrero D , Colombo L , Salmona M , Badia A |
| Ref : Journal of Molecular Neuroscience , 30 :89 , 2006 |
| Abstract : Clos_2006_J.Mol.Neurosci_30_89 |
| ESTHER : Clos_2006_J.Mol.Neurosci_30_89 |
| PubMedSearch : Clos_2006_J.Mol.Neurosci_30_89 |
| PubMedID: 17192641 |
| Title : Dimeric and hybrid anti-Alzheimer drug candidates - Munoz-Torrero_2006_Curr.Med.Chem_13_399 |
| Author(s) : Munoz-Torrero D , Camps P |
| Ref : Curr Med Chem , 13 :399 , 2006 |
| Abstract : Munoz-Torrero_2006_Curr.Med.Chem_13_399 |
| ESTHER : Munoz-Torrero_2006_Curr.Med.Chem_13_399 |
| PubMedSearch : Munoz-Torrero_2006_Curr.Med.Chem_13_399 |
| PubMedID: 16475930 |
| Title : Acetylcholinesterase triggers the aggregation of PrP 106-126 - Pera_2006_Biochem.Biophys.Res.Commun_346_89 |
| Author(s) : Pera M , Roman S , Ratia M , Camps P , Munoz-Torrero D , Colombo L , Manzoni C , Salmona M , Badia A , Clos MV |
| Ref : Biochemical & Biophysical Research Communications , 346 :89 , 2006 |
| Abstract : Pera_2006_Biochem.Biophys.Res.Commun_346_89 |
| ESTHER : Pera_2006_Biochem.Biophys.Res.Commun_346_89 |
| PubMedSearch : Pera_2006_Biochem.Biophys.Res.Commun_346_89 |
| PubMedID: 16750169 |
| Title : Binding of 13-amidohuprines to acetylcholinesterase: exploring the ligand-induced conformational change of the gly117-gly118 peptide bond in the oxyanion hole - Camps_2006_J.Med.Chem_49_6833 |
| Author(s) : Camps P , Gomez E , Munoz-Torrero D , Badia A , Clos MV , Curutchet C , Munoz-Muriedas J , Luque FJ |
| Ref : Journal of Medicinal Chemistry , 49 :6833 , 2006 |
| Abstract : Camps_2006_J.Med.Chem_49_6833 |
| ESTHER : Camps_2006_J.Med.Chem_49_6833 |
| PubMedSearch : Camps_2006_J.Med.Chem_49_6833 |
| PubMedID: 17154513 |
| Title : Nicotinic-receptor potentiator drugs, huprine X and galantamine, increase ACh release by blocking AChE activity but not acting on nicotinic receptors - Roman_2005_Brain.Res_1061_73 |
| Author(s) : Roman S , Badia A , Camps P , Munoz-Torrero D , Clos MV |
| Ref : Brain Research , 1061 :73 , 2005 |
| Abstract : Roman_2005_Brain.Res_1061_73 |
| ESTHER : Roman_2005_Brain.Res_1061_73 |
| PubMedSearch : Roman_2005_Brain.Res_1061_73 |
| PubMedID: 16248990 |
| Title : Synthesis and pharmacological evaluation of huprine-tacrine heterodimers: subnanomolar dual binding site acetylcholinesterase inhibitors - Camps_2005_J.Med.Chem_48_1701 |
| Author(s) : Camps P , Formosa X , Munoz-Torrero D , Petrignet J , Badia A , Clos MV |
| Ref : Journal of Medicinal Chemistry , 48 :1701 , 2005 |
| Abstract : Camps_2005_J.Med.Chem_48_1701 |
| ESTHER : Camps_2005_J.Med.Chem_48_1701 |
| PubMedSearch : Camps_2005_J.Med.Chem_48_1701 |
| PubMedID: 15771413 |
| Title : Potentiation effects of (+\/-)huprine X, a new acetylcholinesterase inhibitor, on nicotinic receptors in rat cortical synaptosomes - Roman_2004_Neuropharmacol_46_95 |
| Author(s) : Roman S , Badia A , Camps P , Clos MV |
