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Family Report for: Hepatic_Lipase

Hepatic_Lipase



Relationship
Block L
Comment
Pancreatic, hepatic and gastric/lingual lipase are closely related to each other and to lipoprotein lipase (EC: 3.1.1.34), which hydrolyses triglycerides of chylomicrons and very low density lipoproteins (VLDL). Familial human hepatic lipase deficiency is a rare recessive disorder Two variants (S267F and T383M) are rare mutations found to date only in HL deficient subjects and their relatives. Of the six HL variants described to date, only S267F and T383M are associated with hyperlipidemia. human-LIPC. The disease is characterised by premature atherosclerosis and abnormal circulating lipoproteins
2 Disease(s)


Database
Sequences
Interpro
|
IPR000734 (Lipase), IPR002333 (Hepatic lipase), IPR016272 (Lipase, LIPH-type), IPR013818 (Lipase)
PIRSF
|
Pdoc
|
PFam
|
PF00151 (Lipase)
Prints
|
Prosite
|
EC at KEGG
|
EC at EXPASY
|


Peptide in
|Fasta
Nucleotide in
|Fasta
Alignment with Multalin
|Text only/graphic display
Seed alignment with MAFFT
|No colour/coloured with Mview
Alignment with MAFFT
|No colour/coloured with Mview
Dendrogram
|Graphical display, obtained with the dnd file produced by Clustalw

References
    Title: Vertebrate hepatic lipase genes and proteins: a review supported by bioinformatic studies
    Holmes RS, Vandeberg JL, Cox LA
    Ref: Open Access Bioinformatics, 2011:85, 2011 : PubMed

            

    Title: Human hepatic lipase mutations and polymorphisms
    Hegele RA, Tu L, Connelly PW
    Ref: Hum Mutat, 1:320, 1992 : PubMed

            

Other Papers


No structure scheme yet for this family

No Structure yet in this family

Genes Proteins in Hepatic_Lipase family (116)

Fragments of genes in Hepatic_Lipase family (68)

Substrates of some enzymes in the Hepatic_Lipase family (8)

Inhibitors of some enzymes in the Hepatic_Lipase family (1)



Send your questions or comments to :
Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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