hGluN1/hGluN2B RIa (1 microM) 35.0 +/- 1.4 ; IC50 hAChE 8.52 +/-+/- 0.41 ; IC50 hBCHE 5.48 +/- 0.19 microM
Type : Multitarget, NMDA-Ligand, Derivative of Tacrine
Chemical_Nomenclature : 7-(2-methoxyphenoxy)-2,3-dihydro-1H-cyclopenta[b]quinolin-9-amine
Canonical SMILES : COC1=CC=CC=C1OC2=CC3=C(C=C2)N=C4CCCC4=C3N
InChI : InChI=1S\/C19H18N2O2\/c1-22-17-7-2-3-8-18(17)23-12-9-10-16-14(11-12)19(20)13-5-4-6-15(13)21-16\/h2-3,7-11H,4-6H2,1H3,(H2,20,21)
InChIKey : DFOGOJMEWLSLGH-UHFFFAOYSA-N
Other name(s) : I-52
MW : 306.4
Formula : C19H18N2O2
CAS_number :
PubChem : 164597062
UniChem : DFOGOJMEWLSLGH-UHFFFAOYSA-N
Title : Phenoxytacrine derivatives: Low-toxicity neuroprotectants exerting affinity to ifenprodil-binding site and cholinesterase inhibition - Misiachna_2024_Eur.J.Med.Chem_266_116130 |
Author(s) : Misiachna A , Svobodova B , Netolicky J , Chvojkova M , Kleteckova L , Prchal L , Novak M , Hrabinova M , Kucera T , Muckova L , Moravcova Z , Karasova JZ , Pejchal J , Blazek F , Malinak D , Hakenova K , Krausova BH , Kolcheva M , Ladislav M , Korabecny J , Pahnke J , Vales K , Horak M , Soukup O |
Ref : Eur Journal of Medicinal Chemistry , 266 :116130 , 2024 |
Abstract : |
PubMedSearch : Misiachna_2024_Eur.J.Med.Chem_266_116130 |
PubMedID: 38218127 |