Egea J

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Title : New Dual Small Molecules for Alzheimer's Disease Therapy Combining Histamine H3 Receptor (H3R) Antagonism and Calcium Channels Blockade with Additional Cholinesterase Inhibition - Malek_2019_J.Med.Chem_62_11416
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Title : QuinoxalineTacrine QT78, a Cholinesterase Inhibitor as a Potential Ligand for Alzheimer's Disease Therapy - Ramos_2019_Molecules_24_
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Title : Multitarget-Directed Ligands Combining Cholinesterase and Monoamine Oxidase Inhibition with Histamine H3 R Antagonism for Neurodegenerative Diseases - Bautista-Aguilera_2017_Angew.Chem.Int.Ed.Engl_56_12765
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Title : Subthreshold Concentrations of Melatonin and Galantamine Improves Pathological AD-Hallmarks in Hippocampal Organotypic Cultures - Buendia_2016_Mol.Neurobiol_53_3338
Author(s) : Buendia I , Parada E , Navarro E , Leon R , Negredo P , Egea J , Lopez MG
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Title : The Antioxidant Additive Approach for Alzheimer's Disease Therapy: New Ferulic (Lipoic) Acid Plus Melatonin Modified Tacrines as Cholinesterases Inhibitors, Direct Antioxidants, and Nuclear Factor (Erythroid-Derived 2)-Like 2 Activators - Benchekroun_2016_J.Med.Chem_59_9967
Author(s) : Benchekroun M , Romero A , Egea J , Leon R , Michalska P , Buendia I , Jimeno ML , Jun D , Janockova J , Sepsova V , Soukup O , Bautista-Aguilera OM , Refouvelet B , Ouari O , Marco-Contelles J , Ismaili L
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Title : Novel Tacrine-Benzofuran Hybrids as Potent Multitarget-Directed Ligands for the Treatment of Alzheimer's Disease: Design, Synthesis, Biological Evaluation, and X-ray Crystallography - Zha_2016_J.Med.Chem_59_114
Author(s) : Zha X , Lamba D , Zhang L , Lou Y , Xu C , Kang D , Chen L , Xu Y , De Simone A , Samez S , Pesaresi A , Stojan J , Lopez MG , Egea J , Andrisano V , Bartolini M
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Gene_locus related to this paper: torca-ACHE

