Ma_2010_Nature_464_367

Reference

Title : Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium - Ma_2010_Nature_464_367
Author(s) : Ma LJ , van der Does HC , Borkovich KA , Coleman JJ , Daboussi MJ , Di Pietro A , Dufresne M , Freitag M , Grabherr M , Henrissat B , Houterman PM , Kang S , Shim WB , Woloshuk C , Xie X , Xu JR , Antoniw J , Baker SE , Bluhm BH , Breakspear A , Brown DW , Butchko RA , Chapman S , Coulson R , Coutinho PM , Danchin EG , Diener A , Gale LR , Gardiner DM , Goff S , Hammond-Kosack KE , Hilburn K , Hua-Van A , Jonkers W , Kazan K , Kodira CD , Koehrsen M , Kumar L , Lee YH , Li L , Manners JM , Miranda-Saavedra D , Mukherjee M , Park G , Park J , Park SY , Proctor RH , Regev A , Ruiz-Roldan MC , Sain D , Sakthikumar S , Sykes S , Schwartz DC , Turgeon BG , Wapinski I , Yoder O , Young S , Zeng Q , Zhou S , Galagan J , Cuomo CA , Kistler HC , Rep M
Ref : Nature , 464 :367 , 2010
Abstract :

Fusarium species are among the most important phytopathogenic and toxigenic fungi. To understand the molecular underpinnings of pathogenicity in the genus Fusarium, we compared the genomes of three phenotypically diverse species: Fusarium graminearum, Fusarium verticillioides and Fusarium oxysporum f. sp. lycopersici. Our analysis revealed lineage-specific (LS) genomic regions in F. oxysporum that include four entire chromosomes and account for more than one-quarter of the genome. LS regions are rich in transposons and genes with distinct evolutionary profiles but related to pathogenicity, indicative of horizontal acquisition. Experimentally, we demonstrate the transfer of two LS chromosomes between strains of F. oxysporum, converting a non-pathogenic strain into a pathogen. Transfer of LS chromosomes between otherwise genetically isolated strains explains the polyphyletic origin of host specificity and the emergence of new pathogenic lineages in F. oxysporum. These findings put the evolution of fungal pathogenicity into a new perspective.

