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  3. Nicotinic agonist

Nicotinic agonist

General

Not an alpha/beta hydrolase target but can be used as a building block for larger inhibitors of enzymes of the family designed as multitarget compounds
Inhibitor Main targeted enzyme families Type Structure
Naphthalen-pyridin-quinuclidin-carbamate-Cpd6b BCHE Nicotinic agonist Multitarget Naphthalen Quinuclidine Azabicyclo Carbamate Pyridine
Pyridin-quinuclidin-phenylcarbamate-Cpd7a BCHE Nicotinic agonist Multitarget Quinuclidine Carbamate Pyridine Azabicyclo
Cotinine Pectinacetylesterase-Notum Derivative of Nicotine Pyrrolidine Natural Alkaloid Drug Nicotinic agonist Not AlphaBeta Hydrolase target
BisQ ACHE Analogue of substrate Trimethylammonium Ammonium Bisquaternary Not AlphaBeta Hydrolase target Nicotinic agonist Photoswitch Diazenyl
p-phenylazophenyltrimethylammonium ACHE Photoswitch Trimethylammonium Ammonium Not AlphaBeta Hydrolase target Nicotinic agonist Diazenyl
N-p-phenylazophenylcarbamylcholine ACHE Photoswitch Trimethylammonium Ammonium Not AlphaBeta Hydrolase target Nicotinic agonist Diazenyl
Carbachol ACHE BCHE Not AlphaBeta Hydrolase target Carbamate Trimethylammonium Ammonium Analogue of substrate Drug Muscarinic agonist Nicotinic agonist
Galanthamine ACHE Derivative of Galanthamine Natural Alkaloid Drug Benzazepin Azepane Multitarget Nicotinic agonist Azocine
Nicotine ACHE BCHE Pectinacetylesterase-Notum Derivative of Nicotine Pyrrolidine Nicotinic agonist Natural Alkaloid Drug Not AlphaBeta Hydrolase target
Naphthalen-pyridin-quinuclidin-carbamate-Cpd6b BCHE Nicotinic agonist Multitarget Naphthalen Quinuclidine Azabicyclo Carbamate Pyridine
Pyridin-quinuclidin-phenylcarbamate-Cpd7a BCHE Nicotinic agonist Multitarget Quinuclidine Carbamate Pyridine Azabicyclo
Cotinine Pectinacetylesterase-Notum Derivative of Nicotine Pyrrolidine Natural Alkaloid Drug Nicotinic agonist Not AlphaBeta Hydrolase target
BisQ ACHE Analogue of substrate Trimethylammonium Ammonium Bisquaternary Not AlphaBeta Hydrolase target Nicotinic agonist Photoswitch Diazenyl
p-phenylazophenyltrimethylammonium ACHE Photoswitch Trimethylammonium Ammonium Not AlphaBeta Hydrolase target Nicotinic agonist Diazenyl
N-p-phenylazophenylcarbamylcholine ACHE Photoswitch Trimethylammonium Ammonium Not AlphaBeta Hydrolase target Nicotinic agonist Diazenyl
Carbachol ACHE BCHE Not AlphaBeta Hydrolase target Carbamate Trimethylammonium Ammonium Analogue of substrate Drug Muscarinic agonist Nicotinic agonist
Galanthamine ACHE Derivative of Galanthamine Natural Alkaloid Drug Benzazepin Azepane Multitarget Nicotinic agonist Azocine
Nicotine ACHE BCHE Pectinacetylesterase-Notum Derivative of Nicotine Pyrrolidine Nicotinic agonist Natural Alkaloid Drug Not AlphaBeta Hydrolase target
Naphthalen-pyridin-quinuclidin-carbamate-Cpd6b BCHE Nicotinic agonist Multitarget Naphthalen Quinuclidine Azabicyclo Carbamate Pyridine
Pyridin-quinuclidin-phenylcarbamate-Cpd7a BCHE Nicotinic agonist Multitarget Quinuclidine Carbamate Pyridine Azabicyclo
Cotinine Pectinacetylesterase-Notum Derivative of Nicotine Pyrrolidine Natural Alkaloid Drug Nicotinic agonist Not AlphaBeta Hydrolase target
BisQ ACHE Analogue of substrate Trimethylammonium Ammonium Bisquaternary Not AlphaBeta Hydrolase target Nicotinic agonist Photoswitch Diazenyl
p-phenylazophenyltrimethylammonium ACHE Photoswitch Trimethylammonium Ammonium Not AlphaBeta Hydrolase target Nicotinic agonist Diazenyl
N-p-phenylazophenylcarbamylcholine ACHE Photoswitch Trimethylammonium Ammonium Not AlphaBeta Hydrolase target Nicotinic agonist Diazenyl
Carbachol ACHE BCHE Not AlphaBeta Hydrolase target Carbamate Trimethylammonium Ammonium Analogue of substrate Drug Muscarinic agonist Nicotinic agonist
Galanthamine ACHE Derivative of Galanthamine Natural Alkaloid Drug Benzazepin Azepane Multitarget Nicotinic agonist Azocine
Nicotine ACHE BCHE Pectinacetylesterase-Notum Derivative of Nicotine Pyrrolidine Nicotinic agonist Natural Alkaloid Drug Not AlphaBeta Hydrolase target