| Ref : Neuropharmacology , 46 :95 , 2004 |
| Abstract : Roman_2004_Neuropharmacol_46_95 |
| ESTHER : Roman_2004_Neuropharmacol_46_95 |
| PubMedSearch : Roman_2004_Neuropharmacol_46_95 |
| PubMedID: 14654101 |
| Title : (+\/-)-huprine Y, (-)-huperzine A and tacrine do not show neuroprotective properties in an apoptotic model of neuronal cytoskeletal alteration - Jorda_2004_J.Alzheimers.Dis_6_577 |
| Author(s) : Jorda EG , Verdaguer E , Jimenez A , Canudas AM , Rimbau V , Camps P , Munoz-Torrero D , Camins A , Pallas M |
| Ref : J Alzheimers Dis , 6 :577 , 2004 |
| Abstract : Jorda_2004_J.Alzheimers.Dis_6_577 |
| ESTHER : Jorda_2004_J.Alzheimers.Dis_6_577 |
| PubMedSearch : Jorda_2004_J.Alzheimers.Dis_6_577 |
| PubMedID: 15665397 |
| Title : Characterisation of the anticholinesterase activity of two new tacrine-huperzine A hybrids - Alcala_2003_Neuropharmacol_44_749 |
| Author(s) : Alcala Mdel M , Vivas NM , Hospital S , Camps P , Munoz-Torrero D , Badia A |
| Ref : Neuropharmacology , 44 :749 , 2003 |
| Abstract : Alcala_2003_Neuropharmacol_44_749 |
| ESTHER : Alcala_2003_Neuropharmacol_44_749 |
| PubMedSearch : Alcala_2003_Neuropharmacol_44_749 |
| PubMedID: 12681373 |
| Title : 3D structure of Torpedo californica acetylcholinesterase complexed with huprine X at 2.1 A resolution: kinetic and molecular dynamic correlates - Dvir_2002_Biochemistry_41_2970 |
| Author(s) : Dvir H , Wong DM , Harel M , Barril X , Orozco M , Luque FJ , Munoz-Torrero D , Camps P , Rosenberry TL , Silman I , Sussman JL |
| Ref : Biochemistry , 41 :2970 , 2002 |
| Abstract : Dvir_2002_Biochemistry_41_2970 |
| ESTHER : Dvir_2002_Biochemistry_41_2970 |
| PubMedSearch : Dvir_2002_Biochemistry_41_2970 |
| PubMedID: 11863435 |
| Gene_locus related to this paper: torca-ACHE |
| Title : Cholinergic drugs in pharmacotherapy of Alzheimer's disease - Camps_2002_Mini.Rev.Med.Chem_2_11 |
| Author(s) : Camps P , Munoz-Torrero D |
| Ref : Mini Rev Med Chem , 2 :11 , 2002 |
| Abstract : Camps_2002_Mini.Rev.Med.Chem_2_11 |
| ESTHER : Camps_2002_Mini.Rev.Med.Chem_2_11 |
| PubMedSearch : Camps_2002_Mini.Rev.Med.Chem_2_11 |
| PubMedID: 12369954 |
| Title : The pharmacology of novel acetylcholinesterase inhibitors, (+\/-)- huprines Y and X, on the Torpedo electric organ - Ros_2001_Eur.J.Pharmacol_421_77 |
| Author(s) : Ros E , Aleu J , Gomez de Aranda I , Munoz-Torrero D , Camps P , Badia A , Marsal J , Solsona C |
| Ref : European Journal of Pharmacology , 421 :77 , 2001 |
| Abstract : Ros_2001_Eur.J.Pharmacol_421_77 |
| ESTHER : Ros_2001_Eur.J.Pharmacol_421_77 |
| PubMedSearch : Ros_2001_Eur.J.Pharmacol_421_77 |
| PubMedID: 11399262 |
| Title : Tacrine-huperzine A hybrids (huprines): a new class of highly potent and selective acetylcholinesterase inhibitors of interest for the treatment of Alzheimer's disease - Camps_2001_Mini.Rev.Med.Chem_1_163 |
| Author(s) : Camps P , Munoz-Torrero D |