PubMedSearch : Ma_2010_Nature_464_367
PubMedID: 20237561
Gene_locus related to this paper: fusox-a0a1d3s5h0 , gibf5-fus2 , fusof-f9f2k2 , fusof-f9f3l6 , fusof-f9f6t8 , fusof-f9f6v2 , fusof-f9f132 , fusof-f9f781 , fusof-f9fd72 , fusof-f9fd90 , fusof-f9fem0 , fusof-f9fhk2 , fusof-f9fj19 , fusof-f9fj20 , fusof-f9fki8 , fusof-f9fmx2 , fusof-f9fnt4 , fusof-f9fpy4 , fusof-f9fvs6 , fusof-f9fwu0 , fusof-f9fxz4 , fusof-f9fzy5 , fusof-f9g2a2 , fusof-f9g3b1 , fusof-f9g5h7 , fusof-f9g6e6 , fusof-f9g6y7 , fusof-f9g7b0 , fusof-f9g797 , fusof-f9g972 , fusof-f9ga50 , fusof-f9gck4 , fusof-f9gd15 , gibze-a8w610 , gibze-b1pdn0 , gibze-i1r9e6 , gibze-i1rda9 , gibze-i1rdk7 , gibze-i1rec8 , gibze-i1rgs0 , gibze-i1rgy0 , gibze-i1rh52 , gibze-i1rhi8 , gibze-i1rig9 , gibze-i1rip5 , gibze-i1rpg6 , gibze-i1rsg2 , gibze-i1rv36 , gibze-i1rxm5 , gibze-i1rxp8 , gibze-i1rxv5 , gibze-i1s1u3 , gibze-i1s3j9 , gibze-i1s6l7 , gibze-i1s8i8 , gibze-i1s9x4 , gibze-q4huy1 , gibze-i1rg17 , fuso4-j9mvr9 , fuso4-j9ngs6 , fuso4-j9niq8 , fuso4-j9nqm2 , gibze-i1rb76 , gibze-i1s1m7 , gibze-i1s3z6 , gibze-i1rd78 , gibze-i1rgl9 , gibze-i1rjp7 , gibze-i1s1q6 , gibze-i1ri35 , gibze-i1rf76 , gibze-i1rhp3 , fusc1-n4uj11 , fusc4-n1s9p6 , gibf5-s0dqr2 , gibm7-w7n1b5 , fusof-f9g6q0 , gibm7-w7n497 , fusox-x0bme4 , gibm7-w7mcf8 , gibm7-w7mak5 , fusox-x0a2c5 , gibm7-w7mum7 , fusox-w9iyc7 , gibm7-w7maw6 , gibm7-w7msi0 , gibm7-w7luf0 , gibm7-w7msa3 , gibm7-w7mna8 , gibm7-w7n8b7 , gibm7-w7n564 , fusox-w9jpi0 , gibm7-w7ngc3 , gibm7-w7m4v6 , gibm7-w7m4v2 , gibm7-w7lt61 , gibm7-w7mly6 , gibm7-w7ncn3 , fusox-w9ibd7 , fusof-f9fnm6 , gibm7-w7n526 , gibza-a0a016pda4 , gibza-a0a016pl96 , gibm7-w7muq1 , fusof-f9gfd3 , gibm7-w7mt52 , gibze-i1rjb5 , gibf5-s0ehu3 , fusox-w9hvf0 , gibze-i1rkc4 , gibm7-w7mv30 , gibze-a0a1c3ylb1 , fuso4-a0a0c4diy4 , gibm7-w7n4n0 , gibze-gra11 , gibze-fsl2 , gibf5-fub4 , gibf5-fub5 , gibf5-fus5 , gibm7-dlh1

Related information

Gene_locus fusox-a0a1d3s5h0    gibf5-fus2    fusof-f9f2k2    fusof-f9f3l6    fusof-f9f6t8    fusof-f9f6v2    fusof-f9f132    fusof-f9f781    fusof-f9fd72    fusof-f9fd90    fusof-f9fem0    fusof-f9fhk2    fusof-f9fj19    fusof-f9fj20    fusof-f9fki8    fusof-f9fmx2    fusof-f9fnt4    fusof-f9fpy4    fusof-f9fvs6    fusof-f9fwu0    fusof-f9fxz4    fusof-f9fzy5    fusof-f9g2a2    fusof-f9g3b1    fusof-f9g5h7    fusof-f9g6e6    fusof-f9g6y7    fusof-f9g7b0    fusof-f9g797    fusof-f9g972    fusof-f9ga50    fusof-f9gck4    fusof-f9gd15    gibze-a8w610    gibze-b1pdn0    gibze-i1r9e6    gibze-i1rda9    gibze-i1rdk7    gibze-i1rec8    gibze-i1rgs0    gibze-i1rgy0    gibze-i1rh52    gibze-i1rhi8    gibze-i1rig9    gibze-i1rip5    gibze-i1rpg6    gibze-i1rsg2    gibze-i1rv36    gibze-i1rxm5    gibze-i1rxp8    gibze-i1rxv5    gibze-i1s1u3    gibze-i1s3j9    gibze-i1s6l7    gibze-i1s8i8    gibze-i1s9x4    gibze-q4huy1    gibze-i1rg17    fuso4-j9mvr9    fuso4-j9ngs6    fuso4-j9niq8    fuso4-j9nqm2    gibze-i1rb76    gibze-i1s1m7    gibze-i1s3z6    gibze-i1rd78    gibze-i1rgl9    gibze-i1rjp7    gibze-i1s1q6    gibze-i1ri35    gibze-i1rf76    gibze-i1rhp3    fusc1-n4uj11    fusc4-n1s9p6    gibf5-s0dqr2    gibm7-w7n1b5    fusof-f9g6q0    gibm7-w7n497    fusox-x0bme4    gibm7-w7mcf8    gibm7-w7mak5    fusox-x0a2c5    gibm7-w7mum7    fusox-w9iyc7    gibm7-w7maw6    gibm7-w7msi0    gibm7-w7luf0    gibm7-w7msa3    gibm7-w7mna8    gibm7-w7n8b7    gibm7-w7n564    fusox-w9jpi0    gibm7-w7ngc3    gibm7-w7m4v6    gibm7-w7m4v2    gibm7-w7lt61    gibm7-w7mly6    gibm7-w7ncn3    fusox-w9ibd7    fusof-f9fnm6    gibm7-w7n526    gibza-a0a016pda4    gibza-a0a016pl96    gibm7-w7muq1    fusof-f9gfd3    gibm7-w7mt52    gibze-i1rjb5    gibf5-s0ehu3    fusox-w9hvf0    gibze-i1rkc4    gibm7-w7mv30    gibze-a0a1c3ylb1    fuso4-a0a0c4diy4    gibm7-w7n4n0    gibze-gra11    gibze-fsl2    gibf5-fub4    gibf5-fub5    gibf5-fus5    gibm7-dlh1
Gene_locus_frgt fusof-f9fj23    gibze-i1rkh2    gibze-i1s445    gibze-i1rb77    gibm7-w7n141    gibm7-w7mxq4    gibm7-w7mxl3    gibm7-w7mzr6    gibm7-w7med8    fuso4-a0a0c4djk4    gibm7-dlh2

