MAGL-IN-10-Cpd28
IC50 = 1.3 +/- 0.1 nM
General
Type : Pyridine, Piperidine, Trifluoro, Sulfur Compound
Chemical_Nomenclature : (2-fluoro-5-hydroxyphenyl)-[4-[[3-[4-(trifluoromethyl)pyridin-2-yl]sulfanylphenyl]methyl]piperidin-1-yl]methanone
Canonical SMILES : C1CN(CCC1CC2=CC(=CC=C2)SC3=NC=CC(=C3)C(F)(F)F)C(=O)C4=C(C=CC(=C4)O)F
InChI : InChI=1S\/C25H22F4N2O2S\/c26-22-5-4-19(32)15-21(22)24(33)31-10-7-16(8-11-31)12-17-2-1-3-20(13-17)34-23-14-18(6-9-30-23)25(27,28)29\/h1-6,9,13-16,32H,7-8,10-12H2
InChIKey : XVJTVRACOGMHHO-UHFFFAOYSA-N
Other name(s) : (2-Fluoro-5-hydroxyphenyl) (4-(3-((4-(trifluoromethyl)pyridin-2-yl)thio)benzyl)piperidin-1-yl)methanone || MAGL-IN-10 || HY-157041 || CS-0904551 || MAGL Inhibitor Compound 28 || Compound 28
MW : 490.5
Formula : C25H22F4N2O2S
CAS_number :
PubChem : 169450391
UniChem : XVJTVRACOGMHHO-UHFFFAOYSA-N
Target
Families : MAGL-IN-10-Cpd28 ligand of proteins in family
Monoglyceridelipase_lysophospholip
Protein :
human-MGLL
References (1)
| Title : Design, synthesis, ADME and biological evaluation of benzylpiperidine and benzylpiperazine derivatives as novel reversible monoacylglycerol lipase (MAGL) inhibitors - Di Stefano_2023_Eur.J.Med.Chem_263_115916 |
| Author(s) : Di Stefano M , Masoni S , Bononi G , Poli G , Galati S , Gado F , Manzi S , Vagaggini C , Brai A , Caligiuri I , Asif K , Rizzolio F , Macchia M , Chicca A , Sodi A , Di Bussolo V , Minutolo F , Meier P , Gertsch J , Granchi C , Dreassi E , Tuccinardi T |
| Ref : Eur Journal of Medicinal Chemistry , 263 :115916 , 2023 |
| Abstract : |
| PubMedSearch : Di Stefano_2023_Eur.J.Med.Chem_263_115916 |
| PubMedID: 37976705 |
| Gene_locus related to this paper: human-ABHD6 |