Amiridine-Salicylamide-7c
IC50: AChE 1.53 +/- 0.03 microM; BChE, 0.0111 +/- 0.0001 microM) no activity against off-target carboxylesterase (CES)
General
Type : Derivative of Amiridine, Salicylic, Multitarget
Chemical_Nomenclature : N-{8-[(2,3,5,6,7,8-hexahydro-1H-cyclopenta[b]quinolin-9-yl)amino]octyl}2-hydroxybenzamide
Canonical SMILES : C14=C(N=C3C(=C1NCCCCCCCCNC(=O)C2=C(C=CC=C2)O)CCCC3)CCC4
InChI : InChI=1S\/C27H37N3O2\/c31-25-17-8-6-13-22(25)27(32)29-19-10-4-2-1-3-9-18-28-26-20-12-5-7-15-23(20)30-24-16-11-14-21(24)26\/h6,8,13,17,31H,1-5,7,9-12,14-16,18-19H2,(H,28,30)(H,29,32)
InChIKey : KWVDVIKUKFDMSD-UHFFFAOYSA-N
Other name(s) : compound 7c
Target
References (1)
| Title : Conjugates of amiridine and salicylic derivatives as promising multifunctional CNS agents for potential treatment of Alzheimer's disease - Makhaeva_2025_Arch.Pharm.(Weinheim)_358_e2400819 |
| Author(s) : Makhaeva GF , Grishchenko MV , Kovaleva NV , Boltneva NP , Rudakova EV , Astakhova TY , Timokhina EN , Pronkin PG , Lushchekina SV , Khudina OG , Zhilina EF , Shchegolkov EV , Lapshina MA , Dubrovskaya ES , Radchenko EV , Palyulin VA , Burgart YV , Saloutin VI , Charushin VN , Richardson RJ |
| Ref : Arch Pharm (Weinheim) , 358 :e2400819 , 2025 |
| Abstract : |
| PubMedSearch : Makhaeva_2025_Arch.Pharm.(Weinheim)_358_e2400819 |
| PubMedID: 39686878 |