Citations formats

Ma LJ, van der Does HC, Borkovich KA, Coleman JJ, Daboussi MJ, Di Pietro A, Dufresne M, Freitag M, Grabherr M, Henrissat B, Houterman PM, Kang S, Shim WB, Woloshuk C, Xie X, Xu JR, Antoniw J, Baker SE, Bluhm BH, Breakspear A, Brown DW, Butchko RA, Chapman S, Coulson R, Coutinho PM, Danchin EG, Diener A, Gale LR, Gardiner DM, Goff S, Hammond-Kosack KE, Hilburn K, Hua-Van A, Jonkers W, Kazan K, Kodira CD, Koehrsen M, Kumar L, Lee YH, Li L, Manners JM, Miranda-Saavedra D, Mukherjee M, Park G, Park J, Park SY, Proctor RH, Regev A, Ruiz-Roldan MC, Sain D, Sakthikumar S, Sykes S, Schwartz DC, Turgeon BG, Wapinski I, Yoder O, Young S, Zeng Q, Zhou S, Galagan J, Cuomo CA, Kistler HC, Rep M (2010)
Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium
Nature 464 :367

Ma LJ, van der Does HC, Borkovich KA, Coleman JJ, Daboussi MJ, Di Pietro A, Dufresne M, Freitag M, Grabherr M, Henrissat B, Houterman PM, Kang S, Shim WB, Woloshuk C, Xie X, Xu JR, Antoniw J, Baker SE, Bluhm BH, Breakspear A, Brown DW, Butchko RA, Chapman S, Coulson R, Coutinho PM, Danchin EG, Diener A, Gale LR, Gardiner DM, Goff S, Hammond-Kosack KE, Hilburn K, Hua-Van A, Jonkers W, Kazan K, Kodira CD, Koehrsen M, Kumar L, Lee YH, Li L, Manners JM, Miranda-Saavedra D, Mukherjee M, Park G, Park J, Park SY, Proctor RH, Regev A, Ruiz-Roldan MC, Sain D, Sakthikumar S, Sykes S, Schwartz DC, Turgeon BG, Wapinski I, Yoder O, Young S, Zeng Q, Zhou S, Galagan J, Cuomo CA, Kistler HC, Rep M (2010)
Nature 464 :367