| Title : Novel tacrine-based multi-target directed Ligands: Enhancing cholinesterase inhibition, NMDA receptor antagonism, and CNS bioavailability for Alzheimer's disease treatment - Svobodova_2025_Eur.J.Med.Chem_292_117678 |
| Author(s) : Svobodova B , Moravcova Z , Misiachna A , Novakova G , Marek A , Finger V , Odvarkova J , Pejchal J , Karasova JZ , Netolicky J , Ladislav M , Hrabinova M , Sorf A , Muckova L , Fikejzlova L , Benkova M , Novak M , Prchal L , Capek J , Handl J , Rousar T , Greber KE , Ciura K , Horak M , Soukup O , Korabecny J |
| Ref : Eur Journal of Medicinal Chemistry , 292 :117678 , 2025 |
| Abstract : |
| PubMedSearch : Svobodova_2025_Eur.J.Med.Chem_292_117678 |
| PubMedID: 40288120 |
| Title : Novel tacrine-based multi-target directed Ligands: Enhancing cholinesterase inhibition, NMDA receptor antagonism, and CNS bioavailability for Alzheimer's disease treatment - Svobodova_2025_Eur.J.Med.Chem_292_117678 |
| Author(s) : Svobodova B , Moravcova Z , Misiachna A , Novakova G , Marek A , Finger V , Odvarkova J , Pejchal J , Karasova JZ , Netolicky J , Ladislav M , Hrabinova M , Sorf A , Muckova L , Fikejzlova L , Benkova M , Novak M , Prchal L , Capek J , Handl J , Rousar T , Greber KE , Ciura K , Horak M , Soukup O , Korabecny J |
| Ref : Eur Journal of Medicinal Chemistry , 292 :117678 , 2025 |
| Abstract : |
| PubMedSearch : Svobodova_2025_Eur.J.Med.Chem_292_117678 |
| PubMedID: 40288120 |
| Title : Novel tacrine-based multi-target directed Ligands: Enhancing cholinesterase inhibition, NMDA receptor antagonism, and CNS bioavailability for Alzheimer's disease treatment - Svobodova_2025_Eur.J.Med.Chem_292_117678 |
| Author(s) : Svobodova B , Moravcova Z , Misiachna A , Novakova G , Marek A , Finger V , Odvarkova J , Pejchal J , Karasova JZ , Netolicky J , Ladislav M , Hrabinova M , Sorf A , Muckova L , Fikejzlova L , Benkova M , Novak M , Prchal L , Capek J , Handl J , Rousar T , Greber KE , Ciura K , Horak M , Soukup O , Korabecny J |
| Ref : Eur Journal of Medicinal Chemistry , 292 :117678 , 2025 |
| Abstract : |
| PubMedSearch : Svobodova_2025_Eur.J.Med.Chem_292_117678 |
| PubMedID: 40288120 |
| Title : Multifunctional, fluorene-based modulator of cholinergic and GABAergic neurotransmission as a novel drug candidate for palliative treatment of Alzheimer's disease - Panek_2024_Angew.Chem.Int.Ed.Engl__e202420510 |
| Author(s) : Panek D , Pasieka A , Jonczyk JJ , Gawlinska M , Zareba P , Siwek A , Wolak M , Mordyl B , Gluch-Lutwin M , Latacz G , Brazzolotto X , Chantegreil F , Nachon F , Zdarova Karasova J , Pejchal J , Mzik M , Sestak V , Prchal L , Odvarkova J , Soukup O , Korabecny J , Sorf A , Hamsikova M , Zemanova L , Muckova L , Vanova N , Dryja P , Salat K , Hofner G , Wanner K , Wieckowska A , Malawska B |
| Ref : Angew Chem Int Ed Engl , :e202420510 , 2024 |
| Abstract : |
| PubMedSearch : Panek_2024_Angew.Chem.Int.Ed.Engl__e202420510 |
| PubMedID: 39523866 |
| Gene_locus related to this paper: human-BCHE |
| Title : Multifunctional, fluorene-based modulator of cholinergic and GABAergic neurotransmission as a novel drug candidate for palliative treatment of Alzheimer's disease - Panek_2024_Angew.Chem.Int.Ed.Engl__e202420510 |
| Author(s) : Panek D , Pasieka A , Jonczyk JJ , Gawlinska M , Zareba P , Siwek A , Wolak M , Mordyl B , Gluch-Lutwin M , Latacz G , Brazzolotto X , Chantegreil F , Nachon F , Zdarova Karasova J , Pejchal J , Mzik M , Sestak V , Prchal L , Odvarkova J , Soukup O , Korabecny J , Sorf A , Hamsikova M , Zemanova L , Muckova L , Vanova N , Dryja P , Salat K , Hofner G , Wanner K , Wieckowska A , Malawska B |
| Ref : Angew Chem Int Ed Engl , :e202420510 , 2024 |
| Abstract : |
| PubMedSearch : Panek_2024_Angew.Chem.Int.Ed.Engl__e202420510 |
| PubMedID: 39523866 |
| Gene_locus related to this paper: human-BCHE |
| Title : Multifunctional, fluorene-based modulator of cholinergic and GABAergic neurotransmission as a novel drug candidate for palliative treatment of Alzheimer's disease - Panek_2024_Angew.Chem.Int.Ed.Engl__e202420510 |
| Author(s) : Panek D , Pasieka A , Jonczyk JJ , Gawlinska M , Zareba P , Siwek A , Wolak M , Mordyl B , Gluch-Lutwin M , Latacz G , Brazzolotto X , Chantegreil F , Nachon F , Zdarova Karasova J , Pejchal J , Mzik M , Sestak V , Prchal L , Odvarkova J , Soukup O , Korabecny J , Sorf A , Hamsikova M , Zemanova L , Muckova L , Vanova N , Dryja P , Salat K , Hofner G , Wanner K , Wieckowska A , Malawska B |
| Ref : Angew Chem Int Ed Engl , :e202420510 , 2024 |
| Abstract : |
| PubMedSearch : Panek_2024_Angew.Chem.Int.Ed.Engl__e202420510 |
| PubMedID: 39523866 |
| Gene_locus related to this paper: human-BCHE |