aspfu-fmac

 
Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus). Fumagillin biosynthesis acyltransferase

Relationship
Block X
Neosartorya fumigata position in NCBI Life Tree :
N link to NCBI taxonomic web page and E link to ESTHER gene locus found in this strain.
> cellular organisms: N E > Eukaryota: N E > Opisthokonta: N E > Fungi: N E > Dikarya: N E > Ascomycota: N E > saccharomyceta: N E > Pezizomycotina: N E > leotiomyceta: N E > Eurotiomycetes: N E > Eurotiomycetidae: N E > Eurotiales: N E > Aspergillaceae: N E > Aspergillus: N E > Aspergillus fumigatus: N E

Molecular evidence
Database
No mutation
No structure
No kinetic



2 Genbank : AAHF01000014, XP_747166
1 UniProt : Q4WAY4
1 UniProtTrembl : Q4WAY4
1 Interpro : Q4WAY4
1 Prodom : Q4WAY4
1 Pfam : Q4WAY4
1 PIRSF : Q4WAY4
1 SUPERFAM : Q4WAY4
1 QuickSwissBlast : Q4WAY4
 
Sequence
Graphical view for this peptide sequence: aspfu-fmac
Colored MSA for Thiohydrolase (raw)
MNREDVEFPTCDGLILRGWLYPGTIRGPAIVMNQGFNTPKEILLPDVAVW
FQQQGVTVLLYDNRCIGASDGEPRNDVKPAKLVEDFHDALTFMARHPMVD
EDKIILYGYSFSAMTALVAAGLDHRVGAAISVTPIANYDFREKEKNNVMA
LAMQDRVSTLAGNDPVYIPFVGDDGYNPAGWGNQYNMEQFRAFLGTSFFT
NRTTVQSYYHVLAWQPYGAMRLIKGTPVMMVTPAEDTISSPADQRAVFDM
IPEPNKEFDLVAGRGHMDVINGEGAEEVLQRQLAFMRKHLDF
Legend This sequence has been compared to family alignement (MSA)
red => minority aminoacid
blue => majority aminoacid
color intensity => conservation rate
title => sequence position(MSA position)aminoacid rate
Catalytic site
Catalytic site in the MSA

MNREDVEFPTCDGLILRGWLYPGTIRGPAIVMNQGFNTPKEILLPDVAVW
FQQQGVTVLLYDNRCIGASDGEPRNDVKPAKLVEDFHDALTFMARHPMVD
EDKIILYGYSFSAMTALVAAGLDHRVGAAISVTPIANYDFREKEKNNVMA
LAMQDRVSTLAGNDPVYIPFVGDDGYNPAGWGNQYNMEQFRAFLGTSFFT
NRTTVQSYYHVLAWQPYGAMRLIKGTPVMMVTPAEDTISSPADQRAVFDM
IPEPNKEFDLVAGRGHMDVINGEGAEEVLQRQLAFMRKHLDF

no DNA




References
6 more
    Title: Genomic sequence of the pathogenic and allergenic filamentous fungus Aspergillus fumigatus
    Nierman WC, Pain A, Anderson MJ, Wortman JR, Kim HS, Arroyo J, Berriman M, Abe K, Archer DB and Denning DW <87 more author(s)>
    Ref: Nature, 438:1151, 2005 : PubMed

            

    Title: The anti-angiogenic agent fumagillin covalently binds and inhibits the methionine aminopeptidase, MetAP-2
    Sin N, Meng L, Wang MQ, Wen JJ, Bornmann WG, Crews CM
    Ref: Proc Natl Acad Sci U S A, 94:6099, 1997 : PubMed

            

    Title: The treatment of amebiasis with fumagillin
    Killough JH, Magill GB, Smith RC
    Ref: Science, 115:71, 1952 : PubMed

            


Other Papers


Send your questions or comments to :
Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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