| Ref : Mini Rev Med Chem , 1 :163 , 2001 |
| Abstract : Camps_2001_Mini.Rev.Med.Chem_1_163 |
| ESTHER : Camps_2001_Mini.Rev.Med.Chem_1_163 |
| PubMedSearch : Camps_2001_Mini.Rev.Med.Chem_1_163 |
| PubMedID: 12369981 |
| Title : Synthesis, in Vitro Pharmacology, and Molecular Modeling of syn-Huprines as Acetylcholinesterase Inhibitors - Camps_2001_J.Med.Chem_44_4733 |
| Author(s) : Camps P , Gomez E , Munoz-Torrero D , Badia A , Vivas NM , Barril X , Orozco M , Luque FJ |
| Ref : Journal of Medicinal Chemistry , 44 :4733 , 2001 |
| Abstract : Camps_2001_J.Med.Chem_44_4733 |
| ESTHER : Camps_2001_J.Med.Chem_44_4733 |
| PubMedSearch : Camps_2001_J.Med.Chem_44_4733 |
| PubMedID: 11741490 |
| Title : Huprine X is a Novel High-Affinity Inhibitor of Acetylcholinesterase That Is of Interest for Treatment of Alzheimer's Disease - Camps_2000_Mol.Pharmacol_57_409 |
| Author(s) : Camps P , Cusack B , Mallender WD , Achab RE , Morral J , Munoz-Torrero D , Rosenberry TL |
| Ref : Molecular Pharmacology , 57 :409 , 2000 |
| Abstract : Camps_2000_Mol.Pharmacol_57_409 |
| ESTHER : Camps_2000_Mol.Pharmacol_57_409 |
| PubMedSearch : Camps_2000_Mol.Pharmacol_57_409 |
| PubMedID: 10648652 |
| Title : New tacrine-huperzine A hybrids (huprines): highly potent tight-binding acetylcholinesterase inhibitors of interest for the treatment of Alzheimer's disease - Camps_2000_J.Med.Chem_43_4657 |
| Author(s) : Camps P , El Achab R , Morral J , Munoz-Torrero D , Badia A , Banos JE , Vivas NM , Barril X , Orozco M , Luque FJ |
| Ref : Journal of Medicinal Chemistry , 43 :4657 , 2000 |
| Abstract : Camps_2000_J.Med.Chem_43_4657 |
| ESTHER : Camps_2000_J.Med.Chem_43_4657 |
| PubMedSearch : Camps_2000_J.Med.Chem_43_4657 |
| PubMedID: 11101357 |
| Title : Synthesis, in vitro pharmacology, and molecular modeling of very potent tacrine-huperzine A hybrids as acetylcholinesterase inhibitors of potential interest for the treatment of Alzheimer's disease - Camps_1999_J.Med.Chem_42_3227 |
| Author(s) : Camps P , El Achab R , Gorbig DM , Morral J , Munoz-Torrero D , Badia A , Eladi Banos J , Vivas NM , Barril X , Orozco M , Luque FJ |
| Ref : Journal of Medicinal Chemistry , 42 :3227 , 1999 |
| Abstract : Camps_1999_J.Med.Chem_42_3227 |
| ESTHER : Camps_1999_J.Med.Chem_42_3227 |
| PubMedSearch : Camps_1999_J.Med.Chem_42_3227 |
| PubMedID: 10464010 |
| Title : Synthesis and evaluation of tacrine-huperzine A hybrids as acetylcholinesterase inhibitors of potential interest for the treatment of Alzheimer's disease - Badia_1998_Bioorg.Med.Chem_6_427 |
| Author(s) : Badia A , Banos JE , Camps P , Contreras J , Gorbig DM , Munoz-Torrero D , Simon M , Vivas NM |
| Ref : Bioorganic & Medicinal Chemistry , 6 :427 , 1998 |
| Abstract : Badia_1998_Bioorg.Med.Chem_6_427 |
| ESTHER : Badia_1998_Bioorg.Med.Chem_6_427 |
| PubMedSearch : Badia_1998_Bioorg.Med.Chem_6_427 |
| PubMedID: 9597187 |