Title : Poster: Importance of microglial alpha7 nicotinic receptors in neuroprotection: The central cholinergic anti-inflammatory pathway -
Author(s) : Lopez MG , Parada E , Egea J
Ref : Biochemical Pharmacology , 97 :625 , 2015
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Title : Novel tacrine-grafted ugi adducts as multipotent anti-Alzheimer drugs: a synthetic renewal in tacrine-ferulic Acid hybrids - Benchekroun_2015_ChemMedChem_10_523
Author(s) : Benchekroun M , Bartolini M , Egea J , Romero A , Soriano E , Pudlo M , Luzet V , Andrisano V , Jimeno ML , Lopez MG , Wehle S , Gharbi T , Refouvelet B , de Andres L , Herrera-Arozamena C , Monti B , Bolognesi ML , Rodriguez-Franco MI , Decker M , Marco-Contelles J , Ismaili L
Ref : ChemMedChem , 10 :523 , 2015
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Title : Anti-inflammatory role of microglial alpha7 nAChRs and its role in neuroprotection - Egea_2015_Biochem.Pharmacol_97(4)_463
Author(s) : Egea J , Buendia I , Parada E , Navarro E , Leon R , Lopez MG
Ref : Biochemical Pharmacology , 97 :463 , 2015
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Title : Alpha7 nicotinic receptor activation protects against oxidative stress via heme-oxygenase I induction - Navarro_2015_Biochem.Pharmacol_97(4)_473
Author(s) : Navarro E , Buendia I , Parada E , Leon R , Jansen-Duerr P , Pircher H , Egea J , Lopez MG
Ref : Biochemical Pharmacology , 97 :473 , 2015
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Title : Synthesis and biological assessment of diversely substituted furo[2,3-b]quinolin-4-amine and pyrrolo[2,3-b]quinolin-4-amine derivatives, as novel tacrine analogues - Martins_2011_Eur.J.Med.Chem_46_6119
Author(s) : Martins C , Carreiras MC , Leon R , de los Rios C , Bartolini M , Andrisano V , Iriepa I , Moraleda I , Galvez E , Garcia M , Egea J , Samadi A , Chioua M , Marco-Contelles J
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Title : Neurotoxicity induced by okadaic acid in the human neuroblastoma SH-SY5Y line can be differentially prevented by alpha7 and beta2* nicotinic stimulation - Del Barrio_2011_Toxicol.Sci_123_193
Author(s) : Del Barrio L , Martin-de-Saavedra MD , Romero A , Parada E , Egea J , Avila J , McIntosh JM , Wonnacott S , Lopez MG
Ref : Toxicol Sci , 123 :193 , 2011
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Title : N-acylaminophenothiazines: neuroprotective agents displaying multifunctional activities for a potential treatment of Alzheimer's disease - Gonzalez-Munoz_2011_Eur.J.Med.Chem_46_2224
Author(s) : Gonzalez-Munoz GC , Arce MP , Lopez B , Perez C , Romero A , Del Barrio L , Martin-de-Saavedra MD , Egea J , Leon R , Villarroya M , Lopez MG , Garcia AG , Conde S , Rodriguez-Franco MI
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Title : 1,8-Naphthyridine derivatives as cholinesterases inhibitors and cell Ca2+ regulators, a multitarget strategy for Alzheimer's disease - Egea_2011_Curr.Top.Med.Chem_11_2807
Author(s) : Egea J , de los Rios C
Ref : Curr Top Med Chem , 11 :2807 , 2011
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Title : Synthesis, inhibitory activity of cholinesterases, and neuroprotective profile of novel 1,8-naphthyridine derivatives - de Los Rios_2010_J.Med.Chem_53_5129
Author(s) : de los Rios C , Egea J , Marco-Contelles J , Leon R , Samadi A , Iriepa I , Moraleda I , Galvez E , Garcia AG , Lopez MG , Villarroya M , Romero A
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Title : Synergistic neuroprotective effect of combined low concentrations of galantamine and melatonin against oxidative stress in SH-SY5Y neuroblastoma cells - Romero_2010_J.Pineal.Res_49_141
Author(s) : Romero A , Egea J , Garcia AG , Lopez MG
Ref : J Pineal Res , 49 :141 , 2010
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Title : Desensitized nicotinic receptors that, however, afford cytoprotection in bovine chromaffin cells - Egea_2006_J.Mol.Neurosci_30_59
Author(s) : Egea J , Hernandez-Guijo JM , Olivares R , Lopez MG , Garcia AG
Ref : Journal of Molecular Neuroscience , 30 :59 , 2006
PubMedID: 17192627

Title : Neuroprotection by nicotine in hippocampal slices subjected to oxygen-glucose deprivation: involvement of the alpha7 nAChR subtype - Rosa_2006_J.Mol.Neurosci_30_61
Author(s) : Rosa AO , Egea J , Gandia L , Lopez MG , Garcia AG
Ref : Journal of Molecular Neuroscience , 30 :61 , 2006
PubMedID: 17192628

Title : Enhancement of secretion by threshold nicotinic stimulation in bovine chromaffin cells - Tapia_2006_J.Mol.Neurosci_30_81
Author(s) : Tapia L , Eguiagaray JG , Egea J , Garcia AG , Gandia L
Ref : Journal of Molecular Neuroscience , 30 :81 , 2006
PubMedID: 17192638

Title : Galantamine and memantine produce different degrees of neuroprotection in rat hippocampal slices subjected to oxygen-glucose deprivation - Sobrado_2004_Neurosci.Lett_365_132
Author(s) : Sobrado M , Roda JM , Lopez MG , Egea J , Garcia AG
Ref : Neuroscience Letters , 365 :132 , 2004
PubMedID: 15245794