4-methylumbelliferyl-acetate

General

Type : Coumarin || Acetate

Chemical_Nomenclature : (4-methyl-2-oxochromen-7-yl) acetate

Canonical SMILES : CC1=CC(=O)OC2=C1C=CC(=C2)OC(=O)C

InChI : InChI=1S\/C12H10O4\/c1-7-5-12(14)16-11-6-9(15-8(2)13)3-4-10(7)11\/h3-6H,1-2H3

InChIKey : HXVZGASCDAGAPS-UHFFFAOYSA-N

Other name(s) : 7-Acetoxy-4-methylcoumarin,     4-methylumbelliferyl acetate,     4-Methyl-2-oxo-2H-chromen-7-yl acetate,     MUFA,     MU-Ac,     4MUA,     4MU-Ac,     4MU-C2,     4-MU-Acetate,     4-MU Acetate,     B-methylumbelliferyl acetate,     4-methylumbelliferone-acetate,     4-methylumbelliferone acetate,     4-Methyl umbelliferone acetate


MW : 218.20

Formula : C12H10O4

CAS_number : 2747-05-9

PubChem :

UniChem :

Iuphar :

References (15)

Title : Purification and Crystallographic Analysis of a Novel Cold-Active Esterase (HaEst1) from Halocynthiibacter arcticus - Jeon_2021_Crystals_11_170
Author(s) : Jeon S , Hwang J , Yoo W , Chang JW , Do H , Kim HW , Kim KK , Lee JH , Kim TD
Ref : Crystals , 11 :170 , 2021
Abstract : Jeon_2021_Crystals_11_170
ESTHER : Jeon_2021_Crystals_11_170
PubMedSearch : Jeon_2021_Crystals_11_170
PubMedID:
Gene_locus related to this paper: 9rhob-a0a126uwz8

Title : Role of an N-terminal extension in stability and catalytic activity of a hyperthermostable alpha\/beta hydrolase fold esterase - Singh_2017_Protein.Eng.Des.Sel_30_559
Author(s) : Singh MK , Shivakumaraswamy S , Gummadi SN , Manoj N
Ref : Protein Engineering Des Sel , 30 :559 , 2017
Abstract : Singh_2017_Protein.Eng.Des.Sel_30_559
ESTHER : Singh_2017_Protein.Eng.Des.Sel_30_559
PubMedSearch : Singh_2017_Protein.Eng.Des.Sel_30_559
PubMedID: 28967962
Gene_locus related to this paper: thema-TM0077

Title : An extended loop in CE7 carbohydrate esterase family is dispensable for oligomerization but required for activity and thermostability - Singh_2016_J.Struct.Biol_194_434
Author(s) : Singh MK , Manoj N
Ref : J Struct Biol , 194 :434 , 2016
Abstract : Singh_2016_J.Struct.Biol_194_434
ESTHER : Singh_2016_J.Struct.Biol_194_434
PubMedSearch : Singh_2016_J.Struct.Biol_194_434
PubMedID: 27085421
Gene_locus related to this paper: thema-TM0077

Title : Crystal structure of Thermotoga maritima acetyl esterase complex with a substrate analog: Insights into the distinctive substrate specificity in the CE7 carbohydrate esterase family - Singh_2016_Biochem.Biophys.Res.Commun_476_63
Author(s) : Singh MK , Manoj N
Ref : Biochemical & Biophysical Research Communications , 476 :63 , 2016
Abstract : Singh_2016_Biochem.Biophys.Res.Commun_476_63
ESTHER : Singh_2016_Biochem.Biophys.Res.Commun_476_63
PubMedSearch : Singh_2016_Biochem.Biophys.Res.Commun_476_63
PubMedID: 27181355
Gene_locus related to this paper: thema-TM0077

Title : Comparative study of the hydrolytic metabolism of methyl-, ethyl-, propyl-, butyl-, heptyl- and dodecylparaben by microsomes of various rat and human tissues - Ozaki_2013_Xenobiotica_43_1064
Author(s) : Ozaki H , Sugihara K , Watanabe Y , Fujino C , Uramaru N , Sone T , Ohta S , Kitamura S
Ref : Xenobiotica , 43 :1064 , 2013
Abstract : Ozaki_2013_Xenobiotica_43_1064
ESTHER : Ozaki_2013_Xenobiotica_43_1064
PubMedSearch : Ozaki_2013_Xenobiotica_43_1064
PubMedID: 23742084

Title : High-resolution crystal structure of plant carboxylesterase AeCXE1, from Actinidia eriantha, and its complex with a high-affinity inhibitor paraoxon - Ileperuma_2007_Biochemistry_46_1851
Author(s) : Ileperuma NR , Marshall SD , Squire CJ , Baker HM , Oakeshott JG , Russell RJ , Plummer KM , Newcomb RD , Baker EN
Ref : Biochemistry , 46 :1851 , 2007
Abstract : Ileperuma_2007_Biochemistry_46_1851
ESTHER : Ileperuma_2007_Biochemistry_46_1851
PubMedSearch : Ileperuma_2007_Biochemistry_46_1851
PubMedID: 17256879
Gene_locus related to this paper: actde-CXE1

Title : Expression and characterization of a human carboxylesterase 2 splice variant - Schiel_2007_J.Pharmacol.Exp.Ther_323_94
Author(s) : Schiel MA , Green SL , Davis WI , Sanghani PC , Bosron WF , Sanghani SP
Ref : Journal of Pharmacology & Experimental Therapeutics , 323 :94 , 2007
Abstract : Schiel_2007_J.Pharmacol.Exp.Ther_323_94
ESTHER : Schiel_2007_J.Pharmacol.Exp.Ther_323_94
PubMedSearch : Schiel_2007_J.Pharmacol.Exp.Ther_323_94
PubMedID: 17636009

