MAGL-2305
hMAGL IC50 1.59 nM
General
Type : PET probe, Piperidine, Azaspiro
Chemical_Nomenclature : (2s,4R)-2-(4-((S)-1-(2-chloro-4-fluorophenoxy)ethyl)piperidine-1-carbonyl)-7-oxa-5-azaspiro[3.4]octan-6-one || 2-[4-[1-(2-chloro-4-fluorophenoxy)ethyl]piperidine-1-carbonyl]-7-oxa-5-azaspiro[3.4]octan-6-one
Canonical SMILES : CC(C1CCN(CC1)C(=O)C2CC3(C2)COC(=O)N3)OC4=C(C=C(C=C4)F)Cl
InChI : InChI=1S\/C20H24ClFN2O4\/c1-12(28-17-3-2-15(22)8-16(17)21)13-4-6-24(7-5-13)18(25)14-9-20(10-14)11-27-19(26)23-20\/h2-3,8,12-14H,4-7,9-11H2,1H3,(H,23,26)
InChIKey : RXCYCKJENKBPPV-UHFFFAOYSA-N
Other name(s) : (S)-6 || CHEMBL4860900 || SCHEMBL19409581 || SCHEMBL19409582 || SCHEMBL19421057 || BDBM50566988
MW : 410.9
Formula : C20H24ClFN2O4
CAS_number :
PubChem : 130475918
UniChem : RXCYCKJENKBPPV-UHFFFAOYSA-N
Target
Families : MAGL-2305 ligand of proteins in family
Monoglyceridelipase_lysophospholip
Protein :
human-MGLL
References (2)
| Title : Radiosynthesis and evaluation of novel (18)F labeled PET ligands for imaging monoacylglycerol lipase - Li_2025_Eur.J.Med.Chem_285_117246 |
| Author(s) : Li Y , Mori W , Chaudhary A , Zhao C , Yamasaki T , Zhang Z , Feng S , Ware T , Rong J , Fujinaga M , Chen J , Kumata K , Zhang Y , Hu K , Xie L , Zhou X , Song Z , Gao Y , Sun Z , Patel JS , Zhai C , Yuan KY , Collier TL , Ran C , Collin L , Haider A , Grether U , Wittwer MB , Cravatt BF , Zhang MR , Liang SH |
| Ref : Eur Journal of Medicinal Chemistry , 285 :117246 , 2025 |
| Abstract : |
| PubMedSearch : Li_2025_Eur.J.Med.Chem_285_117246 |
| PubMedID: 39793441 |
| Gene_locus related to this paper: human-MGLL |
| Title : Design and Synthesis of Novel Spiro Derivatives as Potent and Reversible Monoacylglycerol Lipase (MAGL) Inhibitors: Bioisosteric Transformation from 3-Oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl Moiety - Ikeda_2021_J.Med.Chem__ |
| Author(s) : Ikeda S , Sugiyama H , Tokuhara H , Murakami M , Nakamura M , Oguro Y , Aida J , Morishita N , Sogabe S , Dougan DR , Gay SC , Qin L , Arimura N , Takahashi Y , Sasaki M , Kamada Y , Aoyama K , Kimoto K , Kamata M |
| Ref : Journal of Medicinal Chemistry , : , 2021 |
| Abstract : |
| PubMedSearch : Ikeda_2021_J.Med.Chem__ |
| PubMedID: 34328319 |
| Gene_locus related to this paper: human-MGLL |