Family

Go to basket

Tree Display

AceDB Schema

XML Display

Feedback

Family Report for: Hepatic_Lipase


Hepatic_Lipase



Relationship
Block L


Comments

Pancreatic, hepatic and gastric/lingual lipase are closely related to each other and to lipoprotein lipase (EC: 3.1.1.34), which hydrolyses triglycerides of chylomicrons and very low density lipoproteins (VLDL). Familial human hepatic lipase deficiency is a rare recessive disorder Two variants (S267F and T383M) are rare mutations found to date only in HL deficient subjects and their relatives. Of the six HL variants described to date, only S267F and T383M are associated with hyperlipidemia. human-LIPC. The disease is characterised by premature atherosclerosis and abnormal circulating lipoproteins



2 Disease(s)


Database
Sequences
Interpro : IPR000734 (Lipase), IPR002333 (Hepatic lipase), IPR016272 (Lipase, LIPH-type)
PIRSF :
PFam : PF00151 (Lipase)
Prosite : PS00120
EC at KEGG : 3.1.1.3
EC at EXPASY : 3.1.1.3
Peptide in Fasta
Nucleotide in Fasta
Alignment with Multalin : Text only/graphic display
Seed alignment with MAFFT : No colour/coloured with Mview
Alignment with MAFFT : No colour/coloured with Mview
Dendrogram : Graphical display, obtained with the dnd file produced by Clustalw
HMM profile : HMM profile


No Image

No Structure

If the number of entries is too large in this family (>4000) or the page is too slow follow this link






Send your questions or comments to :
Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
For technical information about these pages see:
ESTHER Home Page and ACEDB Home Page
AcePerl Lincoln Stein Home Page
webmaster

Acknowledgements and disclaimer