Title : Specificity of procaine and ester hydrolysis by human, minipig, and rat skin and liver - Jewell_2007_Drug.Metab.Dispos_35_2015
Author(s) : Jewell C , Ackermann C , Payne NA , Fate G , Voorman R , Williams FM
Ref : Drug Metabolism & Disposition: The Biological Fate of Chemicals , 35 :2015 , 2007
Abstract : Jewell_2007_Drug.Metab.Dispos_35_2015
ESTHER : Jewell_2007_Drug.Metab.Dispos_35_2015
PubMedSearch : Jewell_2007_Drug.Metab.Dispos_35_2015
PubMedID: 17664252

Title : Molecular cloning, and characterization of a modular acetyl xylan esterase from the edible straw mushroom Volvariella volvacea - Ding_2007_FEMS.Microbiol.Lett_274_304
Author(s) : Ding S , Cao J , Zhou R , Zheng F
Ref : FEMS Microbiology Letters , 274 :304 , 2007
Abstract : Ding_2007_FEMS.Microbiol.Lett_274_304
ESTHER : Ding_2007_FEMS.Microbiol.Lett_274_304
PubMedSearch : Ding_2007_FEMS.Microbiol.Lett_274_304
PubMedID: 17623028

Title : Unique regulation of the active site of the serine esterase S-formylglutathione hydrolase - Cummins_2006_J.Mol.Biol_359_422
Author(s) : Cummins I , McAuley K , Fordham-Skelton A , Schwoerer R , Steel PG , Davis BG , Edwards R
Ref : Journal of Molecular Biology , 359 :422 , 2006
Abstract : Cummins_2006_J.Mol.Biol_359_422
ESTHER : Cummins_2006_J.Mol.Biol_359_422
PubMedSearch : Cummins_2006_J.Mol.Biol_359_422
PubMedID: 16626737
Gene_locus related to this paper: arath-SFGH

Title : Functional characterization of three naturally occurring single nucleotide polymorphisms in the CES2 gene encoding carboxylesterase 2 (HCE-2) - Kubo_2005_Drug.Metab.Dispos_33_1482
Author(s) : Kubo T , Kim SR , Sai K , Saito Y , Nakajima T , Matsumoto K , Saito H , Shirao K , Yamamoto N , Minami H , Ohtsu A , Yoshida T , Saijo N , Ohno Y , Ozawa S , Sawada J
Ref : Drug Metabolism & Disposition: The Biological Fate of Chemicals , 33 :1482 , 2005
Abstract : Kubo_2005_Drug.Metab.Dispos_33_1482
ESTHER : Kubo_2005_Drug.Metab.Dispos_33_1482
PubMedSearch : Kubo_2005_Drug.Metab.Dispos_33_1482
PubMedID: 16033949

Title : Identification and characterization of novel benzil (diphenylethane-1,2-dione) analogues as inhibitors of mammalian carboxylesterases - Wadkins_2005_J.Med.Chem_48_2906
Author(s) : Wadkins RM , Hyatt JL , Wei X , Yoon KJ , Wierdl M , Edwards CC , Morton CL , Obenauer JC , Damodaran K , Beroza P , Danks MK , Potter PM
Ref : Journal of Medicinal Chemistry , 48 :2906 , 2005
Abstract : Wadkins_2005_J.Med.Chem_48_2906
ESTHER : Wadkins_2005_J.Med.Chem_48_2906
PubMedSearch : Wadkins_2005_J.Med.Chem_48_2906
PubMedID: 15828829

Title : Evaluation of alpha-cyanoesters as fluorescent substrates for examining interindividual variation in general and pyrethroid-selective esterases in human liver microsomes - Wheelock_2003_Anal.Biochem_315_208
Author(s) : Wheelock CE , Wheelock AM , Zhang R , Stok JE , Morisseau C , Le Valley SE , Green CE , Hammock BD
Ref : Analytical Biochemistry , 315 :208 , 2003
Abstract : Wheelock_2003_Anal.Biochem_315_208
ESTHER : Wheelock_2003_Anal.Biochem_315_208
PubMedSearch : Wheelock_2003_Anal.Biochem_315_208
PubMedID: 12689831
Gene_locus related to this paper: mouse-Ces2e

Title : Cloning and characterization of an S-formylglutathione hydrolase from Arabidopsis thaliana - Kordic_2002_Arch.Biochem.Biophys_399_232
Author(s) : Kordic S , Cummins I , Edwards R
Ref : Archives of Biochemistry & Biophysics , 399 :232 , 2002
Abstract : Kordic_2002_Arch.Biochem.Biophys_399_232
ESTHER : Kordic_2002_Arch.Biochem.Biophys_399_232
PubMedSearch : Kordic_2002_Arch.Biochem.Biophys_399_232
PubMedID: 11888210
Gene_locus related to this paper: arath-SFGH

Title : S-formylglutathione hydrolase of Paracoccus denitrificans is homologous to human esterase D: a universal pathway for formaldehyde detoxification. - Harms_1996_J.Bacteriol_178_6296
Author(s) : Harms N , Ras J , Reijnders WNM , van Spanning RJM , Stouthamer AH
Ref : Journal of Bacteriology , 178 :6296 , 1996
Abstract : Harms_1996_J.Bacteriol_178_6296
ESTHER : Harms_1996_J.Bacteriol_178_6296
PubMedSearch : Harms_1996_J.Bacteriol_178_6296
PubMedID: 8892832
Gene_locus related to this paper: parde-FGHA