Amiridine-thiouracil-13c
IC50 AChE 9.3+/-1.3 BChE 0.752+/-0.021 microM
General
Type : Quinoline, Derivative of Tacrine, Derivative of Amiridine, Pyrimidine, Sulfur Compound
Chemical_Nomenclature : N-(2,3,5,6,7,8-hexahydro-1H-cyclopenta[b]quinolin-9-yl)-4-((6-oxo-4-(1,1,2,2-tetrafluoroethyl)-1,6-dihydropyrimidin-2-yl)thio)butanamide
Canonical SMILES : [C]1=C(N=C([N]C1=O)SCCCC(=O)[N]C2=C4C(=NC3=C2CCC3)CCCC4)C([C](F)F)(F)F
InChI : InChI=1S\/C22H24F4N4O2S\/c23-20(24)22(25,26)16-11-18(32)30-21(28-16)33-10-4-9-17(31)29-19-12-5-1-2-7-14(12)27-15-8-3-6-13(15)19\/h11,20H,1-10H2,(H,27,29,31)(H,28,30,32)
InChIKey : SUBCUDCEZXVKGB-UHFFFAOYSA-N
Other name(s) : Amiridin-thiouracil, Amyridin-thiouracil
Target
Families : Amiridine-thiouracil-13c ligand of proteins in family
BCHE
Protein :
human-BCHE
References (1)
| Title : Conjugates of amiridine and thiouracil derivatives as effective inhibitors of butyrylcholinesterase with the potential to block beta-amyloid aggregation - Khudina_2023_Arch.Pharm.(Weinheim)__e2300447 |
| Author(s) : Khudina OG , Grishchenko MV , Makhaeva GF , Kovaleva NV , Boltneva NP , Rudakova EV , Lushchekina SV , Shchegolkov EV , Borisevich SS , Burgart YV , Saloutin VI , Charushin VN |
| Ref : Arch Pharm (Weinheim) , :e2300447 , 2023 |
| PubMedID: 38072670 |